In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 187035-79-6, name is Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate, the common compound, a new synthetic route is introduced below. Recommanded Product: 187035-79-6
To a solution of l-isopropyl-7-(methylsulfonyl)-l,2,3,4- tetrahydrobenzo[4,5]imidazo[l,2-a]pyrazine (5.0 mg, 0.02 mmol, prepared according to example 1) in DMSO (1 mL) was added ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5- carboxylate (8.7 mg, 0.03 mmol), DIEA (6.6 mg, 0.05 mmol) under N2. The mixture was stirred at 100 C for 2 h. The mixture was diluted with water (5 mL) and extracted with EtOAc (3 x5 mL). The combined organic layers were washed with brine (5 mL), dried over anhydrous Na2S04, filtered, concentrated and then purified by preparative TLC to afford a racemic mixture of ethyl 2-(l-isopropyl-7-(methylsulfonyl)-3,4- dihydrobenzo[4,5]imidazo[l,2-a]pyrazin-2(lH)-yl)-4-(trifluoromethyl)pyrimidine-5- carboxylate (5.6 mg, 64% yield) as a white solid. LC- m/z 512.2 [M+H]+. 1H NMR (CDC13 400MHz): delta 8.98 (s, 1H), 8.07-7.98 (m, 1H), 7.93-7.83 (m, 2H), 6.16 (d, J = 6.4 Hz, 1H), 5.53-5.41 (m, 1H), 4.43-4.32 (m, 3H), 4.28-4.16 (m, 1H), 3.92-3.79 (m, 1H), 3.09 (s, 3H), 2.61-2.46 (m, 1H), 1.40 (s, 3H), 1.38-1.32 (m, 3H), 1.08 (d, J = 6.8 Hz, 3H).
The synthetic route of 187035-79-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VITAE PHARMACEUTICALS, INC.; DONG, Chengguo; FAN, Yi; LEFTHERIS, Katerina; LOTESTA, Stephen; SINGH, Suresh, B.; TICE, Colin; ZHAO, Wei; ZHENG, Yajun; ZHUANG, Linghang; WO2013/138568; (2013); A1;,
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