Day: November 13, 2020

289042-12-2, Adding some certain compound to certain chemical reactions, such as: 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate,molecular formula is C29H40FN3O6S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 289042-12-2.

Preparation of LDA: To a 500 mL three-necked flask was added 5.75 g of diisopropylamine and 180 mL of THF, three times with nitrogen, nitrogenGas protection, the temperature to -25 (internal temperature), slowly dropping n-BuLi, keep the internal temperature is not higher than -20 , after the dropTo -10 C, continue stirring for 30min, that is, LDA.A solution of ROS01 (10 g) in tetrahydrofuran (50 mL) was cooled to below -70 C, and freshly prepared bisSolution of lithium isopropylamide in tetrahydrofuran was added dropwise. After stirring for 30 min, 1.6 mL of acetone was slowly added dropwise.60min after the addition of 10mL of acetone, reaction 30min, then add 5mL of acetone, the reaction is completed, add 80mL saturated ammonium chlorideThe solution was quenched, separated, and the tetrahydrofuran phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, evaporated to dryness,The crude product was purified by column chromatography (ethyl acetate: petroleum ether = 4: 1) to give the title compound, 4.93 g, 45% yield.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 289042-12-2.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Zhang Zhenfeng; Chen Zhijun; Liu Daobo; Li Dasheng; (8 pag.)CN104557885; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

213265-83-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine, molecular formula is C4HCl2FN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Ethyl 5-aminobenzo [b] selenophene-2-carboxylate (1 eq), 4,6-dichloro-5-fluoropyrimidine (3eq)Was dissolved in ethanolUsing a microwave reactor, stir three times for 30 min at 80 C.After completion of the reaction,Solvent was removed from the rotary evaporator and colum.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 213265-83-9, 4,6-Dichloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INDUSTRY ACADEMY COOPERATION FOUNDATION OF SEJONG UNIVERSITY; SAMSUNG LIFE PUBLIC WELFARE FOUNDATION; LIM, DONG-YEOL; CHOI, HONG-LIM; Metrea, Amul; Heo, Su-Yang; Kim, Sun-Young; Nam, Do-Hyun; (55 pag.)KR2017/41562; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 2380-63-4, blongs to pyrimidines compound. 2380-63-4

NIS(1.1eq, 4.95 g, 22 mmol) was slowly added into the mixture of 9(1eq, 2.70 g, 20 mmol) and DMF (50 mL) at r.t. The reaction mixturewas continued stirred at r.t. overnight. The solvent was removed invacuo and water was added. The mixture was subjected to sonicationfor 10 min. The precipitate was collected by filtration, rinsedwith water, and dried. The solid 10 was used for the next stepwithout further purification (5.01 g, 96% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,2380-63-4, its application will become more common.

Reference:
Article; He, Linhong; Pei, Heying; Zhang, Chufeng; Shao, Mingfeng; Li, Dan; Tang, Mingli; Wang, Taijing; Chen, Xiaoxin; Xiang, Mingli; Chen, Lijuan; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 96 – 112;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

3680-71-5, A common compound: 3680-71-5, name is 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one,molecular formula is C6H5N3O, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Phosphorous oxychloride (20 mL) was added to 7H-pyrrolo[2,3-d]pyrimidine-4-ol?(1.15 g, 8.5 mmol) and the reaction was heated under N2?atmosphere to 100 ¡ãC for 2.5 hours. The initial suspension becomes?an?homogeneous dark liquid which was then allowed to cool to room temperature. Excess phosphorous oxychloride was removed?in vacuo?and the residue was cooled in ice bath and crushed ice was added with stirring. The mixture was diluted with water (20 mL) and extracted with ethyl acetate (2 x 30 mL). The combined organic extracts were washed with sat NaCl (aq) solution,?then?dried over anhydrous Na2SO4. Mixture was filtered and filtrate solvents removed in vacuo to afford the title compound as a white solid (0.811 g; (62percent):?LC/MS: RT = 1.619 min;?m/z?= 154 [M+H]+.?Total run time 3.75 mins;?1H NMR (d6?DMSO):?d?6.60 (dd, 1H, J = 3.5, 1.8Hz); 7.69 (dd, 1H, J = 3.6, 2.3 Hz); 8.59 (s,1H), 12.57 (brs 1H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3680-71-5.

Reference:
Article; Davies, Nicholas G.M.; Browne, Helen; Davis, Ben; Drysdale, Martin J.; Foloppe, Nicolas; Geoffrey, Stephanie; Gibbons, Ben; Hart, Terance; Hubbard, Roderick; Jensen, Michael Rugaard; Mansell, Howard; Massey, Andrew; Matassova, Natalia; Moore, Jonathan D.; Murray, James; Pratt, Robert; Ray, Stuart; Robertson, Alan; Roughley, Stephen D.; Schoepfer, Joseph; Scriven, Kirsten; Simmonite, Heather; Stokes, Stephen; Surgenor, Allan; Webb, Paul; Wood, Mike; Wright, Lisa; Brough, Paul; Bioorganic and Medicinal Chemistry; vol. 20; 22; (2012); p. 6770 – 6789;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

147118-40-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 147118-40-9, name is Rosuvastatin methyl ester. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 16 (149 mg, 0.3 mmol) in MeOH (2 mL) at 0 ¡ãC was added NaOH (0.36 mL, 1.0 M, 0.36 mmol), then reacted at 0 ¡ãC for 1 h before being added the solution of CaCl2 (1.5 mL, 0.2 M, 0.3 mmol). The mixture was stirred at 20 ¡ãC for 0.5 h before filtrated the resulting white slurry, washed, and dried in vacuum to afford 1 (133 mg, 89percent) as a white powder; mp 145-149 ¡ãC, lit. 17 mp 145-150 ¡ãC; [a]D14.5 7.3 (c 0.5, CHCl3); 1H NMR (400 MHz, CDCl3) d 1.20 (d, J=6.0 Hz, 6H), 1.28-1.36 (m, 1H), 1.47-1.54 (m, 1H), 1.97-2.03 (m, 1H), 2.12-2.16 (m, 1H), 3.36-3.43 (m, 1H), 3.43 (s,3H), 3.54 (s, 3H), 3.76 (m, 1H), 4.20 (m, 1H), 5.52 (dd, J=5.6, 16.0 Hz, 1H), 6.50 (d, J=16.0 Hz, 1H), 7.27 (t, J=8.4 Hz, 2H), 7.70 (dd, J=6.0,8.0 Hz, 2H); MS (ESI): m/z 482 (acid, MH), 504 (acid, MNa); IR (KBr): 3376, 2973, 2931, 2875, 1604, 1548, 1442, 1073, 968, 844, 776 cm-1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 147118-40-9, Rosuvastatin methyl ester.

Reference:
Article; Chen, Xiaofei; Xiong, Fangjun; Zheng, Chen; Li, Jie; Chen, Fener; Tetrahedron; vol. 70; 35; (2014); p. 5794 – 5799;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

32779-36-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 32779-36-5, name is 5-Bromo-2-chloropyrimidine, molecular formula is C4H2BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: To a solution of 5-bromo-2-chloropyrimidine (2.3 g, 11.9 mmol) and aniline (1.5 mL, 16.1 mmol) in n-BuOH (20 mL) was added DIEA (2 mL, 12,8 mmol). The mixture was stirred at 110-120 C overnight, then cooled to rt and concentrated to dryness to afford 5- bromo-N-phenylpyrimidin-2-amine as a brown solid (2.0 g, 70%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 32779-36-5, 5-Bromo-2-chloropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PLEXXIKON INC.; HOLLADAY, Mark W.; LIU, Gang; (267 pag.)WO2017/19804; (2017); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

137281-39-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 137281-39-1, name is 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid. A new synthetic method of this compound is introduced below.

Example -1: Preparation of Pemetrexed Dimethyl ester of Formula V (R=methyl)4-(2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid (lOg, 0.034 moles) and N,N-dimethylformamide (50 mL) were stirred for 10-15 minutes under nitrogen atmosphere at room temperature and the reaction mass was cooled to 0 – 5C. 1 -Hydroxybenzotriazole (4.53g) and l-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (6.43) was added at 0 -5C and the reaction mass was maintained for 1-2 hours at 0 – 5C. Then L- glutamic acid dimethyl ester Hydrochloride (8.50g, 0.040 moles) and Diisopropyl ethylamine (4.34g) was then added to reaction mass at 0-5C and the temperature was raised to room temperature. The reaction mass was stirred at room temperature for 2-3 hours and DM Water (500ml) was added. The reaction mass was stirred at room temperature for 10-15 hours. The product was thus filtered under vacuum was crystallized with methanol: acetone mixture and Methanol and Dichloromethane mixture. The product was dried under vacuum oven at 50- 55C for 10-15 hours. Yield (w/w) : 12.5gYield (%) : 80.4%Purity : 98.0%

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 137281-39-1, 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; FRESENIUS KABI ONCOLOGY LTD.; SINGH, Govind; GIRIGANI, Sathyanarayana; KUMAR, Sruzen, Suneel; LAHIRI, Saswata; BUBEY, Sushil, Kumar; WO2012/56285; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

5909-24-0, Adding a certain compound to certain chemical reactions, such as: 5909-24-0, Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5909-24-0, blongs to pyrimidines compound.

step 1: To ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate (370.0 g, 1.59 mol) in DCM (7.4 L) at -78 C. was added diisobutylaluminum hydride (1.5 M in toluene, 2.1 L, 3.18 mol). The reaction mixture was allowed to warm to 0 C. over 2 h. To the reaction was added a 20% Rochelle’s salt solution (5.0 L). The emulsion was stirred for 30 min. The mixture was filtered through a bed of CELITE. The organic layer was separated and the aqueous layer extracted with EtOAc (1.0 L¡Á3). The combined organic layers were dried ((Na2SO4)), filtered, and concentrated in vacuo to give the crude product (4-chloro-2-(methylthio)pyrimidin-5-yl)methanol as a solid. The crude product was purified by SiO2 chromatography eluting with DCM/EtOAc (1:1) to afford the pure product (4-chloro-2-(methylthio)pyrimidin-5-yl)methanol (133.0 g, 44.0%) as a solid. 1H NMR (400 MHz, CDCl3) delta 8.55 (s, 1H), 4.74 (s, 2H), 2.58 (s, 3H); MS: 191 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5909-24-0, its application will become more common.

Reference:
Patent; GENENTECH, INC.; Rudolph, Joachim; Gazzard, Lewis J.; Crawford, James J.; Ndubaku, Chudi; Drobnick, Joy; Lee, Wendy; US2015/31674; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 36315-01-2

STR163 A mixture of 15.5 g (0.1 mole) of 2-amino-4,6-dimethoxy-pyrimidine, 13.1 g (0.1 mole) of ethoxycarbonyl isothiocyanate and 200 ml of acetonitrile is stirred at 60 C. for 2 hours. It is then cooled to 10 C. and the product obtained as crystals is isolated by filtration with suction. 22.5 g (79% of theory) of 1-(ethoxycarbonyl)-3-(4,6-dimethoxy-pyrimidin-2-yl)-thiourea of melting point 194 C. (decomposition) are obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 36315-01-2, 2-Amino-4,6-dimethoxypyrimidine.

Reference:
Patent; Bayer Aktiengesellschaft; US4658027; (1987); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The common heterocyclic compound, 49845-33-2, name is 2,4-Dichloro-5-nitropyrimidine, molecular formula is C4HCl2N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route. 49845-33-2

A mixture of 2,4-dichloro-5-nitropyrimidine (3.86 g, 20 mmol)Iron powder (5.6 g, 100 mmol)Was added to glacial acetic acid (50 mL)Stir at room temperature for 6 h.Add ethyl acetate to dilute,Filter,The filtrate was washed with saturated aqueous sodium carbonate solution,Saturated salt water wash,dry,Spin dry,To give a crude product of 3.3 g.

The synthetic route of 49845-33-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KBP Biosciences Co., Ltd.; Zhang, Qian; Zhang, Yan; (50 pag.)CN103864792; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia