Some scientific research about 4,5-Dichloro-6-ethylpyrimidine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115617-41-9, its application will become more common.

Related Products of 115617-41-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115617-41-9 as follows.

(2) Synthesis of dl-5-chloro-6-ethyl-4-(alpha-methyl-4-methylthiobenzylamino)pyrimidine (Compound No. 62) 2 g (3.3 mmol) of 4,5-dichloro-6-ethylpyrimidine which is a material compound (IIc), 1.9 g (11 mmol) of dl-alpha-methyl-4-methylthiobenzylamine which is a material compound (IIId), 2 ml of triethylamine and a catalytic amount of 4-(N,N-dimethylamino)pyridine were dissolved in 10 ml of N,N-dimethylformamide and the solution was heated under reflux for 8 hours. After the reaction, extraction with toluene and washing with water were conducted, followed by drying over anhydrous sodium sulfate. The solvent was removed under reduced pressure and the resulting oily product was purified by silicagel column chromatography (Wako gel C-200, eluted with toluene:ethyl acetate = 4:1). The resultant was crystallized with hexane to give 1.8 g of the desired compound as colorless crystals (indicated in Table 19 as Compound No. 62).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115617-41-9, its application will become more common.

Reference:
Patent; UBE INDUSTRIES, LTD.; EP424125; (1991); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The origin of a common compound about 1004-38-2

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1004-38-2, 2,4,6-Triaminopyrimidine.

Related Products of 1004-38-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1004-38-2, name is 2,4,6-Triaminopyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 1 2,4-Diamino-6-(carboxaldehyde)pyrido[2,3-d]pyrimidine (III; Y=CHO) Phosphorus oxychloride (27.5 ml, 46.0 g, 300 mmol) was added over 15 minutes with stirring to N,N-dimethylformamide (11.0 g, 150 mmol), which was cooled with an ice bath. After stirring at room temperature for 1 hour, the reaction mixture was treated with bromoacetic acid (13.9 g, 100 mmol). The resulting solution, protected by a calcium chloride tube was heated at 92 C. for 10 hours and evaporated to dryness in vacuo. The colored oil (~30 g) was dissolved in water (1000 ml), and the solution was neutralized with 50% sodium hydroxide to pH 7. After addition of 2,4,6-triaminopyrimidine (5.00 g, 40.0 mmol), the solution was refluxed for 3 hours and filtered hot through a fluted filter. The filtrate was cooled and the solid that precipitated was collected by filtration and dried in vacuo over P2 O5: yield, 2.53 g (33%). Mass spectrum, m/e 189 (M+). HPLC [0.1M NH4 OAc (pH 3.6)–CH3 OH (9:1)] indicated that this product was 86% pure. A sample (200 mg) was dissolved in 0.1N HCl (15 ml) and diluted with acetone (225 ml) to precipitate impure III (Y=CHO): yield, 91 mg. The filtrate was evaporated to dryness under reduced pressure and the residue was dried in vacuo over P2 O5 to give Compound III (Y=CHO): yield, 128 mg; mp, gradual darkening and decomposition with white sublimate when taken to 360 C. lambdamax nm (epsilon*10-3): 0.1N HCl-258 (16.4), 317 (9.12), 326 sh (8.24); pH 7-263 (15.0), 316 (10.1), 345 (10.8); 0.1N NaOH-254 (13.2), 267 (13.5), 316 (8.56), 347 (10.0). 1 H-NMR (CF3 CO2 D, 6% w/v), 9.48 s, 9.75 s (5-CH, 7-CH), 10.21 s (6-CHO). Anal. Calcd for C8 H7 N5 O.HCL.1.3H2 O: C, 38.57; H, 4.30; N, 28.12. Found: C, 38.44; H, 4.15; N, 28.14.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1004-38-2, 2,4,6-Triaminopyrimidine.

Reference:
Patent; Southern Research Institute; US4526964; (1985); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extracurricular laboratory: Synthetic route of 857641-46-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound,857641-46-4, 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 857641-46-4, 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, blongs to pyrimidines compound. Recommanded Product: 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine

A solution containing 2-(4-bromo-pyrazol-1-yl)-pyrimidine (300 mg, 1.34 mmol), 4-(4,4,5,5-tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (280 mg, 1.34 mmol), PdCI2(dppf) (95 mg, 0.13 mmol) and potassium phosphate (800 mg, 4 mmol) in dioxane was heated at 80 C under argon for overnight. After removed the solvent, ethylacetate was added and the mixture was filtered, washed with water.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,857641-46-4, 2-(4-Bromo-1H-pyrazol-1-yl)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SCHERING CORPORATION; WO2008/153858; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 1006599-54-7

With the rapid development of chemical substances, we look forward to future research findings about 1006599-54-7.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1006599-54-7, name is 5-(2-(Methylthio)ethoxy)pyrimidin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 5-(2-(Methylthio)ethoxy)pyrimidin-2-amine

To a solution of 2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)benzaldehyde (3.34 g, 11.2 mmol) obtained in Step 3 and 5-[2-(methylthio)ethoxy]pyrimidin-2-amine (2.27 g, 12.3 mmol) obtained in Step 1 in toluene (80 mL) was added acetic acid (317 mg, 5.19 mmol), and the mixture was refluxed by heating for 4 hours with a Dean-Stark apparatus. The reaction mixture was left to cool to room temperature, and then added with sodium triacetoxyborohydride (4.73 g, 22.3 mmol) on an ice bath with stirring, and the mixture was stirred at room temperature for 60 hours. The reaction mixture was added with water, and extracted with chloroform, and then the organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=20:1?10:1?4:1) to obtain N-({2-[(cyclopentylmethyl)(ethyl)amino]-5-(trifluoromethyl)phenyl}methyl)-5-[2-(methylthio)ethoxy]pyrimidin-2-amine (4.39 g, 84%) as a pale yellow oil.1H-NMR (CDCl3) delta: 1.03 (3H, t, J=7.1 Hz), 1.15-1.23 (2H, m), 1.43-1.66 (4H, m), 1.67-1.76 (2H, m), 2.00 (1H, m), 2.20 (3H, s), 2.85 (2H, t, J=6.8 Hz), 2.95 (2H, d, J=7.6 Hz), 3.04 (2H, q, J=7.1 Hz), 4.12 (2H, t, J=6.8 Hz), 4.69 (2H, d, J=5.6 Hz), 5.54 (1H, t, J=5.6 Hz), 7.21 (1H, d, J=8.3 Hz), 7.44 (1H, d, J=8.3 Hz), 7.62 (1H, s), 8.07 (2H, s).

With the rapid development of chemical substances, we look forward to future research findings about 1006599-54-7.

Reference:
Patent; KOWA COMPANY, LTD.; US2009/82352; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Simple exploration of 2927-71-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2927-71-1, 2,4-Dichloro-5-fluoropyrimidine, and friends who are interested can also refer to it.

Application of 2927-71-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2927-71-1, name is 2,4-Dichloro-5-fluoropyrimidine. A new synthetic method of this compound is introduced below.

2,4-Dichloro-5-fluoropyrimidine (110 mg, 0.65880 mmol) (represented by formula 1-b), 4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-benzimidazole (180 mg, 0.5657 mmol), (bis(triphenylphosphine))palladium dichloride (30 mg) were added to 2M sodium carbonate solution (1 mL) and ethylene glycol dimethyl ether (3 mL), and the mixture was stirred under nitrogen atmosphere at 85 C. for 2 hours. After cooling to room temperature, the reaction solution was diluted with 10 mL ethyl acetate, washed with saturated brine, and dried over anhydrous sodium sulfate. The organic phase was concentrated and recrystallized from acetonitrile, filtered to give compound 6-(2-chloro-5-fluoro-pyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-benzimidazole represented by formula 1-c (135 mg, 0.4183 mmol). LC-MS: m/z: (M+H)+=323.2.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2927-71-1, 2,4-Dichloro-5-fluoropyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Shanghai Pharmaceuticals Holding Co., Ltd.; XIA, Guangxin; WANG, Qian; SHI, Chen; ZHAI, Xiong; GE, Hui; LIAO, Xuemei; MAO, Yu; XIANG, Zhixiong; HAN, Yanan; HUO, Guoyong; LIU, Yanjun; (202 pag.)US2019/10153; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

New learning discoveries about 5-Amino-2,4-dichloropyrimidine

According to the analysis of related databases, 5177-27-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 5177-27-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5177-27-5, name is 5-Amino-2,4-dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

5-Amino-2,4-dichloropyrimidine (1.33 g, 10 mmol) and 5-aminoindazole (1.64 g, 10 mmol) were slurried in a solution of sodium acetate (20 mL, 0.1 M buffered to pH 4 with acetic acid). The reaction mixture was then heated to 60-65 C for 16 hours at which point no starting materials remained by t.l.c. The reaction mixture was cooled and the precipitate filtered off washed with water (20 mL), saturated sodium bicarbonate solution (10 mL) and again with water (2×20 mL). The solid was dried under vacuum for 12 hours (2.00 g, 7.6 mmol, 76% Yield). 1H,400MHz, delta (d6-DMSO): 5.68 (3H, br s, NH), 7.52 (2H, s, ArH), 7.61 (IH, s, ArH), 8.05 (IH, s, ArH), 8.06 (IH, s, ArH), 9.09 (IH, s, NH); HPLC: 3.95 min; LRMS: m/z = 261.1 (M+H)

According to the analysis of related databases, 5177-27-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DCAM PHARMA INC; AJAMI, Alfred, M.; DUNCAN, Kenneth, W.; FANG, Xinqin; WO2011/106168; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Share a compound : 4,6-Dichloro-5-methoxypyrimidine

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5018-38-2, 4,6-Dichloro-5-methoxypyrimidine.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5018-38-2, name is 4,6-Dichloro-5-methoxypyrimidine. A new synthetic method of this compound is introduced below., Application In Synthesis of 4,6-Dichloro-5-methoxypyrimidine

A 500 ml, 4-necked flask equipped with thermometer, mechanical stirrer and condenser with gas inlet was purged with N2 and charged with NaH (4.4 g; 0.1 1 mol) and N,N-dimethylformamide (50 ml). In a separate flask were dissolved 4-hydroxy-piperidine-1-carboxylic acid isopropyl ester (18.7 g; 0.1 mol) and 4,6-dichloro-5-methoxy-pyrimidine (17.9 g; 0.1 mol) in DMF (50 ml; 0.5 L/mol). The prepared solution was then added dropwise to the above- mentioned NaH/DMF suspension while maintaining the temperature between – 10 and -5C. The resulting mixture is then stirred for one hour, then allowed to warm up to room temperature and stirred for 17 hours. Water (300 ml; 3 L/mol) was added dropwise while maintaining the temperature between 15-300C by cooling with tap water. Heptane (125 ml; 1.25 L/mol) was added and the resulting mixture was heated up to 55C. The aqueous layer was discarded; the organic layer was cooled down to 200C and stirred for another 3-2Oh. The resulting precipitate was filtered and dried in vacuum (at) 500C for 2Oh to yield the title compound as a residue.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5018-38-2, 4,6-Dichloro-5-methoxypyrimidine.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; WELLS, Kenneth M.; FECH, Gary; WU, Wenju; FAWZY, Nagy E.; WO2010/135505; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Sources of common compounds: 7-Bromothieno[3,2-d]pyrimidin-4(3H)-one

According to the analysis of related databases, 31169-25-2, the application of this compound in the production field has become more and more popular.

Electric Literature of 31169-25-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 31169-25-2, name is 7-Bromothieno[3,2-d]pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows.

Dimethylformamide (25.8 mL, 0.33 mol) and dichloromethane (150 mL) were placed in a reaction vessel, to which a dilution of oxalyl chloride (46.4 mL, 0.53 mol) in dichloromethane (150 mL) was then added over about 30 min. Subsequently, 7- bromothieno[3,2-d]pyrimidin-4(3H)-one (35 g, 0.15 mol) was added, and heated under reflux for 3 hrs. Thereafter, the reaction mixture was quenched before water was added carefully. The Organic layer thus formed was isolated, while the aqueous layer was extracted with dichloromethane. The organic layers were pooled and dried over anhydrous sodium sulfate, and the dried organic layer was subjected to vacuum filtration and vacuum distillation, followed by desiccation with a nitrogen gas to obtain the desired compound (30.5 g, 85percent). ‘H-NMR^OOMHz, DMSO-d6): delta 9.16(s, 1H), 8.79(s, 1H).

According to the analysis of related databases, 31169-25-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; HANMI PHARM. CO., LTD.; BANG, Keuk Chan; PARK, Chang Hee; CHOI, Jae Yul; KIM, Seo Hee; HAM, Young Jin; WO2014/3483; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Analyzing the synthesis route of Pyrimidine-4,6-dicarboxylic acid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16490-02-1, Pyrimidine-4,6-dicarboxylic acid, other downstream synthetic routes, hurry up and to see.

Application of 16490-02-1, Adding some certain compound to certain chemical reactions, such as: 16490-02-1, name is Pyrimidine-4,6-dicarboxylic acid,molecular formula is C6H4N2O4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16490-02-1.

Dimethyl pyrimidine-4,6-dicalpharboxylalphate (llalpha)To a heated solution (75C) of 4,6-dimethylpyrimidine (846 mg, 8.00 mmol) and NaOH (211 mg, 5.28 mmol) in water (3 mL) was added a solution OfKMnO4 (5.28 g in 25 mL water) overl5 min. The resulting mixture was stirred at 80C for 3 hrs. The hot solution was filtered hot and manganese dioxide washed with hot water (8 mL). The filtrate and washings were concentrated to 5 mL and acidified with cone. HCl to pH 2-3. After cooling, the precipitation was collected, yielding 591 mg of crude pyridine-4,6-dicarboxylic acid. The diacid was then dissolved in MeOH (15 mL) and cone. H2SO4 (1.5 mL) was added dropwise carefully. The mixture was refluxed for 24 hrs, cooled to room temperature and concentrated in vacuo. The resultant oily residue was neutralised with sat. NaHCO3 and extracted with EtOAc (3 x 30 mL). The combined organic extracts were washed with H2O (50 mL) and brine (5OmL), dried over Na2SO4, filtered and concentrated. The product was then purified by column chromatography (petroleum ether 40-60 : EtOAc 5 : 5 to 3 :7) yielding 311 mg (20%) of 11 a as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16490-02-1, Pyrimidine-4,6-dicarboxylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ISIS INNOVATION LIMITED; SCHOFIELD, Christopher, Joseph; MCDONOUGH, Michael; ROSE, Nathan; THALHAMMER, Armin; WO2010/43866; (2010); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Extracurricular laboratory: Synthetic route of 6320-15-6

The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 6320-15-6 , The common heterocyclic compound, 6320-15-6, name is 4-Chloro-2,6-dimethoxypyrimidine, molecular formula is C6H7ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The 3,5-dimethylbenzene acetonitrile (725mg, 5mmol) was dissolved in 40ml DMF, underice-cooling conditions , added NaH (120mg, 5mmol). Under the protection of nitrogen gas stirred for 1 hour, the system changed from colorless to red winecolor, afterwards added 2,4-dimethoxy-6-chloropyrimidine (924mg,5mmol). At theroom temperature stirred for 48 h, pass the air into the reaction system and stirringwas continued for 48~72 hours. The reaction was stopped , after the solvent wasdistilled off under reduced pressure added 200ml water to adjust the PH toneutral with hydrochloric acid. Extracted with Ethyl acetate (100ml X 3),combined the organic phases and for drying added Anhydrous sodium sulfate.Purified through column chromatography (petroleum ether / ethyl acetate) to obtaina pale yellow solid. Yield 89%; melting point. 110-112 C

The synthetic route of 6320-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Peking University; LIU, JUNYI; LI, CHAO; WANG, XIAOWEI; ZHANG, ZHILI; GUO, YING; TIAN, CHAO; (12 pag.)CN104119283; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia