Month: August 2021

Electric Literature of 120747-84-4, Adding some certain compound to certain chemical reactions, such as: 120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde,molecular formula is C5H5N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 120747-84-4.

Sodium triacetoxy borohydride (883 mg, 4.166 rnmol) was added slowly at 0 C to a solution of (trans)-2-(4-(benzyloxy)phenyl)cyclopropanamine (Intermediate B, 500 mg, 2.083 mmol), 2-aminopyrimidine-5-carbaldehyde (256 mg, 2.083 mmol) in DCE (10 mL) and stirred for 20 h. After completion, the solvent was evaporated. The residue was dissolved in Methanol (15 mL), NaBH4 (237 mg, 6.249 mmol) was added slowly at 0 C and stirred for 3 h. After completion, the solvent was evaporated, the residue was dissolved in ice water (20 mL) and extracted with EtOAc (2 x 20 mL). The combined organic layers were washed with brine (20 mL) and dried over anhydrous Na2S04; filtered and evaporated. The crude residue was purified by prep HPLC to afford 5-(((tran_?)-2-(4- (benzyloxy)phenyl)cyclopropylamino)methyl)pyrimidin-2-amine (180 mg, 25 %) as white solid. .H-NMR (400 MHz, DMSO-d6) delta (ppm): 0.85 (q, 1H), 0.90 (quin, 1H), 1.73 (m, 1H), 2.07 (m, 1H), 2.75 (brs, 1 H), 3.53 (s, 2H), 5.04 (s, 2H), 6.46 (s, 2H), 6.85 (d, 2H), 6.92 (d, 2H), 7.33 (m, 1H), 7.42 (m, 4H), 8.1 1 (s, 2H). Mass (M+H): 347.3

According to the analysis of related databases, 120747-84-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORYZON GENOMICS S.A.; ORTEGA MUNOZ, Alberto; FYFE, Matthew, Colin, Thor; MARTINELL PEDEMONTE, Marc; TIRAPU FERNANDEZ DE LA CUESTA, Inigo; ESTIARTE-MARTINEZ, Maria de los Angeles; WO2012/13728; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 39876-88-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 39876-88-5, name is 4-Chlorobenzofuro[3,2-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

N-(3-(9H-carbazol-3-yl)phenyl)-N-phenyldibenzo[b,d]furan-2-amine (2.5 g, 5.0 mmol) and sodium hydride (0.34 g, 8.5 mmol) were mixed in 30 mL of dry DMF. The solution was stirred for 1 hour at room temperature. 4-chlorobenzofuro[3,2-d]pyrimidine (1.9 g, 9.5 mmol) was added. The mixture was stirred overnight under nitrogen. The reaction mixture was poured into water and the precipitate was filtered. The residue was then purified by column chromatography using THF:hexane (1:3, v/v) as the eluent. 2.4 g (74%) of a pale yellow solid was obtained as the product.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 39876-88-5, 4-Chlorobenzofuro[3,2-d]pyrimidine.

Reference:
Patent; Universal Display Corporation; Joseph, Scott; Kwang, Raymond; Lee, Chi Hang; Shia, Chuan Jun; Ram, SiV Cheung; (131 pag.)KR2015/9461; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 22536-65-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.22536-65-8, name is 2-Chloro-5-methoxypyrimidine, molecular formula is C5H5ClN2O, molecular weight is 144.56, as common compound, the synthetic route is as follows.

To (1 -(3-(difluoromethyl)phenyl)-5-methyl-1 H-i 2,3- triazol-4-yl)methanol (45 mg, 0.19 mmol) stirring in THF (1 mL) was added NaH (60percent dispersion in mineral oil, 22.6 mg, 0.56 mmol) and the reaction wasstirred for 5 mi 2-Chloro-5-methoxypyrimidine was then added and the reaction was stirred at rt for 1 h. The reaction was quenched with H20, then diluted with EtOAc and H20. The layers were separated and the aqueous layer was extracted with EtOAc (3X). The combined organic layers were washed with H20 (ix), brine (ix), then dried (Na2504) and concentratedunder reduced pressure. Purification (FCC, 5i02, EtOAc/hexanes 0 – 60percent)afforded the title compound (41 mg, 62percent). MS (ESI): mass calcd. forC15H15F2N502, 347.1; m/zfound, 348.0 [M+H]. 1H NMR (400 MHz, CDCI3) O8.24 (5, 2H), 7.71 ? 7.56 (m, 4H), 6.73 (t, J = 56.1 Hz, 1 H), 5.56 (5, 2H), 3.88(5, 3H), 2.45 (5, 3H).

The chemical industry reduces the impact on the environment during synthesis 22536-65-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; CHEN, Gang; CHROVIAN, Christa C.; COATE, Heather R.; DVORAK, Curt A.; GELIN, Christine F.; HISCOX, Afton; LETAVIC, Michael A.; RECH, Jason C.; SOYODE-JOHNSON, Akinola; STENNE, Brice; WALL, Jessica L.; ZHANG, Wei; (583 pag.)WO2017/139428; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1088994-22-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1088994-22-2, name is 5-Methyl-2-(pyrimidin-2-yl)benzoicacid, molecular formula is C12H10N2O2, molecular weight is 214.22, as common compound, the synthetic route is as follows.

To a solution of 5-methyl-2-(pyrimidin-2-yl)benzoic acid(0.040 g, 0.19 mmol) in CHCl3 (1.5 mL) were added DIPEA(0.092 ml, 0.53 mmol), 43d (0.037 g, 0.15 mmol) and a solution of1-propanephosphonic acid cyclic anhydride (T3P, 1.7 mol/L inEtOAc, 0.30 ml, 0.52 mmol) at room temperature. After this mixturewas stirred at 60 C for 5 h, water was added, and the mixturewas extracted with CHCl3. The organic layer was washed withbrine, dried over Na2SO4, filtered, and concentrated under reducedpressure. The resulting residue was purified by preparative HPLC toobtain the titled compound 12 as a colorless amorphous (0.024 g,36% yield). HRMS (ESI/APCI dual) for C24H24FN6O2 [M+H]+, calcd:447.1939, found: 447.1923; LC-MS t = 0.87 min, [M+H]+ = 447.Please see the Supplementary data for pictures of 500 MHz 1Hand 125 MHz 13C NMR spectra in CDCl3 at 25 C.

Statistics shows that 1088994-22-2 is playing an increasingly important role. we look forward to future research findings about 5-Methyl-2-(pyrimidin-2-yl)benzoicacid.

Reference:
Article; Futamura, Aya; Nozawa, Dai; Araki, Yuko; Tamura, Yunoshin; Tokura, Seiken; Kawamoto, Hiroshi; Tokumaru, Yuichi; Kakihara, Sora; Aoki, Takeshi; Ohtake, Norikazu; Bioorganic and Medicinal Chemistry; vol. 25; 20; (2017); p. 5203 – 5215;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1235450-86-8, name is 5-Bromo-2-ethylpyrimidine-4-carboxylic acid, molecular formula is C7H7BrN2O2, molecular weight is 231.05, as common compound, the synthetic route is as follows.Quality Control of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid

A mixture of 5-Bromo-2-ethylpyrimidine-4-carboxylic acid (5.6 g, 24.3 mmol) in xylene (50 mL) was refluxed for 2 h. After cooling, the mixture was applied directly to a silica column, which was eluted with petroleum ether, then ethyl acetate in petroleum ether (5%) to give compound 0601-121 (1.7 g, 38%) as a yellow liquid. 1H NMR (400 MHz, DMSO-d6): 1.26 (t, J=7.6 Hz, 3H), 2.87 (q, J=7.6 Hz, 2H), 8.90 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235450-86-8, 5-Bromo-2-ethylpyrimidine-4-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; Curis, Inc.; Bao, Rudi; Lai, Chengjung; Qian, Changgeng; US2013/102595; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2380-63-4, name is 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, molecular formula is C5H5N5, molecular weight is 135.1267, as common compound, the synthetic route is as follows.Computed Properties of C5H5N5

1H-pyrazolo [3,4-d] pyrimidin-4-amine (18.0 g, 130.54 mmol) was dissolved in DMF (150 mL),Then, N-iodosuccinimide (45g, 195.81mmol, Aldrich) was slowly added to the reaction solution, and the reaction was stirred at 80 C for 12 hours.Stop heating, cool, add water (200mL) to the reaction solution, suction filter,Washed with water (80 mL), washed with ethanol (60 mL), and dried to obtain 25.8 g of gray solid, yield: 75.7%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2380-63-4, 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, and friends who are interested can also refer to it.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Yang Tiping; Zhou Youbo; Zhang Yingjun; Zheng Changchun; Luo Ming; Li Shixi; Peng Dahua; Wu Shuang; Xiong Jinfeng; (203 pag.)CN107344940; (2020); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4595-59-9, name is 5-Bromopyrimidine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C4H3BrN2

General procedure: Nucleophile (1-3 mol equiv), tris-(dibenzylideneacetone)dipalladium (2.5 mol %), tris-(2-furyl)phosphine (10 mol %) and potassium carbonate (2 mol equiv) were added to a solution of the aryl halide (1 mmol) in dry dimethylformamide (10 mL) in a Schlenk tube. The reaction mixture was then degassed using the freeze, pump, thaw (F.P.T.) technique (one cycle). Allene gas was then introduced at the required pressure (1 atm) and the Schlenk tube contents stirred and heated at 80 C for 16 h. After cooling and venting, DCM (20 mL) was added and the mixture filtered to remove inorganic salts. The filtrate was concentrated in vacuo and the residue was purified by column chromatography.

The synthetic route of 4595-59-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Elboray, Elghareeb E.; Gao, Chuanjun; Grigg, Ronald; Tetrahedron; vol. 68; 14; (2012); p. 3103 – 3111;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 13036-57-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13036-57-2, name is 2-Chloro-4-methylpyrimidine, molecular formula is C5H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a suspension of intermediate 15(1.04 g, 4.0 mmol) and 6-chloro-7H-purine (640.0 mg, 4.0 mmol) inEtOH (20.0 ml) Et3N (80.1 mg, 0.62 mmol) was added. The reactionmixture was heated to 90 C and stirred for 24 h. The resultingmixture was concentrated under reduced pressure and purified by column chromatography using a solvent gradient of 1-5% MeOH inDCM to give the compound 4k as a white solid. Yield: 970.0 mg,64.2%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13036-57-2, 2-Chloro-4-methylpyrimidine.

Reference:
Article; Yu, Jiang; Zhou, Peiting; Hu, Mingxing; Yang, Liuqing; Yan, Guoyi; Xu, Ruixue; Deng, Yufang; Li, Xinghai; Chen, Yuanwei; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1316216-05-3, Ethyl 2-(diphenylamino)pyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of Ethyl 2-(diphenylamino)pyrimidine-5-carboxylate, blongs to pyrimidines compound. Application In Synthesis of Ethyl 2-(diphenylamino)pyrimidine-5-carboxylate

0128] 2N NaOH (200 mL) was added to a solution of intermediate 3 (3.0 g, 9.4 mmol) in EtOH (200 mL). The mixture was stirred at 60C for 30 min. After evaporation of the solvent, the solution was neutralized with 2N HCl to give a white precipitate. The suspension was extracted with EtOAc (2 x 200 mL) and the organic layer was separated, washed with water (2 x 100 mL), brine (2 x 100 mL) and dried over Na2SO4. Removal of solvent gave a brown solid (2.5 g, 92%).

The synthetic route of 1316216-05-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; Golonzhka, Olga; Jarpe, Matthew B.; (30 pag.)US2017/114023; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 99979-77-8, name is 2-Chloro-5-methoxypyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-Chloro-5-methoxypyrimidin-4-amine

Synthesis of 4-amino-2-chloropyrimidin-5-ol [0346] To a stirred solution of 2-chloro-5-methoxypyrimidin-4-amine (5 g, 31.44 mmol) in CH2CI2 (750 mL) under argon atmosphere at 0 °C was added BBr3 (45.5 mL, 471.69 mmol) drop-wise. The reaction was allowed to warm to RT and stirred for 32 h. After completion of the reaction (monitored by TLC), the reaction was quenched with methanol (22.5 mL) and stirred for lh. The suspension was filtered and the resultant solid dried in vacuo to afford 4-amino-2-chloropyrimidin-5-ol (4.5 g) as a brown solid and used without further purification. 1H-NMR (DMSO-< 5, 500 MHz): delta 10.04 (brs, 1H), 7.48 (s, 1H); LC- MS: 146.2 (M+l); (column; Eclipse XDB C-18 (150 4.6 mm, 5 mupiiota); RT 3.37 min. 0.05percent Aq TFA: ACN; 1.0 ml/min); TLC: 60percent EtOAc:hexanes (R/. 0.5). If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 99979-77-8, 2-Chloro-5-methoxypyrimidin-4-amine. Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66697; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia