Day: July 13, 2021

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13223-25-1, name is 2-Chloro-4,6-dimethoxypyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

A mixture of 2-chloro-4,6-dimethoxypyrimidine (87 mg, 0.50 mmol, 1 equiv), 2- napthylboronic acid (95 mg, 0.55 mmol, 1.1 equiv), THF (150 tL) were stirred into slurry. Then K3P045H20 (0.33 g, 1.1 mmol, 2.2 equiv) was added followed by a THF stock solution of 3 andPAd3 (10 pL, 0.025 pmo1 of Pd/PAd3). The reaction vial was capped then taken outside the glove box to an oil bath preset at 100 C for 5 h. The reaction mixture was diluted with ethyl acetate then extracted with water. The combine organic layers were evaporated and the crude product was purified by flash chromatography. After drying, 106 mg (80 %) of 10 was obtained as a white solid.?H NMR (501 MHz, CDC13) 6 8.99- 8.92 (m, 1H), 8.22 (ddt, J- 7.0, 2.7, 1.4 Hz, 1H), 7.97(ddt, J 23.5, 8.1, 1.4 Hz, 2H), 7.64-7.51 (m, 3H), 6.14 -6.09 (m, 1H), 4.11 -4.06 (m, 6H).13C{1H}{?H} NMR (126 MHz, CDC13) 6 171.3, 165.7, 135.5, 134.2, 131.1, 130.6, 129.4, 128.5,126.5, 126.3, 125.7, 125.1, 88.0, 54.2.HRMS (ESI) m/z calculated for C16H,4N202 (M+1) 267.1128, found 267.1123.

With the rapid development of chemical substances, we look forward to future research findings about 13223-25-1.

Reference:
Patent; THE TRUSTEES OF PRINCETON UNIVERSITY; CARROW, Brad P.; CHEN, Liye; (51 pag.)WO2017/75581; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1514-96-1, name is 4-Chloro-2-(trifluoromethyl)pyrimidine, the common compound, a new synthetic route is introduced below. Product Details of 1514-96-1

To a solution of 4-aminophenol (1.64 g, 15 mmol) in DMF (40 mL) was added potassium tert-butoxide (1.69 g, 15 mmol) and the resulting mixture was stirred at room temp for 15 min. 4-chloro-2-(trifluoiOmethyl)pyrirnidine in DMF (10 mL) was then added and the resulting mixture was stirred at room temp for 16 h. Water was then added and the mixture was extracted with ethyl acetate, dried over anhydrous sodium sulfate and concentrated in vacuo. The crude was purified using Biotage flash 4OM (2: 1, Hexane, Ethyl acetate) to afford 4-{[2-(trifluoromethyl)pyrimidin-4-yl]oxy}aniline (2.2 g, 63%). 1H NMR (DMSO-J6) delta 8.78 (d, IH), 7.16 (d, IH), 6.90 (d, 2H), 6.60 (d, 2H), 5.17 (brs, 2H); MS ES 256 (M+H)+, calcd 256, RT = 2.42 min.

The synthetic route of 1514-96-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2006/99231; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 776-53-4, name is Ethyl 4-amino-2-(methylthio)pyrimidin-5-carboxylate, molecular formula is C8H11N3O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 776-53-4

The mixture of ethyl 4-chloro-2-methylthio-5 -pyrimidine carboxylate (20.0 mmol), Et3N (10 ml), and 50% aq NH3. H20 (8 ml) in THF (100 mL) was stirred at room temperature for 4 h. After evaporation of the resulting residue,the mixture was diluted with H20 and extracted with EtOAc. After evaporation, get the crude amino substituted pyrimidine. To this crude amino substituted pyrimidine in THF (100 mL) was added dropwise LiA1H4 (11.0 mmol) in 30 ml Et20 at 0C. After stirring at room temperature for 8 h, H20 (3.0 mL), 2N NaOH (10 mL), and H20 (3.0 mL) were added sequentially. The crude product waspurified by column chromatography to afford intermediate alcohol 1 (73 % yield for steps).

With the rapid development of chemical substances, we look forward to future research findings about 776-53-4.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; FENG, Yangbo; LOGRASSO, Philip; ZHENG, Ke; PARK, Chul Min; WO2015/84936; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14080-23-0, name is 2-Cyanopyrimidine, molecular formula is C5H3N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Cyanopyrimidine

Reference Example 2-1 To a mixed solution of 25 g of 2-pyrimidinecarbonitrile in 100 mL of acetic acid and 100 mL of ethyl acetate, 1 g of 10% palladium/carbon was added, and the mixture was stirred for 14 hours at room temperature in a hydrogen atmosphere at ambient pressure. The palladium/carbon was removed from the reaction mixture by filtration through Celite, and an operation of adding toluene to a residue obtained by distilling off the solvent, and concentrating the mixture, was repeated four times. MeCN was added to the obtained residue to solidify the residue, and the solids were collected by filtration, to obtain 15.7 g of 1-pyrimidin-2-ylmethylamine acetate as a colorless solid.1-Pyrimidin-2-ylmethylamine acetateNMR-DMSOd6:1.88 (3H, s), 3.91 (2H, brs), 4.1-5.3 (3H, m), 7.38 (1H, t, J=4.9 Hz), 8.78 (2H, d, J=4.9 Hz) EI: 109

With the rapid development of chemical substances, we look forward to future research findings about 14080-23-0.

Reference:
Patent; ASTELLAS PHARMA INC.; US2010/256152; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 22536-61-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22536-61-4, name is 2-Chloro-5-methylpyrimidine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The compound (600 mg, 1.08 mmol) obtained in Example 52-2), 2-chloro-5-methylpyrimidine (155 mg, 1.19 mmol), tris(dibenzylideneacetone)dipalladium (50 mg, 0.05 mmol), tricyclohexylphosphine (36 mg, 0.13 mmol), and tripotassium phosphate (400 mg, 1.84 mmol) were dissolved in a mixed solvent of 1,4-dioxane (3 mL) and water (1.5 mL), and the mixture was stirred at 140C for 2 h under microwave irradiation. The reaction mixture was cooled to room temperature, then diluted with methylene chloride (100 mL), and separated into organic and aqueous layers by the addition of saturated aqueous sodium hydrogencarbonate (30 mL). The organic layer was washed with saturated sodium chloride solution and then dried with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, and the obtained residue was purified by silica gel column chromatography (elution solvent: methanol/ethyl acetate = 0% to 20%) to obtain the title compound (348 mg, 62%) in a light yellow solid form. 1H-NMR (400 MHz, CDCl3) delta: 0.05 (3H, s), 0.07 (3H, s), 0.91 (9H, s), 1.19 (3H, s), 1.46-1.53 (2H, m), 1.61-1.68 (2H, m), 2.34 (3H, s), 2.50 (1H, ddd, J = 15.6, 7.8, 2.3 Hz), 2.63 (1H, ddd, J = 15.7, 7.7, 2.2 Hz), 3.40 (2H, s), 3.52 (2H, dd, J = 15.8, 10.0 Hz), 4.06 (1H, ddd, J = 14.5, 7.8, 2.3 Hz), 4.31 (1H, ddd, J = 14.5, 7.8, 2.3 Hz), 7.17 (2H, d, J = 8.6 Hz), 8.32 (2H, d, J = 8.6 Hz), 8.62 (2H, d, J = 0.8 Hz)

According to the analysis of related databases, 22536-61-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Daiichi Sankyo Company, Limited; MORI, Makoto; FUJII, Kunihiko; INUI, Masaharu; BABA, Takayuki; ONISHI, Yukari; AOYAGI, Atsushi; EP2700643; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 50270-27-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 50270-27-4, name is 2,4,6-Trichloropyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of the chloroaldehyde (3.7 g, 17.5 mmol) dissolved in EtOH (50 mL) cooled to -78 C. was added methyl hydrazine (0.93 mL, 17.5 mmol) and TEA (8 mL). The mixture was stirred for 30 minutes at -78 C. then 2 hr at 0 C. The solution was concentrated in vacuo without heating. To the reduced volume solution EtOAc was added and the solution washed with a sat NaHCO3 solution and concentrated in vacuo without heating. Filtration over a small silica gel plug (2:1 EtOAc:Hex) and concentration afforded the desired product as a yellow solid.

According to the analysis of related databases, 50270-27-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Wyeth; US2010/15141; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 10244-24-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10244-24-3, name is 4,4′-(6-Chloropyrimidine-2,4-diyl)dimorpholine, molecular formula is C12H17ClN4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: 2,4,6-trichlorotriazine (1.84 g, 0.01 mol)Soluble in anhydrous acetone (10 mL), ice-salt bath cooled to -10 C,Morpholine (1.74 mL, 0.02 mol)And triethylamine (2.02 g, 0.02 mol)Of the mixed liquid droplets added to the reaction system, 0 C reaction 3h, room temperature reaction 3h.The mixture was poured into crushed ice, filtered, washed with water and dried to give 2.70 g of a white solid, 94.4% yield

According to the analysis of related databases, 10244-24-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Xi’an Jiaotong University; YU, YAN; WANG, XIAO MENG; ZHANG, SAN QI; HU, SEN KE; LU, SHE MIN; MEI, QI BING; (10 pag.)CN104151256; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4433-40-3, name is 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4433-40-3

Thionyl chloride ((10 ml) was added to a suspension of 5-(hydroxymethyl)-2,4(1H,3H)-pyrimidinedione (0.60 g, 4.2 mmol)from step (11a) in dioxane (15 ml). The reaction was heated to reflux for 4 h, allowed to cool, and concentrated in vacuo to give the 5-(chloromethyl)-2,4 (1H,3H)-pyrimidinedione (0.62 g, 100%) as a yellow solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4433-40-3, 5-(Hydroxymethyl)pyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Maduskuie, Thomas P.; US2003/229081; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1197953-49-3, (2-((2,5-Dichloropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 1197953-49-3, blongs to pyrimidines compound. Product Details of 1197953-49-3

General procedure: To asolution of (2-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)dimethylphosphine oxide (3f) (0.1 g, 0.334 mmol) and 4-fluoro-2-methoxy-5-nitroaniline (0.124 g, 0.667 mmol) in sec-butanol(2 mL) was added potassium carbonate (0.231 g, 1.669 mmol). Thereaction mixturewas stirred at 80 C for 10 min and then Pd2 (dba)3(0.031 g, 0.033 mmol) and Xphos (0.016 g, 0.033 mmol) were addedrapidly. The reaction mixture was stirred at 100 C for 2 h. Aftercompletion of the reaction, the resulting mixture was hot-filteredthrough Celite and washed with DCM. The filtrate was concentratedunder reduced pressure and then purified by flash columnchromatography on silica gel (0-20% MeOH in DCM) to afford 4f asa yellowish solid (0.128 g, 85%).

The synthetic route of 1197953-49-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Jang, Jaebong; Son, Jung Beom; To, Ciric; Bahcall, Magda; Kim, So Young; Kang, Seock Yong; Mushajiang, Mierzhati; Lee, Younho; Jaenne, Pasi A.; Choi, Hwan Geun; Gray, Nathanael S.; European Journal of Medicinal Chemistry; vol. 136; (2017); p. 497 – 510;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1005-38-5 , The common heterocyclic compound, 1005-38-5, name is 4-Amino-6-chloro-2-(methylthio)pyrimidine, molecular formula is C5H6ClN3S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Acetic anhydride (10.4 MI, 0. 11 MOL) was added to 6-chloro-2- (methylthio) pyrimidin-4-amine (2.5 g, 0.01 mol) and the reaction mixture was refluxed at 135 C for 5 hr. The reaction mixture was cooled to room temperature and basified to pH 7 with saturated sodium bicarbonate solution (20 ML). The mixture was partitioned between EtOAc and water, the organic layer was washed with water and brine, dried over MgS04 and concentrated to give the title compound (2.62 g). MS (ES . : 218 (MH+) for C7HGCINO3S

The synthetic route of 1005-38-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/26149; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia