Day: January 20, 2021

Related Products of 157335-93-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 157335-93-8, name is 4,6-Dimethylpyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of N1-cyclopropyl-5-fluorobenzene-1,2-diamine Int-1 (300 mg, 1.80 mmol) in DMF (6 mL) under an inert atmosphere was added 4,6-dimethylpyrimidine-5-carboxylic acid (274 mg, 1.80 mmol), HATU (829 mg, 2.16 mmol) and diisopropylethylamine (1.3 mL, 7.20 mmol) at 0 C. The reaction mixture was stirred at room temperature for 16 h. After consumption of starting material (by TLC), the reaction mixture was quenched with water (20 mL) to obtain a solid. The solid was filtered and dried under reduced pressure to obtain N-(2-(cyclopropylamino)-4-fluorophenyl)-4,6dimethylpyrimidine-5-carboxamide (200 mg, crude) as an off-white solid which was used directly without further purification. LC-MS: m/z 301[M+H]+ at 2.39 RT (82.67% purity).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 157335-93-8, 4,6-Dimethylpyrimidine-5-carboxylic acid.

Reference:
Patent; Viamet Pharmaceuticals (NC), Inc.; Sparks, Steven; Yates, Christopher M.; Shaver, Sammy R.; (93 pag.)US2018/186773; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 62802-38-4, name is 5-Bromo-2-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 5-Bromo-2-fluoropyrimidine

To a vial is added R-12 (200 mg, 1.13 mmol) in DMF (5 ml), followed by the addition of K2CO3 (312 mg, 2.26 mmol) and isopropylamine (134 mg, 2.27 mmol). The reaction mixture is stirred at 70 C for 3 hours. The reaction mixture is concentrated in vacuo. The residue is dissolved in EtOAc, washed with water, brine, dried under anhy. Na2S04, fitered and concentrated to afford the title intermediate (221 mg); m/z 216.0/218.0 [M/M+2H] .

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62802-38-4, 5-Bromo-2-fluoropyrimidine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; HUBER, John; LO, Ho Yin; LOKE, Pui Leng; LIU, Weimin; MORWICK, Tina Marie; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee; WO2012/24150; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 111196-81-7, 2-Chloro-5-ethylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 111196-81-7, blongs to pyrimidines compound. Computed Properties of C6H7ClN2

Step B: Preparation of 4-((lr,4r)-4-((l-(5-Ethylpyrimidin-2-yl)piperidin-4- yl)methoxy)cyclohexyl)-3-fluoro-N,N-dimethylbenzamide.; A mixture of 3-fluoro-N,N-dimethyl-4-(((lr,4r)-4-(piperidin-4- ylmethoxy)cyclohexyl)benzamide hydrochloride (14.0 mg, 0.035 mmol), prepared in Step A above, 2-chloro-5-ethylpyrimidine (20 mu, 0.165 mmol), and triethylamine (30 muEpsilon, 0.220 mmol) in iPrOH (1.3 mL) was heated under microwave irradiation at 120 C for 2 h. The mixture was purified by HPLC (5-95% CH3CN). Fractions containing the title compound were partly concentrated and the residue was extracted with 1M NaOH and CH2C12. The organic phase was dried over MgS04, filtered, and concentrated to give the title compound (10.2 mg, 0.022 mmol, 62.0% yield) as a white solid. Exact mass calculated for C27H37FN4O2: 468.2, found: LCMS m/z= 469.4 [M+H]+; lU NMR (400 MHz, CDC13) delta ppm 1.18 (t, = 7.6 Hz, 3H), 1.19-1.26 (m, 2H), 1.34-1.58 (m, 4H), 1.83-1.93 (m, 5H), 2.15-2.17 (m, 2H), 2.45 (q, = 7.6 Hz, 2H), 2.81- 2.91 (m, 3H), 2.99 (s, 3H), 3.09 (s, 3H), 3.23-3.30 (m, IH), 3.36 (d, = 5.8 Hz, 2H), 4.69-4.76 (m, 2H), 7.06-7.09 (m, IH), 7.12-7.14 (m, IH), 7.20-7.25 (m, IH), 8.16 (s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111196-81-7, its application will become more common.

Reference:
Patent; ARENA PHARMACEUTICALS, INC.; JONES, Robert M.; HAN, Sangdon; LEHMANN, Juerg; THORESEN, Lars; WO2012/135570; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6840-45-5, 3-Bromoimidazo[1,2-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 6840-45-5, blongs to pyrimidines compound. Product Details of 6840-45-5

A mixture of 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyridin-2-amine (1.0g, 4.54mmol), 3-bromoimidazo[1 ,2-a]pyrimidine (899mg, 4.54mmol) and Na2C03 (963mg, 9.09mmol) in DMF:H20 (3: 1 , 20ml_) was degassed with N2 for 15 min at rt. Pd(PPh3)4 (525mg, 0.45mmol) was added to this degassed mixture at rt. The reaction mixture was again purged with N2 for 5 min. The reaction vessel was sealed and stirred at 90 C for 16h. The TLC showed reaction to be complete. The reaction mixture was allowed to cool to rt and concentrated under reduced pressure. The crude residue was triturated with MeOH (25ml_) and the precipitated solid was filtered through the sintered funnel. The filtrate was concentrated under reduced pressure. The residue was purified by combiflash chromatography using 12g silica column, eluting with 10% MeOH in DCM to afford 4-(imidazo[1 ,2-a]pyrimidin-3- yl)pyridin-2-amine as a brown solid. Yield: 500mg (51 %); MS (ESI+) for CHNOS m/z 212.0[M+H]+; 1 H NMR (400 MHz, DMSO-d6): <5 8.96-9.05 (m, 1 H), 8.55-8.61 (m, 1 H), 8.40 (s, 1 H), 7.94-8.01 (m, 1 H), 6.98-7.15 (m, 3H), 6.05-6.15 (bs, 2H). These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6840-45-5, its application will become more common. Reference:
Patent; DISCUVA LTD.; MEO, Paul; KHAN, Nawaz; CHARRIER, Cedric; (252 pag.)WO2019/86890; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 611-08-5, name is 5-Nitrouracil. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 611-08-5

Preparation of 2,4-dichloro-5-nitropyrimidine. 5-Nitrouracil, was treated with phosphorous oxychloride and N, N- [DIMETHYLANILINE,] according to the procedure of Whittaker (J. Chem. Soc. 1951,1565), to give the title compound, which is also available from City Chemical (West Haven, CT).

With the rapid development of chemical substances, we look forward to future research findings about 611-08-5.

Reference:
Patent; ELAN PHARMACEUTICALS, INC.; WO2003/99231; (2003); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 62458-96-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62458-96-2, name is 7-Benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one. A new synthetic method of this compound is introduced below.

To 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one (Step A, 1.50 g, 6.22 mmol) in toluene (25 mL) were sequentially added DIPEA (0.87 mL, 5.0 mmol) and POCl3 (0.70 mL, 7.46 mmol). The contents were heated at 105 C. for 2 hour, cooled to rt, diluted with dichloromethane (100 mL) and stirred with cold aq. sat’d NaHCO3 (150 mL) for 1 h. The dichloromethane layer was dried over sodium sulfate and concentrated under reduced pressure to afford the title compound b (1.61 g) as a dark oil. LCMS [M+H]+ 260.08.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62458-96-2, its application will become more common.

Reference:
Patent; Bristol-Myers Squibb Company; US2008/275052; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 60025-09-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 60025-09-4 as follows.

To a stirred solution of 1-(3-(pyridin-2-yl)-1,6-naphthyridin-2-yl)ethanamine (15 mg, 0.060 mmol) in butanol (1.5 mL) was added 4-amino-6-chloropyrimidine-5-carbonitrile (9.26 mg, 0.060 mmol) and N-ethyl-N-isopropylpropan-2-amine (20.93 muL, 0.120 mmol). The reaction was heated at 120 C. for 2 h. After this time the reaction was cooled to rt. The resulting precipitate was filtered and washed with hexanes to give racemic 4-amino-6-(((1S,1R)-1-(3-(2-pyridinyl)-1,6-naphthyridin-2-yl)ethyl)amino)-5-pyrimidinecarbonitrile. 1H NMR (400 MHz, chloroform-d) delta ppm 9.33 (1H, s), 8.83 (2H, d, J=5.9 Hz), 8.33 (1H, s), 8.14 (1H, s), 8.02 (1H, d, J=5.9 Hz), 7.93 (1H, td, J=7.7, 1.8 Hz), 7.64 (2H, d, J=7.8 Hz), 7.44 (1H, ddd, J=7.6, 4.9, 1.0 Hz), 6.15 (1H, m), 5.28 (2H, bs), 1.38-1.43 (3H, m). Mass Spectrum (ESI) m/e=251.0. Mass Spectrum (ESI) m/e=369.2.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60025-09-4, its application will become more common.

Reference:
Patent; AMGEN INC.; US2010/331306; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 4316-97-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4316-97-6, name is 4,6-Dichloro-5-methylpyrimidine. A new synthetic method of this compound is introduced below.

4,6-dichloro-5-methylpyrimidine (0.60g, 3.68mmol) and (3R, 4R) -1- benzyl -N, 4- dimethyl-piperidin-3-amine (0.80g, 3.68 mmol) were dissolved DMF (5mL), was added potassium carbonate (1.02g, 7.36mmol), 70 reaction was stirred overnight under nitrogen.Water was added (100 mL) to quench the reaction, extracted with ethyl acetate (70mL ¡Á 3), the organic phase water (50mL) washed with saturated aqueous sodium chloride solution (50 mL), dried the organic layer was dried over anhydrous sodium sulfate, and concentrated under reduced pressure, performed column chromatography (eluent: PE / EtOAc (v / v) = 1/1), to give the product 1.08g, yield: 85.0%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4316-97-6, 4,6-Dichloro-5-methylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd.; Liu, Bing; Huang, Jiuzhong; Ren, Xingye; Li, Zhi; Zhang, Yingjun; Zhang, Changchun; (55 pag.)CN105566321; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 139756-21-1, name is 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one. A new synthetic method of this compound is introduced below., Application In Synthesis of 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one

Example 1 Preparation of 5-(2-ethoxy-5-chlorosulfonyl)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyr azolo[4,3-d]pyrimidine-7-one Chlorosulfuric acid (50ml)was added into a 100ml three-neck flask with a stirrer, 5-(2-ethoxy)-phenyl-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidi ne-7-one (31.2g (0.1mol)) was added in batches under stirring in an ice bath. The reaction was exothermic and was performed for 12 hrs. The reaction solution was slowly poured into icy water (100g), a white solid was separated out, filtered, dried. A white solid (30g)was obtained with a yield of 76%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 139756-21-1, 5-(2-Ethoxyphenyl)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one.

Reference:
Patent; Zhejiang Dade Pharmaceutical Group Co., Ltd.; WANG, Jianping; WANG, Jianguo; EP2666776; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 25193-95-7 ,Some common heterocyclic compound, 25193-95-7, molecular formula is C5H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of pyrimidin-5-ylmethanol (5.00 g, 45.4 mmol) in dichloromethane (125 mL) was added thionyl chloride (9.88 mL, 136 mmol) drop wise at 0 C, and allowed to stirred at room temperature for 2 h. The reaction mixture was analyzed by TLC (50% EtOAc/hexanes) and it showed no starting material. The reaction mixture was concentrated under reduced pressure to afford title compound (4.2 g, 69.3%) as a light brown solid. NMR (400 MHz, DMSO-c/6): delta 9.17 (s, 1 H), 8.91 (s, 2H), 4.85 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25193-95-7, 5-(Hydroxymethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; STOLLER, Andre; BIGOT, Aurelien; JUNG, Pierre, Joseph, Marcel; GAGNEPAIN, Julien, Daniel, Henri; RENDINE, Stefano; (155 pag.)WO2019/86474; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia