Some scientific research about 26032-72-4

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26032-72-4, 2,4-Dichloro-6-phenylpyrimidine.

Synthetic Route of 26032-72-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 26032-72-4, name is 2,4-Dichloro-6-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

To the reaction flask were added 2,4-dichloro-6-phenylpyrimidine (0.30 g, 1.30 mmol), potassium carbonate (0.37 g, 2.70 mmol), (R)-methyl 3-amino-4,4-dimethylpentanoate (0.46 g,1.70 mmol) and DMF (10 mL).The mixture was stirred at 80 C for 24 h. Water (40 mL) was added, and the resulting mixture was extracted with EtOAc (30 mL x 3). The combined organic phases were washed with saturated brine (60 mL), dried over anhydrous Na2SO4, filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel chromatograph (PE/EtOAc (v/v) = 15/1) to give the tilte compound as a white solid (120 mg, 26 %).MS (ESI, pos. ion) m/z: 348.1[M+H].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26032-72-4, 2,4-Dichloro-6-phenylpyrimidine.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; REN, Qingyun; TANG, Changhua; LIN, Xiaohong; YIN, Junjun; YI, Kai; (270 pag.)WO2017/97234; (2017); A1;,
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Simple exploration of 38696-20-7

The chemical industry reduces the impact on the environment during synthesis 38696-20-7, I believe this compound will play a more active role in future production and life.

Electric Literature of 38696-20-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.38696-20-7, name is 5-Bromo-2-phenylpyrimidine, molecular formula is C10H7BrN2, molecular weight is 235.08, as common compound, the synthetic route is as follows.

Oxazole (124 mg, 1.8 mmol) was dissolved in stirring tetrahydrofuran (20 mL) under nitrogen at -78° C. and treated with n-butyllithium (2.0 M in cyclohexane, 1.1 mL, 2.2 mmol) maintaining internal temperature below -60° C. After stirring ten minutes, ZnCl2 (0.48 g, 3.5 mmol) was added portionwise. The cooling bath was removed and the solution was allowed to reach room temperature. Tetrakis(triphenylphosphine)palladium(0) (30 mg, 5 mole percent) and 5-bromo-2-phenylpyrimidine (309 mg, 1.30 mmol) were added and the mixture heated at 60° C. for four hours. Solvent was removed under reduced pressure and the mixture partitioned between saturated aqueous ammonium chloride and ethyl acetate. The organic phase was retained and additional ethyl acetate extractions of the aqueous phase performed. The combined extracts were dried with anhydrous sodium sulfate, the solution filtered, and solvent removed under reduced pressure. Purification by silica gel flash chromatography (9:1 to 7:3 v/v hexane-ethyl acetate) through a 12-g Silicycle.(R). flash silica cartridge afforded the title compound as an off-white solid (17 mg, 6percent yield); Rf 0.66 with 3:1 v/v hexane-ethyl acetate; melting point 175-177° C.; 1H-NMR (300 MHz; DMSO-d6) delta 9.42 (s, 2H), 8.48 (dd, 2H), 8.41 (s, 1H), 7.56-7.62 (m, 3H), 7.54 (s, 1H); MS (ESI+) m/z 224 (M+1), (ESI-) m/z 222 (M-1); H-PGDS FPBA IC50: 7.8 muM.

The chemical industry reduces the impact on the environment during synthesis 38696-20-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CAYMAN CHEMICAL COMPANY; US2010/75990; (2010); A1;,
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Brief introduction of 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6972-27-6, 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 6972-27-6, 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

Method C: The stirred solution of solution of 6-chloro-l ,3-dimethylpyrimidine- 2,4(lH,3H)-dione (1 Kg) in ethanol (12 L) was added portion wise sodium hydrosulphide hydrate (1 kg) over a period of 1 h at 0 to 5C. After addition, the reaction mixture was stirred at 25 to 30C for 2 h. The reaction mixture was filtered and washed with ethanol (2 L). The filtrate was collected and concentrated under vacuum to obtain residue which was then dissolved in water (8 L). The aqueous solution was washed with dichloromethane (3 L) followed by petroleum ether (2 L). The aqueous layer was separated and was acidified using hydrochloric acid solution [4 L, cone, hydrochloric acid and water (1 : 1)]. The precipitated solid was filtered and washed with water followed by ethanol and dried to obtain the 0.8 Kg of the title compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6972-27-6, 6-Chloro-1,3-dimethylpyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; GLENMARK PHARMACEUTICALS S.A.; KADAM, Suresh Mahadev; THOMAS, Abraham; SINHA, Sukumar; KUMAR, Sukeerthi; KANSAGRA, Bipin Parsottam; GAVHANE, Sachin; KHANDAGALE, Sandeep Bandu; PAWASE, Shailesh; PATIL, Jayant Prakashrao; BHADANE, Shailendra; MISHRA, Bhavna; DWIVEDI, Rajesh; WO2013/183035; (2013); A2;,
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Extended knowledge of 926663-00-5

Statistics shows that 926663-00-5 is playing an increasingly important role. we look forward to future research findings about Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate.

Related Products of 926663-00-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.926663-00-5, name is Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate, molecular formula is C9H9N3O3, molecular weight is 207.19, as common compound, the synthetic route is as follows.

The 5-hydroxy pyrazole [1,5-a] pyrimidine-3-carboxylic acid ethyl ester (20.8g), tetrahydrofuran (223 ml) and ethanol (111 ml) is added in the mixture 2M of aqueous sodium hydroxide solution (201 ml). In the reaction mixture is 50 C stirring overnight, and the evaporation of the organic solvent under reduced pressure. Adding the aid hemostasis 2M hydrochloric acid (201 ml), will precipitate and collect the solid by filtration, but also to water/ethanol cleaning and generates a title compound (17.7g).

Statistics shows that 926663-00-5 is playing an increasingly important role. we look forward to future research findings about Ethyl 5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate.

Reference:
Patent; TAKED A PHARMACEUTICAL COMPANY LIMITED; KAWASAKI, MASANORI; MIKAMI, SATOSHI; NAKAMURA, SHINJI; NEGORO, NOBUYUKI; IKEDA, SHUHEI; ASHIZAWA, TOMOKO; MARUI, SHOGO; TANIGUCHI, TAKAHIKO; (135 pag.)TW2016/520; (2016); A;,
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Brief introduction of 2-Cyanopyrimidine

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14080-23-0, 2-Cyanopyrimidine.

Synthetic Route of 14080-23-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14080-23-0, name is 2-Cyanopyrimidine, molecular formula is C5H3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step-2:Preparation of 2-amidinopyrimidinium hydrochloride (II)2-Cyanopyrimidine (XIII) (5Og, 475.73 mmol) was added to the solution of sodium ethoxide (3.24g, 47.64 mmol) in methanol (500 ml) at -3 to O0C and was stirred for 8 hrs. The reaction mass was allowed to a temperature of 25-3O0C and treated with ammonium chloride (26.72g, 499.43 mmol) to yield 2-amidinopyrimidinium hydrochloride (II).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 14080-23-0, 2-Cyanopyrimidine.

Reference:
Patent; AUROBINDO PHARMA LIMITED; BRAJESH, Kumar, Sinha; KONDURU, Rajasekhara, Raju; BUDIDET, Shankar, Reddy; VADDI, Pandu, RangaRao; AMINUL, Islam; MEENAKSHISUNDERAM, Sivakumaran; WO2011/24056; (2011); A2;,
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Share a compound : N-Boc-2-Amino-5-bromopyrimidine

The chemical industry reduces the impact on the environment during synthesis 883231-23-0, I believe this compound will play a more active role in future production and life.

Related Products of 883231-23-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.883231-23-0, name is N-Boc-2-Amino-5-bromopyrimidine, molecular formula is C9H12BrN3O2, molecular weight is 274.11, as common compound, the synthetic route is as follows.

A mixture of tert-butyl (5-bromopyrimidin-2-yl) carbamate (17a) (360 mg, 0.96 mmol) , N, N-dimethylpiperidin-4-amine (246 mg, 1.92 mmol) , Pd2 (dba) 3 (44 mg, 0.048 mmol) , Xantphos (56 mg, 0.096 mmol) , t-BuONa (184 mg, 1.92 mmol) in toluene (11 mL) was heated at 110 for 18 h under N2. The mixture was cooled to room temperature and concentrated in vacco. The residue was purified by chromatography on silica gel eluting with DCM /MeOH (10: 1) to give tert-butyl (5- (4- (dimethylamino) piperidin-1-yl) pyrimidin-2-yl) carbamate (17b) . MS-ESI (m/z) : 322 [M + 1] +.

The chemical industry reduces the impact on the environment during synthesis 883231-23-0, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CHONGQING FOCHON PHARMACEUTICAL CO., LTD.; SHANGHAI FOCHON PHARMACEUTICAL CO., LTD.; ZHAO, Xingdong; LI, Tongshuang; ZHANG, Huajie; LI, Zhifu; LIU, Bin; LIU, Qihong; TAN, Rui; RONG, Yue; YANG, Lijun; CHEN, Zhifang; TAN, Haohan; JIANG, Lihua; LIU, Yanxin; LINGHU, Li; LIN, Min; SUN, Jing; WANG, Weibo; (89 pag.)WO2017/114351; (2017); A1;,
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Extracurricular laboratory: Synthetic route of 22536-63-6

With the rapid development of chemical substances, we look forward to future research findings about 22536-63-6.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22536-63-6, name is 2-Chloro-4-methoxypyrimidine, molecular formula is C5H5ClN2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 22536-63-6

2-Bromopyridine or 2-chloropyrimidine (2equiv.), 5-amino-2-substitutedphenol (lequiv) and 37% HCl solution (2equiv) in 10% aqueous EtOH solution (0.2M) was stirred at 9O0C for 24h. The reaction mixture was diluted with AcOEt and washed with 5% aqueous K2CO3 solution and brine. The organic phase was dried over Na2SO4, concentrated and the crude product was purified by flash chromatography on silica gel.; Following the general procedure for the synthesis of 2-R-5-(heteroaryl-2-ylamino)phenol, 2- chloro-4-methoxypyrimidine (44 mg, 0.30 mmol) and 4-amino-o-cresol (37 mg, 0.30 mmol) in 10% aqueous EtOH (2 mL) was heated at 90 0C for 18h. The title compound was obtained in 21 % yield a (14 mg) and used for the next step without addittional purification. 1H NMR (500 MHz, CD3OD) £8.06 (d, J= 5.8 Hz, IH), 7.25 (d, J= 2.0 Hz, IH), 6.98 (d, J = 8.2 Hz, IH), 6.92 (dd, J= 8.2, 2.0 Hz, IH), 6.18 (d, J= 5.8 Hz, IH), 3.97 (s, 3H), 2.16 (s, 3H); 13C NMR (125 MHz, CD3OD) £ 172.1, 162.1, 159.1, 156.8, 140.3, 131.9, 120.2, 112.9, 108.5, 99.8, 54.5, 16.1.

With the rapid development of chemical substances, we look forward to future research findings about 22536-63-6.

Reference:
Patent; YALE UNIVERSITY; WO2007/38387; (2007); A2;,
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Share a compound : 2,4-Bis((trimethylsilyl)oxy)pyrimidine

With the rapid development of chemical substances, we look forward to future research findings about 10457-14-4.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10457-14-4, name is 2,4-Bis((trimethylsilyl)oxy)pyrimidine, molecular formula is C10H20N2O2Si2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C10H20N2O2Si2

A mixture of uracil (6.00 g, 53.53 mmol) and ammonium chloride (0.3 g, 5.60 mmol) in HMDS (15 ml) was refluxed for 10 h with the exclusion of moisture until a clear solution was obtained. The excess of silylating agent was removed under vacuum. The residual clear oil of 2,4-bis(trimethylsilyloxy)pyrimidine was dissolved in 25 ml of anhydrous 1,2-dichloroethane, and ethyl bromoacetate (5.92 ml, 53.53 mmol) was added. The reaction mixture was heated at reflux for 20 h, cooled to room temperature and treated with 15 ml of iPrOH. The resulting precipitate was collected and purified by flash chromatography eluting with 1:10 EtOH/1,2-dichloroethane to give 13 (9.45 g, 92%) as white crystals, mp 118-120 C, Rf 0.42 (EtOAc); 1H NMR (400 MHz, DMSO-d6) delta ppm 1.21 (3H, t, J = 7.1 Hz, CH3), 4.15 (2H, q, J = 7.1 Hz, CH2), 4.51 (2H, s, NCH2), 5.62 (1H, d, J = 7.8 Hz, H-5), 7.62 (1H, d, J = 7.8 Hz, H-6), 11.40 (1H, br s, H-3); 13C NMR (100 MHz, DMSO-d6) delta ppm 14.0, 39.1, 39.3, 39.5, 39.7, 39.9, 48.6, 61.2, 101.1, 145.9, 151.0, 163.8, 168.2.

With the rapid development of chemical substances, we look forward to future research findings about 10457-14-4.

Reference:
Article; Babkov, Denis A.; Valuev-Elliston, Vladimir T.; Paramonova, Maria P.; Ozerov, Alexander A.; Ivanov, Alexander V.; Chizhov, Alexander O.; Khandazhinskaya, Anastasia L.; Kochetkov, Sergey N.; Balzarini, Jan; Daelemans, Dirk; Pannecouque, Christophe; Seley-Radtke, Katherine L.; Novikov, Mikhail S.; Bioorganic and Medicinal Chemistry; vol. 23; 5; (2015); p. 1069 – 1081;,
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The important role of 56686-16-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56686-16-9, its application will become more common.

Reference of 56686-16-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 56686-16-9 as follows.

t-BuLi (Aldrich; 1.7 M soln in pentane, 1.1 mL) was added to a mixture of 8 (Aldrich; 200 mg, 0.9 mmol) and dry THF (2 mL) at -78 C under argon. The mixture was left at -78 C for 30 min and then compound 3 (190 mg, 0.8 mmol) was added. The mixture was allowed to warm to room temperature. The reaction was followed by TLC (CHCl3/acetone, 85/15, v/v) at 30 min intervals. After stirring for 3 h at room temperature, when 3 was no longer detected by TLC, Et2O (20 mL) was added. The mixture was washed with H2O (5 mL) and evaporated to dryness. The residue was dissolved in 1,4-dioxane (6 mL) and CH2Cl2 (2 mL). Cu(OAc)2 (40 mg), NH3 (aq) (0.3 mL) and H2O (1 mL) were added. The mixture was stirred at room temperature for 1 d. The organic layer was separated, washed with H2O (10 mL), dried (MgSO4) and concentrated to dryness. Column chromatography of the residue (CHCl3/acetone, 85/15, v/v) gave 9 (70 mg, 39%), 10 (89 mg, 71%), and 11 (50 mg, 17%). 9: A white solid (mp >180 C, dec). deltaH (CDCl3, 200 MHz) 1.43-1.56 (16H, m), 1.90 (4H, m), 2.35 (4H, m), 3.29 (4H, m), 3.56 and 4.34 (8H, AB quartet, 2JAB 11.4 Hz); deltaC (CDCl3, 50 MHz) 22.34, 22.58, 25.42, 26.16, 27.48, 28.49, 36.98, 64.28, 66.43, 72.57, 98.80, 136.38; numax (KBr) 2936, 2860, 1496, 1448, 1380, 1240, 1156, 1044, 920; HRMS (EI, 70 eV) m/z calcd for C24H36O6N2 (M+) 448.2573, found 448.2557. 11: A white solid (mp 151-152 C). deltaH (CDCl3, 200 MHz) 1.34-1.84 (8H, m), 2.1 (2H, m), 2.39 (2H, m), 3.12 (2H, m), 3.63 and 4.57 (4H, AB quartet, 2JAB 11.4), 4.00 (3H, s), 4.02 (3H, s), 10.09 (1H, s); deltaC (CDCl3, 50 MHz) 22.39, 22.67, 25.49, 27.42, 28.21, 28.84, 37.29, 54.21, 55.19, 64.36, 72.23, 98.77, 105.98, 136.72, 159.26, 165.04, 167.74; numax (KBr) 2948, 2936, 1716, 1688, 1556, 1536, 1480, 1464, 1356, 1252, 1244, 1108; HRMS (EI, 70 eV) m/z calcd for C18H25O5N3 (M+) 363.1794, found 363.1812. The NMR spectra of 10 were consistent with those described: H. Pelissier, J. Rodriguez and K.P.C. Volhardt, Chem. Eur. J. 5 (1999), p. 3549. Full Text via CrossRef | View Record in Scopus | Cited By in Scopus (27)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56686-16-9, its application will become more common.

Reference:
Article; Koszytkowska-Stawi?ska, Mariola; Mironiuk-Puchalska, Ewa; Sas, Wojciech; Tetrahedron Letters; vol. 52; 16; (2011); p. 1866 – 1870;,
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The origin of a common compound about 3177-24-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3177-24-0, its application will become more common.

Reference of 3177-24-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 3177-24-0 as follows.

To a cooled (-60 °C) solution of (lr,4r)-4-ethoxycyclohexanamine (6.82 g, 37.9 mmol) and 2,4-dichloropyrimidine-5-carbonitrile (6 g, 34.5 mmol) in THF (115 mL) was added DIEA (15.02 mL, 86 mmol) dropwise. The resulting mixture was stirred at -60 °C for 1 h and then allowed to warm to room temperature overnight. The resulting mixture was concentrated and the residue was purified by silica gel column- 125 -ATI-2514175vl chromatography (14 percent ethyl acetate in petroleum ether). The product fractions were combined and concentrated to afford 2-chloro-4-((lr,4r)-4-ethoxycyclohexylamino)- pyrimidine-5-carbonitrile (3.33 g, 11.86 mmol, 34.4 percent yield) and 4-chloro-2-((lr,4r)-4- ethoxycyclohexylamino)pyrimidine-5-carbonitrile (5.5 g, 19.59 mmol, 56.8 percent yield;1H NMR (400 MHz, DMSO-d6) delta ppm 8.62 – 8.87 (m, 2 H), 3.61 – 3.86 (m, 1 H), 3.44 (dd, J=7.03, 2.34 Hz, 2 H), 3.12 – 3.26 (m, 1 H), 1.75 – 2.15 (m, 4 H), 1.13 – 1.44 (m, 4 H), 1.08 (td, J=6.93, 1.76 Hz, 3 H); MS (ESI) m/z 281.1 [M+l]+) as white solids. Theregiochemistry of the major isomer was confirmed by comparison with the proton spectra of 4-chloro-2-((lr,4r)-4-methoxycyclohexylamino)pyrimidine-5-carbonitrile (synthesis described herein).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3177-24-0, its application will become more common.

Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; BENNETT, Brydon, L.; ELSNER, Jan; ERDMAN, Paul; HILGRAF, Robert; LEBRUN, Laurie, Ann; MCCARRICK, Meg; MOGHADDAM, Mehran, F.; NAGY, Mark, A.; NORRIS, Stephen; PAISNER, David, A.; SLOSS, Marianne; ROMANOW, William, J.; SATOH, Yoshitaka; TIKHE, Jayashree; YOON, Won, Hyung; DELGADO, Mercedes; WO2012/145569; (2012); A1;,
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