Day: July 23, 2021

Related Products of 7627-44-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 7627-44-3, name is 2,4-Dichloro-5-(iodomethyl)pyrimidine, molecular formula is C5H3Cl2IN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 12b. (R)-2-chloro-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][l,4]oxazepineA solution of 2,4-dichloro-5-(iodomethyl)pyrimidine (1.428 g, 4.94 mmol) in THF (2 mL) was cooled to -78°C. (R)-2-amino-l-phenylethanol (0.616 g, 4.49 mmol) in THF (2 mL) was added dropwise. The reaction mixture was stirred at -78°C for 10 minutes. The reaction mixture was cooled in an ice water bath and sodium hydride (60percent dispensed in mineral oil, 0.216 g, 8.99 mmol) was added. After 10 minutes, 2 eq of sodium hydride (60percent dispensed in mineral oil, 0.216 g, 8.99 mmol) were added and the reaction mixture stirred at room temperature for 30 minutes. Water (3 mL) was added and the solvent was evaporated. The residue was partitioned between saturated NaHCObeta (aq) and dichloromethane. The water layer was extracted twice with dichloromethane. The combined organic layers was dried (MgSC^) and concentrated. The crude product was purified by silica flash chromatography using a gradient of methanol (0 to 3percent) in dichloromethane giving 0.193 g of the title compound (16 percent Yield). 1H NMR (500 MHz, DMSO-J6) delta ppm 8.48 (d, 1 H) 7.40 – 7.49 (m, 5 H) 5.60 – 5.67 (m, 1 H) 4.20 (d, 1 H) 3.77 (d, 1 H) 3.20 (br s, 1 H) 3.14 – 3.18 (m, 1 H) 3.04 (br s, 1 H). MS (ES+) m/z 262 [M+H]+.

According to the analysis of related databases, 7627-44-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; LO-ALFREDSSON, Yvonne; PAULSEN, Kim; RAKOS, Laszlo; ROTTICCI, Didier; WALDMAN, Magnus; WO2010/132015; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14080-50-3, name is Thieno[2,3-d]pyrimidin-4(3H)-one, molecular formula is C6H4N2OS, molecular weight is 152.1738, as common compound, the synthetic route is as follows.Product Details of 14080-50-3

EXAMPLE 19 This Example illustrates the preparation of several 4-amino-6-bromo-thieno [2,3-d] pyrimidines according to the invention (Compound Nos. 235-6, 241-2). A mixture of 3,4-dihydrothieno[2,3-d]pyrimidine-4-one (21 g), bromine (30 ml) and acetic acid (300 ml) was stirred at room temperature for three hours, poured into water/ice (1 l) and the 6-bromo derivative filtered off and dried (18.2 g). A portion (17.0 g) was treated with thionyl chloride (230 ml) and N,N-dimethylformamide (3 ml) and refluxed for forty minutes. Excess acid chloride was removed in vacuo and the residue was partitioned between chloroform and water. The organic layer was washed, dried and evaporated to give 6-bromo-4-chlorothieno[2,3-d]pyrimidine (14.7 g). This was treated with a number of amines basically as described in Example 5.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14080-50-3, Thieno[2,3-d]pyrimidin-4(3H)-one, and friends who are interested can also refer to it.

Reference:
Patent; ICI Australia Limited; US4196207; (1980); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 62968-37-0 ,Some common heterocyclic compound, 62968-37-0, molecular formula is C8H10ClN3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a solution of 2-chloroheteroaryl compound 1 (0.50 mmol) in 1,4-dioxane (4.0 mL) were added pinacol boronate 3, 5, or 7 (0.60 mmol), Pd(OAc)2 (1.1 mg, 5.0 mumol), S-Phos (4.1 mg, 10.0 mumol), and 2 M LiOH solution (1.0 mL, 2.0 mmol) at room temperature, and the mixture was stirred for 30 min at 80 C under N2 atmosphere. The reaction was quenched by adding water, and then the mixture was extracted with ethyl acetate. The organic layer was washed with brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was removed in vacuo, and the residue was purified by silica-gel column chromatography. The solvent was removed in vacuo, and the residue was triturated with Et2O to give biaryl compounds.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 62968-37-0, 4-(2-Chloropyrimidin-4-yl)morpholine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Asano, Shigehiro; Kamioka, Seiji; Isobe, Yoshiaki; Tetrahedron; vol. 68; 1; (2012); p. 272 – 279;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 13223-25-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13223-25-1 as follows.

A mixture of (2R*, 4S*) -4-amino-2-ethyl-6-methoxy-3, 4-dihydro-2H- [1, 5] naphthyridine-l-carboxylic acid ethyl ester (300 mg), 2-chloro-4,6- dimethoxypyrimidin (468 mg), N, N-diisopropylethylamine (0.467 ml) and 1,4-dioxane (5 ml) is heated under reflux for 2 days. The reaction solution is concentrated under reduced pressure, and the resulting residue is purified by column chromatography (silica gel; hexane: ethyl acetate = 80 : 20-60 : 40) to give (2R*, 4S*)-4- (4, 6-dimethoxypyrimidin-2-yl) amino-2- ethyl-6-methoxy-3, 4-dihydro-2H- [1, 5] naphthyridine-1-carboxylic acid ethyl ester (280 g). MS (m/z) : 418 [M+H] +

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13223-25-1, its application will become more common.

Reference:
Patent; TANABE SEIYAKU CO., LTD.; WO2005/95395; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 39906-04-2 , The common heterocyclic compound, 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 1 (800 mg, 4.48 mmol) and benzenamine (510 mg, 5.44 mmol) were suspended in EtOH/H2O (30 mL, 1:8). Concentrated hydrochloric acid (0.5 mL) was added at room temperature followed by warming reaction to reflux. After stirring for 10 h the reaction was cooled to room temperature and stirred for 6 h. The precipitate was collected on a sintered glass funnel and rinsed with water (10 mL) followed by hexanes (10 mL). After drying in vacuo, Compound 2a (850 mg) was obtained. Yield: 81%; gray solid. MS (EI) m/z (%)=234 (M+).

The synthetic route of 39906-04-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xu, Dan; Sun, Li-Ping; You, Qi-Dong; Tetrahedron; vol. 68; 22; (2012); p. 4248 – 4251;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 99844-02-7, name is 4-(4-Methoxyphenyl)pyrimidin-2-amine, the common compound, a new synthetic route is introduced below. Recommanded Product: 4-(4-Methoxyphenyl)pyrimidin-2-amine

General procedure: The pyrimidine amine 3a-i (1.1 mmol), CuI (1.0 mmol) andanhydrous Cs2CO3 (2.0 mmol) were added to a round bottom flaskalong with magnetic stir bar and closed well with a septum. Theflask was evacuated and back filled with nitrogen gas three times.Dioxane (15 mL), 1-(5-bromo-1H-indol-3-yl)-2-(piperidin-1-yl)ethane-1,2-dione (6) (1.0 mmol) and DMEDA (1.0 mmol) wereadded by syringe at room temperature. The reaction mixture wasstirred at 80 C for 20 h under nitrogen atmosphere and then cooledto room temperature. Concentrated ammonia (4 mL) was added,and the mixture was extracted with ethyl acetate (3 x 20 mL). Thecombined organic layer was concentrated in vacuo, and the residuewas purified by column chromatography on silica gel.

The synthetic route of 99844-02-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Guggilapu, Sravanthi Devi; Lalita, Guntuku; Reddy, T. Srinivasa; Prajapti, Santosh Kumar; Nagarsenkar, Atulya; Ramu, Shymala; Brahma, Uma Rani; Lakshmi, Uppa Jaya; Vegi, Ganga Modi Naidu; Bhargava, Suresh K.; Babu, Bathini Nagendra; European Journal of Medicinal Chemistry; vol. 128; (2017); p. 1 – 12;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 105742-66-3, Adding some certain compound to certain chemical reactions, such as: 105742-66-3, name is 4,5-Dichloro-2,6-dimethylpyrimidine,molecular formula is C6H6Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 105742-66-3.

General procedure: Compound 5 was synthesized as described.33 Compounds 6 and 7were synthesized in our previous work.34 Compounds 4 (5 mmol), 7(5 mmol) and anhydrous potassium carbonate (5 mmol, 0.69 g) wereadded to a mixed solvent of dimethyl formamide (20 mL) and water(10 mL), and then refluxed for 2-4 h. The progress was monitored byTLC. After the reaction was complete, the reaction solution was pouredinto saturated saline and extracted with ethyl acetate (3×80 mL). Theextract was dried, filtered, and the solvent was removed under reducedpressure to give a crude product. Recrystallization from the mixedsolvent of petroleum ether and ethyl acetate gave pure target compoundsO1-17 (Scheme 2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105742-66-3, 4,5-Dichloro-2,6-dimethylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Yan, Zhongzhong; Liu, Aiping; Ou, Yingcan; Li, Jianming; Yi; Zhang, Ning; Liu, Minhua; Huang, Lu; Ren, Jianwei; Liu, Weidong; Hu, Aixi; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3218 – 3228;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 57489-77-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 57489-77-7, name is 5,7-Dichloropyrazolo[1,5-a]pyrimidine, molecular formula is C6H3Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a well stirred 8-aminoquinoline (1 mmol) indry DMF (5 mL), sodium hydride (1.2 mmol, 60% in mineral oil) was added at 0 C.After 10 min stirring, the corresponding heterocyclic chloro compound (1.2mmol) was added and stirred for 10 min at rt then heated at 60 C for 5-12 h.Upon completion, the reaction mixture was poured into crushed ice and theresulting solid was filtered, washed with water and dried under vacuum. Thesolid was triturated with methanol and dried under vacuum to afford targetcompound as a solid.

According to the analysis of related databases, 57489-77-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Kannan, Murugan; Raichurkar, Anandkumar V.; Khan, Fazlur Rahman Nawaz; Iyer, Pravin S.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 5; (2015); p. 1100 – 1103;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4349-07-9, name is 5-Iodopyrimidin-4-ol, the common compound, a new synthetic route is introduced below. name: 5-Iodopyrimidin-4-ol

To a stirred solution containing 7.7 mL (99 MMOL) of DMF and 150 mL of DICHLOROETHANE at 0C was added 12.7 mL (144.6 MMOL) of OXALYL chloride slowly to control vigorous gas evolution. After the evolution of gas had ceased, 10.0 g of iodopyrimidone was added and the reaction mixture was heated at reflux for 3h, then cooled to room temperature and partitioned between water and DICHLOROMETHANE. The organic layers were dried over MGS04 and the solvent was removed under reduced pressure to give 9.6 g (88%) of the title COMPOUND. 1H-NMR (300 MHz, CDCI3) A 8. 89 (s, 1H) and 8.98 (s, 1H) ; ESIMS : 241.1 (M+H)+

The synthetic route of 4349-07-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/16914; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 607740-08-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 607740-08-9, name is 4-(3,5-Dibromophenyl)-2,6-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

In the argon atmosphere,Intermediate A (4.4 g, 21 mmol) synthesized according to the method described in JP-A-2010-180204,Intermediate B (4.7 g, 10 mmol) according to the method described in International Publication No. 2003/080760,(Dibenzylideneacetone) dipalladium (0.37 g, 0.4 mmol)Tri-butyl-tetrafluoroborate (0.46 g, 1.6 mmol)Sodium butoxide (2.7 g, 28 mmol)Anhydrous toluene (100 mL),And heated to reflux for 8 hours.After the reaction solution was allowed to cool to room temperature,Separating the organic layer,The organic solvent was distilled off under reduced pressure.The resulting residue was purified by silica gel column chromatography,The title compound GH-4 (3.6 g, yield 50%) was obtained.

According to the analysis of related databases, 607740-08-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; Ogiwara, Toshinari; Hosokawa, Chishio; (82 pag.)TW2016/38086; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia