Day: July 2, 2021

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 193746-84-8, name is 4-(Dimethoxymethyl)-2-methoxypyrimidine, molecular formula is C8H12N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 4-(Dimethoxymethyl)-2-methoxypyrimidine

Step 5: 2-methoxypyrimidine-4-carbaldehyde, 61 is prepared as follows: 4-(dimethoxymethyl)-2-methoxypyrimidine, 60 (1.50 g) is dissolved in dilute hydrochloric acid (1M, 12.3 mL) and the mixture heated to 55 C. for 3 h. The reaction mixture is partitioned between water and dichloromethane and the aqueous layer extracted with further portions of dichloromethane. The combined organics are dried (magnesium sulfate), filtered and concentrated to a yellow gum (1.10 g). The aldehyde is used immediately in the next step without further purification. The compound obtained in this step shows the following mass spectral data: LC/MS: C6H6N2O2 requires 138.0; observed M/Z 139.1 [M+H]+. RT 0.85 min.

With the rapid development of chemical substances, we look forward to future research findings about 193746-84-8.

Reference:
Patent; Griffin, John; Lanza, Guido; Yu, Jessen; US2005/261354; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 39551-54-7, 2,4-Dichloropyrido[3,2-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 39551-54-7, blongs to pyrimidines compound. Recommanded Product: 39551-54-7

To a solution of 2,4-dichloropyrido[3,2-d]pyrimidine (CAS39551-54-7, supplied by Astatech, Inc.) (50 mg, 0.25 mmol) in THF (2 mL) was added butan-1-amine (0.03 mL, 0.28 mmol) and N,N-diisopropylethylamine (0.13 ml, 0.75 mmol). After stirring at room temperature for 30 minutes, 2,4-dimethoxybenzylamine (0.19 ml, 1.25 mmol) and N,N-diisopropylethylamine (0.13 ml, 0.75 mmol) were added and the mixture was heated to 100 C. After 16 hours, the reaction was cooled to room temperature, diluted with ethyl acetate, washed with water and brine, dried over Na2SO4, and concentrated in vacuo. The product ( 1A) was obtained after flash chromatography. MS (m/z): 368.14 [M+H]+

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,39551-54-7, its application will become more common.

Reference:
Patent; Gilead Sciences, Inc.; Aktoudianakis, Evangelos; Chin, Gregory; Mackman, Richard L.; Metobo, Samuel E.; Mish, Michael R.; Pyun, Hyung-jung; Zablocki, Jeff; (175 pag.)US2016/289229; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 874-14-6, name is 1,3-Dimethyluracil, the common compound, a new synthetic route is introduced below. Formula: C6H8N2O2

A mechanically stirred mixture of 3-aminopyrazole (9.38 g, 0.11 mM, 1.0 equiv), 1,3-dimethyluracil (14.7 g, 0.11 mM, 1.0 equiv) and 21percent sodium ethoxide in ethanol (170 mL, 5.0 equiv) was heated to reflux. Within minutes, a heavy precipitate formed. After refluxing for 1 hour, 1,3-dimethyluracil could no longer be detected by thin layer chromatography (tlc) (92:8 dichloromethane (dichloromethane):MeOH). The reaction mixture was cooled, filtered, washed with cold ethanol and vacuum dried to give 13.47 g (95percent) of sodium pyrazolo[1,5-a]pyrimidin-5-olate. LCMS (ESI) m+H=136.0; 1H NMR (400 MHz, DMSO-d6) delta: 8.0 (d, 1H), 7.43 (d, 1H), 5.65 (d, 1H), 5.37 (d, 1H).

The synthetic route of 874-14-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Genentech, Inc.; US2012/22043; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 893755-98-1, name is 1-(Pyrimidin-2-yl)piperidin-4-ol, molecular formula is C9H13N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 1-(Pyrimidin-2-yl)piperidin-4-ol

Step 2: 1-(1,4,5,6-Tetrahydro-2-pyrimidinyl)-4-piperidinol (181) Compound 180 (300 mg, 1.67 mmol) was combined with 10% palladium on carbon(Degussa type) (100 mg, cat.) and concentrated hydrochloric acid (500 mul_) into 10 ml. of acetic acid. The mixture was subjected to hydrogenation for 18 h at room temperature. The reaction mixture was then filtered and the solvent was removed under reduced pressure to give 304 mg (84%) of the desired compound lambdaZlambda_. 1H NMR (400 MHz, DMSOd6): delta 8.25 (m, 2 H), 4.03 – 3.41 (m, 3 H), 2.95 – 2.86 (m, 4 H), 2.09 – 1.55 (m, 6 H), 1.55 – 1.18 (m, 2 H).

With the rapid development of chemical substances, we look forward to future research findings about 893755-98-1.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/8895; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 205672-25-9 ,Some common heterocyclic compound, 205672-25-9, molecular formula is C4H3BrClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A 500 mL round bottomed flask is charged with 5-bromo-2-chloropyrimidin-4-ylamine (1) (lOg, 48 mmol), tetrakis(triphenylphosphine)palladium(0) (2.8g, 2.5 mmol), and toluene (200 mL). Tributyl- (2-ethoxyvinyl)-stannane (22g, 60 mmol) is added and the reaction heated to 110C with stirring for approximately 15 hours. After cooling to room temperature, the solution is diluted with 100 mL ethyl acetate and washed with water and brine. The organic extract is dried over Na2S04, filtered, and concentrated under reduced pressure. Purification by column chromatography (Si02, Hexane : Ethyl acetate/ 5 :1) provides 2 (4.4 g, 46%) as a yellow solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,205672-25-9, its application will become more common.

Reference:
Patent; IRM LLC; WO2005/107760; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 42839-09-8, name is 2-Pyrimidinemethanol. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Pyrimidinemethanol

EXAMPLE 11 5-Butyl-9-[1-(2,4-dimethyl-pyridine-3-carbonyl)-4-methyl-piperidin-4-yl]-3-pyrimidin-2-ylmethyl-1-oxa-3,9-diaza-spiro[5.5]undecan-2-one (IV-5) Pyrimidin-2-ylmethyl methanesulfonate (48)-To a solution of pyrimidin-2-yl-methanol (CASRN 42839-09-8, 2 g, 1.8 mmol) and DCM (1 mL) cooled to 0 C. was added sequentially TEA (0.062 mL) and methanesulfonyl chloride (0.2 mL). The reaction mixture was stirred for 3 h then washed with aqueous NH4Cl. The solvent was removed in vacuo and residue was purified by SiO2 chromatography eluding with MeOH/DCM (1:20) to afford 0.2 g (58%) of 48. The title compound was prepared by the procedure described in steps 10-12 of example 2 except in step 10, 3-methoxy-cyclohexylmethyl tosylate was replaced with 48, and in step 12, 4,6-dimethyl-pyrimidine-5-carboxylic acid was replaced with 2,4-dimethyl-nicotinic acid. The product was purified by preparative HPLC (acetonitrile-0.01M TFA) to afford IV-5 as the trifluoroacetate salt: MS [M+]=549.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42839-09-8, 2-Pyrimidinemethanol.

Reference:
Patent; Rotstein, David Mark; Melville, Chris Richard; US2008/249087; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 5767-35-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5767-35-1, name is 4-Chloro-6-hydrazinopyrimidine. A new synthetic method of this compound is introduced below.

A mixture of N-cyano-N’-(4-morpholinopheny)-O-phenylisourea (8.76 g, 27.2 mmol, 4-chloro-6-hydrazino-pyrimidine (4.12 g, 28.5 mmol) and di-iso-propylethylamine (18.9 mL, 109 mmol) in N-methyl-pyrrolidinone (50 mL) was heated in the microwave apparatus at 220C for 5 min, cooled, poured into ice-water, stirred 0.5h and filtered to obtain crude product (9.30 g). Purification by flash chromatography (SiO2) eluted with 2:98 methanol : dichloromethane provided the title compound (3.91 g, 39% yield) as a yellow powder.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5767-35-1, 4-Chloro-6-hydrazinopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2004/46120; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 66131-68-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 66131-68-8, name is 2-Chloro-N-methylpyrimidin-4-amine. A new synthetic method of this compound is introduced below.

Potassium t-butoxide (165MG) was added to the product of example 1 step b) (0.2g) and 2-chloro-N-methyl-4-pyrimidinamine (105MG) in NMP (3ML). THE mixture was stirred at 60 C for 20h. The resulting mixture was cooled, acidified with acetic acid (LML) and purified by reverse phase HPLC (Symmetry gradient 90-50% aqueous, ammonium acetate (0.2% aq. ) in acetonitrile) to give the title compound as a solid (40mg). MS (APCI+) 383 [M+H] + H NMR 8 (DMSO 9O O 8.32 (d, lH), 7.82 (d, LH), 7.68 (dd, LH), 6.97 (s, LH), 6.81 (d, lH), 6.08 (d, LH), 5.15 (heptet, 1H), 4.05-3. 97 (m, 2H), 3.51-3. 44 (m, 4H), 3.43-3. 36 (m, 2H), 2.78 (d, 3H), 2.07-2. 00 (m, 2H), 1.87-1. 82 (m, 4H), 1.73-1. 63 (m, 2H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,66131-68-8, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; WO2004/74278; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1780-26-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine. A new synthetic method of this compound is introduced below.

To the stirred solution of 2-amino-N-(2-chloro-6-methylphenyl)thiazole-5- carboxamide 9 (15.0 g, 0.06 mol) and 4,6-dichloro-2-methylpyrimidine (10.9 g, 0.07 mol) in tetrahydrofuran (THF) (150.0 mL) was added a 29% wt.solution of NaOtBu in THF (64.9 g, 0.2 mol) at 10-20C, over 15-20 minutes. The mixture was stirred at room temperature for 1h and cooled to 0-5C. 1N Hydrochloric acid (~90.0 mL) was added slowly to pH 2-3 followedby the added water 90.0 mL) and stirred for 2h at 0-5C, product was filtered and washed the wet cake with water (60.0 mL) followed by acetone (30.0 mL) gave 5 (20.7 g, 94%).UV (Methanol): max, 319.6 & 203.2 nm; IR (KBr, cm-1): 3420.3 (N-H), 3016.6 (Ar C-H), 1638.6 (C=O); 1H NMR spectrum (400 MHz, DMSO-d6), delta, ppm (J, Hz): 12.23 (s, 1H, thiazole-NH), 10.02 (s, 1H, amide-NH), 8.32 (s,1H, thiazole-H), 7.42-7.40 (m, 1H, Ar-H), 7.31-7.25 (m, 2H, J =7.5, Ar-H), 6.95 (s, 1H, pyrimidine-H), 2.59 (s,3H, Ar-CH3), 2.25 (s, 3H, pyrimidine-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), delta, ppm: 167.4(pyrimidine-C), 161.2 (pyrimidine-C), 159.5 (pyrimidine-C), 158.5 (amide-C), 157.6 (thiazole-C), 140.8 (Ar-C),138.8 (thiazole-C), 133.3 (Ar-C), 132.4 (Ar-C), 129.0 (Ar-C), 128.3 (Ar-C), 127.2 (thiazole-C), 103.4 (pyrimidine-C), 67.0 (pyrimidine-C), 25.2 (Ar-CH3), 18.3 (pyrimidine-CH3); MS (ESI) m/z 391.9 [M – H] – [5].

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1780-26-3, 2-Methyl-4,6-dichloropyrimidine, and friends who are interested can also refer to it.

Reference:
Article; Suresh, Garbapu; Nadh, Ratnakaram Venkata; Srinivasu, Navuluri; Yennity, Durgaprasad; Synthetic Communications; vol. 47; 17; (2017); p. 1610 – 1621;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1500-85-2, name is 7H-Pyrrolo[2,3-d]pyrimidin-4-amine. A new synthetic method of this compound is introduced below., Application In Synthesis of 7H-Pyrrolo[2,3-d]pyrimidin-4-amine

500 mg (3.7 mmol) of 7H-pyrrolo[2,3-d]pyrimidin-4-amine were dissolved in 40 mL of dry DMF and 1.03 g (3.7 mmol) of tert-butyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate were added, followed by 3.87 g (3.7 mmol) of caesium carbonate, under argon atmosphere. The mixture was heated in a microwave apparatus at 100 C for 4 hours, then the solvent removed under vacuum.The residue was taken up with dicholomethane and washed with brine. Theorganic layer was dried over Na2S04 and evaporated to give, after trituration with diethyleher, 420 mg of the title compound. (36%)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1500-85-2, 7H-Pyrrolo[2,3-d]pyrimidin-4-amine.

Reference:
Patent; NERVIANO MEDICAL SCIENCES S.R.L.; ANGIOLINI, Mauro; BUFFA, Laura; MENICHINCHERI, Maria; MOTTO, Ilaria; POLUCCI, Paolo; TRAQUANDI, Gabriella; ZUCCOTTO, Fabio; WO2014/184069; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia