Adding a certain compound to certain chemical reactions, such as: 32779-37-6, 2,5-Dibromopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 32779-37-6, blongs to pyrimidines compound. Formula: C4H2Br2N2
General procedure: In a dry sealed tube under argon were placed, to a solution of 1-Boc-piperazine (5.04 mmol), potassium carbonate (13.1 mmol) in acetonitrile (12.6 mL) was added 2,5-dibromo pyrimidine13(5.04 mmol). The mixture was allowed to stir at 80 C for 12 h. After completion of the reaction (monitored by TLC), the mixture was then cooled at room temperature, then it was quenched with saturated aqueous NH4Cl (10 mL) and extracted with EtOAc. The organic layers were dried over anhydrous MgSO4and concentrated in vacuo. The resulting residue was purified by flash column chromatography on silica gel (EtOAc:n-hexane = 1:8) to afford piperazine11a. tert-Butyl 4-(5-bromopyrimidin-2-yl)piperazine-1-carboxylate(11a): Yield: 88%;1H-NMR (400 MHz, CDCl3)delta8.30 (s,J= 2.0 Hz, 2H), 3.78-3.75 (t,J= 5.2 Hz, 4H), 3.49-3.47 (t,J= 5.2 Hz, 4H), 1.48 (s, 9H).13C-NMR (100 MHz, CD3OD)delta161.2, 159.2, 156.46, 107.15, 81.5, 44.8, 28.6.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,32779-37-6, its application will become more common.
Reference:
Article; Kim, Juhyeon; Kim, Yoon Jung; Londhe, Ashwini M.; Pae, Ae Nim; Choo, Hyunah; Kim, Hak Joong; Min, Sun-Joon; Molecules; vol. 24; 18; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia