Day: March 10, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1192479-35-8, name is 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine

To a solution of 2-chloro-5-fluoro-4-methoxy-6-methylpyrimidine (2 g) in carbon tetrachloride (24 ml) was added AIBN (0.2 g) and NBS (6 g) and the reaction mixture stirred under reflux for twenty six hours then allowed to cool overnight. The reaction mixture was poured into cold water and extracted with dichloromethane (2 x 100 ml); the combined organic layer was washed with water and brine then dried (MgSC”4) and evaporated. The residue was triturated with diethyl ether / hexane and a white solid filtered off and the filtrate evaporated to give the title compound (2.61 g) which contained an approximately 1 :3 mixture of 4-(bromomethyl)-2-chloro-5-fluoro-6- methoxypyrimidine : 2-chloro-5-fluoro-4-methoxy-6-methylpyrimidine.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1192479-35-8, 2-Chloro-5-fluoro-4-methoxy-6-methylpyrimidine.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; HALL, Adrian; FARTHING, Christopher Neil; EATHERTON, Andrew John; WO2014/13076; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 705263-10-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 705263-10-1 as follows.

Preparative Example 14 Step 1 : 6-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyrazolo[l,5-a]pyrimidine To a solution of 6-bromopyrazolo[l,5-a]pyrimidine (1.5 g, 7.57 mmol) in 1,4-dioxane (20 mL) were added 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (2.12 g, 8.33 mmol), potassium acetate (1.48 g, 15.14 mmol) and l,l’-bis(diphenylphosphino)ferrocene-palladium(II)dichloride (553 mg, 0.76 mmol). The reaction mixture was purged with nitrogen for 2 min and heated to 100 C for 4 h and subsequently concentrated to dryness in vacuo. The resulting viscous mass was diluted with water and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were dried over sodium sulfate and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 30% ethyl acetate in hexane) affording 6-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)pyrazolo[l ,5-a]pyrimidine (1.0 g, 54%): lU NMR (400 MHz, Chloroform-d) delta 8.99 (s, 1H), 8.69 (s, 1H), 8.15 (d, / = 2.4 Hz, 1H), 6.67 (d, J = 2.4 Hz, 1H), 1.42 (s, 12H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,705263-10-1, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; HUESTIS, Malcolm; KELLAR, Terry; PATEL, Snahel; SHORE, Daniel; SIU, Michael; (260 pag.)WO2016/142310; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 330786-24-8, name is 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine. A new synthetic method of this compound is introduced below., Safety of 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Example 1-1 : Preparation of (i?)-3-(4-phenoxyphenyl)-l-(pyrrolidin-3-yl)-lH-pyrazolo[3,4- Patent; PHARMACYCLICS, INC.; CHEN, Wei; LOURY, David, J.; MODY, Tarak, D.; WANG, Longcheng; WO2013/10136; (2013); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 769-42-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.769-42-6, name is 1,3-Dimethylbarbituric acid, molecular formula is C6H8N2O3, molecular weight is 156.1393, as common compound, the synthetic route is as follows.

To a solution of 1,3-dimethylbarbituric acid (3.90 grams, 25.0 mmol) in 100 mL hot H2O was added a solution of benzaldehyde (2.65 grams, 25.0 mmol) in EtOH (20 mL). The resultant mixture was stirred vigorously while heating at reflux. After 5 hours, the mixture was allowed to cool to room temperature, and the precipitate was collected via filtration, washing with additional water. After drying overnight, this provided 5-benzylidene-l,3-dimethylpyrimidine-2,4,6-trione (5.90 grams, 97% yield) as a pale yellow solid.

Statistics shows that 769-42-6 is playing an increasingly important role. we look forward to future research findings about 1,3-Dimethylbarbituric acid.

Reference:
Patent; 3M INNOVATIVE PROPERTIES COMPANY; MOSER, William H.; TOWNSEND, Erik M.; THOMPSON, Zachary J.; CARUSO DAILEY, Mary M.; KROPP, Michael A.; (46 pag.)WO2019/152187; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 330786-24-8 ,Some common heterocyclic compound, 330786-24-8, molecular formula is C17H13N5O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 8 (1 mmol) and substituted benzyl bromide 9 (1.2 mmol) in N, N-dimethylformamide (5 mL) was added K2CO3 (1.5 mmol) and the reaction mixture was stirred for 5 h at room temperature.The reaction solution was poured into water (50 mL). The suspension was filtered and the crude product was purified by silica gel column chromatography with dichloromethane/methanol (80/1-40/1) to give target compounds 10a – 10n.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 330786-24-8, 3-(4-Phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ran, Fansheng; Liu, Yang; Liu, Meixia; Zhang, Daoguang; Wang, Peng; Dong, Junze; Tang, Wendi; Zhao, Guisen; Bioorganic Chemistry; vol. 89; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 13544-44-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13544-44-0, name is 2,4-Dichloro-5-iodopyrimidine, molecular formula is C4HCl2IN2, molecular weight is 274.88, as common compound, the synthetic route is as follows.

S-62 (20 g) was converted to S-63 by reaction S-63b and S-62 in the presence of NaHCOs in DMA at 80 C for 12h. After purification, 12 g of S-63 was obtained .

The chemical industry reduces the impact on the environment during synthesis 13544-44-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; G1 THERAPEUTICS, INC.; STRUM, Jay, Copeland; JUNG, David; (207 pag.)WO2019/136244; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 5305-40-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5305-40-8, name is 4,6-Dichloropyrimidine-5-carbaldehyde, molecular formula is C5H2Cl2N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of aldehyde 14.1 (1.50 g, 8.48 mmol, 1.0 equiv.) in toluene (18 mL) was added 7 M NH3 in MeOH (1.8 mL, 12.7 mmol, 1.5 equiv.) and the reaction mixture was heated to 55 C. Additional NH3 was added (7 M in MeOH, 3.5 mL, 24.5 mmol) over the next 4 hr, and then the reaction mixture was cooled to RT. Water (2 mL) was added and the resultant mixture was concentrated. The residue was dissolve in MeOH and adsorbed onto SiO2 gel. Purification by flash column chromatography (20-25-33-40% EtOAc/hexanes) afforded 15.2 (0.88 g, 66%) as a beige solid. LCMS: m/z: 158 [M+1]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5305-40-8, 4,6-Dichloropyrimidine-5-carbaldehyde.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2009/36419; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 705263-10-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 705263-10-1, name is 6-Bromopyrazolo[1,5-a]pyrimidine, molecular formula is C6H4BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

6-Bromo-pyrazolo [1,5-a] pyrimidine (2.0 g, 10.0 mmol) dissolved in 20 mL of toluene, [1,1′-bis (diphenylphosphino) ferrocene Fe] dichloropalladium (0.7 g, 1 mmol), potassium acetate (4.0 g, 40.0 mmol) and the associated acid pinacol ester (5.1 g, 20.0 mmol) were added in the flask. It was heated to reflux under argon for 5 h, and TLC monitoring of the reaction process until the starting material disappeared stop heating. The reaction solution was cooled to room temperature and concentrated under reduced pressure. The residue was purified by column chromatography (eluent: petroleum ether / ethyl acetate). White solid, yield: 65%. 1H NMR (CDCl3, 400 MHz, delta ppm):8.71 (d, J = 1.6 Hz, 1H), 8.17 (d, J = 2.2 Hz, 1H), 1.38 (s, 12H). ESI-MS(m/z): 246.1 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 705263-10-1, 6-Bromopyrazolo[1,5-a]pyrimidine.

Reference:
Article; Hu, Liming; Cao, Tingting; Lv, Yongjuan; Ding, Yiming; Yang, Leifu; Zhang, Qiang; Guo, Mingzhou; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5830 – 5835;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 155-10-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 155-10-2, name is 4-Amino-2-chloro-5-fluoropyrimidine, molecular formula is C4H3ClFN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

10287] 0.15 g (1.01 mmol) of 2-chloro-5-fluoropyrimi- dine-4-amine, 0.249 g (1.22 mmol) of (2-methyl-4,5,6,7- tetrahydrobenzothiophen-4-yl)ammonium chloride and 0.63 g (0.68 ml, 3.05 mol) of dicyclohexylethylamine in 2.0 ml of 1-methyl-2-pyrrolidone are heated at 180 C. in a closed cuvette in the microwave for 90 minutes (l3iotage Initiator, http://www.biotage.comlproduct-page/biotage-initiator).The crude mixture thus obtained is applied to silica gel and purified by column chromatography with heptane/ethyl acetate as mobile phase. Concentration gives 0.072 g of 5-fluoro-N2-(2-methyl-4,5,6,7-tetrahydro- 1 -benzothiophen-4-yl)pyrimidine-2,4-diamine (in waxy form) (22% yield at 85% purity).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 155-10-2, 4-Amino-2-chloro-5-fluoropyrimidine.

Reference:
Patent; Bayer CropScience Aktiengesellschaft; JAKOBI, Harald; MINN, Klemens; BUSCATO ARSEQUELL, Estella; DIETRICH, Hansjoerg; GATZWEILER, Elmar; ROSINGER, Christopher Hugh; SCHMUTZLER, Dirk; (44 pag.)US2018/213780; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 13036-50-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13036-50-5, name is 2-Chloro-4-phenylpyrimidine, molecular formula is C10H7ClN2, molecular weight is 190.629, as common compound, the synthetic route is as follows.

Example 37 2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetamidePart I: 2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetic acidGeneral Procedure I: Microwave assisted halogen displacement with amino group [0166] A mixture of 2-chloro-4-phenylpyrimidine (0.19 g, 1.0 mmol), 2-(4- aminophenyl)acetic acid (0.38 g, 2.5 mmol), diisopropylethylamine (0.38 mL, 2.0 mmol), THF (3.0 mL) and water (1.0 mL) was placed in a seal tube and heated up to 160C in a microwave (Biotage, Model: Initiator) for 1O h. The reaction mixture was diluted with ether and washed with brine. The organic layer was separated, dried (MgSO4), and concentrated to afford 2-(4-(4-phenylpyrimidin-2-ylamino)phenyl)acetic acid in 77% yield. MS (ESI) 306 (M+H).

Statistics shows that 13036-50-5 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-4-phenylpyrimidine.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2009/32861; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia