Day: July 30, 2021

Application of 4349-07-9 ,Some common heterocyclic compound, 4349-07-9, molecular formula is C4H3IN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

10 g of the compound obtained in step 1) above was added to 60 mL of phosphorus oxychloride and stirred at 110C for 2 hours. After the reaction was completed, the reaction solution was cooled to room temperature and distilled under a reduced pressure to remove solvent therefrom. Toluene was added to the residue, and the resulting residue was concentrated under a reduced pressure to remove the solvent, and this procedure was repeated 3 times. The solid thus obtained was dried under a reduced pressure to obtain the title compound (13 g).1H-NMR (300MHz, DMSO-d6) delta 13.27 bs, 1H), 9.18 (s, 1H), 8.98 (s, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4349-07-9, its application will become more common.

Reference:
Patent; HANMI HOLDINGS CO., LTD.; CHA, Mi Young; KIM, Mi Ra; KANG, Seok Jong; KIM, Se Young; JUNG, Young Hee; LEE, Kwang Ok; SONG, Ji Yeon; KIM, Young Hoon; KIM, Eun Young; KIM, Maeng Sup; WO2011/99764; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14080-23-0, name is 2-Cyanopyrimidine, the common compound, a new synthetic route is introduced below. Safety of 2-Cyanopyrimidine

a) 2-Aminomethyl-pyrimidine 66.2 g (0.63 mole) of 2-cyano-pyrimidine (Liebigs Ann. Chem. 1981, 333) in 1.9 1 of ethanol are hydrogenated in the presence of 130 ml of liquid ammonia and 5 g of Pd-C (5% Pd) at 20 C. and 5-10 bar of hydrogen. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled. Yield: 48.8 g (71% of theory) Boiling point: 82 C./4 mbar

The synthetic route of 14080-23-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer Aktiengesellschaft; US5312823; (1994); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50270-27-4, name is 2,4,6-Trichloropyrimidine-5-carbaldehyde, molecular formula is C5HCl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2,4,6-Trichloropyrimidine-5-carbaldehyde

To a solution of 5-methyl-lH-pyrazol-3-amine (550 mg, 5.67 mmol), DIEA (0.906 mL, 5.2 mmol), and KI (392 mg, 2.36 mmol) in DMF (10 mL) was added 2,4,6-trichloropyrimidine-5-carbaldehyde (1 g, 4.73 mmol). The mixture was stirred at rt for 3 h, then water was added and the mixture was stirred for 20 min at rt. The precipitated solid was collected by filtration to afford 2,4-dichloro-6-(5- methyl-lH-pyrazol-3-ylamino)pyrimidine-5-carbaldehyde (1.4 g) as a yellow solid that was used without further purification. LCMS (ESI) m/z 272 (M + H)+.

With the rapid development of chemical substances, we look forward to future research findings about 50270-27-4.

Reference:
Patent; AMBIT BIOSCIENCES CORPORATION; CHAO, Qi; HADD, Michael, J.; HOLLADAY, Mark, W.; ROWBOTTOM, Martin; WO2012/30924; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 5466-43-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5466-43-3 as follows.

General procedure: To the solution of compound 8 (0.23g, 1.2mmol) in THF (5mL) was added DIPEA (1.8mmol) and bicyclic amine or piperidin amine (1.44mmol). The reaction was stirred at r.t. for overnight. Then the mixture was diluted with ethyl acetate, washed with brine, dried over MgSO4, and evaporated. The residue was purified by column chromatography to give the product. 4.1.4 40 tert-butyl 4-((2-chloro-6, 7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)amino)piperidine-1-carboxylate (9)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5466-43-3, its application will become more common.

Reference:
Article; Fang, Yuanying; Xiong, Lijuan; Hu, Jianguo; Zhang, Shaokun; Xie, Saisai; Tu, Liangxing; Wan, Yang; Jin, Yi; Li, Xiang; Hu, Shaojie; Yang, Zunhua; Bioorganic Chemistry; vol. 86; (2019); p. 103 – 111;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 156-81-0, Adding some certain compound to certain chemical reactions, such as: 156-81-0, name is Pyrimidine-2,4-diamine,molecular formula is C4H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 156-81-0.

1 g of commercial 2,4-diamino pyrimidine was treated in 40 ml tert.-butanol with1.5 g BOC20 in the presence of 3.48 ml DIPEA at ambient temperature for 6 hrs. After evaporation, the product was extracted with ethyl acetate from water, dried with Na2S04, filtered and evaporated to dryness. After digestion with petrolether : ether 3:1 (vol) and drying 849 mg (4-amino-pyrimidin-2-yl)-carbamic acid tert-butyl ester was obtained as a white powder with Rt ~ 1.08 min and correct mass of M+H ~ 211

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 156-81-0, Pyrimidine-2,4-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MERCK PATENT GMBH; JONCZYK, Alfred; DORSCH, Dieter; ZENKE, Frank; AMENDT, Christiane; WO2011/101069; (2011); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 874-14-6, Adding some certain compound to certain chemical reactions, such as: 874-14-6, name is 1,3-Dimethyluracil,molecular formula is C6H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 874-14-6.

General procedure: Uracil1 (1 mmol), the arylboronic acid 2 (3 mmol), Pd(OAc)2 (10molpercent) and 1,10-phenanthroline (15 molpercent) were combined in dry DMF (10 ml) under O2 atmosphereand stirred for 5 min (Note: DMF wasdried over calcium hydride). The reaction mixture was stirred at 90oC and monitored by TLC using EtOAc-petroleum ether as the mobilephase. After completion, the reaction mixture was cooled, and water (10 ml) wasadded. The resulting solution was then extracted with EtOAc (3 QUOTE &13;&10;&13;&10;12?”> &13;&10;&13;&10;12?”> 20 ml). TheEtOAc extract was washed with water (5 QUOTE &13;&10;&13;&10;12?”> &13;&10;&13;&10;12?”> 10 ml) and thenbrine (10 ml). The organic layer was dried with Na2SO4.Evaporation of EtOAc furnished the crude product, which was purified by flash chromatography onsilica gel (EtOAc-Petroleum ether).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 874-14-6, 1,3-Dimethyluracil, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Mondal, Biplab; Hazra, Somjit; Roy; Tetrahedron Letters; vol. 55; 5; (2015); p. 1077 – 1081;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 271-70-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.271-70-5, name is 7H-Pyrrolo[2,3-d]pyrimidine, molecular formula is C6H5N3, molecular weight is 119.124, as common compound, the synthetic route is as follows.

A solution of bromine (0.086 mL, 1.68 mmol) in DMF (5.5 mL) was added to a solution of 7H- pyrrolo[2,3-d]pyrimidine (200 mg, 1.68 mmol) in DMF (5.5 mL). The reaction mixture was stirred at RT for 4 h and poured into a mixture of ice and water containing Na2S203. A saturated aqueous solution of NaHC03 was added (until basic pH), the layers were separated and the aqueous layer was extracted twice with EtOAc. The combined organic extracts were washed with brine, dried (Na2S04), filtered and concentrated. The material thus obtained was used without further purification in the next step. TLC, Rf (CH2CI2/MeOH 9: 1) = 0.45; MS (UPLC/MS): 198.1/200.1 [M+H]+, 196.1/198.1 [M-H]-.

The chemical industry reduces the impact on the environment during synthesis 271-70-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVARTIS AG; ALTMANN, Eva; HOMMEL, Ulrich; LORTHIOIS, Edwige Liliane Jeanne; MAIBAUM, Juergen Klaus; OSTERMANN, Nils; QUANCARD, Jean; RANDL, Stefan Andreas; SIMIC, Oliver; VULPETTI, Anna; ROGEL, Olivier; WO2012/93101; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 39551-54-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.39551-54-7, name is 2,4-Dichloropyrido[3,2-d]pyrimidine, molecular formula is C7H3Cl2N3, molecular weight is 200.0248, as common compound, the synthetic route is as follows.

A mixture of [2-(trifluoromethyl)-3-pyridyl]methanamine (132 mg, 750 umol, 1.00 eq), 2,4-dichloropyrido[3,2-d]pyrimidine (150 mg, 750 umol, 1.00 eq) and Et3 (152 mg, 1.50 mmo, 2.00 eq) in THF (10.00 mL) was stirred at 10-20C for 12 hours. LC S showed ail of 2,4-dichloropyrido[3,2-d]pyrimidine was consumed and a new peak with desired MS. The mixture was concentrated to give a residue. The residue was triturated with EtOAc (2 mL). 2-chloro-N-[[2-(trifluoromethyl)-3-pyridyl]methyl]pyrido[3,2-d]pyrimidin-4-amine (120 mg, 77 umol, 23% yield, 50% purity) was obtained as an off-white solid.

Statistics shows that 39551-54-7 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloropyrido[3,2-d]pyrimidine.

Reference:
Patent; LIVERPOOL SCHOOL OF TROPICAL MEDICINE; THE UNIVERSITY OF LIVERPOOL; EISAI R&D MANAGEMENT CO., LTD.; WARD, Stephen A.; TAYLOR, Mark J.; O’NEILL, Paul M.; HONG, Weiqian David; BENAYOUD, Farid; (300 pag.)WO2018/134685; (2018); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 4595-60-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4595-60-2, name is 2-Bromopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

A mixture of 2-bromopyridine (0.43g,2.70mmol), 2-bromopyridine-5-boronic acid (0.55g,2.72mmol), tetrakis(triphenylphosphine)palladium(0) (3OOmg, 0.259mmol), cesium carbonate (1.15g, 3.03mmol) was stirred in MeOH/toluene/water (15ml, 1/1/1) at reflux temperature overnight. The reaction was cooled to room temperature and diluted with EtOAc (200ml) and water (50ml). The organic layer was separated, dried over MgSO4,filtered and solvent evaporated yielding a residue which was purified on silica gel eluting with 25% v/vEtOAc/hexanes yielding product 76 as white solid. (0.55g, 5%) ESMS (MH, 236).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4595-60-2, 2-Bromopyrimidine.

Reference:
Patent; SCHERING CORPORATION; WO2007/97937; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1193-21-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1193-21-1, name is 4,6-Dichloropyrimidine, molecular formula is C4H2Cl2N2, molecular weight is 148.9781, as common compound, the synthetic route is as follows.

To a solution of 4, 6-dichloro-pyrimidine (10.0 g) in THF (10 mL) were added iPr2NEt (10.4 g) and 50% aqueous MezNH (6.05 g). The mixture was stirred at ambient temperature for 28 hr and poured into saturated aqueous NaHCO3. The aqueous layer was extracted with CHC13 (three times). The combined organic layer was dried over MgS04, filtered, and concentrated under reduced pressure. The residue was suspended in Et20. The precipitate was collected by filtration, washed with Et2O and dried under reduced pressure to give (6-chloro-pyrimidin-4-yl) -dimethyl-amine (6.37 g). ESI MS m/e 157, M ; IH NMR (300 MHz, CDC13) 6 3.12 (s, 6 H), 6.41 (s, 1 H), 8.37 (s, 1 H).

The chemical industry reduces the impact on the environment during synthesis 1193-21-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Arena Pharmaceuticals, Inc; WO2005/95357; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia