Day: May 11, 2021

Related Products of 124703-78-2 , The common heterocyclic compound, 124703-78-2, name is 6-Ethylpyrimidin-4(3H)-one, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(ii) 4,5-Dichloro-6-ethylpyrimidine To a solution of 6-ethylpyrimidin-4(3H)-one (the product of part (i)) (18.6 g, 150 mmol) in concentrated hydrochloric acid (120 ml) at 30-40 C. was added dropwise a 30 wt. % solution of hydrogen peroxide in water (18 ml) over a period of 30 minutes (slight exotherm resulted) and the resulting mixture was stirred overnight at 40 C. The mixture was concentrated under reduced pressure and the residue was suspended/dissolved in toluene and the toluene removed under reduced pressure. The residue was dissolved in phosphorus oxychloride (150 ml) and heated under reflux for 3 hours after which time the excess phosphorus oxychloride was removed under reduced pressure. The residue was poured into ice/water, extracted with methylene chloride (3*50 ml) and the combined organic extracts were washed with water (30 ml) and dried over magnesium sulphate. The solvent was removed under reduced pressure and the resulting oil was distilled under reduced pressure to yield the title compound (5.4 g, 20%), b.p. 104 C. at 22 mm Hg, which was characterised by 1 H-NMR spectroscopy. 1 H-NMR (CDCl3): delta=1.3 (t, 3H, J=10Hz), 3.04 (q, 2H, J=10Hz), 8.75 (s, 1H), ppm.

The synthetic route of 124703-78-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US5278175; (1994); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3435-25-4 , The common heterocyclic compound, 3435-25-4, name is 4-Chloro-6-methylpyrimidine, molecular formula is C5H5ClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

BA-1 (1.00 g, 7.78 mmol) and Ni(dppe)Cl2 (82 mg, 0.16 mmol)The solution in anhydrous Et 2 O (5 mL) was cooled to -10 C.A solution of cyclopropylmagnesium bromide (1.36 g, 8.56 mmol) was added dropwise and the mixture was stirred at -10 C for 2 h.The mixture was quenched with saturated aqueous NH4CI, extracted with DCM and concentrated. The crude BD-1 can continue to be used without further processing.

The synthetic route of 3435-25-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BAKONYI,JOHANNA; BRUNETTE,STEVEN RICHARD; COLLIN,DELPHINE; HUGHES,ROBERT OWEN; LI,XIANG; LIANG,SHUANG; SIBLEY,ROBERT; TURNER,MICHAEL ROBERT; WU,LIFEN; ZHANG,QIANG; (169 pag.)TW2018/38997; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7752-72-9, name is 5-Chloro-6-methylpyrimidin-4(3H)-one, the common compound, a new synthetic route is introduced below. Product Details of 7752-72-9

2) Preparation of 4,5-dichloro-6-methylpyrimidineThe 14.5g (0.1mol) 4-hydroxy-5-chloro-6-methylpyrimidine dissolved in 50ml of toluene, was added dropwise with stirring to the reaction flask 50ml of phosphorus oxychloride dropwise at reflux temperature the reaction completion 5-7 hours after, TLC monitored the reaction is complete. The toluene was evaporated under reduced pressure and an excess of phosphorus oxychloride, while stirring the reaction was poured into ice water, the aqueous phase was extracted with (3 ¡Á 50ml) and extracted with ethyl acetate, the combined organic phase was dried over anhydrous magnesium sulfate, filtered, desolvation . The residue was purified by column chromatography (eluent, ethyl acetate and petroleum ether (boiling range 60-90 ), the volume ratio of 1: 4) was isolated as a yellow liquid 14.43g, yield 88.5%.

The synthetic route of 7752-72-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenyang SinochemAgrochemicals R&D Co., Ltd.; Liu, Zhangling; Xu, Ying; Wang, Junfeng; Sun, Xufeng; Ban, Lanfeng; Xie, Yong; Li, Zhinian; Sun, Geng; (59 pag.)CN105348298; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 90213-66-4 ,Some common heterocyclic compound, 90213-66-4, molecular formula is C6H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of compound (XXIX, 50 g) in DMF (200 mL) was added N-iodosuccinimide (62.14 g) and stirred for 16 hrs. The reaction mixture was poured slowly into water (3.5 L) resulted in precipitation which was filtered, washed with water (1 L) and suck dried. Crude residue was purified by refluxing in ethyl acetate and filtered to give compound(XXX).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 90213-66-4, 2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED; KADIYALA, V.S.N. Murty; DESAI, Dipali Manubhai; RAUT, Virendra Narendra; SAVANT, Pratit Viram; JOSHI, Kiritkumar Parmeshkumar; CHAUDHARI, Umesh Vishnu; RATHOD, Rajendrasinh Jashvantsinh; BHATT, Tushar Bhupendrabhai; CHITTURI, Trinadha Rao; (87 pag.)WO2018/2958; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 64224-60-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.64224-60-8, name is 5-Bromo-4-pyrimidinecarboxylic acid, molecular formula is C5H3BrN2O2, molecular weight is 202.99, as common compound, the synthetic route is as follows.

General procedure: To a solution of Intermediate 7 (110 mg, 0.37 mmol), 3-methoxybenzene-1,2- diamine (50 mg, 0.34 mmol) and DIPEA (0.2 mL, 1 mmol) in DMF (2 mL) was added HATU (160 mg, 0.41 mmol). The reaction mixture was stirred at r.t. for 48 h, then partitioned between DCM and water. The organic phase was separated, then dried and concentrated in vacuo. The crude residue was purified by flash column chromatography (0-100% EtOAc/hexanes) to give the title compound (28.7 mg, 20%) as a white solid. LCMS (Method 5): [M+H]+ m/z 415, RT 1.31 minutes.

The chemical industry reduces the impact on the environment during synthesis 64224-60-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; UCB BIOPHARMA SPRL; BRACE, Gareth Neil; CHAPPELL, Rose Elizabeth; FOULKES, Gregory; FROST, James Richard; HORSLEY, Helen Tracey; JONES, Elizabeth Pearl; LECOMTE, Fabien Claude; REUBERSON, James Thomas; SCHULZE, Monika-Sarah Elisabeth Dorothea; TAYLOR, Richard David; YAU, Wei Tsung; ZHU, Zhaoning; (246 pag.)WO2019/138017; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 216959-91-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 216959-91-0, name is 4-(Pyrimidin-5-yl)benzoic acid. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of Co(NO3)2¡¤6H2O (0.2 mmol, 0.058 g), HL(0.020 g, 0.1 mmol), and H2O 10 mL was placed in a ParrTeflon-lined stainless steel vessel (23 mL). Then the pH valuewas tuned into 8 using NaOH solution (0.5 M). After that themixturewas heated to 160C and held for 60 h. Then the reactantmixture was cooled at a rate of 0.5C/min to lead to the formationof red block crystal 1. Yield: 37% based on HL. ElementalAnal. Calcd. for C22H18CoN4O6 (493.33): C, 53.51; H, 3.65;N, 11.35%. Found: C, 53.50; H, 3.58; N, 11.45%. IR (KBr,cm-1): 3395(w), 1648(s), 1573(s), 1433(m), 1385(s), 1082(s),778(s).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 216959-91-0, 4-(Pyrimidin-5-yl)benzoic acid.

Reference:
Article; An, Zhe; Hu, Ying-Shuang; Zhu, Li-Hua; Zhu, Ling; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 44; 10; (2014); p. 1435 – 1438;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.573675-29-3, name is 7-Bromopyrido[3,2-d]pyrimidin-4(3H)-one, molecular formula is C7H4BrN3O, molecular weight is 226.0302, as common compound, the synthetic route is as follows.COA of Formula: C7H4BrN3O

7-Bromopyrido[3,2-d]pyrimidin-4-ol (1.02 g, 4.51 mmol) was suspended in dry toluene (80 mL) under nitrogen. Phosphorus oxychloride (5.0 mL, 54.6 mmol) was added and the mixture heated to reflux under nitrogen. After 5 hours the reaction was cooled to RT. The solution was placed in a water bath and saturated sodium bicarbonate (50 mL) was added slowly with strong stirring. After 45 minutes the phases were separated and the organic evaporated to dryness under reduced pressure. The crude 7-bromo-4-chloropyrido[3,2-d]pyrimidine (0.46 g, 1.89 mmol, 42% yield) was used without further purification. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 8.59 (d, J=1.96 Hz, 1H) 9.11-9.15 (m, 2H). LC/MS (ESI+) m/z=243.8 (M+H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,573675-29-3, 7-Bromopyrido[3,2-d]pyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; LEWIS, Richard T.; ALLEN, Jennifer R.; BROWN, James; GUZMAN-PEREZ, Angel; HUA, Zihao; JUDD, Ted; LIU, Qingyian; OLIVIERI, Philip R.; ROMERO, Karina; SCHENKEL, Laurie; STELLWAGEN, John; WHITE, Ryan; US2015/38497; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4316-98-7, name is 6-Chloro-4,5-diaminopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 4316-98-7

6-Chloro-8-phenyl-9/-/-purine Experimental procedure taken from Ibrahim et al. [24]. A mixture of 6-chloro-4,5-diaminopyrimidine (1.4 mmol) and ammonium chloride (8.40 mmol) was suspended in POCI3 (10.0 mL). After addition of benzoyl chloride (7.00 mmol) the reaction batch was heated for 24 hours at 100 C. After cooling to room temperature and pouring into ice/water, the mixture was neutralized with ammonia solution (25% v/v) to pH 7-8. The obtained solid was filtered off and washed with water. The product was used without any further purification. Mp = 254 – 255 C. 1 H-NMR (DMSO-de, 400 MHz): d (ppm) = 7.62 (m, 3H, ArH), 8.29 (m, 2H, ArH), 8.73 (s, 1 H, ArH), 14.4 (s, 1 H, NH). 13C-NMR (DMSO-de, 100 MHz): d (ppm) = 127.3, 128.4 (2C), 131 .6 (2C), 151 .4 (tert. C), 129.2 (quart. C).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4316-98-7, 6-Chloro-4,5-diaminopyrimidine.

Reference:
Patent; KTB TUMORFORSCHUNGSGESELLSCHAFT MBH; KUBBUTAT, Michael; SCHAeCHTELE, Christoph; EHLERT, Jan; TOTZKE, Frank; KUNICK, Conrad; WOeLFEL, Sebastian; WEBER, Holger; WO2014/79545; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 873-83-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.873-83-6, name is 6-Aminopyrimidine-2,4(1H,3H)-dione, molecular formula is C4H5N3O2, molecular weight is 127.1, as common compound, the synthetic route is as follows.

General procedure: A mixture of isatin (0.147 g, 1 mmol), acetophenone (0.09 mL, 1.5 mmol), and piperidine (two drops, 0.1 mmol) in ethanol (95.5percent, 1 mL) was heated at 80 ¡ãC for about 5 min. To the solid obtained at this stage was added 6-amino-1,3-dimethyluracil (0.155 g, 1 mmol), p-toluenesulfonic acid monohydrate (0.076 g, 0.04 mmol), and EtOH (95.5percent, 2 mL). The mixture was stirred and heated gently at 80 ¡ãC. After completion of the reaction (115 min), as monitored by TLC using 5:1 ratio of ethyl acetate/n-hexane, the reaction mixture was cooled to room temperature and then filtered. The separated solids were washed twice with 10 mL of water and 3 mL of hot ethanol (95.5percent) to obtain the pure product 4a.

Statistics shows that 873-83-6 is playing an increasingly important role. we look forward to future research findings about 6-Aminopyrimidine-2,4(1H,3H)-dione.

Reference:
Article; Rad-Moghadam, Kurosh; Azimi, Seyyedeh Cobra; Tetrahedron; vol. 68; 47; (2012); p. 9706 – 9712;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 950514-14-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 950514-14-4, name is Methyl 2-oxo-1,2-dihydropyrimidine-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Example 15 2-oxo-1,2-dihydropyrimidine-4-carbohydrazide; The subtitle compound of Step 15A (0.500 g, 3.24 mmol) was dissolved in EtOH (125 mL) and stirred at ambient temperature for 1 h. Hydrazine monohydrate (0.325 g, 6.49 mmol) was added and the reaction was heated at 65 C. for 3 days. The solvent was partially removed under reduced pressure. The solids were filtered off and washed with EtOH to afford the title product (0.351 g, 2.28 mmol).1H NMR (400 MHz, (CD3)2SO): delta 10.05 (bs, 1H), 8.15 (d, 1H), 6.84 (d, 1H), 4.81 (bs, 2H).

According to the analysis of related databases, 950514-14-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GRANBERG, Kenneth; HOLM, Bjorn; US2009/111820; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia