Day: July 9, 2021

Related Products of 33034-67-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33034-67-2, name is 2-Chloro-4-(trifluoromethyl)pyrimidine. A new synthetic method of this compound is introduced below.

Step 3 : A solution of 2-chloro-4-(trifluoromethyl)pyrimidine (0.297 g, 1.626 mmol) in dioxane (4 ml) was added to 3-Bromo-5-(difluoromethyl)aniline (0.314 g, 1.414 mmol) followed by methanesulfonic acid (0.1 1 ml, 1.694 mmol) and the resulting solution was heated overnight to 100 °C. The reaction was diluted with water and extracted with EtOAc. The organic phase was washed with saturated sodium bicarbonate, water, dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified on silica gel (EtOAc/hexane=2/8) to afford N- [3-bromo-5-(difluoromethyl)phenyl]-4-(trifluoromethyl)pyrimidin-2-amine. MS ESI calc’d. for Ci2H7BrF5N3 [M + H]+ 368, 370, found 368, 370. lH NMR (500 MHz, CDCI3) delta 8.65 (d, J= 4.9, IH), 8.09 (s, IH), 7.97 (s, IH), 7.73 (s, IH), 7.27 (s, IH), 7.07 (d, J= 4.9, IH), 6.56 (t, J= 56.2, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,33034-67-2, 2-Chloro-4-(trifluoromethyl)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; ALTMAN, Michael, D.; CHILDERS, Kaleen Konrad; DI FRANCESCO, Maria Emilia; ELLIS, John Michael; FISCHER, Christian; GRIMM, Jonathan; HAIDLE, Andrew, M.; KATTAR, Solomon, D.; NORTHRUP, Alan, B.; OTTE, Ryan, D.; PETROCCHI, Alessia; SCHELL, Adam, J.; ZHOU, Hua; WO2012/154519; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1088994-22-2 , The common heterocyclic compound, 1088994-22-2, name is 5-Methyl-2-(pyrimidin-2-yl)benzoicacid, molecular formula is C12H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 15 N-ethyl-N-{2-[4-(5-fluoropyridin-2-yl)-1H-pyrazol-1-yl]ethyl}-5-methyl-2-(pyrimidin-2-yl)benzamide DIPEA (0.28 mL, 1.6 mmol) was added to a solution of the compound (0.15 g, 0.64 mmol) obtained in Reference Example 2 in CHCl3 (3 mL) at room temperature. 5-Methyl-2-(pyrimidin-2-yl)benzoic acid (0.18 g, 0.83 mmol) and propylphosphonic acid anhydride (cyclic trimer) (50% solution in EtOAc (approximately 1.7 mol/L), 1.1 mL, 1.9 mmol) were added to the reaction solution under cooling in ice water. The resultant mixture was stirred at room temperature for 1 hour and further stirred in an oil bath with a temperature of 50 C. for 3 hours. After standing to cool to room temperature, water was added thereto, followed by extraction with CHCl3. The organic layer was washed with brine. Then, the organic layer was dried over Na2SO4, and the desiccant was filtered off. Then, the solvent was distilled off under reduced pressure. The obtained residue was purified by column chromatography (KP-NH 28 g, hexane/EtOAc=70/30?0/100) and further purified by HPLC to obtain the title compound (0.069 g) (colorless amorphous). LCMS retention time 4.37 min. (Condition 1) MS (ESI pos.) m/z: 431 [M+H]+

The synthetic route of 1088994-22-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Nozawa, Dai; Suzuki, Ryo; Futamura, Aya; Shimono, Rie; Abe, Masahito; Ohta, Hiroshi; Araki, Yuko; US2013/281465; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1193-24-4, name is 4,6-Dihydroxypyrimidine. A new synthetic method of this compound is introduced below., Safety of 4,6-Dihydroxypyrimidine

General procedure: According to the conventional manufacturing method of the present inventors [16], under the condition containing two equivalents of triethylamine in dichloromethane at 25 , 4,6- dihydroxy-pyrimidine with 2 equivalents of Compound 2 by acylating a new and compounds 4, 6-pyrimidyl di (2-halo-benzoate) (compound 3) is prepared. After evaporation of dichloromethane, the mixture is dissolved in anhydrous THF, to remove the triethylamine hydrochloride by filtration. The concentrated residue was purified by short length silica gel (Davisil, pH = 7) was purified by column chromatography, or the Compound 3 is prepared by purification was recrystallized with 75% EtOAc / n- hexane

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1193-24-4, 4,6-Dihydroxypyrimidine.

Reference:
Patent; Duksung Women’s University Academic Cooperation; Lee, Jae In; Song, Yun jU; Choe, Jin Son; (12 pag.)KR2015/106483; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10244-24-3, name is 4,4′-(6-Chloropyrimidine-2,4-diyl)dimorpholine, the common compound, a new synthetic route is introduced below. Quality Control of 4,4′-(6-Chloropyrimidine-2,4-diyl)dimorpholine

The 4,4 ‘ – (6-chloro-pyrimidine -2,4-diyl) two morpholine (5.0g, 17 . 6mmol), pinacone esterjoint boric acid (5.8g, 22 . 8mmol) and potassium acetate (2.59g, 26 . 4mmol) into acetonitrile (100 ml) in, under the protection of nitrogen by adding three ring hexyl phosphine (395 mg, 1 . 4mmol) and three (dibenzalacetone) palladium II (645 mg, 0 . 7mmol), the temperature is increased to 84 C reaction 3 hours, to take advantage of heat filtering, the filtrate after turns on lathe does adding toluene (30 ml) and petroleum ether (100 ml), stirring, precipitate, filtered, the filter cake is washed with petroleum ether washing, to obtain the title compound (3.8g, yield 57.4%).

The synthetic route of 10244-24-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong Xuanzhu Oharma Co., Ltd.; Wu, Yongjian; (47 pag.)CN105541792; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 271-70-5, Adding some certain compound to certain chemical reactions, such as: 271-70-5, name is 7H-Pyrrolo[2,3-d]pyrimidine,molecular formula is C6H5N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 271-70-5.

7H-Pyrrolo[2,3-d]pyrimidine (6, 0.450 g, 3.78 mmol), (5-formyl-pyridin-2-yl)-(6-methoxy-pyridin-3-ylmethyl)-carbamic acid tert-butyl ester (71, 1.43 g, 4.16 mmol), potassium hydroxide (0.689 g, 12.3 mmol) and 6.6 mL methanol were combined in a reaction vessel. The reaction mixture was allowed to stir at room temperature for 36 hours, then concentrated under vacuum to provide a thick brown slurry, which was combined with ethyl acetate and aqueous saturated sodium bicarbonate. The organic layer was dried with sodium sulfate, filtered and the filtrate adsorbed onto silica. This was purified by silica gel column chromatography, eluting with a gradient of 1-10% methanol in dichloromethane over 30 minutes. Appropriate fractions were combined and the solvents removed under vacuum to provide the desired compound (72, 380 mg). 1H NMR was consistent with the compound structure.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 271-70-5, 7H-Pyrrolo[2,3-d]pyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Ibrahim, Prabha N.; Bremer, Ryan; Zhang, Jiazhong; Nespi, Marika; Cho, Hanna; US2009/286782; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 13479-88-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13479-88-4, name is 5,7-Dichlorothiazolo[5,4-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Example 6. General Procedure F A mixture of the desired chlorothiazolopyrimidines i-F (1 equiv), desired aminomethyl heterocycle or benzylamine ii-F (1.1 equiv), and triethylamine (NEt3) (1.5 equiv) in 1,4-dioxane (~0.1 M) was stirred at room temperature until the reaction was complete by LC-MS and/or TLC analysis. The reaction mixture was concentrated to dryness then re-dissolved in CH2Cl2 and washed with saturated NaHCO3 solution. The organic extract was dried over Na2SO4, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel chromatography (typical eluents included, for example, a mixture of hexanes and EtOAc, or a mixture of CH2Cl2 and MeOH, or an 80:18:2 mixture of CH2Cl2/CH3OH/concentrated NH4OH) to afford the desired product iii-F. The product structures prepared according to General Procedure F were confirmed by 1H NMR and/or by mass analysis.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13479-88-4, 5,7-Dichlorothiazolo[5,4-d]pyrimidine.

Reference:
Patent; THE GENERAL HOSPITAL CORPORATION; UNITED STATES DEPARTMENT OF HEALTH AND HUMAN SERVICES; SLAUGENHAUPT, Susan, A.; JOHNSON, Graham; PAQUETTE, William, D.; ZHANG, Wei; MARUGAN, Juan; (306 pag.)WO2016/115434; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 479691-42-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 479691-42-4, name is tert-Butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

(2) 4-phenyl-2-piperazin-1-ylpyrimidine Dihydrochloride To a solution of tert-butyl 4-(4-chloropyrimidin-2-yl)piperazine-1-carboxylate (6.30 g, 20.7 mmol) and phenylboric acid (3.75 g, 31.1 mmol) in anhydrous toluene (250 ml) was added potassium phosphate (9.20 g, 41.5 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethyxanthene (480 mg, 0.83 mmol) and trisdibenzylideneacetone dipalladium (119 mg, 0.21 mmol) under nitrogen atmosphere, and the reaction was degassed and heated under reflux for 14 hours. The reaction was distilled off under reduced pressure and to the residue was added to methylene chloride and water followed by extracted. The extract was washed with saturated brine, dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether:ethyl acetate=5:1) to obtain tert-butyl 4-(4-phenylpyrimidin-2-yl)piperazine-1-carboxylate (5.00 g, 70%).

According to the analysis of related databases, 479691-42-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; US2009/163508; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 857641-46-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 857641-46-4, name is 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, molecular formula is C7H5BrN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The ligand pzpm (47.4mg, 0.32mmol) was dissolved in CH2Cl2 (10ml), and added to a suspension of [NiBr2(DME)] (100mg, 0.32mmol) in CH2Cl2 (20ml), in a Schlenk tube, under nitrogen. The reaction was stirred for 18h at room temperature. The resulting suspension was filtered and the solid product was washed twice with hexane (2×10ml) and dried in vacuum, yielding 94mg (82%) of a mustard yellow powder.

According to the analysis of related databases, 857641-46-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Moreno-Lara, Belen; Carabineiro, Sonia A.; Krishnamoorthy, Paramasivam; Rodriguez, Ana M.; Mano, Joao F.; Manzano, Blanca R.; Jalon, Felix A.; Gomes, Pedro T.; Journal of Organometallic Chemistry; vol. 799-800; (2015); p. 90 – 98;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17321-97-0, name is 2-Amino-4-methylpyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below., Computed Properties of C6H6N4

To a stirred solution of intermediate 41B (500 g, 3730 mmol) in TI-IF (75 mL) andDMF (15 rnL) was added copper (II) bromide (16.65 g, 74.50 rnmol) and Isoamyl nitrite (7.53ml, 55,9 mmol) and the reaction was refluxed for I h. The reaction mixture was cooled to ambient temperature, concentrated to dryness, diluted with the DCM (200 mL), filtered, and washed with THF (200 ml.). The combined organic extracts were washed with 10 % Nai-1C03 (150 mL). Then brine (50 mL), dried over anhydrous sodium sulfate and evaporated underreduced pressure. The residue was puiified by column chromatography (Redisep.-120 g, 0-15 % EtOAc/n.-I-Iexane) to obtain intermediate 41C (0.75 g, 10.00%). ?H NMR (400 MHz, DMSO d6) S ppm 2.65 (s. 3 1-1), 908 (s, 1 H). LCMS MethodL); retention time 0.92 mm, [M±2H1199.1.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17321-97-0, 2-Amino-4-methylpyrimidine-5-carbonitrile.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63234-80-0, name is 3-(2-Chloroethyl)-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one, the common compound, a new synthetic route is introduced below. HPLC of Formula: C11H15ClN2O

General procedure: A creamy white solid of 3-(2-chloroethyl)- 2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a] pyrimidin-4-one (5) (1.0eq) in N,N-dimethylformamide was taken, pottasium carbonate (3.0 eq) was added to the reaction mixture and then the appropriate aliphatic/ aromatic/heterocyclic amines (1.0 eq) were added and the reaction mixture was heated at 80 °C for 8h. The progress of the reaction was monitored by TLC. Upon completion, the solvent was removed by water wash and extracted with ethyl acetate. The organic layer was washed with 10percent ammonium chloride solution and finally water wash was given to organic layer and dried with anhydrous sodium sulphate. The solvent was evaporated to get crude product which was purified by column chromatography over silica gel (60-120mesh) using hexane: ethyl acetate(8:2) as an eluent.

The synthetic route of 63234-80-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Krishnamurthy, Byregowda; Vinaya, Kambappa; Rakshith, Devraj; Prasanna, Doddakunche Shivaramu; Rangappa, Kanchugarakoppal Subbegowda; Medicinal Chemistry; vol. 9; 2; (2013); p. 240 – 248;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia