Day: September 6, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24415-66-5, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 24415-66-5

Adding 85 mg (about 0.5 mmol) to a 10 mL microwave reaction tube.7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, 357 mg (about 1.5 mmol) 1-benzyl-7-methoxy-1H-indole, 14 mg (about 10 mol%) of the catalyst bistrifluoromethylsulfonimide and 1 mL of the solvent HFIP, and then the microwave reaction tube was sealed.Then, the reactant in the microwave reaction tube was stirred at 100 C for 6 hours, and the solvent was distilled off under reduced pressure.And purified by column chromatography using DCM / MeOH as eluent to give about 158 mg of pure product e21 as a white solid in a yield of 85%;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 24415-66-5, 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.

Reference:
Patent; Zhengzhou University; Liu Hongmin; Yu Bin; Yuan Shuo; Wang Shuai; Li Zhonghua; (21 pag.)CN109180684; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 428854-24-4, 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine, blongs to pyrimidines compound. name: 2-(1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine

B, to 500 ml reaction vial the adding step a 29.0g (0.083mol) compound 3,150 ml methanol, 9.7g (0.1mol) carbonic acid dimethyl ester (compound 4), in 30 C stirring reaction under 6h; after the reaction, the obtained reaction solution in the 50 C, vacuum 0.09 MPa reducing pressure and evaporating the solvent, the residue obtained by adding 150 ml ethyl acetate stirring 15 min, filter, the filtration cake at the 65 C, vacuum 0.09 MPa dry the 5h, to obtain 4,6-diamino-2 – [1 – (2-fluorobenzyl) – 1H-pyrazolo [3,4-b] pyridin-3-yl] – 5-pyrimidinyl amino a acid methyl ester (compound 5) 29.8g (yield 88%);

The synthetic route of 428854-24-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Drug Technology Co., Ltd.; Mao, Ying; Bi, Tianhao; Li, Jinhua; Liu, Zhiqing; Lou, Lili; Zhang, Jiamei; (11 pag.)CN105294686; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 63558-65-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 63558-65-6, name is 4-Chloro-5-iodopyrimidine, molecular formula is C4H2ClIN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 7: (R) 4-[(lR)-7-Chloroisochroman-l-yl]-5-methyl-2 hienyl]-(4-chloropyrimidin-5- yl)methanol and (S)-[4-[(lR)-7-Chloroisochroman-l-yl]-5-methyl-2-thienyl]-(4-chloropyrimidin- 5-yl)methanol [00710] A solution of 4-chloro-5-iodopyrimidine (7.05 g, 29.3 mmol) in THF (100 mL) was cooled at -78 C. To the solution was added 2.50 M of n-BuLi in hexane (23.4 mL, 58.6 mmol) at the same temperature. After stirring for 10 min, a solution of 4-[(lR)-7-chloroisochroman- l -yl]-5-rnethyl- thiophene-2-carbaldehyde (7.15 g, 24.4 mmol) in THF (28.6 mL) was added at -78 C, and the resulting mixture was stirred for 10 min at the same temperature. The reaction was quenched by addition of water and extracted with EtOAc. The combined organic layers were washed with brine, dried over Na2S04, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography (0 to 50% EtOAc in hexane) to give 9.34 g (94%) of the title compound mixture. NMR (400 MHz, DMSO-d6) delta 8.99 (s, 1 H), 8.94 (d, J = 3.1 Hz, 1 H), 7.23 (d, J = 2.6 Hz, 2H), 6.67 (d, J = 4.6 Hz, 1 H), 6.61 (d, J = 6.9 Hz, 1 H), 6.53 (d, J = 5.5 Hz, 1 H), 6.02 (dd, J = 8.1 , 4.6 Hz, 1 H), 5.74 (s, 1 H), 4.1 1 – 4.04 (m, 1 H), 3.84 – 3.74 (m, 1 H), 3.02 – 2.92 (m, 1 H), 2.73 (d, J = 16.6 Hz, 1 H), 2.37 (s, 2H), 2.36 (s, 1 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 63558-65-6, 4-Chloro-5-iodopyrimidine.

Reference:
Patent; DUFFEY, Matthew O.; ENGLAND, Dylan; FREEZE, Scott; HU, Zhigen; LANGSTON, Steven, P.; MCINTYRE, Charles; MIZUTANI, Hirotake; ONO, Koji; XU, He; (684 pag.)WO2016/4136; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 84905-80-6, Adding some certain compound to certain chemical reactions, such as: 84905-80-6, name is 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine,molecular formula is C6H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84905-80-6.

Example 67 Production of N-[4-(benzyloxy)-3-methoxyphenyl]-5H-pyrrolo[3,2-d]pyrimidin-4-amine A mixture of 4-chloro-5H-pyrrolo[3,2-d]pyrimidine (200 mg), 4-(benzyloxy)-3-methoxyaniline (298 mg) and 1-methyl-2-pyrrolidone (5 mL) was stirred at 80C for 4 hrs. Methanol and activated carbon were added to the reaction mixture and the mixture was stirred. The activated carbon was filtered off, aqueous sodium hydrogen carbonate solution was added and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the obtained residue was purified by silica gel column chromatography (eluent, methanol:ethyl acetate=10:80 ? 20:80) and recrystallized from methanol-ethyl acetate to give the title compound (269 mg) as a pale-gray powder. 1H-NMR (DMSO-d6) delta: 3.82 (3H, s), 5.06 (2H, s), 6.45 (1H, m), 7.03 (1H, d, J= 8.9 Hz), 7.30-7.49 (6H, m), 7.51 (1H, d, J= 2.5 Hz), 7.63 (1H, t, J= 2.9 Hz), 8.30 (1H, s), 9.07 (1H, s), 11.06 (1H, s).

According to the analysis of related databases, 84905-80-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Takeda Pharmaceutical Company Limited; EP1752457; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 120747-84-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.120747-84-4, name is 2-Aminopyrimidine-5-carbaldehyde, molecular formula is C5H5N3O, molecular weight is 123.11, as common compound, the synthetic route is as follows.

To a mixture of 166 mg (1.35 mmol) of aminopyrimidine 67, 17 mg (0.14 mmol) of DMAP and 418 muL (3.00 mmol) OfEt3N in 10 mL of THF was added 589 mg (2.7 mmol) of (BOC)2O. The mixture was stirred at room temperature for 5 h, concentrated-dry loaded on silica gel and flash chromatographed (1-3% acetone/ CH2Cl2) to produce 117 mg (0.36 mmol; 27%) of 68 as a clear oil.

The chemical industry reduces the impact on the environment during synthesis 120747-84-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; SCHERING CORPORATION; WO2008/108957; (2008); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 3680-69-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3680-69-1, name is 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

METHOD L 7-Benzyl-4-chloro-7H-pyrrolo[2,3-d]pyrimidine To a stirred solution of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (250 mg/1.63 mmol) in 12 mL of DMF was added 676 mg (4.89 mmol) of potassium carbonate and the resulting mixture stirred at room temperature for 20 min. Benzylchloride (310 mg/2.45 mmol) was added and the new mixture stirred at room temperature for 24 h then filtered, concentrated and the residue purified by silica gel chromatography (3:1 hexanes/ethyl acetate) affording 318 mg (80%) of the title compound. LRMS: 244.1 (M+1).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 3680-69-1, 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine.

Reference:
Patent; Blumenkopf, Todd A.; Flanagan, Mark E.; Brown, Matthew F.; Changelian, Paul S.; US2002/19526; (2002); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 26305-13-5, Adding some certain compound to certain chemical reactions, such as: 26305-13-5, name is 2,4-Dihydroxy-5,6-dimethylpyrimidine,molecular formula is C6H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26305-13-5.

Step 1 5,6-Dimethyl-2,4-dichloropyrimidine A mixture solution of 5,6-dimethyl-2,4-dihydroxypyrimidine(72 g, 0.51 mol), phosphorous oxychloride(250 ml) and N,N-dimethylaniline(41 ml) was heated to reflux for 3 hours and cooled to room temperature. The reaction mixture was added to ice water and the resulting solid was filtered and recrystallized from dichloromethane to give 58.5 g of the titled compound. (Yield: 64.7%)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 26305-13-5, 2,4-Dihydroxy-5,6-dimethylpyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Yuhan Corporation; US5750531; (1998); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1004-39-3, 4,6-Diaminopyrimidine-2-thiol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1004-39-3, blongs to pyrimidines compound. SDS of cas: 1004-39-3

(R)-N-(2-(5-(4-(1-((4,6-diaminopyrimidin-2-yl)thio)ethyl)-5-methylthiazol-2-yl)-2- methoxyphenoxy)ethyl)methanesulfonamide (10R) and (S)-N-(2-(5-(4-(1-((4,6- diaminopyrimidin-2-yl)thio)ethyl)-5-methylthiazol-2-yl)-2- methoxyphenoxy)ethyl)methane-sulfonamide (10S)A mixture of crude chloride F from previous step and 4,6-diamino-2-mercaptopyrimidine (112 mg, 0.86 mmol) in DMF (5 mL) was stirred at 80 C for 1 h. The solution was cooled, concentrated in vacuo and purified by flash column chromatography over silica gel (25: 1 dichloromethane: methanol) to give the couple of enantiomers 10R and 10S (178 mg, 0.35 mmol, ee 40% of 10R, 61% total yield in two steps) as a white solid. Recrystallization of the enantiomers with MeOHacetone solvent system gave the 10R with >93% ee. NMR (500 MHz, Acetone-d6) delta 7.55 (d, J= 2.0 Hz, 1H), 7.48 (dd, J= 8.5, 2.0 Hz, 1H), 7.06 (d, J= 8.5 Hz, 1H), 6.26 (br s, 1H), 5.60 – 5.55 (m, 4H), 5.37 (s, 1H), 5.30 (q, J= 7.0 Hz, 1H), 4.23 (t, J= 5.5 Hz, 2 H), 3.89 (s, 3H), 3.58 (dt, J= 5.5, 5.5 Hz, 2H), 3.05 (s, 3H), 2.52 (s, 3H), 1.74 (d, J= 7.0 Hz, 3H); 13C NMR (125 MHz, DMSO-d6) delta 168.0, 163.5 (2), 162.9, 153.6, 150.6, 147.8, 126.6, 126.2, 119.5, 1 12.3, 110.4, 79.0, 67.9, 55.7, 41.9, 36.1, 30.7, 22.2, 11.2; HRMS-ESI (m/z) [M+H]+ calcd for C20H26N6O4S3 H, 511.1256; found 51 1.1259; 10R [a]19D = +340.0 (c = 0.12 acetone) (ee = 93%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1004-39-3, its application will become more common.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS; RADU, Caius G.; LI, Zheng; GIPSON, Raymond M.; WANG, Jue; SATYAMURTHY, Nagichettiar; LAVIE, Arnon; MURPHY, Jennifer M.; NATHANSON, David A.; JUNG, Michael E.; WO2015/23776; (2015); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62802-42-0, name is 2-Chloro-5-fluoropyrimidine. A new synthetic method of this compound is introduced below., SDS of cas: 62802-42-0

Part 1: Preparation of 5-fluoropyrimidin-2-amine 2-Chloro-5-fluoropyrimidine (1.34 g, 10 mmol) was stirred with ammonium hydroxide (30%, 15 mL) at 100 C. in a sealed tube overnight. The mixture was cooled to room temperature and filtered. The solid was washed with water and dried to give the title compound (0.95 g, 80%) as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62802-42-0, 2-Chloro-5-fluoropyrimidine.

Reference:
Patent; PTC Therapeutics, Inc.; F. Hoffmann-La Roche AG; Woll, Matthew G.; Chen, Guangming; Choi, Soongyu; Dakka, Amal; Huang, Song; Karp, Gary Mitchell; Lee, Chang-Sun; Li, Chunshi; Narasimhan, Jana; Naryshkin, Nikolai; Paushkin, Sergey; Qi, Hongyan; Turpoff, Anthony A.; Weetall, Marla L.; Welch, Ellen; Yang, Tianle; Zhang, Nanjing; Zhang, Xiaoyan; Zhao, Xin; Pinard, Emmanuel; Ratni, Hasane; (317 pag.)US9617268; (2017); B2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 941685-26-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 941685-26-3, name is 4-Chloro-7-((2-(trimethylsilyl)ethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine. A new synthetic method of this compound is introduced below.

2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethyl-decane (3.5 g, 12.3 mmol) and lithium hydroxide hydrate (5.17) g, 123 mmol) was stirred in a mixture of PDO (20 ml) and water (20 ml) at 100C for 116 hours. The reaction mixture was filtered, the filtrate was acidified with aqueous HCl (1 N, 80 ml), and the resulting solid compound was filtered off, washed with water and dried to give the title product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,941685-26-3, its application will become more common.

Reference:
Patent; LES LABORATOIRES SERVIER; VERNALIS (R&D) LTD; KOTSCHY, ANDRAS; WEBER, CSABA; VASAS, ATTILA; MOLNAR, BALAZS; KISS, ARPAD; MACIAS, ALBA; MURRAY, JAMES BROOKE; LEWKOWICZ, ELODIE; GENESTE, OLIVIER; CHANRION, MAIA; DEMARLES, DIDIER; IVANSCHITZ, LISA; (502 pag.)TW2018/2094; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia