Day: August 9, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 74901-69-2, name is 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine

25.4 (S)-5-(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-1-methylpiperidin-2-one (III-5) 0.27 g (II) are placed in 3 ml dioxane, then 0.45 ml diisopropylethylamine and 0.25 g (S)-5-amino-1-methylpiperidin-2-one are added. The reaction mixture is heated to 130 C. until there is no further reaction, then cooled and evaporated down. The product is extracted with dichloromethane and purified by chromatography (preparative HPLC, method B). 0.26 g (III-5) are obtained in the form of a solid. Analytical HPLC-MS (method A): RT=1.06 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 74901-69-2, 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/28932; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1012785-51-1, 2,4-Dichloro-5-iodo-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1012785-51-1, blongs to pyrimidines compound. SDS of cas: 1012785-51-1

I0444 To a solution of 2,4-dichloro-5-iodo-7H-pyrrolo[2,3-djpyrimidine (131a) (7.2 g,23 mmoi) in thy THF (200.0 mL) was added Pyridine (1.9 mL, 22.94 nunol), Tributyiphosphane(11.5 mL, 45.87 mmoi) and DIAD (9.5 rnL, 4817 mrnoi) lrnderN2, [()-(3,4-dif1uoro phenyl)[(2S,3 S,4R,5R)-3,4,5 -trihydroxytetrahydrofuran-2-yijniethyl] 4-phenyibenzoate (I 31b) (10.1 g,2294 inmol) in dry TI-IF (100.0 mL) was added to the reaction mixture at once. The reactionmixture was stirred at 25 C fbr 2 h under N2. The mixture was concentrated in vacuum to give crude product which was purified by combi-flash eluted with CH3CN in 1-120 from 100% to90 0%to afford (R,)-[2S 3S 4R 5R) -5-(2 4dichlo1oSiodornHolo[2 3-dIprimidin–d)3 4-dihvdroxy-tetrahydrofiiran-2-yi]-(3.4-difiuorophenvi) -methyl] 4-phenyibenzoate (131 c) (6,6 g,8.9 rnmoi, 39 % yield) as a yellow solid. LCMS [M±H]: 7380.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1012785-51-1, its application will become more common.

Reference:
Patent; PRELUDE THERAPEUTICS, INCORPORATED; LUENGO, Juan; LEAL, Raul, A.; LIN, Hong; SHETTY, Rupa; (166 pag.)WO2018/85833; (2018); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 1032452-86-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1032452-86-0, name is 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole. This compound has unique chemical properties. The synthetic route is as follows.

3-(2-Chloropyrimidin-4-yl)-1-methylindole 9 (5 g, 20.5 mmol) was placed in 1,4-dioxane, and compound 10 (3.8 g, 20.5 mmol) was added at room temperature, After p-toluenesulfonic acid monohydrate (4.7 g, 24.6 mmol) was added dropwise, the reaction was stirred at 105 C for 2 hours. After the reaction is completed, the temperature is lowered to room temperature, and the solution is precipitated as a solid, which is suction filtered, and the cake is washed with ethyl acetate and dried. Dry to give a yellow solid 8.0 g, yield 100%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1032452-86-0, 3-(2-Chloropyrimidin-4-yl)-1-methyl-1H-indole.

Reference:
Patent; Hangzhou Oulian Pharmaceutical Technology Co., Ltd.; Zhang Xingxian; (22 pag.)CN109928956; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 90213-67-5, 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

Step 2: 2,4-dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (2.39 g, 11.8 mmol) was treated with a 2M aqueous potassium hydroxide solution (70 mL, 140 mmol). The reaction was warmed to 100 C., where it was stirred overnight. The reaction was allowed to cool down to room temperature gradually, where it stirred for an additional 2 nights. The reaction was brought to pH 7-8 with a 3N aqueous hydrochloric acid solution. The resulting light yellow mixture was cooled in an ice/water bath and filtered, rinsing twice with a small amount of water. The filtrate was brought to pH 2-3 with additional 3N aqueous hydrochloric acid solution. The resulting opaque light yellow mixture was filtered through the original filter cake. The solids were dried in vacuo to afford 2-chloro-7-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-4-one as an off-white solid (2.18 g, 100%). NMR (300 MHz, DMSO-d6) delta ppm 3.67 (s, 3H) 6.46 (d, J=3.39 Hz, 1H) 7.11 (d, J=3.39 Hz, 1H) 12.83 (br. s., 1H). LC-MS calcd. for C7H7ClN3O [(M+H)+] 184, obsd, 183.9.

The synthetic route of 90213-67-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Haynes, Nancy-Ellen; Hermann, Johannes; Kim, Kyungjin; Scott, Nathan Robert; Yi, Lin; Zak, Mark; US2013/331375; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 105806-13-1, 4,6-Dichloro-5-fluoro-2-methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H3Cl2FN2, blongs to pyrimidines compound. COA of Formula: C5H3Cl2FN2

Part A: 4-(2,5-Dihydro-1H-pyrrol-1-yl)-5-fluoro-6-hydrazino-2-methylpyrimidine. 4,6-Dichloro-5-fluoro-2-methylpyrimidine (181 mg, 1.0 mmol) was dissolved in 4 ml. of DMSO and stirred at room temperature. 3-Pyrroline (71 mg, 1.05 mmol) was added, followed by DIPEA (244 mul_, 1.4 mmol). The resulting reaction mixture was stirred until displacement of the first chloride was complete, and then hydrazine (350 mul_) and MeOH (~2 ml.) were added to the reaction mixture. The contents were then heated to 70 0C for ~2 h, until displacement of the second chloride was complete. The reaction mixture was then cooled to room temperature and purified by RP-HPLC to provide 4-(2,5-dihydro-1H- pyrrol-1-yl)-5-fluoro-6-hydrazino-2-methylpyrimidine (142 mg, 68%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,105806-13-1, 4,6-Dichloro-5-fluoro-2-methylpyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/61879; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 4270-27-3 ,Some common heterocyclic compound, 4270-27-3, molecular formula is C4H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 6-chloro-uracil (3.0 g, 20.47 mmol, 1 equiv.) and LiBr (1.78 g, 20.5 mmol, 1.0 equiv.) in NMP (70 mL) at 0 C was added NaH (60% dispersion in mineral oil, 0.82 g, 20.5 mmol, 1.0 equiv.). The reaction mixture was stirred at 0 C for 10 min, and 2-(trimethylsilyl)ethoxymethyl chloride (3.75g, 22.5 mmol, 1.1 equiv.) was slowly added via an addition funnel. The reaction mixture was stirred overnight at room temperature and then diluted with EtOAc (150 mL). The mixture was washed with a saturated aqueous NH4C1 solution (50 mL), saturated aqueous NaHC03 (50 mL), and brine (50 mL). The organic layer was dried with anhydrous Na2S04 and concentrated under reduced pressure to provide 3.2 g (57%) of the title compound as a white solid. LC/MS: m/z (ES+) 299 (M+Na)+. 1H NMR (400 MHz, CDC13): delta ppm 9.00-8.80 (br-s, 1H), 5.95 (s, 1H), 5.45 (s, 2H)), 3.63 (t, J = 7.0 Hz, 2H), 1.48 (t, J = 7.0 Hz, 2H), 0.01 (s, 9H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4270-27-3, 6-Chloropyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; MYOKARDIA, INC.; OSLOB, Johan; ANDERSON, Robert; AUBELE, Danielle; EVANCHIK, Marc; FOX, Jonathan Charles; KANE, Brian; LU, Puping; MCDOWELL, Robert; RODRIGUEZ, Hector; SONG, Yonghong; SRAN, Arvinder; WO2014/205223; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 635698-56-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 635698-56-5, name is tert-Butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

A solution of tert-butyl 2,4-dichloro-7,8-dihydropyrido[4,3-d]pyrimidine-6(5//)- carboxylate (100 mg, 0.329 mmol) and TEA (0.137 mL, 0.986 mmol) in DMF (1.5 mL) was treated with 2-(2-pyridyl)ethyl amine (40.2 mg, 0.329 mmol). The mixture was stirred overnight at room temperature. The reaction mixture was EtOAc (10 mL) and H2O (10 mL), and extracted with EtOAc (2x 10 mL). The combined organic phases were washed with H2O (10 mL) and brine (10 mL), dried over Na2SO4, filtered, and concentrated in vacuo. The resulting residue was purified by gradient elution on silica gel (0 to 100% EtOAc in hexanes to afford the title compound as a pale yellow gum (96 mg, 75%). Data for G-1 : 1H NMR (500 MHz, CDCl3) delta 8.524-8.64 (br m, IH), 7.61-7.69 (br m, IH), 7.15-7.24 (m, 2H), 6.67-6.89 (br m, IH), 4.24 (s, 2H), 3.67 (br m, 2H), 3.08 (t, J= 9.0 Hz, 2H), 2.75 (br s, 2H), 1.51 (s, 9H); LC/MS: rt= 1.35 min, m/z (M+H)= 390.1 found; 390.2 calcd..

According to the analysis of related databases, 635698-56-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; BRESLIN, Michael, J.; COLEMAN, Paul, J.; COX, Christopher, D.; RAHEEM, Izzat, T.; SCHREIER, John, D.; WO2011/22213; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 2927-71-1, Adding some certain compound to certain chemical reactions, such as: 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine,molecular formula is C4HCl2FN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2927-71-1.

Add the third step product, 5-fluoro-1,1-dimethyl-7- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl) -2,3-dihydro-1H-benzo [d] pyrrole [1,2-a] imidazole (1.2 g, 3.6 mmol)to the reaction flask,2,4-dichloro-5-fluoropyrimidine (0.664 g, 4.0 mmol) Pd (PPh3) 2Cl2 (282 mg, 0.40 mmol), Sodium carbonate (763 mg, 7.2 mmol) and DME / H2O (40 mL / 10 mL). In a nitrogen atmosphere, the mixture was stirred at 80 C for 3 hours. Cooling to room temperature, the reaction solution suction filter, The filtrate was concentrated in vacuo. The resulting residue was purified by silica gel column chromatography (ethyl acetate / petroleum ether = 1/3) To give the title compound (0.51 g, white solid) in 42% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Gan & Lee Pharmaceuticals; Liu, Wenjian; Yin, Lei; Li, Heng; (94 pag.)CN106608879; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 4214-57-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4214-57-7, name is 2-Amino-5-bromo-4,6-dimethylpyrimidine. A new synthetic method of this compound is introduced below.

To a stirred solution containing 2.00 g (9.89 mmol) of 2-amino-5-bromo-4,6-dimethylpyrimidine (5) in 16 mL of toluene was added 1.36 mL (1.32 g; 11.5 mmol) of 2,5-hexanedione followed by 96 mg (0.50 mmol) of p-toluenesulfonic acid. The reaction mixture was heated and stirred at reflux for 12 h. The reaction mixture was poured into 150 mL of water and then extracted with 200 mL of ethyl acetate. The organic solution was washed with 150 mL of brine, dried (MgSO4) and concentrated under diminished pressure. The residue was purified by chromatography on a silica gel column (15 * 5 cm). Elution with 5:1 hexanes/ethyl acetate afforded 6 as light yellow crystals: yield 2.23 g (81%); mp 64-65 C; silica gel TLC Rf 0.65 (6:1 hexanes/ethyl acetate); 1H NMR (CDCl3) delta 2.34 (s, 6H), 2.67 (s, 6H) and 5.89 (s, 2H); 13C NMR (CDCl3) delta 14.5, 24.9, 108.7, 118.6, 129.5, 155.3 and 166.9; mass spectrum (APCI), m/z 280.0458 (M+H)+ (C12H15N3Br requires 280.0449).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4214-57-7, 2-Amino-5-bromo-4,6-dimethylpyrimidine, and friends who are interested can also refer to it.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 852180-74-6, name is 3-(Pyrimidin-5-yl)benzoic acid, the common compound, a new synthetic route is introduced below. Safety of 3-(Pyrimidin-5-yl)benzoic acid

To a stirred solution of XVII (0.100 g, 0.50 mmol) in 5 mL of DMF were added DIPEA (0.17 mL,1.0 mmol), HATU (0.380 g, 1.0 mmol) and XIII (0.203 g, 0.50 mmol) and stirred at RT for 12 h. Reactionmixture was diluted with ice-cold water and extracted with ethyl acetate (20 mL x 3). Organic layer wasthen washed with brine solution, dried over anhydrous sodium sulphate, concentrated under reducedpressure to afford crude product which was purified by reverse phase HPLC to afford desired product (0.053g, 18%).LCMS: 589 [M+1]+1H NMR (DMSO-d6): 10.50 (s, 1H), 10.20 (s, 1H), 9.25 (m, 3H), 8.43 (s, 1H), 8.20 (s, 1H), 8.10-8.05(m, 2H), 8.0 (m, 2H), 7.85 (d, 1H), 7.70 (m, 2H), 7.50 (d, 1H), 3.58 (s, 2H), 2.40-2.20 (m, 11H), 2.18 (s,3H).

The synthetic route of 852180-74-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia