Day: May 17, 2021

Related Products of 1337532-51-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1337532-51-0, name is 5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine, molecular formula is C7H7BrN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Add Pd(II) acetate (635 mg, 2.83 mmol), cataCXium A (2.03 g, 5.65 mmol), and aqueous saturated NaHC03(186 mL, 188 mmol) to a suspension of 5-bromo-7- methyl-pyrrolo[2,3-d]pyrimidin-4-amine (21.4 g, 94.3 mmol) and 3-methyl-4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)aniline (28.6 g, 123 mmol) in 2-methyl- tetrahydrofuran (214 mL) at 23 C, and stir the mixture in a sealed tube at 100 C for 3 h. Cool to 23 C, filter through a pad of diatomaceous earth, and rinse the solid with H20 (50 mL) and ethyl acetate (100 mL). Separate the organic layer, wash it with aqueous saturated NaCl (50 mL), and concentrate under reduced pressure. Purify the residue by chromatography (eluent: hexane / acetone 0-100%) to obtain the title compound (12.1 g, 51%) as a yellow solid. ES/MS m/z 254.1 (M+H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1337532-51-0, 5-Bromo-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine.

Reference:
Patent; ELI LILLY AND COMPANY; CIFUENTES-GARCIA, Marta Maria; GARCIA-PAREDES, Maria Cristina; (34 pag.)WO2018/194885; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 36822-08-9 ,Some common heterocyclic compound, 36822-08-9, molecular formula is C10H6N2OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Benzo[4,5]thieno[3,2-d]pyrimidin-4(3H)-one (10.78 g, 26.7 mmol) was treated with pyridine (2.68 mL, 33.3 mmol) and phosphoryl trichloride (53.4 mL, 573 mmol), then heated to reflux at 110C for 1 hr. Excess POCl3 was removed and cautiously quenched with ice water in an ice bath. The pH was adjusted to ?5 with ammonium hydroxide. Solid was collected by filtration washed with water. The solid was dried to give 4-chlorobenzo[4,5]thieno[3,2-d]pyrimidine (10 g, 85% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,36822-08-9, its application will become more common.

Reference:
Patent; Universal Display Corporation; Xia, Chuanjun; Joseph, Scott; EP2826781; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 101803-06-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 101803-06-9, name is 5-Iodo-2-methoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 2 1-(2-Deoxy-beta-D-Ribofuranosyl)-5 -(1-propynyl)-2-pyrimidinone 31.67 g (0.13 mol) of 5-iodo-2-methoxypyrimidine, 0.73 g (2.9 mol %) of CuI and 1.02 g (1.1 mol%) of bis(triphenylphosphine)PdCl2 were suspended in 200 ml of anhydrous triethylamine (distilled over BaO) in Parr pressure bottle. The bottle was evacuated and filled with 85% propyne. The bottle was repeatedly shaken and filled with propyne until the pressure had stabilized at 20 psi, and then the mixture was shaken, in a Parr hydrogenator, for 24 hours. More propyne was added at this time shaking was continued for an additional 48 hours. On tlc (methylene chloride), there was only one major product; no starting material was observed. The mixture was diluted with methylene chloride (300 ml), washed with saturated bicarbonate solution (2*60 ml), dried over magnesium sulfate and concentrated to a minimum volume with attendant precipitation. Petroleum ether was added to the mixture and after cooling, the first crop was obtained by filtration. The filtrate was concentrated to give a second crop. Both crops were dried and sublimed at 0.3 mm Hg (max. oil bath temp. 100 C.) to yield 15.26 g (76.7%) of analytically pure, white-crystalline material, 2-methoxy-5-(1-propynyl)pyrimidine; mp 88-89.5 C.).

According to the analysis of related databases, 101803-06-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; The Research Foundation of State University of New York; US4895937; (1990); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 5750-76-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5750-76-5, name is 2,4,5-Trichloropyrimidine, molecular formula is C4HCl3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Take 9 (23.44 mmol) and DIPEA (4.5 g, 35.16 mmol) in 50 mL dioxane,8 (3.8 g, 23.44 mmol) was added slowly, warmed to 60 C,After 5 hours reaction, the reaction was completed, cooled, 400mL water was added,Precipitation yellow-white solid, suction filtration, drying,Obtained as a white solid, without purification directly to the next reaction.

According to the analysis of related databases, 5750-76-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dalian Medical University; Ma Xiaodong; Ge Yang; Song Zhendong; Huang Shanshan; Wang Changyuan; Zhang Jianbin; Tang Zeyao; Liu Kexin; (22 pag.)CN106565782; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 4595-61-3 , The common heterocyclic compound, 4595-61-3, name is Pyrimidine-5-carboxylic acid, molecular formula is C5H4N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: General CouIinQ Procedure 4 COMU (1 .5 eq.) and DIPEA (4 eq.) were added to a stirred solutionCarboxylic acid A (1.0 eq.) and Amine B (1.2 eq.) in THF (2 mL) at RT. Thereaction mixture was stirred for 16 h at RT. The reaction mixture was then poured in ice water, stirred for 5 mm. and the resulting precipitate was filtered and washed with water. The cake was dried under reduced pressure and washed with diethyl ether and n-pentane to obtain a crude product. Additional purification by flash chromatography over silica was performedwhen necessary.

The synthetic route of 4595-61-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FROST BIOLOGIC, INC.; SIDDIQUI-JAIN, Adam; WO2015/127284; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 944129-00-4, name is Methyl 6-amino-2-chloropyrimidine-4-carboxylate, the common compound, a new synthetic route is introduced below. Recommanded Product: 944129-00-4

Example 4 Preparation of methyl 6-amino-2-(4-chloro-2,3-difluorophenyl)-pyrimidine-4-carboxylate 2-(4-Chloro-2,3-difluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (1.4 g, 5.1 mmol, 1.2 equiv) and methyl 6-amino-2-chloropyrimidine-4-carboxylate (800 mg, 4.3 mmol, 1.0 equiv) were sequentially added to a 20 mL Biotage microwave vessel, followed by cesium fluoride (1.3 g, 8.5 mmol, 2.0 equiv), palladium(II) acetate (38 mg, 0.17 mmol, 0.04 equiv), and sodium 3,3′,3″-phosphinetriyltribenzenesulfonate (190 mg, 0.34 mmol, 0.08 equiv). A 3:1 mixture of water:acetonitrile (8.5 mL) was added and the resulting brown mixture was placed in a Biotage microwave and heated at 150 C. for 5 m. The cooled reaction mixture was diluted with water (300 mL) and extracted with dichloromethane (5*100 mL). The combined organic layers were dried (magnesium sulfate), gravity-filtered, and concentrated under vacuum. The product was purified by flash chromatography (SiO2, 40% ethyl acetate in hexane) to afford the title compound as an off-white powder (880 mg, 68% yield): mp 192-195 C.; 1H NMR (300 MHz, CDCl3) delta 7.77 (m, 1H), 7.21-7.28 (m, 2H), 7.15 (s, 1H), 5.23 (br s, 2H), 4.00 (s, 3H); IR (neat film) 3493 (w), 3393 (m), 3342 (m), 3211 (s), 1730 (m), 1649 (m); ESIMS m/z 300 ([M+H]+).

The synthetic route of 944129-00-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DOW AGROSCIENCES LLC; US2012/190549; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 130838-36-7, name is 2,6-Dichloropyrimidine-4,5-diamine, the common compound, a new synthetic route is introduced below. Recommanded Product: 130838-36-7

4, 5-Diamino-1,6-DICHLOROPYRIMIDINE (0,55MMMOL), prepared as described in Example 16, was suspended in water (2 ml) and heated to dissolve. After cooling the solution in the ice-water bath, acetic acid (2ml) was added to the solution. Sodium nitrite in water (0,5 MOL/1-2 ml) was added to this stirred solution at 0C during 15 minutes. After next 20 minutes in the ice-water bath, the reaction mixture was etracted with diethyl ether. The etheric solution was neutralized and dried and then evaporated to give the crude product (100%). This product was purified by crystallization from absolute diethyl ether. Yield= 47% m. p. 260C. TLC (I, 12: 2: 1). RF= 0,22. MS: 188,0 (100%, M-H+), 190,0 (65 %, M-H+)

The synthetic route of 130838-36-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INSTITUTE OF EXPERIMENTAL BOTANY ASCR; WO2004/18473; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 22536-66-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22536-66-9, name is 2-Chloropyrimidine-4-carboxamide. A new synthetic method of this compound is introduced below.

A tube containing a solution of 2-chloropyrimidine-4-carboxamide (0.24 g, 1 eq) and potassium(S)-trifluoro(3- ((3-hydroxy- 1 -methyl-2-oxopyrrolidin-3y1)ethynyl)phenyl)borate (1 eq) in Ethanol (0.25 M) was purged with nitrogen before addition of Pd(OAc)2 (0.06 eq), RuPhos (0.12 eq), and Sodium Carbonate (2 eq). The tube was sealed and stuffed at 85 C for 18 hours. The reaction mixture was cooled to room temperature and extracted with dichloromethane and saturated ammonium chloride then dried with Magnesium sulfate, filtered and concentrated todryness. The crude material subjected to reverse phase purification to afford 53 mg of the title compound (10%). M+H = 337.0; 1H NMR (400 MHz, DMSO-d6) oe 9.16-9.11 (m, 1H), 8.70- 8.60 (m, 3H), 7.98 (s, 1H), 7.94 (d, J = 5.0 Hz, 1H), 7.64 – 7.54 (m, 2H), 6.47 (s, 1H), 3.40 – 3.35 (m, 2H), 2.81 (s, 3H), 2.48 – 2.43 (m, 1H), 2.25 – 2.17 (m, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,22536-66-9, 2-Chloropyrimidine-4-carboxamide, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; BLAQUIERE, Nicole; BURCH, Jason; CASTANEDO, Georgette; FENG, Jianwen A.; HU, Baihua; LIN, Xingyu; STABEN, Steven; WU, Guosheng; YUEN, Po-wai; WO2015/25026; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 302964-08-5 ,Some common heterocyclic compound, 302964-08-5, molecular formula is C16H13Cl2N5OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 34; Procedure for the Preparation of Dasatinib Form N2A mixture of compound 1 (1.5 mmol), N-(2-hydroxyethyl)piperazine (3 mmol) and N-ethyldiisopropylamine (3 mmol) was heated in DMSO (1.3 ml) at 80-85 C. for 1.5 hours. n-Butanol (7.0 ml) was slowly added at this temperature. The suspension was slowly cooled to 0-5 C. Product was filtered off and washed with n-butanol (10.0 ml) and dried on the filter.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,302964-08-5, its application will become more common.

Reference:
Patent; SIMO, Ondrej; Filipcik, Jiri; Martaus, Alexandr; Jegorov, Alexandr; Gavenda, Ales; Aronhime, Judith; Vraspir, Pavel; Koltai, Tamas; Faustmann, Jiri; Gabriel, Roman; US2009/118297; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1004-39-3, Adding some certain compound to certain chemical reactions, such as: 1004-39-3, name is 4,6-Diaminopyrimidine-2-thiol,molecular formula is C4H6N4S, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1004-39-3.

EXAMPLE 47 N-[4-(4-Piperidinomethyl-2-pyridyloxy)-cis-2-butenyl]-4-(4,6-diamino-2-pyrimidinylthio)butyramide Following a procedure similar to that described in Example 34, but using N-[4-(4-piperidinomethyl-2-pyridyloxy) -cis-2-butenyl]-4-chlorobutyramide (prepared as described in Preparation 2) and 4,6-diamino-2-mercaptopyrimidine as starting materials, in relative proportions similar to those used in that Example, the title compound was obtained as an oil in a 48% yield. Nuclear Magnetic Resonance Spectrum (CDCl3), delta ppm: 1.39-1.50 (2H, multiplet); 1.55-1.67 (4H, multiplet); 1.83-2.14 (4H, multiplet); 2.30-2.47 (6H, multiplet); 3.10 (2H, triplet, J=6.8 Hz); 3.45 (2H, singlet); 3.99-4.09 (2H, multiplet); 4.61 (2H, broad singlet); 4.92 (2H, doublet, J=6.8 Hz); 5.24 (1H, singlet); 5.63-5.72 (1H, multiplet); 5.78-5.87 (1H, multiplet); 6.12-6.23 (1H, broad); 6.72-6.79 (1H, multiplet); 6.91 (1H, doublet, J=4.4 Hz); 8.05 (1H, doublet, J=4.4 Hz). Infrared Absorption Spectrum (CHCl3) numax cm-1: 2940, 1655, 1610, 1580, 1555, 1310.

According to the analysis of related databases, 1004-39-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sankyo Company, Limited; US5616579; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia