Day: March 8, 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. A new synthetic method of this compound is introduced below., Product Details of 1032452-86-0

3. Synthesis of intermediate 006-5 The intermediates 006-2 (75 mg, 307.8 mmol) and 006-4 (57.4 g, 308.4 mmol), 975 mL of isopropyl alcohol, and p-toluenesulfonic acid (63.7 g, 369.9 mmol) were sequentially added into a 2 L four-necked flask under nitrogen atmosphere, and the reaction was heated and maintained at 105C for 5 h. The reaction mixture was cooled to room temperature and filtered, and the filter cake was washed with 750 mL of isopropanol three times. The filter cake was washed three times with 750 mL of acetonitrile and dried to give 75 g of the intermediate 006-5 (62%) as a yellow solid. LC-MS: 394.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1032452-86-0, 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole.

Reference:
Patent; Shanghai Shaletech Technology Co., Ltd.; JIANG, Yueheng; (143 pag.)EP3216786; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3435-25-4 ,Some common heterocyclic compound, 3435-25-4, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

c) 8-(3,4-Difluorophenyl)-N-((3S,4R)-3-methoxy-1-(6-methylpyrimidin-4-yl)piperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine; 8-(3,4-Difluorophenyl)-N-((3S,4R)-3-methoxypiperidin-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine dihydrochloride (28 mg, 64.8 mumol) was extracted with dichloromethane/2 M NaOH. The organic layers were washed with brine, dried over sodium sulfate and evaporated. The residue was dissolved in dioxane (0.5 mL) and to this solution 4-chloro-6-methylpyrimidine (9.2 mg, 71.2 mumol) and DIPEA (17.0 muL, 97.2 mumol) were added. Argon was bubbled through the solution for 5 minutes, and then heated in the microwave at 130 C. for 2¡Á30 minutes. After evaporation, purification by chromatography (silica gel, 10 g, 0 to 10% methanol in dichloromethane) afforded the title compound (18 mg, 62%) as an off white foam.MS ISP (m/e): 452.3 [(M+H)+].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3435-25-4, 4-Chloro-6-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Baumann, Karlheinz; Flohr, Alexander; Goetschi, Erwin; Green, Luke; Jolidon, Synese; Knust, Henner; Limberg, Anja; Luebbers, Thomas; Thomas, Andrew; US2011/201605; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 13036-57-2, 2-Chloro-4-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H5ClN2, blongs to pyrimidines compound. COA of Formula: C5H5ClN2

Example 4 [00154] The compound is prepared as follows: [00155] The synthetic route to obtain compound 4 started from a chloration of 4-methyl-2- chloropyrimidine. Compound 1 was obtained in 28% yield after purification. The SNAr reactionwas carried out in 52% yield. The Stille reaction was then realised. The product 3 was obtained in 72% yield. The introduction of piperidine was then carried out under microwave conditions. After purification, the final product was obtained in 19% yield.

The synthetic route of 13036-57-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOGRA PHARMA LIMITED; HOMMES, Daan; VERHAAR, Auke; VAN DEN BRINK, Gijs; VITI, Francesa; WO2013/178816; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 4270-27-3, Adding some certain compound to certain chemical reactions, such as: 4270-27-3, name is 6-Chloropyrimidine-2,4(1H,3H)-dione,molecular formula is C4H3ClN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4270-27-3.

Step – I: Preparation of 2-((6-chloro-2,4-dioxo-3,4-dihydropyrimidin-l(2H)- yl)methyl)benzonitrileTo a 6-chloropyrimidine-2,4(l H,3H)-dione (21 gm) was added N- methylpyrrolidone (80 ml) under stirring and then added diisopropylethylamine (17 ml) slowly for 30 minutes. To the solution was added a solution of 2- (bromomethyl)benzonitrile (20 gm) in toluene (80 ml) slowly for 1 hour and the temperature of the reaction mass was raised to 70 to 80C. The reaction mass was maintained for 4 hours at 70 to 80C and then cooled to 15 to 20C. The reaction mass was quenched with water and maintained for 30 minutes at 15 to 20C. The reaction mass was then cooled to 0 to 5C and stirred for 1 hour. The reaction mass was filtered and washed with water and hexane to obtain a wet solid. To the wet solid thus obtained was added water (200 ml) and pH was adjusted to 9.0 to 10.0 with sodium hydroxide (IN). The reaction mass was stirred for 30 minutes and then added methylene chloride (300 ml) and then the layers were separated. The pH of the aqueous layer was adjusted to 4.0 to 5.0 with hydrochloric acid (IN) and stirred for 30 minutes. The solid obtained was collected by filtration and then dried to obtain 19.3 gm of 2-((6-chloro-2,4-dioxo-3,4- dihydropyrimidin-l(2H)-yl)methyl)benzonitrile.

According to the analysis of related databases, 4270-27-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MOHANBABU, Maradolla; VAMSI KRISHNA, Bandi; WO2013/46229; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74901-69-2, name is 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, molecular formula is C6H4Cl2N2S, molecular weight is 207.08, as common compound, the synthetic route is as follows.category: pyrimidines

To a suspension of 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrinnidine ( 100 mg, 0.483 mmol) in DMSO (3.0 mL) was added DIPEA (0.59 mL, 3.4 mmol) and N-propyltetra- hydropyran-4-amine (83 mg, 0.58 mmol). The pale yellow suspension was shaken for 4 hours at 80 C and then at 60 C for 12 days. Aqueous HCI (0.5 M, 30 mL) was added and mixture was extracted three times with EtOAc (3 x 30 mL). The organic phases was washing with brine ( 15 mL), dried over MgSO4, filtered and evaporated to dryness under reduced pressure. Freeze drying afforded the title compound as brown oil, which was used without further purification in the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,74901-69-2, 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; LEO PHARMA A/S; LARSEN, Jens; (110 pag.)WO2019/57806; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3435-29-8, Adding some certain compound to certain chemical reactions, such as: 3435-29-8, name is 4-Amino-6-phenylpyrimidine,molecular formula is C10H9N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3435-29-8.

Quinoline-4-carboxylic acid (36.4 mg, 0.226 mmol),3-chloro-5 – (methylthio) benzene amine (50.0 mg, 0.205 mmol) and POCl3 (34.6 mg, 0.226 mmol), pyridine (1 mL) was dissolved in, 80 was stirred for 1 hour dongan. When thin layer chromatography (TLC) check when, a new spot is confirmed, water was added to the reaction mixture, and extracted twice with dichloromethane. And the extracted organic layer was dried using magnesium sulfate, vacuum concentrated and, after the water was removed by filtration of the organic extract over MgSO4 and concentrated by silica gel preparative thin layer chromatography (preparative TLC, ethyl acetate / n- hexane = l / l ) to give to give the title compound (11%) of a white solid.

According to the analysis of related databases, 3435-29-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; JUNG, YOUNG SIK; KIM, PIL HO; HAN, SOO BONG; RAGHAVENDRA, ACHARY; KIM, MEE HYEIN; LEE, CHONG KYO; SHIN, JIN SOO; (131 pag.)KR2015/25531; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H4Cl2N2S, blongs to pyrimidines compound. COA of Formula: C5H4Cl2N2S

Example 42a3-[6-chloro-2-(methylthio)pyrimidin-4-yl]-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; A mixture of 4,6-dichloro-2-(methylthio)pyrimidine (0.558 g, 2.86 mmol), Example 1c (1 g, 2.60 mmol), 2M aqueous Cs2CO3 solution (1.30 mL, 2.60 mmol), 1,2-dimethoxyethane/dimethylfomamide (9/l, 12 mL), and tetrakis(triphenylphosphine)palladium (0.120 g, 0.104 mmol) was evacuated and purged with nitrogen. The mixture was heated at 80 C. under nitrogen for 30 minutes, then cooled to room temperature. Solids were collected by filtration, washed with hexanes, and dried under vacuum to give the title compound (606 mg, 56% yield).

The synthetic route of 6299-25-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ABBOTT LABORATORIES; US2011/15173; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 126728-20-9, name is 2,4-Dichloropyrido[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 2,4-Dichloropyrido[2,3-d]pyrimidine

Intermediate 8 (200 mg, 0.584 mmol) was dissolved in ethanol (10 mL), then 2,4-dichloropyrido[2,3-d]pyrimidine 24 (117 mg, 0.58 mmol) and triethylamine (177 mg,1.75 mmol) were added. The resulting mixture was stirred at 90C for 12 hours. The solvent was evaporated. This crude product was purified by column chromatography over silica gel (eluent: methanol ethyl acetate ll0). The resulting residue waslyophilized to yield a white solid (78.3 mg, 27%).

With the rapid development of chemical substances, we look forward to future research findings about 126728-20-9.

Reference:
Patent; JANSSEN SCIENCES IRELAND UC; TAHRI, Abdellah; VENDEVILLE, Sandrine, Marie, Helene; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; DEMIN, Samuel, Dominique; HU, Lili; COOYMANS, Ludwig, Paul; (105 pag.)WO2016/91774; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5750-76-5, name is 2,4,5-Trichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2,4,5-Trichloropyrimidine

2,4,5-trichioropyrimidine (16.7 g, 91.0 mmoi) was added to a tared, sealed fiask and weighed. The oii was dissoiyed in 54 mL THF and cooled to O C. lM aqueous NaOH solution (182 mL, 182 mmoi) was added dropwise via an addition funnel, keeping the reaction at O c. This was aliowed to warm to room temperature and concentrated to remoye THF. Additional water was added to maintain dissoiution. The pH was adjusted to 6 with a smali quantity of Hoi, and the aqueous was washed 3 times with ethyi acetate. The pH was then brought below 1 with more Hoi, and extracted six times with ethyi acetate. This iayer was washed with brine and dried oyer sodium suifate. Product solution was filtered, concentrated, and dried on the high yacuum to giye 14.1 g of 2,5-dichioropyrimidin-4-oi as an oil (96%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5750-76-5, 2,4,5-Trichloropyrimidine.

Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; MCMURTRIE, Darren; KOLLURI, Rao; MASUDA, Esteban; TSO, Kin; ALVAREZ, Salvador; HECKRODT, Thilo; HOLLAND, Sacha; KELLEY, Ryan; DUNCTON, Matthew; SINGH, Rajinder; WO2014/89112; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 137281-08-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 137281-08-4, name is N-(4-Oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: 7-Iodo-N2-pivaloyl-7-deazaguanine 1a (0.0363 g, 0.101 mmol) and DMAP (0.0272 g, 0.223mmol) were dried by repeated co-evaporation with dry pyridine and dry toluene, and dissolved in dry DMF (0.50mL) under argon. DPC-Cl (0.0263 g, 0.114 mmol) was added, and the mixture was stirred for 24 h at 80 C. Themixture was then cooled to rt, poured into a saturated aqueous solution of NaHCO3 (15 mL), and extracted with CH2Cl2 (3 ¡Á 10 mL). The organic layers were combined, dried over Na2SO4, filtered, and concentrated underreduced pressure. The residue was then purified by column chromatography on silica gel (hexane/AcOEt = 2:1,v/v) to afford 2a (0.0432 g, 0.0777 mmol, 78%) as a pale yellow solid.

According to the analysis of related databases, 137281-08-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Oka, Natsuhisa; Nakano, Koki; Fukuta, Akane; Ando, Kaori; Tetrahedron Letters; vol. 61; 28; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia