One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 4318-56-3, Name is 6-Chloro-3-methylpyrimidine-2,4(1H,3H)-dione, formurla is C5H5ClN2O2. In a document, author is Ren, Hong, introducing its new discovery. Formula: C5H5ClN2O2.
Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview
A robust, green, and sustainable manufacturing process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refractory and unexplained chronic cough. The newly developed commercial process features low process mass intensity (PMI), short synthetic sequence, high overall yield, minimal environmental impact, and significantly reduced API costs. The key innovations are the implementation of a highly efficient two-step methoxyphenol synthesis, an innovative pyrimidine synthesis in flow, a simplified sulfonamide synthesis, and a novel salt metathesis approach to consistently deliver the correct active pharmaceutical ingredient (API) salt form in high purity.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 4318-56-3 help many people in the next few years. Formula: C5H5ClN2O2.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia