Day: May 10, 2021

Related Products of 934524-10-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 934524-10-4, name is 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

(+/-)-trans-Methyl 3 -aminobicyclo[2.2.2]octane-2-carboxylate (500 mg, 2.51 mmol) and 2,4-dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine (780 mg, 2.28 mmol) were dissolved in DMF (10 mL), then potassium carbonate (630 mg, 4.56 mmol) was added. The mixture was stirred at rt overnight. To the reaction mixture was added water (50 mL) to quench the reaction, and the resulting mixture was extracted with ethyl acetate (50 mL x 2). The combined organic layers were washed with saturated brine (80 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 10/1) to give the title compound as a yellow solid (803 mg, 72 %).MS (ESI, pos.ion) m/z: 490.50 [M+H]+1H NMR (400 MHz, CDC13) (ppm): 8.09 (d, J = 8.2 Hz, 2H), 7.44 (d, J = 3.9 Hz, 1H), 7.32 (d, J = 8.1 Hz, 2H), 6.48 (s, 1H), 4.52 (t, J = 5.8 Hz, 1H), 3.73 (s, 3H), 2.42 (s, 3H), 1.99 (s, 1H), 1.86 (s, 1H), 1.73 (s, 2H), 1.70 – 1.37 (m, 9H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,934524-10-4, 2,4-Dichloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; TANG, Changhua; LIN, Xiaohong; YIN, Junjun; YI, Kai; (270 pag.)WO2017/97234; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 187035-79-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 187035-79-6 as follows.

To a solution of (R)-methyl l-isopropyl-7-(methylsulfonyl)-l,2,3,4- tetrahydrobenzo[4,5]imidazo[l,2-a]pyrazine-8-carboxylate (80 mg, 0.228 mmol) in ‘PrOH (2 mL) and DCM (1 mL) was added ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate (174 mg, 0.684 mmol) and DIEA (177 mg, 1.37 mmol). The mixture was stirred at 60 C overnight. Water (5 mL) was added to the mixture and the aqueous layer was extracted with EtOAc (2 X 10 mL). The combined organic layers were washed with water (2 X 10 mL) and brine, dried over anhydrous Na2S04, filtered and concentrated under vacuum. The residue was purified by preparative TLC to afford (R)-methyl 2-(5-(ethoxycarbonyl)-4- (trifluoromethyl)pyrimidin-2-yl)-l-isopropyl-7-(methylsulfonyl)- 1,2,3,4- tetrahydrobenzo[4,5]imidazo[l,2-a]pyrazine-8-carboxylate (75 mg, 57.8% yield) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,187035-79-6, its application will become more common.

Reference:
Patent; VITAE PHARMACEUTICALS, INC.; GREGG, Richard, E.; (143 pag.)WO2015/195922; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2565-47-1, name is 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione, the common compound, a new synthetic route is introduced below. Safety of 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione

General procedure: A mixture of compound 4a (1 mmol, 245 mg) and 5a (1 mmol, 156 mg) was taken in a round bottomed flask containing ethanol (5 ml). To this, catalytic amount of diisopropylethylamine (DIPEA) was added and the reaction mixture was stirred at room temperature for 1 h. The solid formed in the reaction process was filtered and purified by washing with ethanol and dried. The structure of the compound was ascertained as 6a from spectroscopic data.

The synthetic route of 2565-47-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Borah, Pallabi; Bhuyan, Pulak J.; Tetrahedron Letters; vol. 54; 50; (2013); p. 6949 – 6951;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4316-93-2, name is 4,6-Dichloro-5-nitropyrimidine, the common compound, a new synthetic route is introduced below. Product Details of 4316-93-2

General procedure: A solution of 3a-e (2 mmol) in10 mL THF was added slowly to a cooled solution of 4,6-dichloro-5-nitropyrimidine (0.43 g, 2.2 mmol) and TEA (0.20 g, 2 mmol) in THF (20 mL), and mixture was stirred for about 30 min at 0 C. Stirring was continued for 4 h at room temperature and the reaction was monitored by TLC. The reaction mixture was added into 60 mL H2O, and extracted with EA (50 mL ¡Á 2). The combined organic extract was washed with brine, dried over anhydrous Na2SO4, and concentrated in vacuo to get the crude product which was next purified by column chromatography on silica employing ethyl acetate/petroleum ether as eluted to obtain the pure product to give the product 3a-e.

The synthetic route of 4316-93-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yu, Xu-Ri; Tang, Yun; Wang, Wen-Jing; Ji, Sen; Ma, Shuang; Zhong, Lei; Zhang, Chun-Hui; Yang, Jiao; Wu, Xiao-Ai; Fu, Zheng-Yan; Li, Lin-Li; Yang, Sheng-Yong; Bioorganic and Medicinal Chemistry Letters; vol. 25; 22; (2015); p. 5449 – 5453;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 7752-82-1, 5-Bromopyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 7752-82-1, blongs to pyrimidines compound. Recommanded Product: 7752-82-1

Sodium carbonate (1.59 g) in water (6.0 mL) was added to a mixture of tert-butyl 4-[5- (4,4,5,5-tetramethyl- 1 ,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine- 1 -carboxylate (0.205 g, 0.526 mmol), 5-bromopyrimidin-2-amine (0.0940 g, 0.54 mmol) and tetrakis(triphenylphosphine)palladium (35 mg, 0.03 mmol) in ethanol (6.0 mL) and toluene (6.0 mL). The resulting mixture was heated at 120 0C for 1 h. The mixture was diluted with EtOAc and water. The precipitate was collected by filtration to give the desired product (120 mg, 63.9%). LCMS: (M+H) = 357.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,7752-82-1, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; ZHUO, Jincong; METCALF, Brian; WO2008/64157; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 37972-24-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 37972-24-0, name is 2-Ethynylpyrimidine, molecular formula is C6H4N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 223(200mg, 0.694mmol) and 4(80mg, 0.764mmol) in 2OmL of Et3N was addedPd(PPh3)2C12 (24.37mg, 0.O3SmrnoI) and CuT (13.22mg, 0.O69mmol). The mixture wasprotected under N2 atmosphere, then was heated at 70¡ãC for 24 hours. TLC analysis showed complete conversion of starting material to a major product. The reaction mixture was then concentrated in vacuo. The crude product was purified by Prep-HPLC to give the target product Compound 86(18mg, yield c. 80 percent,).LCMS: m/ 265 (M+H)?H N?Ik (400 Mhz ( D( i) cS 8 5 (d J 49 lIz, 211) 8 16 (s, 111) 96 (s ill) 69- 61 (m, 2H), 725-7.22 (in, 1H), 7.22-7.11 (m, 2H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 37972-24-0, 2-Ethynylpyrimidine.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 110099-94-0, name is 2-(Methylthio)pyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below., Formula: C6H6N2O2S

The N-{5-[(cyclopropylamino) carbollyl]-2-methylphenyl}-2-(methylthio) pyrimidine- 5-carboxamide used as starting material was prepared as follows:- To a solution of2- (methylthio) pyrimidine-5-carboxylic acid (1. 50g, 8.82 mmol) and 3-amino-N-cyclopropyl-4-methylbenzamide (1. 6Sg, 8.82 mmol) in DMF (7.5 mL) was added HATU (3.69 g, 9.70 mmol) and DIPEA (4. 30 mL, 26.46 mmol) and the resulting mixture stirred for 16 h at room temperature. Saturated aqueous sodium bicarbonate was added and the mixture extracted with ethyl acetate, washed with brine and concentrated under reduced pressure to give the title compound as a solid (3.04 g, 100%); NMR Spectrum: (DMSOdo) 0.57 (m, 2H), 0.69 (m, 2H), 2. 28 (s, 3H), 2.60 (s, 3H), 2.86 (m, 1H), 7.36 (m, 1H), 7.65 (m, 1H), 7.85 (m, 1H), 8.39 (m, 1H), 9.12 (s, 2H), 10. 18 (m, 1H) ; Mass Spectrum : M-H-341.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 110099-94-0, 2-(Methylthio)pyrimidine-5-carboxylic acid.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/61465; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 22536-66-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 22536-66-9, name is 2-Chloropyrimidine-4-carboxamide. This compound has unique chemical properties. The synthetic route is as follows.

2.3. 2-[[3-[[2-(2-Methoxyphenoxy)ethyl]methylamino]-propyl]amino]pyrimidine-4-carboxamide (E)-2-butenedioate. 5.55 g (0.233 mol) of the compound 2.2., 3.75 g (0.0238 mol) of 2-chloropyrimidine-4-carboxamide, 120 ml of N,N-dimethylformamide and a few crystals of sodium iodide are introduced under argon into a 500-ml round-bottomed flask. Lastly, 4.83 g (0.0350 mol) of potassium carbonate are added and the mixture is stirred at 50 C. for 8.5 hours. The reaction mixture is treated with a mixture of water and ice and extracted with ethyl acetate. The organic phase is washed with water, dried and concentrated under reduced pressure. 6.0 g of a yellow oil are obtained, which product is chromatographed on silica with a 92:8 dichloromethane/methanol mixture. The fumarate is prepared from 6.0 g (0.0167 mol) of base in 100 ml of ethanol and 1.94 g (0.0167 mol) of fumaric acid in 200 ml of ethanol. The clear, light yellow solution is concentrated and a yellow oil is obtained. Ethyl acetate is added and the mixture is triturated in the heated state. A white solid is obtained, which product is recrystallized in ethanol (49.6% yield). M.p. 133-136 C.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 22536-66-9, 2-Chloropyrimidine-4-carboxamide.

Reference:
Patent; Synthelabo; US5229392; (1993); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 32779-36-5, name is 5-Bromo-2-chloropyrimidine, molecular formula is C4H2BrClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 5-Bromo-2-chloropyrimidine

[000295] Synthesis of 5 -bromo-2-iodopyrimidine (361): To a stirred solution of 5 -bromo-2- chloropyrimidine 360 (1 g, 5.16 mmol) in CH2C12 (10 mL) was added hydrogen iodide (5 mL, 57% aqueous solution) at -10 C; warmed to 0 C and stirred for 5 h. The reaction was monitored by TLC; after completion of the reaction, the reaction mixture was quenched with solid K2C03 (2 g), diluted with water (100 mL) and extracted with CH2C12 (2 x 100 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain crude compound 361 (1.4 g, 94%) as yellow solid. TLC: 10% EtOAc/ hexanes (R 0.7); 1H-NMR (DMSO-d6, 400 MHz): oe 8.55 (s, 2H).

With the rapid development of chemical substances, we look forward to future research findings about 32779-36-5.

Reference:
Patent; INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION; ASSEMBLY BIOSCIENCES, INC.; TURNER, William W.; ARNOLD, Lee Daniel; MAAG, Hans; ZLOTNICK, Adam; WO2015/138895; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1074-40-4 ,Some common heterocyclic compound, 1074-40-4, molecular formula is C5H4Cl2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

solution of 4,6-dichloro-2-methoxypyrimidine (1 g, 5.59 mmol), 2-aminoindan (0.72 mL, 5.59 mmol) and sodium bicarbonate (0.7 g, 8.38 mmol) in EtOH (25 mL) is refluxed overnight. The reaction is cooled to room temperature, quenched with water (100 mL) and stirred for one hour. The formed precipitate is suction filtered and air dried to afford (6-chloro-2-methoxy-pyrimidin-4-yl)- indan-1-yl-amine (1.5 g). LCMS: Rtau = 3.35 minutes, LCMS: 276, 278 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1074-40-4, 4,6-Dichloro-2-methoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SANOFI-AVENTIS U.S. LLC; HARRIS, Keith John; WO2008/39882; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia