Day: August 24, 2021

Synthetic Route of 939986-65-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.939986-65-9, name is 6-Chloropyrimidine-4-carbonitrile, molecular formula is C5H2ClN3, molecular weight is 139.5425, as common compound, the synthetic route is as follows.

To a stirred solution of compound 3 (55 mg, 0.29 mmol) inN-methyl-2-pyrrolidone (5 mL) at RT, were added 6-chloropyrimidine-4-carbonitrile (60 mg, 0.43 mmol) and Cs2CO3 (189 mg, 0.58 mmol), and the mixture was stirred for 12 h. The reaction mixture was diluted with water (10 mL) and extracted with EtOAc (2 x 15 mL). The combined organic extracts were washed with brine (10 mL), dried over Na2SO4, filtered, and concentrated under reduced pressure. The crude was purified via trituration with n-pentane (2 x 2 mL) to afford compound 4 (55 mg, 65%) as pale brown solid. ?HNMR (500MHz, DMSO-d6): 8.85 (d, J 0.9 Hz, 1H), 8.00 (d, J= 0.9 Hz, 1H), 7.77 (d, J= 3.2 Hz, 1H), 7.56 (d, J 8.4 Hz, 1H), 7.23 (t, J 8.0 Hz, 1H), 6.95 (d, J= 7.5 Hz, 1H), 6.32 (d, J= 3.2 Hz, 1H), 5.86-5.78 (m, 1H), 5.05 (t, J 7.4 Hz, 2H), 4.95 (t, J= 6.7 Hz, 2H); LCMS Mass: 293.0 (M+1).

The chemical industry reduces the impact on the environment during synthesis 939986-65-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; PHARMAKEA, INC.; ROWBOTTOM, Martin, W.; HUTCHINSON, John, Howard; (185 pag.)WO2017/3862; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 7752-74-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 7752-74-1, name is 5-Iodo-6-methylpyrimidin-4(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of 90 g (0.38 mol) 4-hydroxy-5-iodo-6-methyl pyrimidine in 600 mL POCl3 is heated for 1 h at 90 C. The reaction mixture is concentrated under reduced pressure and the residue is poured into crushed ice. The precipitated solid is collected by filtration and washed with water. After drying, the desired product is obtained as a solid (90 g; 93%).

According to the analysis of related databases, 7752-74-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/28958; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.24391-41-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, molecular formula is C7H3ClN4, molecular weight is 178.58, as common compound, the synthetic route is as follows.Quality Control of 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Step 13-3 (5)-4-(2-(7-fiuoro-4-oxo-3,4-dihydropyrrolo[l,2-f][l,2,4]triazin-2-yl) pyrrolidin- 1 -yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (106) Compound 106 A mixture of 13b (0.16 mmol), 4-chloro-7H-pyrrolo[2,3-d]pyrimidine- 5-carbonitrile (28 mg, 0.16 mmol) and TEA (0.08 mL, 0.58 mmol) in n-BuOH (5 mL) was stirred at reflux for 2 hours. The reaction mixture was concentrated and purified by flash column chromatography eluting with MeOH/water to afford Compound 106 as a white solid (27 mg, yield: 62%). MS (m/z): 364.7 (M+H)+. 1H NMR (400 MHz, DMSO-d6) delta: 13.07-12.72 (m, 1H), 11.76 (s, 1H), 8.30 (s, 1H), 8.13 (s, 1H), 6.81-6.73 (m, 1H), 6.31-6.09 (m, 1H), 5.15-5.07 (m, 1H), 4.32-4.24 (m, 1H), 3.96-3.92 (m, 1H), 2.40-2.30 (m, 1H), 2.18-2.02 (m, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,24391-41-1, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DAI, Guangxiu; XIAO, Kun; JIA, Hong; VENABLE, Jennifer Diane; BEMBENEK, Scott Damian; WO2014/15675; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 137281-39-1, name is 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid. This compound has unique chemical properties. The synthetic route is as follows. Formula: C15H14N4O3

To a suspension of intermediate G (0.50 g, 1.68 mmol) in dry DMF (10 mL) was added 2-chloro-4,6-dimethoxy-1,3,5-triazine (0.35 g, 2.01 mmol) and N-methylmorpholine (0.37 mL, 3.4 mmol) and the resulting mixture was stirred at room temperature for 3 h. A solution of intermediate E (assumed 2.5 mmol) and N-methylmorpholine (0.37 mL, 3.4 mmol) in DMF (5 mL) was added and stirring was continued at room temperature overnight. The solvent was removed under reduced pressure and the residue was purified by silica gel column chromatography (CH2Cl2/MeOH, 15/1 to 5/1) to afford (S)-benzyl 5-acetoxy-4-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanoate (0.70 g, 77%). LC-MS (Waters): Rt 6.14 min; m/z calculated for C29H31N5O6 [M+H]+ 546.23. found 546.0.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 137281-39-1, 4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoic acid.

Reference:
Patent; Craighead, Mark; Palin, Ronald; Murray, Neil; Lindsay, Derek; US2013/225594; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1780-26-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine, molecular formula is C5H4Cl2N2, molecular weight is 163.0047, as common compound, the synthetic route is as follows.

Example 127. 2-[4-(6-Chloro-2-methvl-pyrimidin-4-vl)-piperaziii-l-vll-ethano?71); [0307] To a solution of 4,6-dichloro-2-methyl-pyrimidine (5.0 g, 31 mmol) and 2- pirhoerazin-1-yl-ethanol (2.7 g, 21 mmol) in dioxane (25 mL) was added DEPEA (3.0 mL, 17 mmol). The mixture was heated at reflux for 16 h. The mixture was allowed to cool to room temperature and poured into water. The resulting aqueous layer was extracted with EtOAc and the combined organic layers washed with brine, dried over Na2SO4 and filtered. The filtrate was concentrated and the residue purified by flash chromatography on silica gel (5-10% MeOH/DCM) to afford the title compound as a brown liquid (2.1 g, 39%). MS (ES+): m/z 257 (M+H)+.

Statistics shows that 1780-26-3 is playing an increasingly important role. we look forward to future research findings about 2-Methyl-4,6-dichloropyrimidine.

Reference:
Patent; TARGEGEN, INC.; WO2006/101977; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 504-17-6 , The common heterocyclic compound, 504-17-6, name is 4,6-Dihydroxy-2-mercaptopyrimidine, molecular formula is C4H4N2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Nano-sawdust-OSO3H (0.02 g) was added to a stirred mixture of the aromatic aldehyde (1 mmol), malononitrile (1 mmol) and barbituric acid or thiobarbituric acid (1 mmol) in EtOH (5 mL). The materials were mixed and refluxed for the appropriate time. The progress of the reaction was followed by TLC (n-hexane:ethyl acetate 3:1). After completion of the reaction, the mixture was filtered to remove the catalyst. After evaporation of the solvent, the crude product was re-crystallized from hot ethanol to obtain the pure compound.

The synthetic route of 504-17-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sadeghi; Bouslik; Shishehbore; Journal of the Iranian Chemical Society; vol. 12; 10; (2015); p. 1801 – 1808;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 105806-13-1 ,Some common heterocyclic compound, 105806-13-1, molecular formula is C5H3Cl2FN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Part I: (9aS)-(-(6-Chloro-5-fluoro-2-methyl-4-pyrimidinyl)octahydropyrazino[2,1-c][1,4]oxazine. To a mixture of (9aS)-octahydropyrazino[2,1-c][1,4]oxazine dihydrochloride (23.28 g, 108.2 mmol) in DCM (360 mL) was added 4,6-dichloro-5-fluoro-2-methylpyrimidine (19.59 g, 108.2 mmol) and N,N-diisopropylethylamine (68 mL, 390.4 mmol). The mixture was stirred for 2 h, and the resulting solution was diluted with DCM (100 mL) and washed with saturated aq. NaHCO3 (200 mL). The aqueous phase was extracted with a fresh portion of DCM (100 mL), and this organic phase was washed with saturated aq. NaHCO3 (50 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, and concentrated in vacuo to give (9aS)-8-(6-chloro-5-fluoro-2-methyl-4- pyrimidinyl)octahydropyrazino[2,1-c][1,4]oxazine as a light yellow oil that was used without further purification. LCMS: (M+H)+: 287.1.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 105806-13-1, 4,6-Dichloro-5-fluoro-2-methylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/61879; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 931-61-3, name is 2-Methylaminopyrimidine, molecular formula is C5H7N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Methylaminopyrimidine

Example 7(15) A mixture of 1-76 (220 mg, 0.528 mmol), 2-methylaminopyrimidine (58 mg, 0.528 mmol) and 4-(dimethylamino)pyridine (0.6 mg, 0.005 mmol) in acetonitrile (2 mL) was stirred at 85 C for 16 h. Then, hydrazine hydrate (179 mu, 3.7 mmol) was added and the mixture was stirred at 100 C for 10 min under microwave irradiation. Then, the solvent was evaporated in vacuo and the crude product was purified by flash column chromatography (silica; MeOH in DCM 0/100 to 10/90). The desired fractions were collected and the solvents evaporated in vacuo to yield Co. No. 15 (135 mg, 65%) as a yellow solid. 1H NMR (500 MHz, CDC13) delta ppm 1.70 (d, J=6.4 Hz, 3 H) 2.94 (s, 3 H) 3.96 (dd, J=12.6, 7.4 Hz, 1 H) 4.23 (dd, J=12.6, 4.2 Hz, 1 H) 4.26 (br. s., 1 H) 4.66 – 4.75 (m, 1 H) 7.07 (s, 1 H) 7.51 (d, J=8.4 Hz, 2 H) 7.75 (d, J=8.4 Hz, 2 H) 7.83 (s, 1 H) 11.10 (br. s., 1 H).

With the rapid development of chemical substances, we look forward to future research findings about 931-61-3.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; VAN GOOL, Michiel, Luc, Maria; ALCAZAR-VACA, Manuel, Jesus; ALONSO-DE DIEGO, Sergio-Alvar; DE LUCAS OLIVARES, Ana, Isabel; (105 pag.)WO2016/87487; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 22276-95-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22276-95-5, name is 5-Bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

METHOD L; 7-Benzenesulfonyl-5-bromo-4-chloro-7H-pyrrolo[2,3-d]pyrimidine; [0192] To a slurry of the product from Method K (4.1 g/0.018 mol) in DMF (15 mL) and cooled to 0[deg.] C. was added 1.0 g (0.025 mol) of 60% sodium hydride in mineral oil and the resulting mixture stirred at 0[deg.] C. for 15 minutes. Benzenesulfonyl chloride (3.2 g/0.018 mol) was added, the reaction mixture warmed to room temperature and stirred for 2 hours. Water was then added (15 mL) and the resulting solid removed by filtration and dried in vacuo affording 5.9 grams (89%) of the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,22276-95-5, its application will become more common.

Reference:
Patent; Pfizer Inc.; US6635762; (2003); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 873-83-6 ,Some common heterocyclic compound, 873-83-6, molecular formula is C4H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of 6-aminouracil 1 (2 mmol), aromatic aldehyde 2 (2 mmol), urea (3, 2.5 mmol) and CuI NPs (2.9 mg,15 molpercent) in water (4 mL) was stirred at room temperature for the appropriate time. The progress of the reaction was monitored by TLC. After completion of the reaction,the resulting mixture was filtered. The solid residue was diluted with DMF (10 mL) and centrifuged at 2000?3000 rpm for 5 min to remove the CuI catalyst which was washed with DMF and dried at 100 °C for several hours in a vacuum for reuse. The organic solution was then poured into ice-cold water (10 mL) to give a solid precipitate, which was filtered off and recrystallized from DMF and H2O to afford the pure product.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 873-83-6, 6-Aminopyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Abdolmohammadi, Shahrzad; Afsharpour, Maryam; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 70; 3; (2015); p. 171 – 176;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia