Day: March 16, 2021

Related Products of 3435-25-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3435-25-4, name is 4-Chloro-6-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Example 8: Synthesis of (S)-methyl-2-((2R,3R)-3-((S)-1 -((3R,4S,5S)-4-((S)-N,3-dimethyl- 2-((4-methylpyrimidin-2-yl)amino)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2- yl)-3-methoxy-2-methylpropanamido)-3-phenylpropanoate (FP-8)To a solution of Val-Dil-Dap-PheOMe TFA salt (5.0 mg, 0.0067 mmol) in 2-propanol (2 ml) in a 4 oz. vial were added 2-chloro-4-methylpyrimidine (2.6 mg, 0.020 mmol) and DIEA (4.3 mg, 0.033 mmol). The vial was sealed and heated at 100 oC for 4 days. The crude was purified by preparative HPLC using a 20-50% gradient to obtain (S)-methyl-2- ((2R,3R)-3-((S)-1 -((3R,4S,5S)-4-((S)-N,3-dimethyl-2-((4-methylpyrimidin-2- yl)amino)butanamido)-3-methoxy-5-methylheptanoyl)pyrrolidin-2-yl)-3-methoxy-2- methylpropanamido)-3-phenylpropanoate (FP-8) as a TFA salt

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3435-25-4, 4-Chloro-6-methylpyrimidine.

Reference:
Patent; NOVARTIS AG; GEIERSTANGER, Bernhard; GRUNEWALD, Jan; OU, Weijia; PAN, Shifeng; UNO, Tetsuo; WAN, Yongqin; WANG, Xing; WO2015/189791; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1683-75-6, name is 2-Amino-4-chloro-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Amino-4-chloro-5-fluoropyrimidine

To a solution of 6-bromo-4-methoxy-lH-indole-3-carbaldehyde A.140 (0.65 g, 2.56 mmol) in DMF (13 mL) at room temperature was added Cs2CO3 (2.50 g, 7.67 mmol) followed by 4-chloro-5-fluoropyrimidin-2-amine A.53 (0.453 g, 3.07 mmol) and the mixture was stirred at 80 0C for 6 hours. The mixture was concentrated under reduced pressure and purified by silica gel column chromatography using 0% to 100% gradient of dichloromethane-methanol- NH4OH (89:9:1) in dichloromethane as eluent to give l-(2-amino-5-fiuoropyrimidin-4-yl)-6- bromo-4-methoxy-lH-indole-3-carbaldehyde A.141 (0.319 g, 34.2% yield) as a yellow solid: 1H NMR (500 MHz, DMSO-d6) 5 ppm 10.39 (1 H, s), 8.56 (1 H, d, J=3.7 Hz), 8.32 (1 H, d, J=2.7 Hz), 7.95 (1 H, s), 7.13 (2 H, s), 7.12 (1 H, d, J=1.4 Hz), 4.01 (3 H, s); Mass Spectrum(ESI) m/e = 365.0 [M+l ( 79Br] and 367.0 [M+l (81Br)].

With the rapid development of chemical substances, we look forward to future research findings about 1683-75-6.

Reference:
Patent; AMGEN INC.; WO2009/158011; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 26032-72-4 ,Some common heterocyclic compound, 26032-72-4, molecular formula is C10H6Cl2N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

2.3 g (10 mmol) of intermediate product (A), 7.5 g (22 mmol) of l-(4- (4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl)isoquinoline (D), and 0.6 g (0.5 mmol) of tetrakis-(triphenylphosphine)palladium were suspended in a mixed solvent of 70 ml of tetrahydrofuran and 50 ml of toluene to provide a suspension. The suspension was added to a solution in which 5.7 g (41 mmol) of potassium carbonate was dissolved in 50 ml of water. The obtained mixture was heated and refluxed for 12 hours. After separating the reaction fluid into two layers, an organic layer thereof was washed with a saturated sodium chloride aqueous solution and dried with anhydrous sodium sulfate. <134> The organic solvent was disti Hated and removed under reduced pressure, and then the residue was recrystallized with toluene. The extracted crystal was separated by filtration and washed with toluene to obtain 3.9 g (yield- 68.0 %) of compound (10).<135> 1H NMR (300MHz, CDCl3) 8.94 (d,2H), 8.68 (d,2H), 8.52 (d,2H), 8.39(d,2H), 8.21 (d,2H), 8.16 (s,lH), 7.94 (m,6H), 7.72 (m,4H), 7.61 (m,5H); MS[M+1] 563.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,26032-72-4, its application will become more common.

Reference:
Patent; CHEIL INDUSTRIES INC.; KIM, Nam-Soo; KANG, Myeong-Soon; JUNG, Ho-Kuk; KANG, Eui-Su; PARK, Young-Sung; CHAE, Mi-Young; PARK, Jin-Seong; WO2010/24572; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 302964-08-5 ,Some common heterocyclic compound, 302964-08-5, molecular formula is C16H13Cl2N5OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of the starting material 7H (150 mg, 0.38 mmol), dioxane (8 mL) were added piperidine (97 mg, 1.14 mmol, 3 eq) and DIEA (147 mg, 1.14 mmol, 3 eq) at room temperature. The mixture was stirred at 90-91 C. under nitrogen for 15 h. LC-MS analysis showed the product peak. The mixture was not a clear solution. The mixture was concentrated to dryness and suspended in 50 mL acetonitrile containing 20% HPLC grade water. The mixture was then centrifuged at 4000 rpm for 15 min. The pellet was re-suspended in acetonitrile and centrifuged again at 4000 rpm for 15 min. The final pellet was dried under nitrogen to afford the target compound VIII (H-20) (?129 mg) as an off-white solid. LC-MS: 443.14 (M+H); 1H NMR (DMSO-d6): 11.52 (s, 1H. NH), 9.82 (s, 1H, NH), 8.18 (s, 1H), 7.39 (m, 1H), 7.21 (m, 2H), 6.00 (s, 1H), 3.55 (m, 4H), 3.22 (s, 3H), 2.43 (s, 3H), 1.65 (m, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 302964-08-5, 2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Princeton Drug Discovery Inc; He, Kan; (37 pag.)US2018/99960; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6153-44-2, name is Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate, molecular formula is C6H6N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of Methyl 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate

6-morpholin-4-yl-2-pyridin-2-yl-pyrimidine-4-carboxyIic acidMethyl orotate (5 g, 29.41 mmol) was suspended in phosphorous oxychloride (50 ml) and the mixture was heated to reflux for 4 hours. After this time excess phosphorous oxychloride was removed under reduced pressure. The resulting dark residue was poured onto ice with vigorous stirring and the solution was left to stir until all the ice had melted. The crude product was then collected by filtration and the filtrate was extracted with ether (x2). The filtered product was added to the ether washings and dried over magnesium sulfate. The solution was then concentrated to give methyl 2,6-dichloropyrimidine-4- carboxylate (5.25g, 25.37mmol) as a yellow oil that solidified on standing. To this was added morpholine (2.005g, 25.37 mmol) and THF (40ml) and the mixture left for 2 hours at room temperature. The reaction was then evaporated to dryness to afford methyl 2- chloiO-6-morpholin-4-yl-pyrirnidine-4-carboxylate (5.4 Ig, 21 mmol) LCMS Spectrum: MH+ 258.39, Retention time 1.56, Method: Monitor Base Methyl 2-chloro-6-morpholin-4-yl-pyrimidine-4-carboxylate (2.58g, lOmmol), 2- tributylstannyl pyridine (4.055g, 11 mmol) and tetrakis(triphenylphosphine)palladium (0) (1 Omolpercent, lmmol, 1.116g) were suspended in THF (20 ml) and heated to 100 0C for 30 minutes in the microwave. To this mixture was added sodium hydroxide (20 ml) (4M in H2O), and the reaction was stirred for 1 hour. The resulting precipitate was collected by filtration found to be the monosodium salt of 6-morpholin-4-yl-2-pyridin-2-yl-pyrimidine- 4-carboxylic acid, (1.53g). LCMS Spectrum: (M+Na)+ 308.47, Retention Time 1.42, Method: Monitor BaseNMR Spectrum: 1H NMR (300.132 MHz, D2O) 53.70 – 3.86 (m, 8H), 7.11 (s, IH), 7.51 (ddd, IH), 7.94 (td, IH), 8.28 (d, IH), 8.60 (d, IH) ppm.

With the rapid development of chemical substances, we look forward to future research findings about 6153-44-2.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/80382; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22536-61-4, name is 2-Chloro-5-methylpyrimidine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyrimidines

In a sealed glass tube a suspension of l-cyclopropyl-6-(lH-imidazol-5-yl)-3,3-dimethylindolin- 2-one (example 71a, 70 mg), 2-chloro-5-methylpyrimidine (37.0 mg) and cesium carbonate (158 mg) in acetonitrile (1.05 ml) was heated to 120 C for 30 minutes under microwave irradiation. Then again 18 mg 2-chloro-5-methylpyrimidine and 89 mg cesium carbonate were added and the reaction mixture heated to 120C under conventional heating for 2 hours. The reaction mixture was concentrated in vacuo and purified by flash chromatography (silica gel, gradient, 0% to 100% EtOAc in n-heptane). The title compound was obtained as off white solid (75 mg, 80%). MS (ESI, m/z): 360.2 [(M+H)+].

With the rapid development of chemical substances, we look forward to future research findings about 22536-61-4.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; HILPERT, Hans; KOLCZEWSKI, Sabine; LIMBERG, Anja; STOLL, Theodor; WO2015/177110; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 696-82-2 ,Some common heterocyclic compound, 696-82-2, molecular formula is C4HF3N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(1) adding 100% of a 2,4-diaminobenzenesulfonic acid solution (18.8 g) to 400 mL of water, stirring Add sodium bicarbonate solid, adjust the pH to 4, slowly warm to 20 C after dissolution, add 13.94 g (99%) 2,4,6-trifluoropyrimidine, control the pH at 4, continue the reaction 2 Hours, the end point of the reaction was detected by thin layer chromatography, and the reaction solution was used after the condensation was completed;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,696-82-2, its application will become more common.

Reference:
Patent; Jiangsu Demeike Chemical Co., Ltd.; Wang Siliang; Wang Xiaojun; (16 pag.)CN108129875; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

6-hydroxypyrimidine-4-carboxylic acid 1.00 g (7.14 mmol),30 ml of methylene chloride, 3.60 g (28.4 mmol) of oxalyl chloride and 0.05 g (0.68 mmol) of N, N-dimethylformamide were added to 1.00 g (7.14 mmol), and the mixture was heated under reflux for 3 hours. Then, the reaction solution was concentrated under reduced pressure. To the obtained residue was added 30 ml of methylene chloride, 0.70 g (7.18 mmol) of O-ethylhydroxylammonium chloride and 1.45 g (14.3 mmol) of triethylamine were added under ice cooling, and the mixture was stirred at room temperature for 3 hours . Then, the reaction solution was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography Further purification gave 0.79 g (3.92 mmol, yield 55percent) of 6-chloro-N-ethoxypyridine-4-carboxamide.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; NIPPON SODA COMPANY LIMITED; ITO, SYUICHI; AMANO, TOMOHIRO; IPPOSHI, JUNJI; KOUBORI, SHINYA; (44 pag.)JP2016/30742; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3167-50-8, 2-Aminopyrimidine-5-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

To 1.9 g of polyphosphoric acid were added 500 mg (3.59 mmol) of 2-aminopyrimidine-5-carboxylic acid portionwise. It was stirred for 5 mm before 327.6 mg (3.59 mmol) of hydrazinecarbothioamide were added portionwise. It was stirred for 1 h at 140 C. It was allowed to cool down and water was added. The pH was adjusted to 12 by adding 25 vol% aqueous ammonia solution. The precipitate wasfiltered off and washed with water. It was dried under vacuum at 50 C to yield 164 mg (23%) of the title compound, containing ca. 25 mol% of the starting material.?H-NMR (300MHz, DMSO-d6): 6 [ppm]= 7.13 (s, 2H), 7.30 (s, 2H), 8.56 (s, 2H).LC-MS (Method 3): R = 0.44 mm; MS (ESIpos): m/z = 195 [M+H].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3167-50-8, 2-Aminopyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; THEDE, Kai; BENDER, Eckhard; SCOTT, William; RICHTER, Anja; ZORN, Ludwig; LIU, Ningshu; MOeNNING, Ursula; SIEGEL, Franziska; GOLZ, Stefan; HAeGEBARTH, Andrea; LIENAU, Philip; PUEHLER, Florian; BASTING, Daniel; SCHNEIDER, Dirk; MOeWES, Manfred; GEISLER, Jens; WO2015/140195; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 3438-46-8 ,Some common heterocyclic compound, 3438-46-8, molecular formula is C5H6N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

3-Methyl-pyrimidine [(9. 41] g, 100 mmol), potassium permanganate (26.9 g) and sodium carbonate (10.6 g) was refluxed in water (100 ml) for 72 h followed by filtration through celite. The filtrate was washed with several portions of DCM and EtOAc before acidification with conc. HC1. The formed precipitate was collected and washed with water to yield 1.37 g of the title compound as a white solid. 1H NMR (DMSO-d6) d (ppm): 13.94 (br. s, 1H), 9.37 (d, 1H), 9.07 (d, 1H), 8.01 (dd, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3438-46-8, its application will become more common.

Reference:
Patent; ASTRA ZENECA AB; NPS PHARMACEUTICALS, INC.; WO2004/14881; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia