Month: April 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4316-93-2

Sodium methoxide (2.70 g, 50.0 mmol) was added portionwise over 10 min to a 0C suspension OF 4, 6-DICHLORO-5-NITROPYRIMIDINE (4.85 g, 25.0 mmol) in methanol (90 ml). On complete addition the mixture was stirred at 0C for 2 h. The precipitate was filtered and the filtrate evaporated. The residue was suspended in isohexane and filtered. The filtrate was evaporated and the residue purified by flash column chromatography on silica, eluting with 5% ethyl acetate in isohexane. Collecting appropriate fractions gave 4-chloro-6-methoxy-5- nitropyrimidine (3.50 g, 74%) as a white solid

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4316-93-2, 4,6-Dichloro-5-nitropyrimidine.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2004/41826; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1421372-94-2, N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine, blongs to pyrimidines compound. Quality Control of N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine

Compound 6 (7.7 mL) was added to a suspension of N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methylindol-3-yl)pyrimidin-2-amine (compound 5, 15.5 g, 0.79) and K2CO3 (16.3 g) DMF (60 mL). The mixture was heated at 60 C. for 60 min and then water (150 mL) was added. Solids were filtered and rinsed with water. The crude dark red product was directly used in the next step without further purification.

The synthetic route of 1421372-94-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; X-Cutag Therapeutics, Inc.; CHENG, Changfu; WEN, Shuhao; LI, Hui Joyce; (30 pag.)US2019/169171; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 153435-63-3, name is 2-(Tributylstannyl)pyrimidine, the common compound, a new synthetic route is introduced below. Formula: C16H30N2Sn

38(a) ethyl N-{[6-hydroxy-7-(2-pyrimidinyl)-5-quinoxalinyl]carbonyl}glycinate. To a solution of ethyl N-[(7-bromo-6-hydroxy-5-quinoxalinyl)carbonyl]glycinate (0.120 g, 0.339 mmol) (prepared as in N2843-54-A1) in 1,4-dioxane (1.5 ml) was added 2-(tributylstannanyl)pyrimidine (0.138 g, 0.374 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.020 g, 0.017 mmol) followed by heating to 150 C. for 60 min. in a Biotage Initiator microwave synthesizer. Upon cooling, the reaction mixture was concentrated in vacuo and purified via flash column chromatography (0-100% ethyl acetate in hexane) to obtain ethyl N-{[6-hydroxy-7-(2-pyrimidinyl)-5-quinoxalinyl]carbonyl}glycinate (0.083 g, 0.235 mmol, 69.3% yield) as a pale orange solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 14.90 (s, 1H), 10.12 (t, J=5.8 Hz, 1H), 9.09 (s, 1H), 9.07 (s, 1H), 8.97 (d, J=1.8 Hz, 1H), 8.91 (d, J=2.0 Hz, 1H), 8.81 (s, 1H), 7.68 (t, J=4.9 Hz, 1H), 4.23 (d, J=5.8 Hz, 2H), 4.18 (q, J=7.2 Hz, 2H), 1.26 (t, J=7.2 Hz, 3H). MS (ES+) m/e 354 [M+H]+.

The synthetic route of 153435-63-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; US2010/305133; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 145783-15-9, 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 145783-15-9, blongs to pyrimidines compound. category: pyrimidines

(1R,2S)-2-(3,4-difluorophenyl)cyclopropylamine (R)-mandelate (Compound II, 3.31 g, 10 mmol) and4,6-Dichloro-2-(propylthio)-5-aminopyrimidine (Compound I, 2 g, 13 mmol) was placed in a 50 mL three-necked flask, and ethylene glycol (10 mL) and triethylamine (4.24 g, 42 mmol) were added. ). The reaction mixture was heated to 100 C and stirred for 7 hours. Turn off the heat and naturally cool to 40 C. Isopropyl acetate (10 mL) and water (10 mL) were added and stirred for 1 hour. Stirring was stopped, cooled to room temperature, and allowed to stand for liquid separation. The organic phase was separated, washed with water (10 mL) and dried The mixture was filtered with suction, and the residue was purified by silica gel column chromatography (200-300 mesh chromatography, eluent 0-50% ethyl acetate / petroleum ether) to give compound III (2.6 g, 68 %), light gray solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145783-15-9, its application will become more common.

Reference:
Patent; Yangzijiang Pharmaceutical Group Co., Ltd.; Miao Shifeng; Xu Haoyu; Cai Wei; Zhang Haibo; Lv Huimin; Sun Chunyan; Mu Cong; Wang Deguo; Liu Jinglong; Liu Jing; Hu Tao; (11 pag.)CN109553622; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 51-20-7, 5-Bromouracil, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 51-20-7, blongs to pyrimidines compound. HPLC of Formula: C4H3BrN2O2

To 5-bromouracil (50 G) were sequentially added N, N-diethylaniline (60 mL) and phosphoryl chloride (120 mL), and the mixture was refluxed for 5 h. The volatiles were removed by distillation, the residue poured into ice water and the mixture extracted with methyl tert-butyl ether. The combined extracts were washed with brine, dried (NA2SO4) and filtered through Celite. Distillation of the crude product gave the title compound (63.4 g). IH NMR (300 MHz, CDCl3) : O/PPM = 8.69 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,51-20-7, its application will become more common.

Reference:
Patent; SCHERING AKTIENGESELLSCHAFT; WO2004/48343; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 74901-69-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74901-69-2, name is 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, molecular formula is C6H4Cl2N2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

8.3 [1-(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-cyclopropyl]-methanol (III-4) 1.4 g (II) are placed in 10 ml dioxane, then first 3.6 ml diisopropylethylamine are added followed by 1 g 1-aminocyclopropanemethanol (cf. 8.2). The reaction mixture is heated to 160 C. until there is no further reaction, then cooled and evaporated down. The residue is treated with cyclohexane/ethyl acetate (8:2) in the ultrasound bath and the solid is suction filtered and dried. 1.24 g (III-4) are obtained in the form of a solid. Analytical HPLC-MS (method A): RT=1.01 min.

According to the analysis of related databases, 74901-69-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/28932; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5466-43-3, name is 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine, molecular formula is C7H6Cl2N2, molecular weight is 189.04, as common compound, the synthetic route is as follows.Computed Properties of C7H6Cl2N2

A mixture of 2,4-dichloro-6,7-dihydro-5H-cyclopenta[if|pyrimidine (0.250 g, 1.32 mmol) and sodium thiomethoxide (0.093 g, 1.32 mmol) in THF (10 mL) was stirred at rt for 6 h. After this time, the mixture was diluted with saturated aqueous sodium bicarbonate and extracted with ethyl acetate. The combined organic layer was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated. The residue was purified by column chromatography (silica, hexanes/ethyl acetate) to afford the title compound (0.210 g, 84%) as an off-white solid. MW = 200.69. NMR (DMSO- , 300 MHz) delta 2.90 (t, / = 7.6 Hz, 2H), 2.71 (t, / = 7.6 Hz, 2H), 2.56 (s, 3H), 2.10 (quin, / = 7.6 Hz, 2H); APCI MS mJz 201 [M + H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5466-43-3, 2,4-Dichloro-6,7-dihydro-5H-cyclopenta[d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; TETRA DISCOVERY PARTNERS, LLC.; GURNEY, Mark, E.; HAGEN, Timothy, J.; MO, Xuesheng; VELLEKOOP, A.; ROMERO, Donna, L.; CAMPBELL, Robert, F.; WALKER, Joel, R.; ZHU, Lei; WO2014/66659; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 4-(4-Bromophenyl)-2,6-diphenylpyrimidine

Under a nitrogen atmosphere 2- (4- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) phenyl) -1,10-phenanthroline (5.0 g, 13.08 mmol) 4- (4-bromophenyl) -2,6-diphenylpyrimidine (6.10 g, 15.96 mmol), tetrakis-triphenylphosphine palladium (0) (Pd (PPh3) 4) (0.75 g, 0.65 mmol) 4M potassium carbonate aqueous solution (10 mL), toluene 30 mL, ethanol 10 mL And the mixture was stirred under reflux for 12 hours. After the reaction was completed, 50 mL of H2O was added, and the mixture was stirred for 3 hours. The mixture was filtered under reduced pressure, separated by column chromatography using methylene chloride (MC) and methanol as an eluent, EN-145-1 (5.56 g, yield 75.6%).

With the rapid development of chemical substances, we look forward to future research findings about 58536-46-2.

Reference:
Patent; LG Display Co., Ltd.; Shin Ji-cheol; Joo Seong-hun; Ryu Seon-geun; Yoon Seung-hui; (44 pag.)KR2018/67321; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6299-87-2, name is 6-Hydroxypyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., Application In Synthesis of 6-Hydroxypyrimidine-4-carboxylic acid

The 6-chloropyrimidine-4-carbonyl chloride used as a starting material was prepared as follows: Phosphorus oxychloride (10 ml) was added carefully to a stirred sample of 6-hydroxypyrimidine-4-carboxylic acid (1 g) and the mixture was heated to reflux for 16 hours. Phosphorus pentachloride (5.8 g) was added and the resultant mixture was heated to reflux for a further 16 hours. The excess of phosphorus oxychloride was evaporated under reduced pressure and the residue was distilled. A solid formed in the cooling condenser. There was thus obtained 6-chloropyrimidine-4-carboxylic acid (0.5 g); NMR (DMSOd6) 8.07 (s, 1H), 9.2 (s, 1H), 14.0-14.3 (br s, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 6299-87-2, 6-Hydroxypyrimidine-4-carboxylic acid.

Reference:
Patent; Astra Zeneca AB; US6455520; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30129-53-4, name is 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H5ClN4, molecular weight is 168.58, as common compound, the synthetic route is as follows.SDS of cas: 30129-53-4

General procedure: To a solution of 7a (50.0 mg, 0.32 mmol) and aminomethyl-benzoic acids 8a (40.6 mg, 0.27 mmol) in triethylamine (66.8 mkL,0.48 mmol), anhydrous DMF (1.5 mL) was added and the reaction mixture was stirred at 80 C for 4 h. The reaction mixture was diluted with ethyl acetate (8 mL) and was washed with water (3×4 mL). The ethyl acetate layer was then dried with anhydrous Na2SO4, and concentrated to give a residue that was subjected to purification through the column chromatography on silica gel with DCM and MeOH (10:1) as eluent to afford the titled compounds 1a (31.1 mg, 43%) as a yellow solid.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,30129-53-4, 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Qian, Shan; He, Tao; Wang, Wei; He, Yanying; Zhang, Man; Yang, Lingling; Li, Guobo; Wang, Zhouyu; Bioorganic and Medicinal Chemistry; vol. 24; 23; (2016); p. 6194 – 6205;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia