Day: February 18, 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, the common compound, a new synthetic route is introduced below. SDS of cas: 2565-47-1

General procedure: A mixture of barbituric acid 1 (1 mmol) and aldehyde 2 (1mmol) was refluxed in 5 mL of water for an appropriate timeuntil the generation of 5-arylidenebarbituric acid as indicatedby TLC. Next 2-aminothiophenol (3, 1 mmol) and benzaldehyde(2a, 1 mmol) were added, and the reaction mixture was furtherrefluxed for an appropriate time. On completion of the reactionas indicated by TLC the reaction mixture was allowed to cool toroom temperature and was extracted with EtOAc (3 ¡Á 10 mL).After drying with anhydrous Na2SO4 and evaporation underreduced pressure, the crude product was purified suitablyeither by recrystallization from a DCM/EtOH (1:1) solventmixture or column chromatography on silica gel usingEtOAc/hexane (2:8) as the eluent to afford 5-monoalkylbarbiturate4.

The synthetic route of 2565-47-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kalita, Subarna Jyoti; Deka, Dibakar Chandra; Synlett; vol. 29; 4; (2018); p. 477 – 482;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine. A new synthetic method of this compound is introduced below., Safety of 4,6-Dichloro-2-(methylthio)pyrimidine

To a stirred solution of 4,6-dichloro-2- (methylthio)pyrimidine (50 g, 0.26 mol) in dichloromethane (1 L) at 00C was added meta-chloroperoxybenzoic acid (143.6 g, 0.64 mol) over a period of 20 minutes. The solution was allowed to warm to room temperature and was stirred for 4 hours. The mixture was diluted with dichloromethane (1.5 L) and then treated sequentially with 50% Na2S2O3 / NaHCO3 solution (2 x 200 ml), sat. NaHCO3 solution (4 x 300 ml), and brine (200 ml) then dried (MgSO4). The solvent was removed in vacuo to afford an off-white solid, which was redissolved in EtOAc (IL) and treated sequentially with sat. NaHCO3 solution (3 x 300 ml), and brine (100 ml) then dried (MgSO4). The solvent was removed EPO in vacuo to afford the title compound (A) as a white solid (55.6 g, 96% yield). 1H NMR CDCl3 delta 3.40 (3H5 s, CH3), 7.75 (IH. s. ArH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2007/14250; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 126728-20-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 126728-20-9, name is 2,4-Dichloropyrido[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of 5 (5.0 mmol), the respective amine (12 mmol), equimolecular amounts of triethylamine, and ethanol (15 mL) was heated at 70 C for 5 h with stirring. The solvent was removed under vacuum and the residue was dissolved in water (30 mL); the mixture was extracted with chloroform (3 ¡Á 25 mL) and the organic extracts were dried over anhydrous sodium sulfate and the solvent was removed in vacuum. For compounds 6t-y the resulting solid was purified by recrystallization as indicated in Table 1. For compounds 6z-ai the residual material isolated after removal of the solvent was washed with 5% HCl (25 mL) and the resulting solid was isolated and purified as indicated in Table 1.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 126728-20-9, 2,4-Dichloropyrido[2,3-d]pyrimidine.

Reference:
Article; Font, Maria; Gonzalez, Alvaro; Palop, Juan Antonio; Sanmartin, Carmen; European Journal of Medicinal Chemistry; vol. 46; 9; (2011); p. 3887 – 3899;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 153435-63-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153435-63-3, name is 2-(Tributylstannyl)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Example 5 N-[6-(2-tert-Butoxy-ethoxy)-5-(2-methoxy-phenoxy)-[2,2′]bipyrimidinyl-4-yl]-4-ethyl-benzenesulfonamide (14) [Show Image] A solution of 2-tributylstannanyl pyrimidine (212 mg, 0.57 mmol), 2-pyrimidin triflate intermediate (12) (300 mg, 0.44 mmol), and Pd(PPh3)4 (52 mg, 0.044 mmol) in dry dimethylacetamide (4.5 mL) was heated at 130C for 6 h. After being cooled to room temperature, the reaction was filtered through a plug of Celite, the filtrate was diluted with water and extracted twice with ethyl acetate. The combined organic layers were washed with brine, solvent was removed and the residue was purified by silica gel chromatography furnishing the desired compound as a pale yellow solid (216 mg, 80 %). 1H-RMN (200 MHz, CDCl3) : 1.13 (s, 9H); 1.26 (s, 9H); 3.62 (m, 2H); 4.00 (s, 3H); 4.63 (m, 2H); 6.81-7.18 (m, 4H), 7.43 (m, 3H); 8.23 (d, J = 8.0 Hz, 2H); 9.01 (s, 2H) ppm.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 153435-63-3, 2-(Tributylstannyl)pyrimidine.

Reference:
Patent; Laboratorios Lesvi, S.L.; EP2368884; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3177-24-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3177-24-0, name is 2,4-Dichloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows.

PREPARATION 972-Amino-4-chloropyrimidine-5-carbonitrileTo a solution of 2,4-dichloropyrimidine-5-carbonitrile (600mg, 3.45mmol) in dioxane (20ml) was added a 0.5M solution of NH3 in dioxane (20ml, 10 mmol) and the mixture stirred at room temperature for 4h. A mixture of two isomers were obtained and separated by column chromatography using a mixture of hexane/ethyl acetate (from 0percent to 45percent of ethyl acetate). The title compound (304mg, 56percent yield) was found to be the less polar isomer.LRMS (m/z): 153 (M-1 )\

According to the analysis of related databases, 3177-24-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALMIRALL, S.A.; BERNAL ANCHUELA, Francisco Javier; CARRASCAL RIERA, Marta; CATURLA JAVALOYES, Juan Francisco; GRACIA FERRER, Jordi; MATASSA, Victor Giulio; TERRICABRAS BELART, Emma; TALTAVULL MOLL, Joan; ERRA SOLA, Montserrat; WO2012/146666; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 32779-36-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 32779-36-5, name is 5-Bromo-2-chloropyrimidine. A new synthetic method of this compound is introduced below.

In portion wise, Cesium carbonate (6.78 g, 20.6 mmol) was added to a stirred solution of benzyl alcohol (2.25 g, 20.6 mmol) in acetonitrile and dimethylformamide (1:1, 40 mL) under nitrogen atmosphere at room temperature. After 10 min, 5-bromo-2-chloropyrimidine (2.0 g, 10.3 mmol) was added and the mixture was stirred at the same temperature for overnight. The reaction was monitored by TLC; after completion of the reaction, reaction mixture was poured into ice-cold water; the resultant solid was filtered; solid was washed with water (3 x 10 mL) followed by n-pentane (2 x 10 mL) and air dried and recrystallized from benzene gave 3a (2.675 g) as white solid in 97 percentyield, mp 102.9?105.6 ¡ãC, TLC Rf 0.34 (10 percent EtOAc in hexanes as the eluent); 1H NMR (DMSO, 300 MHz); delta 8.78 (s, 2H, Pyrimidine H), 7.34?7.47 (m, 5H, ArH), 5.38 (s, 2H, ArCH2); 13CNMR (DMSO, 100 MHz) delta 163.16,159.83, 136.15, 128.39, 128.02, 127.95, 111.91, 68.95; IR (KBr) 1271(C?O), 1179 (C?N), 525 (C?Br) cm-1; HRMS(ES+) exact mass calculated for [M+H]+ (C11H9BrN2O) requires m/z 264.989, found m/z 265.091, 267.301.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,32779-36-5, 5-Bromo-2-chloropyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Reddy, Onteddu Surendranatha; Suryanarayana, Ch. Venkata; Narayana; Anuradha; Babu, B. Hari; Medicinal Chemistry Research; vol. 24; 5; (2015); p. 1777 – 1788;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 252723-17-4, name is 5-Bromo-4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C12H7BrClN3O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 5-Bromo-4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine

C. Preparation of (S)-5-bromo-4-(3-methylpiperazin-1-yl)-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine. To a mixture of pyrrolopyrimidine from step B (76 mg, 0.2 mmol) and (S)-2-methylpiperazine (21 mg, 0.2 mmol) in isopropanol (2 ml) was added triethylamine (0.11 ml, 0.8 mmol). The mixture was heated at 80 C. for 5 mins via microwave and concentrated under vacuum to give crude (S)-5-bromo-4-(3-methylpiperazin-1-yl)-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine (65 mg, 0.15 mmol, 75%) which was used directly for the next step. MS (ES+) [M+H]+=437.

With the rapid development of chemical substances, we look forward to future research findings about 252723-17-4.

Reference:
Patent; Harrison, Bryce Alden; Kimball, Spencer David; Mabon, Ross; Rawlins, David Brent; Rice, Dennis S.; Voronkov, Michael Victor; Zhang, Yulian; US2009/42893; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3435-25-4, name is 4-Chloro-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-6-methylpyrimidine

To a mixture of (S)-i sopropyl 2-(tert-butoxy)-2-(4-(chroman-6-yl)-2-methyl-6-(3 -(tetrahydro-2H-pyran-4-yl)propyl)-5 -(1,2,3 ,4-tetrahydroi soquinolin-6-yl)pyridin-3 -yl)acetate, 2 HC1 (0.01 g, 0.014 mmol) and 4-chloro-6-methylpyrimidine (0.01 g, 0.078mmol) in dioxane (0.5 mL) was added potassium carbonate (0.02 g, 0.145 mmol) andheated in a seal vial at 100 C for 18 h. Then, filtered off the solid, removed the solvent,and residue was treated with EtOH (1 ml) and sodium hydroxide (0.550 mg, 0.014 mmol)at 85 C for 2 h. Then, cooled and purified by prep HPLC to afford (S)-2-(tert-butoxy)-2- (4-(chroman-6-yl)-2-methyl-5 -(2-(6-methylpyrimidin-4-yl)- 1,2,3 ,4-tetrahydroi soquinolin6-yl)-6-(3 -(tetrahydro-2H-pyran-4-yl)propyl)pyridin-3 -yl)acetic acid (0.0027 g, 3.64 tmol, 26.5 % yield) LCMS (M+H) = 705.3.

With the rapid development of chemical substances, we look forward to future research findings about 3435-25-4.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; TU, Yong; (133 pag.)WO2017/29631; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1450-85-7, name is 2-Mercaptopyrimidine, molecular formula is C4H4N2S, molecular weight is 112.15, as common compound, the synthetic route is as follows.Computed Properties of C4H4N2S

General procedure: To an orange suspension of [Pd2(p-mazb)2Cl2] (0.025 g, 0.035 mmol) in dichloro-methane (5mL), pyridine-2-thione (0.008 g, 0.072 mmol) was added in presence of Et3N base (0.5 mL). The color of the reaction mixture became dark reddish brown and was stirred for 5-6 h. The solution was filtered off and added toluene (1 mL) and left to evaporate slowly. The dark reddish brown crystalline compound was obtained along with the formation of Et3NH+Cl- after a period of 4-5 days. Crystalline compound formed was recrystallized from dichloromethane and methanol. The dark reddish brown crystals were obtained after a period of 4-5 days. (Yield 0.021 g, 68%). .

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1450-85-7, 2-Mercaptopyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Lobana, Tarlok S.; Sandhu, Amanpreet K.; Kaur, Amanpreet; Jasinski, Jerry P.; Journal of Organometallic Chemistry; vol. 751; (2014); p. 519 – 524;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 4318-56-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4318-56-3, name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

7.71 g of 2-cyanobenzyl bromide (R1 is H and R2 is Br), 6.00 g of 3-methyl-6-chlorouracil and 4.20 g of triethylamine were dissolved in a mixed solution of 78 ml of DMSO and THF, and the temperature was raised The reaction was stirred at 50 C for 1 h, and the reaction was cooled to room temperature. 80 ml of ice water was slowly added dropwise, and the mixture was stirred for 1 h under ice-cooling. The crude product of compound III was 9.15 g. The yield was 88.81%. The crude compound III was rinsed with ethyl acetate at 25 C, filtered, washed and dried to give pure Compound III 8.94. The purification yield was 97.90%. The total yield of compound was 86.77% and the purity was 89.70%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4318-56-3, 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Beijing Wansheng Pharmaceutical Co., Ltd.; Lin Guoliang; Wang Qiang; Jiang Yugang; Wang Yiping; Kang Yi; Lv Xiaona; (10 pag.)CN106608853; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia