Month: August 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. A new synthetic method of this compound is introduced below., name: 2-Chloro-5-nitropyrimidine

To a solution of 2-chloro-5-nitropyrimidine (0.200 g, 1.254 mmol) and 6-oxa-3-azabicyclo[3.1.1]heptane 4-methylbenzenesulfonate (0.394 g, 1.452 mmol) in 2Me-THF (6 mL), was added triethylamine (0.4 ml, 2.870 mmol). The reaction was stirred at rt overnight. The reaction was partitioned with DCM and water. The organic extract washed with brine and dried over sodium sulfate to give I-35C. ES/MS: 223.0.9 (M+H+). 1H NMR (400 MHz, Chloroform-d) delta 9.18 (s, 1H), 4.80 (d, J=6.6 Hz, 2H), 4.08 (d, J=13.8 Hz, 2H), 3.97 (d, J=13.9 Hz, 2H), 3.37 (q, J=7.4 Hz, 1H), 1.95 (d, J=9.2 Hz, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10320-42-0, 2-Chloro-5-nitropyrimidine.

Reference:
Patent; Gilead Sciences, Inc.; Bacon, Elizabeth M.; Brizgys, Gediminas; Chin, Elbert; Chou, Cheinhung; Cottell, Jeromy J.; Link, John O.; Taylor, James G.; Tse, winston C.; Wright, Nathan E.; Yang, Zheng-Yu; Zhang, Jennifer R.; Zipfel, Sheila M.; US2018/230157; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1224944-77-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1224944-77-7 as follows.

A mixture of ethyl 5-chloropyrazolo[1,5-a]pyrimidine-3-carboxylate (1.00 g, 4.43 mmol), 2-(2,5-difluorophenyl)pyrrolidine (Intermediate 2, 853 mg, 4.65 mmol) and KF (1.28 g, 22.1 mmol) in DMSO (14 mL) was stirred at 180 C. for 2 hours. After being cooled to room temperature, the reaction mixture was poured into water. The mixture was stirred for 30 min. A precipitated solid was collected by filtration and dried under vacuum to afford ethyl 5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidine-3-carboxylate (1.51 g, 91%) as a yellow solid. 1H-NMR (CDCl3, Varian, 400 MHz): delta 1.30-1.49 (3H, m), 1.98-2.18 (3H, m), 2.43-2.58 (1H, m), 3.95-4.20 (2H, m), 4.25-4.48 (2H, m), 5.18-5.23 (1H, m), 5.82-5.94 (1H, m), 6.68-6.80 (1H, m), 6.86-6.98 (1H, m), 7.00-7.12 (1H, m), 8.08-8.22 (1H, m), 8.29 (1H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1224944-77-7, its application will become more common.

Reference:
Patent; HANDOK INC.; CMG Pharmaceutical Co., Ltd.; Kim, Moonsoo; Lee, Chaewoon; Lee, Gilnam; Yoon, Cheolhwan; Seo, Jeongbeob; Kim, Jay Hak; Lee, Minwoo; Jeong, Hankyul; Choi, Hyang; Jung, Myung Eun; Lee, Ki Nam; Kim, Hyun Jung; Kim, Hye Kyoung; Lee, Jae Il; Lee, MinWoo; Kim, Misoon; Choi, Soongyu; (124 pag.)US2016/168156; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1683-75-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1683-75-6, name is 2-Amino-4-chloro-5-fluoropyrimidine, molecular formula is C4H3ClFN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The reaction bottle was added with mechanical stirring, and then SM4 (200.0g, 0.666mol) and SM6 (98.0g, 0.666mol) were added in sequence.Palladium acetate (7.4g, 0.033mol), tripotassium phosphate trihydrate (354.0g, 1.332mol), 1,4-dioxane (1.4L) and water (0.6L).Under nitrogen protection, the reaction liquid was heated to 100C, kept under heat and stirred for 4 hours, and the final control of the sampling was completed.The reaction solution was cooled to room temperature, the layers were separated, the organic phase was concentrated, and concentrated hydrochloric acid (250 mL) was added to the concentrated residue.Water (750 mL) and activated carbon (10.0 g) were stirred at room temperature for 1 hour.Filtration, the filtrate was reduced to 0 ~ 5 , then 20% aqueous sodium hydroxide solution (1.0 L) was added dropwise, stirred, filtered,After drying, 163.0 g of light yellow solid was obtained with a yield of 85.8% and a purity of 96.8%.

According to the analysis of related databases, 1683-75-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Liu Fuping; Zhang Jingtao; Wu Liyuan; (48 pag.)CN111138413; (2020); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1215787-31-7, name is 6-Bromo-4-chloropyrido[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 1215787-31-7

General procedure: To a solution of compound 4 (2.43 g, 0.01 mol) in 25 mL dioxane was added 1-(2,6-Dichloro-3-fluorophenyl)ethan-1-amine (3.12 g, 0.015 mol), and then the reaction mixture was stirred at room temperature overnight. After that, the mixture was poured into 150 mL H2O, and then the resulting precipitate was filtered, washed with 50% ethanol, and dried overnight under vacuum to give 5a as white solid (3.58 g, yield, 86%).

The synthetic route of 1215787-31-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hou, Ju; Wan, Shanhe; Wang, Guangfa; Zhang, Tingting; Li, Zhonghuang; Tian, Yuanxin; Yu, Yonghuan; Wu, Xiaoyun; Zhang, Jiajie; European Journal of Medicinal Chemistry; vol. 118; (2016); p. 276 – 289;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 26456-59-7, name is Pyrimidin-5-ol. A new synthetic method of this compound is introduced below., Recommanded Product: Pyrimidin-5-ol

To a solution of 5-hydroxypyrimidine (9, 1.73 kg, 18.08 mol) in DMF (23.0 L,10 V), potassium carbonate (6.25 kg, 45.21 mol) was added followed by 4-chloro-6-methylpicolinonitrile (8, 2.3 kg, 15.07 mol) at 25-30 C. The reactionmass was heated at 75-80 C for 36 h. The reaction was monitored by HPLC 8NMT 2.0% by HPLC). Reaction mass was cooled to 25-30 C. The solid wasfiltered and washed the solid with DMF (4.6 L, 2.0 V). The filtrate was cooled to0-5 C and purified water (27.6 L, 12 V) was added drop wise over a period of1 h. The solid precipitated was filtered and washed with purified water (2.3 L,10 V) to afford 10 as off white solid (2.62 kg, 82.1%). 1H NMR (400 MHz, DMSOd6)d 9.17 (s, 1H), 8.85 (s, 2H), 7.74 (d, J = 2.4 Hz, 1H), 7.32 (d, J = 2.3 Hz, 1H),2.48 (s, 3H); 13C NMR (100 MHz, DMSO-d6) d = 164.04, 162.28, 155.51, 150.02,148.75, 133.54, 117.05, 115.59, 115.04, 23.82 ppm; LCMS (Method 1):RT = 0.535 min, m/z = 213.2 [M+H]+; HRMS, calc?d for C11H8N4O [M],212.0698; found 212.0697.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 26456-59-7, Pyrimidin-5-ol.

Reference:
Article; David, Thomas K.; Prashanth, Nayak K.; Rajendraswami; Pallalu, Devendrareddy; Castelhano, Arlindo L.; Kates, Michael J.; Blobaum, Anna L.; Jones, Carrie K.; Emmitte, Kyle A.; Conn, P. Jeffrey; Lindsley, Craig W.; Tetrahedron Letters; vol. 58; 36; (2017); p. 3554 – 3558;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7627-44-3, name is 2,4-Dichloro-5-(iodomethyl)pyrimidine, the common compound, a new synthetic route is introduced below. SDS of cas: 7627-44-3

To a solution of 2,6-dimethylaniline (3.8 g, 31.4 mmol) and 2,4-dichloro-5- (iodomethyl)pyrimidine (7.0 g, 24.2 mmol) in acetone was added K2CO3 (5.0 g, 36.2 mmol), the mixture was stirred at 50 oC for 6 h. then removed acetone, extracted with ethyl acetate (150 mL × 3), washed with water (80 mL × 2), brine (80 mL× 2), dried with Na2SO4. Purified by silica gel (PE/DCM = 2/1, 1/1, DCM) to give N-((2,4- dichloropyrimidin-5-yl)methyl)-2,6-dimethylaniline as a light yellow solid (4.5 g), yield 66percent. LC/MS (ESI) m/z = 282 (M + H) +.

The synthetic route of 7627-44-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THE BROAD INSTITUTE, INC.; DANA-FARBER CANCER INSTITUTE, INC.; THE GENERAL HOSPITAL CORPORATION D/B/A MASSACHUSETTS GENERAL HOSPITAL; GRAY, Nathanael, S.; LIANG, Yanke; CHOI, Hwan, Geun; SUNDBERG, Thomas; SHAMJI, Alykhan; XAVIER, Ramnik; FISHER, David E.; (251 pag.)WO2018/9544; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 767-15-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 767-15-7 as follows.

General procedure: To a stirred mixture of 4-methylbenzaldehyde (1 mmol, 0.120 g) and N,N,N’,N’-tetrabromobenzene-1,3-disulfonamide [TBBDA] (0.05 g, 0.09 mmol) or poly(N-bromo-N-ethyl-benzene-1,3-disulfonamide) [PBBS] (0.12 g) at room temperature, was added 2-amino-4,6-dimethylpyrimidin (1 mmol, 0.123 g). Then, indole (1 mmol, 0.12 g) was added to the mixture after 10 min. The progress of the reaction was monitored by TLC (n-hexane/acetone, 17:2). After completion of the reaction, EtOH (5 mL) was added to the reaction mixture and the colorless precipitate was filtered (after evaporation of the ethanol, cool methylene dichloride (2 mL) was added, and the catalyst was recovered), washed with EtOH and dried and purified by recrystallization from ethanol.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,767-15-7, its application will become more common.

Reference:
Article; Ghorbani-Vaghei, Ramin; Shahbazi, Hajar; Toghraei-Semiromi, Zahra; Comptes Rendus Chimie; vol. 17; 2; (2014); p. 118 – 123;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 633328-95-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 633328-95-7, name is 5-Bromo-2-chloro-4-methylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

STEP A: (1R,5S)-3-(5-bromo-4-methylpyrimidin-2-yl)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid [0631] A 100 mL round-bottom flask was charged with 5-bromo-2-chloro-4- methylpyrimidine (3.09 g, 14.87 mmol), (li?,55)-3-azabicyclo[3.1.0]hexane-2-carboxylic acid (2.08 g, 16.36 mmol), and Et3N (6.22 mL, 44.6 mmol) in EtOH (70 mL) to give a yellow solution. The reaction mixture was stirred at 75C for 18 hours and then partitioned between IN HC1 (40 mL) and ethyl acetate (40 mL). The organic and aqueous layers were separated, and the aqueous layer was back-extracted with ethyl acetate (75 mL). The organic layers were combined, washed with brine (40 mL), dried over Na2S04, filtered, and concentrated to give the title compound as a tan solid which was used without further purification (2.85 g,

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 633328-95-7, 5-Bromo-2-chloro-4-methylpyrimidine.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; CHERUVALLATH, Zacharia; KOMANDLA, Mallareddy; LAWSON, John David; MCBRIDE, Christopher; TANG, Mingnam; WO2014/39831; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1337962-47-6, 5-Bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1337962-47-6, blongs to pyrimidines compound. Quality Control of 5-Bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine

To a suspension of 50mg (0.1633 mmol) of 5-bromo-2,6-di(1H-pyrazol-1-yl)- pyrimidin-4-amine (Form F) in lmL ethyl acetate was added 54.5uL HC1 aqueous solution (6M, 0.3266 mmol) dropwise. The mixture was stirred at 50 degree C for 20 hours. The mixture was cooled to room temperature within 2 hours and the stirring was maintained for another 1 hour. The solid was collected with vacuum filtration and dried at r.t overnight. 5-bromo-2,6-di(1H- pyrazol-1-yl)-pyrimidin-4-amine di-hydrochloride hydrate was obtained as a crystalline Form B. The solid was analyzed by XRPD after isolation.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1337962-47-6, its application will become more common.

Reference:
Patent; NOVARTIS AG; CUI, Kai; KONG, Weiyong; CASTRO-PALOMINO LARIA, Julio Cesar; (100 pag.)WO2018/220546; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 5194-32-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5194-32-1, name is 2-Methylpyrimidine-5-carboxylic acid, molecular formula is C6H6N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 2-methylpyrimidine-5-carboxylic acid (150 mg, 1.23 mml) in ethanol (5 mL) was added sodium borohydride (93 mg, 2.46 mmol). The mixture was stirred at room temperature for 3 h. It was quenched with aqueous HCl (2 N, 2 mL), extracted with DCM, dried over sodium sulfate, filtered and concentrated give the yellow oil product (2-methylpyrimidin-5-yl)methanol (95 mg, 62.6%). LCMS MH+ 125.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5194-32-1, 2-Methylpyrimidine-5-carboxylic acid.

Reference:
Patent; HYDRA BIOSCIENCES, INC.; Chenard, Bertrand L.; Gallaschun, Randall J.; Kimball, Spencer David; US2014/275528; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia