Day: March 11, 2021

Related Products of 1224944-77-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1224944-77-7, name is Ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Combined triethylamine (1 187 mL, 8518 mmol), (R)- 5-fluoro-2-methoxy-3-(pyrrolidin-2-yl) pyridine (7) (889 g, 4259 mmol) in EtOH (200 proof, 5 mL/g, 4.4 L) and then ethyl 5-chloropyrazolo[l,5-a]pyrimidine-3-carboxylate (8)(1001 g, 4259 mmol) were added. The reaction was stirred overnight at ambient temp (19 h). The next day, water (10 mL/g, 8.9 L) was added and after stirring at room temperature for 2 h it was filtered through polypropylene filter cloth (PPFC), 23 C and washed with 2: 1 watenEtOH (2 x 1.8 L) then heptane (1.8 L). The product was placed in trays and dried under vacuum (with N2 bleed) at 55C to give 9.

According to the analysis of related databases, 1224944-77-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ZHAO, Qian; SPENCER, Stacey; JIANG, Yutong; HAAS, Julia; EARY, Charles Todd; (335 pag.)WO2018/81417; (2018); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1753-50-0, name is 2-Chloropyrimidine-5-carbonitrile. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 1753-50-0

To a stirred solution of 2-chloropyrimidine-5-carbonitrile (AF, 3.95 g, 28 mmol) and compound LH (7.0 g, 21.8 mmol) in EtOH (50 mL), DIPEA (18.5 mL, 109 mmol) was added and the reaction was stirred at 90C for 16 h. The progress of the reaction was monitored by TLC. After completion of the reaction, the reaction mixture was concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using 20% EtOAc/hexane to afford racemic compound LI (8.5 g, 91.9%) as an off white solid. 1H NMR (400 MHz, DMSO-d6): _ 8.79 (d, = 8.4 Hz, 1H), 8.67 (d, = 9.6 Hz, 2H), 7.46 (d, = 8.4 Hz, 2H), 7.30 (d, = 7.6 Hz, 2H), 6.99 (m, 1H), 5.22- 5.17 (m, 1H), 3.36 -3.29 (m, 2H), 1.29 (s, 9H). LC-MS: m/z 424.10 [M+H]+; HPLC Purity: 98.60%.

With the rapid development of chemical substances, we look forward to future research findings about 1753-50-0.

Reference:
Patent; VPS-3, INC.; YATES, Christopher, M.; (397 pag.)WO2018/165520; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 63211-98-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63211-98-3, name is 2-Chloro-6-methylpyrimidine-4,5-diamine, molecular formula is C5H7ClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: 2-Chloro-6-methyl-8-propylpurine A mixture of 2-Chloro-4,5-diamino-6-methylpyrimidine (0.80 g, 5.04 mmol), trimethylorthobutyrate (1.2 ml, 7.6 mmol) and p-TsOH (0.08 g) in 2-methoxyethanol (24 ml) was heated in an oil bath at 140 C. for 24 hours. The product was isolated as described in Step 2 of Example 12 and purified by flash chromatography using EtOAc-hexane (1:1) to give the crystalline titled compound (0.5 g, 47%). NMR (CDCl3): delta1.03 (t, J=8 Hz,3H), 1.9 (q,2H), 2.82 (s, 3H), 3.0 (t, J=8 Hz, 2H). FAB-MS: m/e 211 and 213 (M+H). Analysis calculated for C9 H11 N4 Cl: C, 51.31; H, 5.26; N, 26.60. Found: C, 51.43; H, 5.50, N, 26.81.

According to the analysis of related databases, 63211-98-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Merck & Co., Inc.; US5102880; (1992); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 7752-78-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7752-78-5, name is 5-Bromo-2-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

This compound was synthezised according to J. Am. Chem. Soc, 2011, 133, 6948-6951. To a solution of 5-bromo-2-methylpyrimidine (5.78 mmol) and 4-isoxazoleboronic acid pinacol ester (6.07 mmol) in DMSO (40 ml_) was added a solution of potassium fluoride (17.30 mmol) in water (17 ml_). The mixture was flushed with argon, Pd(dppf)CI2.DCM (0.58 mmol) was added and the mixture was heated for 48h at 130¡ãC. It was filtered over a pad of Celite and washed with EtOAc. The filtrate was partitioned between water and EtOAc and the aqueous phase was extracted twice with EtOAc. The combined organic phases were dried over MgS04 and concentrated in vacuo. The crude was purified by CC using DCM/MeOH from 1/0 to 95/5 to give the title compound as brown oil. LC-MS (A): tR = 0.43 min; [M+ H]+: 134.10

According to the analysis of related databases, 7752-78-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; HILPERT, Kurt; HUBLER, Francis; RENNEBERG, Dorte; STAMM, Simon; WO2014/97140; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 148550-51-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.148550-51-0, name is Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate, molecular formula is C8H10N2O4S, molecular weight is 230.24, as common compound, the synthetic route is as follows.

A solution of (E)-2-chloro-l l-(piperazin-l-yl)dibenzo[b,f][l,4]oxazepine (0.25 g, 0.8 mmol) and ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate (0.13 g, 0.57 mmol) in DME was stirred at room temperature for 1 h. The reaction mixture was diluted with water and extracted with ethyl acetate. The organic extract was washed with saturated aqueous solution of bicarbonate, water, acetic acid and sodium acetate (pH=4), dried over sodium sulfate and solvent evaporated. The resulting crude residue was purified by flash chromatography (0percent to 30percent ethyl acetate in hexane) to afford title compound 116 (0.265 g, quant.).

Statistics shows that 148550-51-0 is playing an increasingly important role. we look forward to future research findings about Ethyl 2-(methylsulfonyl)pyrimidine-5-carboxylate.

Reference:
Patent; METHYGENE INC.; EN VIVO PHARMACEUTICALS, INC.; WO2008/55068; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 66131-68-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 66131-68-8, name is 2-Chloro-N-methylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2-(5-chloro-2,4-dimethoxyphenyl)-7-(piperazin-1-yl)imidazo[1,2-a]pyridine 301 (200 mg, 0.53 mmol) and N,N-diisopropylethylamine (0.4 mL, 2.29 mmol) in DMF (5 mL) was charged with 2-chloro-N-methylpyrimidin-4-amine ( 155 mg, 1.07 mmol). The reaction mixture was stirred at 100 C for 16 h. The reaction mixture was cooled to room temperature, suspended in water and stirred for 1 h. The precipitate was collected by filtration; the solid obtained was washed with water, dried under reduced pressure and purified by combi-fash companion (silica gel, CH3OH/CH2Cl2). The product was further triturated with methanol and filtered. The solids were washed with hexanes and dried to provide 2-(4-(2-(5-chloro-2,4-dimethoxyphenyl)imidazo[1,2-a]pyridin-7-yl)piperazin-1-yl)-N-methylpyrimidin-4-amine 418a (20 mg, 8%) as light brown solid. 1H NMR (300 MHz, DMSO-d6) delta 8.34 i d . ./ 7.5 Hz, 1H), 8.15 (s, 1H), 8.04 (s, 1H), 7.75 (br s, 1H), 6.97 (br s, I I I ) . 6.89 (s, IH), 6,87 (s, 1H), 6,71 (s, i l l ). 5.78 (d, ./ 5,7 Hz, 1H), 4.01 (s, 3H), 3.93 (s, 3H), 3.83 (br s, 4H), 3.33 (br s, 4H), 2,78 (d, ,/ 4.2 Hz, 3H): HPLC (Method 1 ) 92.8% (AUC), fR = 1 1.85 min.; ESI+APCI MS m/z 480 [M + Hf.

According to the analysis of related databases, 66131-68-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ONCOTHERAPY SCIENCE, INC.; MATSUO, Yo; HISADA, Shoji; NAKAMURA, Yusuke; CHAKRABARTI, Anjan; RAWAT, Manish; RAI, Sanjay; SATYANARAYANA, Arvapalli, Venkata; DUAN, Zhiyong; TALUKDAR, Arindam; RAVULA, Srinivas; DECORNEZ, Helene; (491 pag.)WO2017/58503; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1780-32-1, name is 2,4-Dichloro-5,6-dimethylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1780-32-1

To a solution of 2,4-dichloro-5,6-dimethylpyrimidine (0.800 g, 4.55 mmol) in EtOH (40 mL) were added Na2CO3 (2.42 g, 22.8 mmol) and 1H-indazol-5-amine (0.605 g, 4.55 mmol). The resulting mixture was stirred for 12 h at 100 C. The solvent was removed under reduced pressure and the residue was poured into water (50 mL) and extracted with EtOAc (3 x 100 mL). The organic phase was dried over Na2 SO4, filtered and concentrated under reduced pressure to give a residue which was purified by column chromatograph on silica gel (eluted with PEEA = 1:1) to provide the title compound (120 mg, yield: 9.7%) as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1780-32-1, 2,4-Dichloro-5,6-dimethylpyrimidine.

Reference:
Patent; KADMON CORPORATION, LLC; KIM, Ji-in; LIU, Kevin; POYUROVSKY, Masha; LU, Dan; ZHU, Zhenping; WO2015/54317; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1215787-31-7, name is 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, molecular formula is C7H3BrClN3, molecular weight is 244.4758, as common compound, the synthetic route is as follows.Formula: C7H3BrClN3

Add 24.2 g (0.1 mol) of 4-chloro-6-bromopyrido[2,3-d]pyrimidine, 7.4 g (0.1 mol) of propylenediamine and 400 ml of 1,4-dioxane to a 1 L round bottom flask. The mixture was heated to 60 C, and the reaction was monitored by TLC until the reaction was completed, and the solvent was evaporated to givethe compound 8-1 18.9 g of white solid (yield: 79.8%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1215787-31-7, 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Heilongjiang University Of Traditional Chinese Medicine; Chen Hong; Chen Qun; Li Yan; Liu Yan; Song Qiannan; Wang Lin; Su Yuming; Liu Linlin; Dai Jinzhu; Guo Jianbo; Li Fei; Lu Lu; Guo Wei; (18 pag.)CN109836423; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106157-82-8, name is 1-(2-Aminopyrimidin-4-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1-(2-Aminopyrimidin-4-yl)ethanone

Step C: Preparation of tert-Butyl [7- {2- [L- (2-AMINO-] [PYRIMIDIN-4-YL)-ETHYLAMINO]-BENZOYLAMINO}-4,] 4-dimethyl-3,4- [DIHYDRO-LH-ISOQUINOLINE-2-CARBOXYLATE] To a solution of [1-(2-AMINO-PYRIMIDIN-4-YL)-ETHANONE] (Step B, 200 mg, 1.46 mmol) in toluene (15 mL) was added, 7- [(2-AMINO-BENZOYLAMINO)-4,] 4-dimethyl-3, [4-DIHYDRO-LH-] isoquinoline-2-carboxylic acid tert-butyl ester (Example 15, Step A) (288 mg, 0.73 mmol), and HOAc (3 drops). The resulting mixture was heated at [95 C] under N2 for 20 h. The reaction was cooled to RT and NaBH (OAc) 3 (620 mg, 2.92 mmol) was added and reheated for 3 h. The reaction was cooled to RT, quenched with [NA2CO3] solution (2 M, 5 mL), solvent was evaporated in vacuo. The residue was extracted with CHC13. The organic layer was washed with saturated [NAHC03,] water, brine, dried over [MGS04,] and evaporated in vacuo. The crude solid was purified by chromatography on silica gel. Elution with [CH2CL2 : MEOH] (95: 5) gave THE final compound. MS [M/Z] : 517.3 (M+H). [CALC’D.] for [C2GH37N603-] 517.63.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106157-82-8, 1-(2-Aminopyrimidin-4-yl)ethanone.

Reference:
Patent; AMGEN INC.; WO2004/5279; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 6299-25-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of 4, 6-Dichloro-2-methylsulfanyl-pyrimidine 0103 (5.0 g, 25.6 mmol) in CH2Cl2 (15 mL) at 0 0C was added meta-chloroperoxybenzoic acid (11.06 g, 64.1 mmol) over a period of 20 minutes. The reaction was allowed to warm to room temperature and stirred for 2.5 hours. The mixture was filtrated and the filtrate was concentrated. The resulting residue was washed with saturated Na2CO3 solution and ether to form a white solid which was dried to obtain the title compound 0104 (2.6g, 44%): LCMS: 227 [M+l]+; 1H NMR (CDCl3) delta 3.4 (s, 3H), 7.75 (s, IH).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6299-25-8, 4,6-Dichloro-2-(methylthio)pyrimidine.

Reference:
Patent; CURIS, INC.; WO2009/86012; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia