Day: May 19, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 479691-42-4, name is tert-Butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C13H19ClN4O2

A mixture of tert-butyl 4-(2-chloropyrimidin-4-yl)piperazine-1-carboxylate (9.00g, 30.1mmol), (2,3-difluorophenyl)boronic acid (7.10g, 45.1mmol), 1M aq Na2CO3 (41 mL, 82.0 mmol), tetrakis(triphenylphosphine)palladium (0) (4.2g, 3.61 mmol), and DME (270 mL) was stirred at 95 C overnight under N2 atmosphere. After cooling to room temperature, the mixture was diluted with water, and extracted with EtOAc. The organic layer was washed with water, dried over anhydrous MgSO4, and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane-EtOAc) to give 12 (11.3g, quant.) as pale yellow crystals.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 479691-42-4, tert-Butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate.

Reference:
Article; Kono, Mitsunori; Matsumoto, Takahiro; Imaeda, Toshihiro; Kawamura, Toru; Fujimoto, Shinji; Kosugi, Yohei; Odani, Tomoyuki; Shimizu, Yuji; Matsui, Hideki; Shimojo, Masato; Kori, Masakuni; Bioorganic and Medicinal Chemistry; vol. 22; 4; (2014); p. 1468 – 1478;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 7627-44-3, Adding some certain compound to certain chemical reactions, such as: 7627-44-3, name is 2,4-Dichloro-5-(iodomethyl)pyrimidine,molecular formula is C5H3Cl2IN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7627-44-3.

A mixture of 2,4-dichloro-5-(iodomethyl)pyrimidine (1.50 g, 5.19 mmol), 2,6- difluoro-3,5-dimethoxyaniline (1.08 g, 5.71 mmol) in N,N-diisopropylethylamine (4 mL) was stirred at 80 °C for 2 hours. After being cooled to room temperature, the reaction mixture was concentrated under reduced pressure. The residue was purified on silica gel (eluting with 0- 40percent EtOAc in DCM) to give 1.70 g of the desired product. LCMS calculated for C13H12CI2F2N3O2 [M+H]+ m/z: 350.0; Found: 350.0.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7627-44-3, 2,4-Dichloro-5-(iodomethyl)pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; INCYTE CORPORATION; LU, Liang; WU, Liangxing; QIAN, Ding-Quan; YAO, Wenqing; (102 pag.)WO2016/134314; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 428854-24-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.428854-24-4, name is 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, molecular formula is C17H15FN8, molecular weight is 350.35, as common compound, the synthetic route is as follows.

Step three, A solution of formic acid (129 g, 1.37 mol)Was added dropwise to acetic anhydride (145 g, 1.42 mol)After stirring for half an hour, compound 4 (80 g, 0.23mo 1) was added at 0 C, stirred at 20 C for 10 hours,TLC detection reaction is completed, concentrated reaction solution, add 500mL of water for half an hour, pumping,Dried to give about 78 g of a yellow solid which was dissolved in 500 mL of tetrahydrofiramidate and sodium borohydride (15.58 g, 0.41 mol) was added at room temperature. A solution of boron trifluoride diethyl ether (90 mL) was slowly added dropwise at room temperature, Slowly heated to reflux for 3 hours. After the reaction, add 120mL methanol to destroy, then add 2N hydrochloric acid 120mL, stir for half an hour after the reaction system, the residue with 2N sodium hydroxide solution to adjust the pH to neutral, and then suction, Drying to obtain a crude product of compound 5a,The crude product of compound 5a was dissolved in a mixed solvent of dichloromethane and methanol (the weight ratio of the crude product of compound 5a to 1: 5, the volume ratio of dichloromethane to methanol in the mixed solvent was 1: 15) ,And the mixture was stirred at room temperature for 10 hours and then filtered and dried to obtain pure product (63.7 g, 0.17 mol, yield: 76%, content: 99%) /

The chemical industry reduces the impact on the environment during synthesis 428854-24-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Anhui Lianchuang Biological Medicine Co.,Ltd; GE, DEPEI; WU, QIHUA; LIU, TAO; (10 pag.)CN104530044; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine, molecular formula is C7H3Cl2N3, molecular weight is 200.0248, as common compound, the synthetic route is as follows.Application In Synthesis of 2,4-Dichloropyrido[3,2-d]pyrimidine

2,4,-dichloropyrido[3,2-d]pyrimidine (33 mg, 0.16 mmol, 1.25 equiv.) was treated with THF (10 mL) followed by N,N-diisopropylethylamine (0.18 mL, 1.0 mmol, 8 equiv.), and (R)-methyl 2-amino-5,5-difluorohexanoate 78C (36 mg, 0.13 mmol, 1 equiv., TFA salt). The reaction mixture was stirred for 1 h to generate 78D and then this mixture was used directly. LCMS (m/z): 345.13 [M+H]+; tR=1.08 min. on LC/MS Method A.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,39551-54-7, 2,4-Dichloropyrido[3,2-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Gilead Sciences, Inc.; Aktoudianakis, Evangelos; Chin, Gregory; Mackman, Richard L.; Metobo, Samuel E.; Mish, Michael R.; Pyun, Hyung-jung; Zablocki, Jeff; (175 pag.)US2016/289229; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 43212-41-5, 2,4-Dichloro-6-methoxypyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 43212-41-5, blongs to pyrimidines compound. name: 2,4-Dichloro-6-methoxypyrimidine

Example I.3 2,4-Dichloro-6-trichloromethoxypyrimidine 303 g (4.27 mol) of chlorine were passed into a mixture of 209 g (1.168 mol) of 2,6-dichloro-4-methoxypyrimidine and 2 g (0.012 mol) of alpha,alpha’-azoisobutyronitrile while stirring at 80 C. for hour, at 100 C. for hour, at 120 C. for 3 hours and at 150 C. for 3 hours and subjecting to UV irradiation, with monitoring of the progress of the reaction by gas chromatography. The reaction mixture was then distilled under reduced pressure. 241.3 g (73% of theory) of the title compound of boiling point 87-88 C./0.4 mbar, melting point 55-56 C. were obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,43212-41-5, its application will become more common.

Reference:
Patent; BASF Aktiengesellschaft; US5237063; (1993); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 98141-42-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 98141-42-5, name is 4,6-Dichloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H4Cl2N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 2,4-dichloropyrrolo[1,2-f][1,2,4]triazine (4a) (0.5 g, 2.7 mmol) in 2-Propanol (6 mL) was added (S)-pyrrolidin-2-ylmethanol (0.39 mL, 4.0 mmol), DIPEA (1.39 mL, 8.0 mmol) and heated at 90 C for 1 hr. The reaction was cooled to room temperature and solid obtained was collected by filtration to afford (S)-(l-(2-chloropyrrolo[2,l-f][l,2,4]triazin-4- yl)pyrrolidin-2-yl)methanol (96a) (0.49 g, 73 % yield) as a white solid; NMR (300 MHz, DMSO-i/e): delta 7.70 (dd, J= 2.6, 1.4 Hz, 1H), 6.97 (dd, J= 4.7, 1.6 Hz, 1H), 6.80 – 6.57 (m, 1H), 5.15 (t, J = 5.7 Hz, 1H, D2O exchangeable), 4.87 (t, J= 5.7 Hz, 1H), 4.44 (d, J= 17.8 Hz, 1H), 4.05 – 3.82 (m, 1H), 3.72 – 3.39 (m, 2H), 2.22 – 1.84 (m, 4H). MS (ES+): 253.3, 255.3 (M+2); MS (ES-): 287.2, 289.2 (M+Cl).

According to the analysis of related databases, 98141-42-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BIOCRYST PHARMACEUTICALS, INC.; KOTIAN, Pravin, L.; BABU, Yarlagadda, S.; KUMAR, V., Satish; ZHANG, Weihe; LU, Peng-Cheng; RAMAN, Krishnan; (747 pag.)WO2018/232094; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 42839-04-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42839-04-3, name is 4-Cyanopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

After dissolving 5.0g (47.6 mmol) of 2-cyanopyrimidine in 100 ml of ethanol at room temperature, 20ml (475.7 mmol) of hydrazine hydrate was added thereto and stirred at room temperature for about two days. After completion of the reaction, the reaction product was concentrated under reduced pressure, and then extracted with 100 ml of salt water and 200 ml of dichloromethane to obtain an organic layer, which was then dried using magnesium sulfate and distilled under reduced pressure. The resulting product was separated and purified using column chromatography to obtain 3.0g (21.9 mmol, Yield 46percent) of Intermediate 40(2). LC-MS m/z = 138(M+H)+

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 42839-04-3, 4-Cyanopyrimidine.

Reference:
Patent; Samsung Display Co., Ltd.; Choi, Jong-Won; Park, Bum-Woo; Lee, Sun-Young; Choi, Wha-Il; Kim, So-Yeon; Lee, Ji-Youn; Kwak, Yoon-Hyun; EP2706064; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 6299-25-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6299-25-8, name is 4,6-Dichloro-2-(methylthio)pyrimidine, molecular formula is C5H4Cl2N2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

[00230] Reagents[00231] Experimental procedure:? ; Take ammonia in THF into a 2 L autoclave and add 4, 6-dichloro-2-(Methylthio) pyrimidine slowly.? Heat the reaction mixture to 50-60 C and maintain the reaction at 50-60 C for 3-4 hours (Inbuilt pressure 7- 8 Kg/cm ).? Check the progress of the reaction by TLC. Upon completion, the reaction was brought to 25-35 C.? Concentrate the reaction mixture under vacuum.? Charge Hexane and stir for 30-45 minutes at 25-35 C.? Filter the solid and wash the solid with Hexane.? Wash the solid with water (2X400 mL).? Dry the solid at 25-35 C till M.C reaches to less than 2%.Yield 352.0 g% of Yield: 97.77%.Purity by HPLC: 99.07%.Other suitable conditions such as ammonia in MeOH or dioxane could be used accordingly when different analogs are used. Example 1- 2. Preparation of 4-Amino-6-chloro-2- meth lthio)pyrimidine, 6.1

According to the analysis of related databases, 6299-25-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KINAGEN, INC.; MURPHY, Eric, A.; CHERESH, David, A.; ARNORD, Lee, Daniel; WO2011/97594; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 26032-72-4, 2,4-Dichloro-6-phenylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2,4-Dichloro-6-phenylpyrimidine, blongs to pyrimidines compound. Recommanded Product: 2,4-Dichloro-6-phenylpyrimidine

Step (i): Synthesis of (2-chloro-6-phenyl-pyrimidin-4-yl)-(1-ethyl-pyrrolidin-2ylmethyl)-amine To 2,4-dichloro-6-phenyl-pyrimidine (1.508 g, 6.6 mmol), dissolved in THF (10 mL), was added 2-(aminomethyl)-1-ethylpyrrolidine (0.96 mL, 6.6 mmol). The resulting mixture was cooled to -60 C. and then treated with lithium bis (trimethylsilyl) amide (13.2 mL, 13.2 mmol, 1M). The resulting solution was allowed to stir at -60 C. for 10 min and was quenched with water slowly. The mixture was diluted with ethylacetate, and washed two times with water and one time with brine. The organic phase was dried over sodium sulfate, filtered, and concentrated by rotary evaporation. Purification (Biotage Horizon HPFC chromatography system, SiO2, 95:5 dichloromethane: MeOH) gave the title compound as a solid (1.1 g, 52% yield) in addition to C-2 regioisomer (not fully characterized).HPLC: Betasil ODS-3V C18, [KH2PO4 (0.01M, pH 3.2): CH3CN], gradient, 264 nm, Rt 10.1 & 10.7 min, 52.8, 43.8% purity respectively.1H NMR (300 MHz, CDC13, TMS): delta 7.98-7.94 (m, 2H), 7.48-7.44 (m, 3H), 6.96 (s, 1H), 6.02-5.87 (m, 1H), 3.75 (b s, 1H), 3.39-3.19 (m, 2H), 2.91-2.65 (m, 2H), 2.29-2.12 (m, 2H), 1.97-1.60 (m, 4H), 1.12 (t, J=7.5 Hz, 3H).LC-MSD (ES+): m/z [317 (M+H)+, 100].;

The synthetic route of 26032-72-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Dr. Reddy’s Laboratories Ltd.; US2010/144722; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 20737-41-1, Adding some certain compound to certain chemical reactions, such as: 20737-41-1, name is 4-Aminopyrimidine-5-carboxylic acid,molecular formula is C5H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20737-41-1.

Example 90; N-Methyl-4-(2-(2-oxoindolin-5-ylamino)-5-(trifluoromethyl)pyridin-4-ylamino)pyrimidine-5-carboxamide; 4-Amino-7V-metb.ylpyrimidine-5-carboxamide; To the mixture of 4-aminopyrimidine-5-carboxylic acid (0.75 g, 5.39 mmol), methylamine hydrogen chloride (0.44 g, 1.2 eq), EDC (1.67 g, 1.5 eq), HOBt (0.87 g, 1.2 eq) in DMF (2OmL) was added DIEA (3.8 mL, 4.0 eq). The mixture was stirred at room temperature overnight. The crude was concentrated and dissolved in EtOAc. It was washed with saturated NaHCO3 solution. The solvent was removed and the crude was purified by silica gel chromatography (0%~20% MeOH/DCM) to obtain the desired product 4-amino-N-methylpyrimidine-5-carboxamide (0.701 g, isolated yield 85%).

According to the analysis of related databases, 20737-41-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2008/115369; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia