Day: March 9, 2021

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6299-85-0, name is Methyl 2,6-dichloropyrimidine-4-carboxylate, the common compound, a new synthetic route is introduced below. Formula: C6H4Cl2N2O2

Reference Example 48: (2-Chloro-6-morpholin-4-yl-pyrimidin-4-vImethyl)- dimethyl-amine.; To a solution of 2,6-dichloro-pyrimidine-4-carboxylic acid methyl ester (5.0 g) in anhydrous methanol (40 mL) was added morpholine (4.20 mL). The reaction mixture was stirred at room temperature for 12 hours, then poured onto ice/water and the white precipitate collected by filtration. The solid was washed with water (30 mL) and dried to give 2-chloro- 6-morpholin-4-yl-pyrimidine-4-carboxylic acid methyl ester (4.94 g).

The synthetic route of 6299-85-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PIRAMED LIMITED; THE INSTITUTE OF CANCER RESEARCH; WO2008/125833; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 941685-26-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 941685-26-3, name is 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

To the quenched reaction mixture, which contains crude 4-chloro-7-[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidine (15, 18.63 g, 65.64 mmol) from previous reaction as described above, was added 1,2-dimethoxyethane (DME, 38 mL), powder potassium carbonate (K2CO3, 23.56 g, 170.5 mmol, 2.6 equiv), 1-(1-ethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (3, 18.60 g, 69.89 mmol, 1.06 equiv) at room temperature. The resulting mixture was degassed four times backfilling with nitrogen gas each time before being treated with tetrakis(triphenylphosphine)palladium(0) (Pd(PPh3)4, 244.2 mg, 0.21 mmol, 0.003 equiv) at room temperature. The resulting reaction mixture was degassed four times backfilling with nitrogen gas each time before being warmed to 80 C. for 4-8 h. When TLC and HPLC showed that the reaction was deemed complete, the reaction mixture was gradually cooled to room temperature and filtered through a short bed of Celite (10 g). The Celite bed was washed with ethyl acetate (EtOAc, 20 mL). The two layers of the filtrate were separated, and the aqueous layer was extracted with ethyl acetate (EtOAc, 2¡Á30 mL). The combined organic extracts were washed with saturated aqueous NaCl solution (20 mL), dried over magnesium sulfate (MgSO4), and concentrated under reduced pressure. The residue, which contains the crude desired Suzuki coupling product (16), was then transferred to a 500 mL round bottom flask with THF (22 mL) for subsequent de-protection reaction without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,941685-26-3, 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Zhou, Jiacheng; Liu, Pingli; Lin, Qiyan; Metcalf, Brian W.; Meloni, David; Pan, Yongchun; Xia, Michael; Li, Mei; Yue, Tai-Yuen; Rodgers, James D.; Wang, Haisheng; US2010/190981; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 39876-88-5, 4-Chlorobenzofuro[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

First of all, 2.42 g of 4-chlorobenzofuran [3, 2-d]pyrimidine, 2.19 g of phenylboronic acid, 1.89 g of sodium carbonate, 0.10 g of bis(triphenylphosphine)palladium chloride(II) (abbreviation: Pd(PPh3)2Cl2), 20 mL of water and 201 mL of acetonitrile were placed in an eggplant type flask equipped with a reflux tube, and the interior of the flask was replaced with argon gas. The reaction vessel was irradiated with microwaves (2.45 GHz, 100 W) for 60 minutes to heat. Then, the obtained residue was filtered with water and washed with hexane. With hexane: The obtained solid was purified by flash column chromatography of ethyl acetate = 2:1 to eluent solvent to give the desired pyrimidine derivative Hpbf pm (white powder, yield 45%). Further, microwaves were irradiated using a microwave synthesizer (manufactured by CEM Corporation, Discover).

The synthetic route of 39876-88-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Co., Ltd. Semiconductor Energies Institute; Jing Shangyingzi; Shan Kouzhiye; Lai Weiguangmei; Lai Weizheshi; (69 pag.)CN103450279; (2018); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 147118-40-9, Rosuvastatin methyl ester, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Rosuvastatin methyl ester, blongs to pyrimidines compound. Recommanded Product: Rosuvastatin methyl ester

Add 150 ml of acetonitrile to the 500 ml reaction flask and add 18.0 g of RSM. After completely dissolving, 40 ml of purified water was added and heated to 35 ¡ã C to 40 ¡ã C. 42 ml of 1N sodium hydroxide solution was added dropwise to control the dropping rate Keep the temperature between 35 ~ 40 , the entire drop process takes about 10 ~ 15min, continue to react and then need 2 to 2.5 hours.The reaction was completed at 40 ¡ã C to 50 ¡ã C under reduced pressure to remove the acetonitrile organic solvent and then 30 ml of purified water was added to open the jacketed cooling water to lower the temperature of the contents to 25 ¡ã C to 30 ¡ã C and washed with ether 3 times, each with ether 50 ml, each stirring 10 ~ 15min, static liquid separation, collecting water layer.Then add 3 g of activated carbon in the water layer, heating to maintain the temperature 35 ~ 40 , stirring 50 ~ 60min, filter, filter with 10 ml of purified water filter cake, combined filtrate and lotion, the filtrate was vacuum distillation RSA 19.0 g

At the same time, in my other blogs, there are other synthetic methods of this type of compound,147118-40-9, Rosuvastatin methyl ester, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing Ouxin Pharmaceutical Technology Co., LTD; Chen, Ben Shun; Zhou, Zhang Yue; Chen, Kai; Qi, Chen Chen; (14 pag.)CN104230817; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1211443-61-6, name is 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

General procedure: To a suspension of 2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (5) (586 mg, 2 mmol) in 20 mL 1,4-dioxane were added compound 3a-f, 3i-u(2 mmol), Pd(OAc)2 (11 mg, 0.05 mmol), BINAP (62 mg, 0.1 mmol) and Cs2CO3 (978 mg, 3 mmol) and the flask was purged with Ar. Then the flask was sealed and the mixture was heated for 12 h at 100. The reaction was cooled to rt, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography to obtain 4a-f, 4i-o, 4r-u.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1211443-61-6, 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide.

Reference:
Article; Li, Yongtao; Guo, Qingxiang; Zhang, Chao; Huang, Zhi; Wang, Tianqi; Wang, Xin; Wang, Xiang; Xu, Guangwei; Liu, Yanhua; Yang, Shengyong; Fan, Yan; Xiang, Rong; Bioorganic and Medicinal Chemistry Letters; vol. 27; 15; (2017); p. 3231 – 3237;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1240390-28-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1240390-28-6, name is 2,4-Dichloropyrimidine-5-carboxylic acid amide. This compound has unique chemical properties. The synthetic route is as follows.

4-(Bicyclo [1.1.1] pentan-l-ylamino)-2-chloropyrimidine-5-carboxamide : A mixture of 2,4-dichloro-pyrimidine-5-carboxamide (2 g), bicyclo[l.l.l]pentan-l-amine hydrochloride (1.18 g), sodium bicarbonate (1.75 g), and NMP (10 mL) was stirred at 25 C for 24 h. Water (10 mL) was charged maintaining the reaction temperature less than 30 C, and the mixture was stirred at 25 C for 2 h. The suspension was filtered, and washed with NMP: water (1 : 1 10 mL), then water (2X10 mL), and dried in a vacuum oven at 40 C with nitrogen sweep to give 4-(bicyclo[l .l . l]pentan-l-ylamino)-2-chloropyrimidine-5 -carboxamide as a white solid (1.97 g, 83 %yield). 1H NMR (DMSO-d6) delta 2.14 (s, 6H), 2.51-2.53 (m, 1H), 7.76 (br. s., 1H), 8.23 (br. s., 1H), 8.60 (s, 1H), 9.57 (s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1240390-28-6, 2,4-Dichloropyrimidine-5-carboxylic acid amide.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; FERRETTI, Antonio Christian; MAN, Hon-Wah; MUSLEHIDDINOGLU, Jale; XU, Jean; YONG, Kelvin Hin-yeong; BEAUCHAMPS, Marie Georges; KOTHARE, Mohit Atul; ZHOU, Nanfei; BOERSEN, Nathan Andrew; LI, Ying; HILGRAF, Robert; NAGY, Mark A.; ZOU, Daozhong; HUANG, Lianfeng; WO2015/116755; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 6299-85-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-85-0, name is Methyl 2,6-dichloropyrimidine-4-carboxylate. A new synthetic method of this compound is introduced below.

A suspension of methyl 2,6-dichloropyrimidine-4-carboxylate (1g, 4.87 mmol) in methanol (20 ml) was cooled to -20C, to this 2,4-difluoro benzylamine (0.627mg, 4.39 mmol) and triethylamine (0.98 mg, 9.74 mmol) were added. The reaction mixture was stirred at same temperature for 1 hr then at room temperature for 4 hrs. Methanol was removed under vacuum. The residue was purified by column chromatography to get the title compound. Yield: 45.93% TLC: Pet ether/Ethyl acetate (7/3): Rf: 0.4 LCMS: Mass found (+MS, 314.0) Rt (min): 4.16 Area %: 97.75 (at max), 98.54 (at 254nm) HPLC: > 99% Rt (min): 4.23 Area %: 99.27 (at max), 98.66(at 254nm) 1H NMR (400MHz, DMSO-d6): delta 8.79-8.76 (m, 1 H), 7.47-7.41 (m, 1 H), 7.30-7.24 (m, 1 H), 7.12 (s, 1 H), 7.10-7.05 (m, 1 H), 4.71 (d, J = 5.52 Hz, 2H), 3.83 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,6299-85-0, its application will become more common.

Reference:
Patent; MERCK PATENT GMBH; HEINRICH, Timo; BRUGGER, Nadia; JOSEPHSON, Kristopher; WO2013/4332; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 3286-55-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3286-55-3, name is 6-Chloro-2-methoxypyrimidin-4-amine, molecular formula is C5H6ClN3O, molecular weight is 159.57, as common compound, the synthetic route is as follows.

Step 1: 4-(6-amino-2-methoxypyrimidin-4-yl)benzonitrile To a mixture of 6-chloro-2-methoxypyrimidin-4-amine (Ark Pharm, catNo.AK-25131: 1.3 g, 8.0 mmol), (4-cyanophenyl)boronic acid (1.41 g, 9.60 mmol) and sodium carbonate (1.7 g, 16 mmol) in 1,4-dioxane (15 mL) and water (5 mL) was added dichloro(bis{di-tert-butyl[4-(dimethylamino)phenyl]phosphoranyl})palladium (170 mg, 0.24 mmol). The reaction mixture was purged with nitrogen then stirred at 95 C. overnight. The reaction mixture was cooled to room temperature then water (20 mL) was added. The resulting precipitate was collected via filtration then dried to give the desired product (1.7 g, 94%), which was used in the next step without further purification. LC-MS calculated for C12H11N4O (M+H)+: m/z=227.1. found 227.1.

Statistics shows that 3286-55-3 is playing an increasingly important role. we look forward to future research findings about 6-Chloro-2-methoxypyrimidin-4-amine.

Reference:
Patent; Incyte Corporation; He, Chunhong; Li, Zhenwu; Wu, Liangxing; Yao, Wenqing; Zhang, Fenglei; (84 pag.)US2016/289238; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1044767-99-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1044767-99-8, name is 5-Bromo-4-chloropyrimidin-2-amine. A new synthetic method of this compound is introduced below.

Step a: 5-bromo-4-chloropyrimidine-2-amine (2) (370.27 mg, 2.94 mmol), and 2-furancarbohydrazide (3a) (300 mg, 1.44 mmol), dissolved in 10 mL n-butanol At 120 C under nitrogen, the reaction was refluxed for 12 hours, concentrated under reduced pressure to remove the solvent, and subjected to silica gel column chromatography (CH2Cl2: MeOH = 10: 1) to obtain N ‘-(2-amino-5-bromopyrimidin-4-yl ) furan-2-carbohydrazide (4a)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1044767-99-8, 5-Bromo-4-chloropyrimidin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; Fudan University; Chang Jun; Wang Meiling; Jin Lin; Zhang Heyanhao; Niu Tong; (9 pag.)CN111018858; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 287714-35-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 287714-35-6, name is Methyl 2-chloropyrimidine-5-carboxylate, molecular formula is C6H5ClN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Preparation 79: 2-[(3i?,45)-3-feri-Butoxycarbonylamino-4-(2,5-difluoro-phenyl)- pyrrolidin-l-yl]-pyrimidine-5-carbox lic acid methyl esterTo a solution of 2-chloro-pyrimidine-5-carboxylic acid methyl ester (2.1 g, 12mmol) and [(3R,45′)-4-(2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester (Preparation 193, 4.0g, 13mmol) in DCE (l OOmL) was added triethylamine (3.3mL, 23mmol) and the resulting reaction mixture was stirred at r.t. for 16 h. The reaction mixture was diluted with DCM (200mL), washed with water (200mL) and brine (400mL), dried (MgS04), filtered and concentrated in vacuo. The remainder was triturated with MeOH and the solid collected by filtration to afford the title compound: RT = 3.95 min; mlz (ES ) = 435.18 [M+ H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 287714-35-6, Methyl 2-chloropyrimidine-5-carboxylate.

Reference:
Patent; PROSIDION LIMITED; BARBA, Oscar; BERTRAM, Lisa, Sarah; CARSWELL, Emma Louise; DAVIS, Susan, Helen; FRY, Peter, Timothy; GLEAVE, Robert James; JEEVARATNAM, Revathy, Perpetua; JOHNSTONE, Craig; KEILY, John; PROCTER, Martin, James; SCHOFIELD, Karen, Lesley; STEWART, Alan, John, William; SWAIN, Simon, Andrew; WO2013/26587; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia