Day: July 8, 2021

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C5H5N5, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine

To a stirred suspension of lH-pyrazolo-[3,4-(i]pyrimidin-4-ylamine (8-1 ; 50 g) in DMF (500 mL) N-bromosuccinimide (66 g) was added and the reaction mass was heated for 5 h at 70 C. The solvent was removed under reduced pressure. Water was added to the residue and stirred for 30 minutes. The reaction mass was filtered and the solid and washed with diethyl ether. The product was dried under reduced pressure overnight to obtain the title compound as a brown solid.

With the rapid development of chemical substances, we look forward to future research findings about 2380-63-4.

Reference:
Patent; SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED; KADIYALA, V.S.N. Murty; RAUT, Virendra Narendra; SAVANT, Pratit; SHETH, Chetana Kaushal; CHAUDHARI, Umesh Vishnu; RATHOD, Rajendrasinh Jashvantsinh; BHATT, Tushar Bhupendrabhai; CHITTURI, Trinadha Rao; (50 pag.)WO2017/134685; (2017); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 18592-13-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18592-13-7, name is 6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.

Intermediate 1 y)methyl)pyrimidine-2,4(lH,3H)-dione A mixture of 6-(chloromethyl)pyrimidine-2,4(lH,3H)-dione (1 g, 6.23 mmol), 2,2,2- trifluoroethanol (2.235 mL, 31.14 mmol) and cesium carbonate (6.09 g, 18.68 mmol) in dimethylformamide (10 mL) was heated in a microwave oven at 100C for 30 min. The mixture was filtered and the volatiles were removed in vacuum. The residue was treated with diluted HCI (pH 4.5) and cooled to 0C. The resulting crystalls were collected by fitration and dried in vacuum cabinet to yield the title compound, 0.92 g (66%). MS (APCI ) m/z 223 (M-H) XH NMR (500 MHz, DMSO-cf6) 0 ppm 4.18 (q, 2 H) 4.36 (s, 2 H) 5.49 (s, 1 H) 10.93 (br. s., 1 H) 11.03 (br. s., 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18592-13-7, its application will become more common.

Reference:
Patent; ACTURUM LIFE SCIENCE AB; BESIDSKI, Yevgeni; YNGVE, Ulrika; PAULSEN, Kim; LINDE, Christian; MACSARI, Istvan; MALMBORG, Jonas; PAPTCHIKHINE, Alexander; ARVIDSSON, Per; WO2014/195323; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 33034-67-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine, molecular formula is C5H2ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 48 mg of potassium carbonate in methanol (3 ml) was added 37 mg of 4-(5- cyano-7-isopropyl-l ,3-benzoxazol-2-yl)-N-[(7S)-l ,4-oxazepan-7-ylmethyl]benzamide(INTERMEDIATE 20) followed by 2-chloro-4-(trifluoromethyl)pyrimidine (16 mg). The mixture was heated via microwave at 12O0C for 35 min, and then cooled and added directly to a 4OM samplet for purification via column chromatography on a Biotage Horizon 4OM column, eluting with 1 column volume of 100percent hexanes, followed by a gradient of 0 to 100percent ethyl acetate in hexanes over 10 column volumes, followed by 4 column volumes of 100percent ethyl acetate, to provide the title compound (37 mg, 76 percent). Mass spectrum (ESI) 565.2 (M+l). 1H NMR (500 MHz, CDCl3): delta 8.52 (s, IH), 8.35 (d, J=8.5 Hz, 2H), 7.96 (d, J=8.3 Hz, 2H), 7.95 (s, IH), 7.54 (s, IH), 6.81 (d, J=4.8 Hz, IH), 6.65 (bs, IH), 4.26 (m, 2H), 3.98 (m, 3H), 3.70 (s, 2H), 3.69 (m, 2H), 3.48 (sept, J=7.0 Hz, IH), 3.25 (m, IH), 2.19 (m, IH), 1.83 (m, IH), 1.48 (d, J=7.1 Hz, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 33034-67-2, 2-Chloro-4-(trifluoromethyl)pyrimidine.

Reference:
Patent; MERCK & CO., INC.; WO2008/156715; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 3680-69-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1. 4-Chloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine (Compound 3) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 10.75 g (70 mmol) (Toronto Research Chemicals, Inc) and N-iodosuccinimide (16.8 g, 75 mmol) were dissolved in 400 mL of dry DMF and left at ambient temperature in the darkness over night. The solvent was evaporated. The yellow residue was suspended in hot 10% solution of Na2SO3, filtered, washed twice with hot water and crystallized from ethanol to yield 14.6 g (74.6%) of the title compound as off-white crystals. The mother liquid was evaporated up to 1/3 volume and crystallized again from ethanol to give 2.47 g (12.3%) of the title product; Total yield is close to 100%; M.p. 212-214 (decomposition); UV lambdamax: 307, 266, 230, 227 nm (methanol); MS: 277.93 (M-H), 313 (M+Cl); 1H-NMR (DMSO-d6): 12.94 (s, 1H, NH), 8.58 (s, 1H, H-2), 7.94 (s, 1H, H-8).

According to the analysis of related databases, 3680-69-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Genelabs Technologies, Inc.; US2005/215510; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 25940-35-6 ,Some common heterocyclic compound, 25940-35-6, molecular formula is C7H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(Benzotriazol-1 -yloxy)tripyrrolidinophosphonium hexafluorophosphate (1 .05 g, 2.02 mmol) was added to a mixture of pyrazolo[1 ,5-a]pyrimidine-3-carboxylic acid (299 mg, 1 .84 mmol, GAS No. 25940-35-6), trans-4-am ino-N-(2-chloro-4-fluorophenyl)cyclohexanecarboxam idehydrochloride (620 mg, 2.02 mmol) and N-ethyl-N-isopropylpropan-2-amine (1.6 ml, 9.2 mmol) in 20 ml N,N-dimethylformamide and the mixture was stirred over night at room temperature. For work-up, the reaction mixuture was concentrated under reduced pressure and the residue was stirred with a mixture of water and methanol. The precipitate was collected by filtration, washed with water and methanol and dried to yield the title compound(525mg, 68% yield).LG-MS (Method 1): R = 1 .01 mm; MS (ESIpos) m/z = 416.3 [M+H].1HNMR (400 MHz, DMSO-d6): 6 [ppm] = 9.51 (5, 1H), 9.38-9.28 (m, 1H), 8.88-8.76 (m, 1H),8.58 (5, 1H), 7.85-7.75 (m, 1H), 7.66-7.57 (m, 1H), 7.54-7.43 (m, 1H), 7.32-7.18 (m, 2H),3.91-3.67 (m, 1H), 2.12-2.01 (m, 2H), 2.01-1.89 (m, 2H), 1.67-1.49 (m, 2H), 1.47-1.27 (m,2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25940-35-6, its application will become more common.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERMANN, Jens; WAGNER, Sarah; BUCHGRABER, Philipp; SUeLZLE, Detlev; HOLTON, Simon; BENDER, Eckhard; LI, Volkhart; LIU, Ningshu; SIEGEL, Franziska; LIENAU, Philip; BAIRLEIN, Michaela; VON NUSSBAUM, Franz; HERBERT,Simon; KOPPITZ, Marcus; (734 pag.)WO2016/177658; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1032452-86-0

Under nitrogen protection,200 mg of (4-fluoro-2-methoxy-5-nitrophenyl) -methylamine was added to the reaction flask in this order(1.0 mmol),244 mg of 3- (2-chloropyrimidin-4-yl) -1-methylindole (CAS 1032452-86-0, 1.0 mmol), 207 mg of p-toluenesulfonic acid monohydrate -pentanol.The mixture was stirred at 105 C for two hours until TLC showed the reaction was complete.The reaction was cooled to room temperature and the resulting solid was collected by filtration;The filtrate was cooled with an ice water bath,The resulting solid was collected by filtration.Two batches of solid were combined and washed with acetonitrile,367 mg of a gray solid was obtained,Yield 90%.

With the rapid development of chemical substances, we look forward to future research findings about 1032452-86-0.

Reference:
Patent; Nantong Yin Nuowei Pharmaceutical Technology Co., Ltd.; Lanzhou University The Second Hospital; Han Zhijian; Bian Hongzhu; (9 pag.)CN107266426; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 4316-93-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 4316-93-2 as follows.

General procedure: To a solution of the nitrochloropyrimidine derivative in tetrahydrofuran (4 mL/mmol) were added the amine (1 equivalent) and NaHC03 (1.1 equivalents). The solution was stirred at room temperature overnight. After concentration under reduced pressure, the crude product was purified by chromatography on silica gel to afford the pure product. This compound was synthetised through general synthesis protocol XVI from 4,6-dichloro-5-nitropyrimidine (1 equivalent) and 4-aminoacetanilide (1 equivalent). It was stuffed at room temperature under argon for 7 h. The suspension was then filtered and the precipitate was washed with ethyl acetate. The filtrate was concentrated until precipitation. The precipitate was filtrated to afford pure compound120 (25%). ?H NMR (400 MHz, d6-DMSO) oe 10.02 (bs, 1H, NH), 9.99 (bs, 1H, NH),8.47 (s, 1H, CH), 7.57 (d, J = 8.9 Hz, 2H, 2 CH), 7.39 (d, J = 8.9 Hz, 2H, 2 CH),2.04 (s, 3H, CH3); HRMS (ESI) calc. for C,2H,,C1N503: [M + H] 308.05449, found308.0543.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4316-93-2, its application will become more common.

Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE PIERRE ET MARIE CURIE – PARIS 6 (UPMC); CALLEBAUT, Isabelle; MORNON, Jean-Paul; DECOUT, Jean-Luc; BECQ, Frederic; LEHN, Pierre; HOFFMANN, Brice; BOUCHERLE, Benjamin; HAUDECOEUR, Romain; FORTUNE, Antoine; BOINOT, Clement; ALLIOT, Julien; (147 pag.)WO2016/87665; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 4595-59-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4595-59-9, name is 5-Bromopyrimidine, molecular formula is C4H3BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A modified procedure of Rho and Abuh (Syn. Commun. 1994, 24, 253-256) was followed for the preparation of the titled aldehyde. Under nitrogen, to a solution of 5-bromopyrimidine (1 g, 6.3 mmol) in 60 mL anhydrous THF, was added BuLi (2.5 M, 2.6 mL, 6.5 mmol) at -78 C. The resulting yellow solution was stirred for 20 min, after which ethyl formate (0.55 mL, 6.7 mmol) was added dropwise over 5 min. After 20 min, the reaction was quenched with 1.5 M THF/HCl solution (4.5 mL, 6.7 mmol). The cold bathwas removed, and the reaction mixture was stirred for 1 h. THF was removed in vacco, 10 mL of water was then added. The mixture was extracted with CHCl3 (2*10 mL), and the combined organics were dried (MgSO4) and concentrated. The crude product was purified via flash column chromatography (5% MeOH/CHCl3) to give 0.35 g (51%) of the titled pyrimidine-5-carboxaldehydepyrimidine-5-carboxaldehyde.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4595-59-9, 5-Bromopyrimidine.

Reference:
Patent; Kosogof, Christi; Liu, Bo; Liu, Gang; Liu, Mei; Nelson, Lissa T. J.; Serby, Michael D.; Sham, Hing L.; Szczepankiewicz, Bruce G.; Xin, Zhili; Zhao, Hongyu; US2005/171131; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1074-40-4 ,Some common heterocyclic compound, 1074-40-4, molecular formula is C5H4Cl2N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 4. A mixture of 4,6-dichloro-2-methoxy-pyrimidine (0.66 g, 3.69 mmol), 2,2-difluoro-2-phenyl- ethylamine (0.58 g, 3.69 mmol), and NaHCO3 (0.93 g, 11.1 mmol) in 95% EtOH (10 mL) is heated to reflux. After stirred at 85C for 5 h. The mixture is diluted with water, filtered, washed (water), and dried to afford (6-chloro-2-methoxy-pyrimidin-4-ylV(2.2-difluoro-2-phenyl-ethyl)-amine as a solid (0.58 g). LCMS: RT = 3.17 minutes, MS: 300 (M+H). 1H NMR (300 MHz, CDCl3) ? 7.57-7.45 (5H, m), 6.1 (IH, s), 5.2 (IH, s), 4.2-4 (2H, m), 3.92 (3H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1074-40-4, 4,6-Dichloro-2-methoxypyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/44732; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1032452-86-0, Adding some certain compound to certain chemical reactions, such as: 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole,molecular formula is C13H10ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1032452-86-0.

c-1 (48 mg, 1.2 eq) was dissolved in isopropanol 5 mL,Then add p-toluenesulfonic acid (56 mg, 2 eq),J-6 (60 mg, 1 eq) was charged with nitrogen and reacted at 60 C, and the reaction was confirmed by TLC.Add sodium hydrogencarbonate to the reaction solution, adjust the pH to 10, and extract.Wash twice with dichloromethane and combine the organic phases.Drying under reduced pressure and separation by column chromatography to give compound 6,The yield of 30 mg was 48%.

According to the analysis of related databases, 1032452-86-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Liaoning University; Chen Ye; Ding Shi; Liu Ju; Ji Jingchao; Hao Xuechen; Liu Yutong; Li Jie; Zhang Mingjuan; Gong Yilin; (29 pag.)CN110283162; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia