Day: November 26, 2020

213265-83-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 213265-83-9, name is 4,6-Dichloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Fluoxastrobin may further be prepared as described in Scheme 3. Particularly, 4,6-dichloro-5-fluoropyrimidine (5) is reacted with 2-chiorophenol in an appropriate solvent and in the presence of a suitable base to give intermediate 4-chloro-6-(2-chlorophenoxy)-5-fluoropyrimidine (17) which is further reacted with (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime (13) to give fluoxastrobin.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 213265-83-9, 4,6-Dichloro-5-fluoropyrimidine.

Reference:
Patent; ARYSTA LIFESCIENCE CORPORATION; PRASAD, Vic; HINDUPUR, Rama Mohan; MANE, Avinash Sheshrao; BALAKRISHNAN, Sankar; PAWAR, Jivan Dhanraj; MADDANI, Mahagundappa Rachappa; WADHWA, Sandeep; WO2015/6203; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

1722-12-9 , The common heterocyclic compound, 1722-12-9, name is 2-Chloropyrimidine, molecular formula is C4H3ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: K3PO4 (5.62 mmol) in DMSO (4 mL), were added Cu(OAc)2 (0.28 mmol). The flask was evacuatedand backfilled with argon for three times. The resulting suspension was heated in a 80 C oil bathwith stirring for the indicated time. The reactor was cooled to r.t., the flask was opened to air and thereaction mixture was poured into water (20 mL), extracted with ethyl acetate (20 mL ¡Á 3), andorganic layer was washed with water (20 mL ¡Á 2) and once with brine (25 mL), dried overmagnesium sulfate and concentrated in vacuo. The product was purified by column chromatographyon silica gel using petroleum ether and ethyl acetate as eluent.1-(2-Methoxyphenyl)-1H-pyrrole (3a) [30]: colorless oil (0.43 g, 88%). 1H-NMR (400 MHz, CDCl3) delta (ppm):7.30-7.23 (2H, m), 7.03-6.98 (4H, m), 6.30 (2H,

According to the analysis of related databases, 1722-12-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Yuan, Chunling; Zhang, Lei; Zhao, Yingdai; Molecules; vol. 24; 22; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36315-01-2, name is 2-Amino-4,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows. 36315-01-2

General procedure: The complexes were prepared by the following general method [26]. 25mL methanol solution of ligand was added to antimony(III) halides dissolved in the same solvent in the mole ratio of 2:1 in hydrochloric acid. The mixture was refluxed for 2days at 60C, after that the mixture was concentrated to 1/3 of its initial volume and allowed to stand for crystallization at room temperature. The obtained colorless, yellow and pink crystals were filtered and dried in air.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 36315-01-2, 2-Amino-4,6-dimethoxypyrimidine.

Reference:
Article; Tunc?, Turgay; Koc?, Yasemin; Ac?ik, Leyla; Karacan, Mehmet Sayim; Karacan, Nurcan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 136; PC; (2015); p. 1418 – 1427;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

1004-40-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1004-40-6, name is 6-Amino-4-hydroxy-2-mercaptopyrimidine, molecular formula is C4H5N3OS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Anhydrous potassium carbonate (1.3821 g, 10 mmol) and substituted phenacyl halides (10 mmol) were added in succession to a suspension of 6-substituted-2-thiouracils(10 mmol) in dry N,N-dimethylformamide (10 mL). After stirring for 3 h at room temperature, the mixture was quenched with water (100 mL) and filtered. The resulting solid was crystallized from a suitable solvent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Cai, Dong; Zhang, Zhi-Hua; Chen, Yu; Yan, Xin-Jia; Zhang, Shi-Ti; Zou, Liang-Jing; Meng, Li-Hong; Li, Fang; Fu, Bing-Jie; Medicinal Chemistry Research; vol. 25; 2; (2016); p. 292 – 302;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

A common compound: 7752-82-1, name is 5-Bromopyrimidin-2-amine,molecular formula is C4H4BrN3, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below., 7752-82-1

Conditions B (procedure using an in situ prepared boronic or boronate partner, see example 9) The halogenated substrate (1 eq), bis(pinacolato)diboron (1-2 eq), a suitable base (usually potassium acetate (1-6 eq), a suitable palladium catalyst with its ligands (usually Pd(dppf)Cl2.DCM 1-30 mol%) are stirred in a degassed solvent (usually dimethylformamide) at 60-120C for 1-16h under argon. After cooling down to room temperature, the halogenated tricyclic template (3-(7-bromo-imidazo[1,2-a]quinoxalin-4-ylamino)-propan-1-ol or 3-(7-iodo-imidazo[1,2-a]quinoxalin-4-ylamino)-propan-1-ol) (0.5 eq) is added with base (usually an aqueous solution of sodium or potassium carbonate, 1-6 eq) and a suitable palladium catalyst (usually Pd(PPh3)4 1-30 mol%). The resulting mixture is stirred under argon at 60-120C for 2 to 48h. Concentration, partition (water / ethyl acetate), extraction of the aqueous phase (ethyl acetate), reunion of the organic phases, drying over sodium or magnesium sulfate and purification by flash chromatography or prep TLC over silicagel using a suitable eluent (usually a mixture dichloromethane / methanol or cyclohexane / ethyl acetate or dichloromethane / ethyl acetate or dichloromethane / methanol / ammonia) affords the desired compound. The following examples were prepared according to these procedures. The following table provides a summary of the operating conditions. Example 20: 3-{[1-(2-aminopyrimidin-5-yl)-7-(trifluoromethyl)imidazo[1,2-a]quinoxalin-4-yl]amino}propan-1-ol [Show Image] Prepared as mentioned beforehand 1H NMR (DMSO-d6), delta (ppm): 8.45 (s, 2H), 8.05 (t, J = 5.7 Hz, 1 H), 7.82 (s, 1 H), 7.66 (d, J = 8.6 Hz, 1 H), 7.58 (s, 1 H), 7.45 (d, J = 8.6 Hz, 1H), 7.15 (s, 2H), 4.62 (t, J = 5.1 Hz, 1 H), 3.65 (q, J = 6.3 Hz, 2H), 3.54 (q, J = 6.0 Hz, 2H), 1.84 (qt, J = 6.6 Hz, 2H) ESI-MS m/z 404 (M+H)+

With the rapid development of chemical substances, we look forward to future research findings about 7752-82-1.

Reference:
Patent; Mutabilis SA; EP1972629; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

271-80-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 271-80-7, name is 1H-Pyrazolo[3,4-d]pyrimidine, molecular formula is C5H4N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

520 mg (4.331 mmol) of 1H-pyrazolo[3,4-d]pyrimidine and 1.461 g (6.496 mmol) of N-iodosuccinimide were dissolved in 10 ml of DMF and the mixture was heated at 80 C. for 3 h. After cooling, the mixture was concentrated on a rotary evaporator and the residue was stirred with dichloromethane, filtered off with suction and dried under high vacuum. 569 mg (53% of theory) of the target compound were obtained. LC-MS (Method 3): Rt=1.23 min; MS (ESIpos): m/z=247 (M+H)+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 271-80-7, 1H-Pyrazolo[3,4-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; FOLLMANN, Markus; STASCH, Johannes-Peter; REDLICH, Gorden; GRIEBENOW, Nils; LANG, Dieter; WUNDER, Frank; PAULSEN, Holger; Huebsch, Walter; US2013/210824; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

96702-03-3 ,Some common heterocyclic compound, 96702-03-3, molecular formula is C6H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 8 6-Carboxy-2-methyl-1,4,5,6-tetrahydropyrimidinium palmitate 20 g of ectoin are dissolved in 25 ml of water in a 250 ml plastic beaker with magnetic stirrer, and 36.894 g of palmitic acid are subsequently added at room temperature with stirring. This reaction mixture is stirred at room temperature for a further half an hour and subsequently evaporated to dryness in a rotary evaporator with a water bath at about 90 C., leaving a white solid. Melting point 61 C.

According to the analysis of related databases, 96702-03-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GESELLSCHAFT; US2011/152292; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 591-55-9 as follows., 591-55-9

Example 4 3-Cyclopentyl-3-(4-(2-(pyrimidin-5-ylamino)thieno[3,2-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile T-04 Synthetic Route Preparation of Compound T-04 To a solution of compound 3 (50 mg, 0.14 mmol) and 5-aminopyrimidine (40 mg, 0.42 mmol) in isobutanol (0.5 mL) was added p-toluene sulfonic acid monohydrate (53 mg, 0.28 mmol). The mixture was heated to 110 C. and stirred for 16 hours. The mixture was then concentrated in vacuum and the residue was purified by preparation HPLC (mobile phase:acetonitrile, water (0.05% trifluoroacetic acid); gradient: 60%-90%-10%) to give compound T-04 (7 mg, yield: 12%) as a yellow solid. LC-MS (ESI): m/z=417 [M+H]+.1H-NMR (400 MHz, CD3OD) delta: 9.37 (s, 2H), 8.76 (s, 1H), 8.65 (s, 1H), 8.41 (s, 1H), 8.21 (d, J=6 Hz, 1H), 7.43 (d, J=6 Hz, 1H), 4.53 (m, 1H), 3.123.28 (m, 2H), 2.56 (m, 1H), 1.97 (m, 1H), 1.411.72 (m, 7H) ppm

The chemical industry reduces the impact on the environment during synthesis 591-55-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SHANGHAI CHEMEXPLORER CO., LTD.; XU, Zusheng; ZHANG, Nong; SUN, Qingrui; WANG, Tinghan; US2015/336982; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

137281-39-1, Adding a certain compound to certain chemical reactions, such as: 137281-39-1, 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 137281-39-1, blongs to pyrimidines compound.

4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic acid(64,6g 0.19mol) was added to a 1L four-neck bottle.Add 650 ml of DMF and stir to dissolve, and warm to 50 C.Add 0.38 mol of N,N-carbonyldiimidazole, and incubate at 60 C for 2 hours.Add L-glutamic acid diethyl ester (0.38 mol), and raise the temperature to 80 C for 3 hours.Evaporated to dryness under reduced pressure, and dissolved in 800 ml of dichloromethane.Pour into a mixed solution of 1600 ml of pure water and 160 ml of triethylamine, and mix and discard.The organic phase was separated and washed twice with pure water 1600 ml X 2 .Dry and evaporated to dryness, add 500 ml of absolute ethanol and stir to dissolve.72 g of water p-toluenesulfonic acid and 200 ml of absolute ethanol solution were added dropwise under reflux.After the addition, reflux reaction for 1 hour, cooling and crystallization,The mixture was suction filtered and dried to give a crude material (yield: 77.2 g (yield: 70.1%, purity: 92.3%, impurity V content: 6.52%).Add 87.2 g of the above crude product to a three-neck reaction flask.Add 350 ml of N,N-dimethylformamide,Heat to 40-45C to stir and dissolve. After total dissolution, add 700ml of absolute ethanol.The solid was slowly precipitated, cooled to room temperature, and stirred for 1-2 h.The solid obtained by filtration was 69.8 g, and the yield was 80.0%.The above-mentioned refining operation was repeated once to obtain a solid 55.4 g (purity 98.2%, impurity V includedThe amount is 0.07%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,137281-39-1, its application will become more common.

Reference:
Patent; Lunan Pharmaceutical Group Co., Ltd.; Zang Chao; Xia Mingjun; (11 pag.)CN110305136; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 32779-36-5, 5-Bromo-2-chloropyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 32779-36-5, blongs to pyrimidines compound. 32779-36-5

In a pressure tube with one end sealed, add 193 mg 5-bromo-2-chloropyrimidine (1.0 mmol) and 285 mg cyclopropylamine (5.0 mmol) in 3.0 mL ethanol, and the mixture is heated to 80 ¡ãCand stirred for 3 h. The reaction mixture was cooled to room temperature, and 203 mg solid product was collected by filitration for direct useyield: 95percent).MS (ESI), m/z: 215 (M+?+ H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,32779-36-5, its application will become more common.

Reference:
Patent; Guangzhou Institute Of Biomedicine And Health, Chinese Academy Of Sciences; DING, Ke; WANG, Deping; PEI, Duanqing; ZHANG, Zhang; SHEN, Mengjie; LUO, Kun; FENG, Yubing; EP2594567; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia