Day: March 9, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 591-55-9, name is 5-Aminopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C4H5N3

(2) 2,2,2-Trichloroethyl pyrimidin-5-ylcarbamate; To a solution of pyrimidine-5-amine (100 mg, 1.05 mmol) and pyridine (0.255 ml, 3.15 mmol) in tetrahydrofuran (3 ml) was added 2,2,2-trichloroethyl chloroformate (0.217 ml, 1.58 mmol) with ice-cooling, the mixture was stirred for 30 minutes with ice-cooling, the reaction mixture was poured into ice-water and the mixture was extracted with ethyl acetate. The extract was washed with water and dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane : ethyl acetate = 1 : 1) to obtain the desired product (100 mg, 35.2%) as a solid. 1H-NMR (CDCl3) delta; 4.87 (2H, s), 7.60 (1H, br s), 8.95 (2H, s), 9.02 (1H, s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 591-55-9, 5-Aminopyrimidine.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1813606; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 25940-35-6, Adding some certain compound to certain chemical reactions, such as: 25940-35-6, name is Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid,molecular formula is C7H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 25940-35-6.

PyBOP (298 mg, 572 pmol) was added to a mixture of 8-amino-3-(2-chlorophenyl)-1,3- diazaspiro[4.5]decane-2,4-dione (mixture of cis-/trans-isomers) (140 mg, 477 pmol, Intermediate 36), pyrazolo[1 ,5-a]pyrimidine-3-carboxylic acid (97.2 mg, 596 pmol) and N,Ndiisopropylethylamine (420 p1, 2.4 mmol) in DMF (1.7 ml) and the mixture was stirred overnight at room temperature. For work-up, water was added and the mixture was extracted with ethyl acetate. The combined organic phases were filtered through a silicone filter and concentrated. The residue was purified by preparative HPLC to give the title compound 45.0 mg (21 % yield).[C-MS (Method 2): R = 0.88 mm; MS (ESIneg): m/z = 437 [M-H]1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 9.34-9.31 (m, 1H), 8.93 (5, 1H), 8.82 (dd, 1H), 8.59 (5, 1H), 8.11 (d, 1H), 7.68-7.64 (m, 1H), 7.56-7.45 (m, 3H), 7.29-7.25 (m, 1H), 4.14-4.04 (m, 1 H), 2.23-1.67 (m, 8H)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 25940-35-6, Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BUCHGRABER, Philipp; WAGNER, Sarah; SUeLZLE, Detlev; BENDER, Eckhard; LI, Volkhart, Min-Jian; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; (232 pag.)WO2018/78009; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.36822-08-9, name is Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one, molecular formula is C10H6N2OS, molecular weight is 202.2324, as common compound, the synthetic route is as follows.Safety of Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one

Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one (10.78 g, 26.7 mmol) was treated with pyridine (2.68 mL, 33.3 mmol) and phosphoryl trichloride (53.4 mL, 573 mmol), then heated to reflux at 110 C. for 1 hr. Excess POC3was removed and cautiously quenched with ice water in an ice bath. The pH was adjusted to 5 with ammonium hydroxide. Solid was collected by filtration washed with water. The solid was dried to give 4-chlorobenzo[4,5]thieno[3,2-d]pyrimidine (10 g, 85% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,36822-08-9, Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; Universal Display Corporation; Joseph, Scott; Kwang, Raymond; Lee, Chi Hang; Shia, Chuan Jun; Ram, SiV Cheung; (131 pag.)KR2015/9461; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 129872-81-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 129872-81-7, name is 2,4-Dichloro-5-methyl-5H-pyrrolo[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: An oven-dried 15 mL pressure tube cooled under nitrogen, charged with 123 mg (0.61 mmol) of 2,6 dichloro-7-methyl-7H-purine (See US 20110086840 A1 for synthesis) and anhydrous ethanol/ DMF (0.5 mL/0.3 mL, 0.76M). N,N-diisopropylethylamine (0.130 mL,0.73mmol) was added via syringe followed by morpholine (0.064 mL, 0.73 mmol). The pressure tube was flushed with nitrogen and the septa replaced by a Teflon screw cap. The reaction mixture stirred overnight at room temperature. The reaction mixture was poured into 50 % ether/ethyl acetate and washed 1x with 50% brine and 1x with brine.The organic layer was dried (MgSO4), filtered , concentrated to yield 119 mg of crude product (77.6%) which was taken directly into the next step. 1H NMR (400MHz, DMSO d6) d 8.44 (s, 1H), 3.96 (s, 3H), 3.80 – 3.71(m, 4H), 3.53 – 3.44 (m, 4H). LC/MS-m/z FontWeight=”Bold” FontSize=”10″ 254.5 (M+H)+.

According to the analysis of related databases, 129872-81-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lee, Wendy; Ortwine, Daniel F.; Bergeron, Philippe; Lau, Kevin; Lin, Lichuan; Malek, Shiva; Nonomiya, Jim; Pei, Zhonghua; Robarge, Kirk D.; Schmidt, Stephen; Sideris, Steve; Lyssikatos, Joseph P.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 18; (2013); p. 5097 – 5104;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 4270-27-3, 6-Chloropyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4270-27-3, blongs to pyrimidines compound. Recommanded Product: 6-Chloropyrimidine-2,4(1H,3H)-dione

Reference Example 17. 6-Chloro-1-(2-trimethylsilyl)ethoxymethylpyrimidine-2,4-dione In a similar manner to the procedures described in Reference Example 3, reactions were carried out using 6-chloropyrimidine-2,4-dione, instead of pyrimidine-2,4-dione, and using 2-(trimethylsilyl)ethoxymethyl chloride, instead of benzyloxymethyl chloride, to give the title compound (yield 71%) as a white powder. 1H-Nuclear magnetic resonance spectrum (400 MHz, CDCl3) delta ppm: 9.10 (1H, br.s), 5.93 (1H, s), 5.45 (2H, s), 3.68 (2H, t, J=8Hz), 0.96 (2H, t, J=8Hz), 0.01 (9H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4270-27-3, its application will become more common.

Reference:
Patent; Sankyo Company Limited; EP1069110; (2001); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1197953-49-3, Adding some certain compound to certain chemical reactions, such as: 1197953-49-3, name is (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide,molecular formula is C12H12Cl2N3OP, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1197953-49-3.

Add compound 20 (150 mg, 0.6 mmol), compound 5 (189 mg, 0.6 mmol) and ethylene glycol monomethyl ether (3 mL) to a 25 mL single-necked flask equipped with a magnetic stirring and a condensing tube, stir and dissolve, and add hydrogen chloride dropwise. Isopropyl alcohol solution(0.9 mmol, 0.18 mL, 5 M), the temperature was raised to 120 C under a nitrogen atmosphere and the reaction was stirred overnight. Cool to room temperature and add water(10 mL) and saturated sodium bicarbonate (5 mL), dichloromethane (15 mL¡Á3)The combined organic layers were washed with brine, dried over anhydrous sodium sulfateThe residue was passed through a silica gel column to give a white solid160mg,The yield was 50.1%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (67 pag.)CN109369721; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 36082-45-8, Adding some certain compound to certain chemical reactions, such as: 36082-45-8, name is 2-Amino-5-bromo-4-methoxypyrimidine,molecular formula is C5H6BrN3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36082-45-8.

Method 15; Synthesis of 4-methoxy-5-(4,4,5,5-tetramethyl- (1,3 ,2-dioxaborolan-2-yl))pyrimidine-2-ylamine; [0256] To a dry 200-mL flask was added 5-bromo-4-methoxypyrimidine-2- ylamine (2.88 g, 14.1 mmol), potassium acetate (4.16 g, 42.4 mmol), 4,4,5,5-tetramethyl- 2-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-l,3,2-dioxaborolane (3.76 g, 14.8 mmol) and dioxane (75 mL). Argon was bubbled through the solution for 15 minutes, at which time 1 , l’-bis(diphenylphosphino)ferrocene palladium(II) chloride dichloromethane adduct (0.58 g, 0.71 mmol). The reaction was refluxed in a 115 0C oil bath for 21 hours under argon. After cooling to room temperature, the dioxane was removed in vacuo. EtOAc (500 mL) was added and the resulting slurry was sonicated and filtered. Additional EtOAc (500 mL) was used to wash the solid. The combined organics were concentrated and the crude material was purified by silica gel chromatography (EtOAc as eluent) yielding 2.4 g of an off white solid. By 1H NMR the material was a 1 :1 mixture of boronate ester and 4-methoxypyrimidine-2-ylamine. The material was used as is in subsequent Suzuki reactions. LCMS (m/z): 170 (MH+ of boronic acid, deriving from in situ product hydrolysis on LC); 1H NMR (CDCl3): delta 8.42 (s, IH), 5.22 (bs, 2H), 3.90 (s, 3H), 1.34 (s, 12H).

According to the analysis of related databases, 36082-45-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS VACCINES AND DIAGNOSTICS, INC.; WO2008/98058; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22276-95-5, name is 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 22276-95-5

N,O-Bis(trimethylsilyl)acetamide (BSA, 0.56 mL, 2.27 mmol) was added to a stirred suspension of 5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine (480 mg, 2.06 mmol) in dry acetonitrile (15 mL). After stirring at rt for 10 min, 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-d-ribofuranose (1.16 g, 2.31 mmol) was added, followed by the addition of trimethylsilyl trifluoromethanesulfonate (0.41 mL, 2.25 mmol). The reaction mixture was stirred at rt for 15 min, after which the flask was transferred to a preheated 80 C oil bath. After stirring for 1 h at 80 C, the reaction mixture was cooled to rt and diluted with EtOAc (75 mL). The organic phase was sequentially washed with aqueous saturated NaHCO3 solution and brine, dried (Na2SO4), filtered, and concentrated under reduced pressure to afford the crude nucleoside. Purification by flash column chromatography (silica gel, 20-100% EtOAc/hexanes gradient) provided (1) as a colorless foam (870 mg, 63%). TLC (silica gel, hexanes/ethyl acetate 3:1): Rf = 0.45. LRMS (ESI): 677.3, 675.2 and 673.2 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 22276-95-5.

Reference:
Article; Yu, Wenyu; Smil, David; Li, Fengling; Tempel, Wolfram; Fedorov, Oleg; Nguyen, Kong T.; Bolshan, Yuri; Al-Awar, Rima; Knapp, Stefan; Arrowsmith, Cheryl H.; Vedadi, Masoud; Brown, Peter J.; Schapira, Matthieu; Bioorganic and Medicinal Chemistry; vol. 21; 7; (2013); p. 1787 – 1794;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.

Preparation 23 4-(5-amino-6-chloro-2-methyl-pyrimidin-4-ylamino)-3-fluoro -phenol; A 10ml flask was charged with EtOH (3ml_). 2-methyl-4,6-dichloro-5-aminopyrimidine was added (140mg, 1.89 mMol) followed by 4-amino-3-fluoro-phenol (100mg, 1.89 mMol) and HCI (2M aq, 0.787ml_, 3.78 mMol). The reaction mixture was heated at 850C under N2 for 6 hours. The reaction mixture was evaporated, partitioned between 10 ml sodium bicarbonate solution and 10 ml ethyl acetate, the aqueous was extracted again twice with 10 ml ethyl acetate, the organics were combined, dried over magnesium sulphate, filtered and evaporated to give a purple gum (416 mg, 82%).LCMS (System 4, acidic run): 2.02 mins m/z (APCI) = 269 [MH+]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PFIZER LIMITED; WO2009/144632; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 2227-98-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine, molecular formula is C6H6N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 8.3: (+/-)-frans-4-Butyl-1-[(9-deaza-adenin-9-yl)methyl]-3-hydroxypyrrolidine (1, X = butyl, A = CH, B = NH2, D = H); Formaldehyde (95 mul_, 1.2 mmol, 37 wt% solution in water) followed by 9-deazaadenine (100 mg, 0.7 mmol) are added to a solution of amine 11 (X = butyl) (88 mg, 0.66 mmol) in 1 ,4- dioxane (1.2 ml.) and water (2.5 ml_). The reaction mixture is stirred at room temperature for 66 h, absorbed on to silica and eluted down a silica column using a gradient 10 – 20% (7 N NH3 in MeOH) in CH2CI2. The crude product is collected, concentrated and subject to flash chromatography (5 :4.8 : 0.2, CH2CI2 : MeOH : NH4OH) to afford the title compound 1 (X = butyl, A = CH, B = NH2, D = H) as a pale yellow solid (89 mg, 47%). 13C NMR (125 MHz, CD3OD): delta = 152.1 , 151.0, 147.0, 130.1 , 115.2, 112.4, 77.7, 62.3, 59.69, 49.0, 48.5, 34.0, 31.5, 23.8 and 14.3 ppm; MS (ESI): 290 ([MH]+, 100%); HRMS (ESI): found: 290.1989, C15H24N5O ([MH]+) requires: 290.1981.

According to the analysis of related databases, 2227-98-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ALBERT EINSTEIN COLLEGE OF YESHIVA UNIVERSITY; INDUSTRIAL RESEARCH LIMITED; EVANS, Gary Brian; LONGSHAW, Alistair Ian; SCHRAMM, Vern L.; TYLER, Peter, Charles; WO2011/8110; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia