6 Sep 2021 News Some tips on 5018-38-2

According to the analysis of related databases, 5018-38-2, the application of this compound in the production field has become more and more popular.

Reference of 5018-38-2, Adding some certain compound to certain chemical reactions, such as: 5018-38-2, name is 4,6-Dichloro-5-methoxypyrimidine,molecular formula is C5H4Cl2N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5018-38-2.

To a solution of 4,6-dichloro-5-methoxypyrimidine (20.00 g, 1 12 mmol) in DCE (250 mL) at 0 C was added aluminum trichloride (22.35 g, 168 mmol) in two portions. The reaction mixture was stirred at 0 C for 10 min, then at 50 C for 4 hr. The mixture was cooled to 0 C and aqueous HCI (1 M, 120 mL) followed by MeOH (50 mL) were added slowly while stirring vigorously. The mixture was poured into water and extracted with Et20 (3x). The combined organic layers were washed with brine, dried over magnesium sulfate, filtered and concentrated. The residue was dried in vacuum to afford INT 15 as a beige solid. UPLC-MS: MS (ESI): [M-H]” 163.0, rt = 0.44 min. 1 H NMR (DMSO-d6): delta (ppm) 1 1 .69 (s, br, 1 H), 8.38 (s, 1 H).

According to the analysis of related databases, 5018-38-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BRIARD, Emmanuelle; AUBERSON, Yves; CENNI, Bruno; PULZ, Robert Alexander; ANGST, Daniela; (62 pag.)WO2016/79669; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

6 Sep 2021 News Extracurricular laboratory: Synthetic route of 7226-23-5

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7226-23-5, 1,3-Dimethyltetrahydropyrimidin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 7226-23-5, Adding some certain compound to certain chemical reactions, such as: 7226-23-5, name is 1,3-Dimethyltetrahydropyrimidin-2(1H)-one,molecular formula is C6H12N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7226-23-5.

A solution of diisopropylamine (29.2 mL, 0.21 mol) in dry tetrahydrofuran (186 mL) and 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (62 mL) was cooled to -78 C. and then treated with a 2.5M solution of n-butyllithium in hexanes (83.4 mL, 0.21 mol). The yellow-orange reaction mixture was stirred at -78 C. for 35 min and then slowly treated with a solution of 4-(methanesulfonyl)phenyl acetic acid methyl ester (45.35 g, 0.20 mol) in dry tetrahydrofuran (186 mL) and 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone (62 mL). The reaction mixture turned dark in color. The reaction mixture was then stirred at -78 C. for 50 min, at which time, a solution of iodomethylcyclopentane (50.08 g, 0.24 mol) in a small amount of dry tetrahydrofuran was added slowly. The reaction mixture was then stirred at -78 C. for 50 min, and then allowed to warm to 25 C., where it was stirred for 36 h. The reaction mixture was quenched with water (100 mL), and the resulting reaction mixture was concentrated in vacuo to remove tetrahydrofuran. The remaining residue was diluted with ethyl acetate (1.5 L). The organic phase was washed with a saturated aqueous sodium chloride solution (1*500 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Flash chromatography (Merck Silica gel 60, 70-230 mesh, 3/1 hexanes/ethyl acetate) afforded 3-cyclopentyl-2-(4-methanesulfonylphenyl)propionic acid methyl ester (41.79 g, 68%) as a yellow viscous oil: EI-HRMS m/e calcd for C16H22O4S (M+) 310.1239, found 310.1230.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 7226-23-5, 1,3-Dimethyltetrahydropyrimidin-2(1H)-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bizzarro, Fred Thomas; Corbett, Wendy Lea; Grippo, Joseph Francis; Haynes, Nancy-Ellen; Holland, George William; Kester, Robert Francis; Sarabu, Ramakanth; US2001/39344; (2001); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

06/9/2021 News New learning discoveries about 14080-59-2

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 14080-59-2, 4-Chlorothieno[2,3-d]pyrimidine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14080-59-2, name is 4-Chlorothieno[2,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

Under argon atmosphere, 2,4-difluorophenylboronic acid (5.9 g, 35 mmol) was added to a 250 mL round bottom flask.4-chlorothiophene [2,3-d]pyrimidine (5.1 g, 30 mmol),Pd(dppf)Cl2 (440 mg, 0.6 mmol), K2CO3 (5.5 g, 40 mmol),60mL 1,4-dioxane and 20mL water,The mixture was heated at 90 C with stirring for 6 h.Cool to room temperature, quench with water, extract with dichloromethane, and remove the solvent on a rotary evaporator.Purification by column chromatography. A white solid (6.1 g, 82%) was obtained.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 14080-59-2, 4-Chlorothieno[2,3-d]pyrimidine.

Reference:
Patent; Wuhan University; Yang Chuluo; Jiang Bei; Ning Xiaowen; (32 pag.)CN107573386; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

06/9/2021 News The origin of a common compound about 89284-85-5

According to the analysis of related databases, 89284-85-5, the application of this compound in the production field has become more and more popular.

Electric Literature of 89284-85-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 89284-85-5, name is Methyl 2,5,6-trichloropyrimidine-4-carboxylate, molecular formula is C6H3Cl3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 1-((R)-2-amino-propoxy)-3-chloro-propan-2-ol hydrochlorideand 3-((R)-2-amino-propoxy)-2-chloro-propan-1 -ol hydrochloride (10,65 g;52,157 mmol; 100,00 mol%) in 2-propanol (1 56,48 ml; 2046,654 mmol;3924,00 mol%) was added N-ethyldiisopropylamine (26,61 ml; 156,472 mmol;300,00 mol%) and stirred for 5 minutes. 2,5,6-Trichloro-pyrimidine-4-carboxylicacid methyl ester (12,59 g; 52,157 mmol; 100,00 mol%) was added and the reaction mixture was stirred at RT for 14 h. To the reaction mixture was addeddichloromethane and 1 N HCI. The aqueous layer was extracted withdichloromethane. The combined organic layers were dried over sodium sulfate, the solvent removed under vacuo and the residue purified by coloumn chromatography (petroleum benzene I ethyl acetate) to afford the product as as yellow oil (1 0.8g, 52 %); LCMS (method C): 1 .52 mm (purity 94.1%); [MH+] 372.00 mlz.

According to the analysis of related databases, 89284-85-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; BURGDORF, Lars; DORSCH, Dieter; TSAKLAKIDIS, Christos; (189 pag.)WO2017/202748; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

06/9/2021 News Sources of common compounds: 25940-35-6

The synthetic route of 25940-35-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 25940-35-6 , The common heterocyclic compound, 25940-35-6, name is Pyrazolo[1,5-a]pyrimidine-3-carboxylic acid, molecular formula is C7H5N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Thionyl chloride (8.92 mL, 123 mmol) was added to pyrazolo[l,5-a]pyrimidine- 3-carboxylic acid (0.2 g, 1.2 mmol) and the mixture was stirred for 2 h at 80 C. The solvent was then removed under reduced pressure and the material was left on the high-vacuum for 3 h. The material was used without further purification.

The synthetic route of 25940-35-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; LIM, Jongwon; ALTMAN, Michael, D.; CHILDERS, Matthew, L.; GIBEAU, Craig, R.; HO, Ginny Dai; TSUI, Honchung; (80 pag.)WO2016/144844; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

06/9/2021 News The origin of a common compound about 90213-67-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,90213-67-5, 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 90213-67-5, 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, blongs to pyrimidines compound. Quality Control of 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine

A suspension of 2, 4-dichloro-7-methyl-7H-pyrrolo [2, 3-d] pyrimidine (200 mg, 0.99 mmol) , (+/-) -trans-methyl 3-aminobicyclo [2.2.2] octane-2-carboxylate (200 mg, 1.09 mmol) and K2CO3(273 mg, 1.98 mmol) in DMF (10 mL) was stirred at rt overnight. The reaction was quenched with H2O (100 mL) , and the resulting mixture was extracted with ethyl acetate (50 mL × 3) . The combined organic layers were washed with saturated brine (100 mL) , dried over anydrous Na2SO4,filtered, and the filtrate was concentrated in vacuo. The residue was purified by silica gel chromatograph (PE/EtOAc (v/v) = 3/1) to give the tilte compound as a white solid (144 mg, 42 %) .MS (ESI, pos. ion) m/z: 349.1 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,90213-67-5, 2,4-Dichloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (0 pag.)WO2018/157830; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

06/9/2021 News Sources of common compounds: 14080-23-0

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 14080-23-0, 2-Cyanopyrimidine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14080-23-0, name is 2-Cyanopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 14080-23-0

l-(pyrimidin-2-yl)ethenone may be prepared as follows:A solution of pyrimidine-2-carbonitrile (75 g, 713.62 mmol) in THF (750 ml, 10 vol) was added dropwise to a solution of Methylmagnesium bromide (3.0M in diethylether) (357 ml, 1070.44 mmol) in THF (750 ml) at -5C. The resulting yellow suspension/solution was stirred at O0C overnight, and added to a rapidly stirred mixture of saturated ammonium chloride solution (750 ml) and 4M HCl (450 ml) at 5C, then pH adjusted to 1 with additional 2M HCl (5mL). The solution was warmed to 2O0C, stirred for 40 minutes, cooled to 00C then pH adjusted to 6.5-7 by addition of saturated K2CO3 solution (37.5 ml), warmed to 1O0C and separated. The aqueous phase was further extracted into ethyl acetate (5 x 750 ml). Sodium chloride was added to saturate the aqueous phase, which was extracted further into ethyl acetate (750 ml). The pH of the aqueous phase was adjusted to 7-8 by addition of saturated K2CO3 solution, and extracted further with ethyl acetate (3 x 750 ml). The combined organics were washed with saturated brine (750 ml), dried over MgSO4, filtered and concentrated in vacuo to give 78.9g of a brown solid. The crude product was purified by flash silica chromatography, elution in EtOAc. Pure fractions were evaporated to dryness to afford 1- (pyrimidin-2-yl)ethanone (65.Og, 74.6 %) as a yellow crystalline solid. 1H NMR (400.132 MHz, DMSO) delta 2.67 (3H, s), 7.72 (IH, t), 9.02 (2H, d); m/z (M+H)+, 123.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 14080-23-0, 2-Cyanopyrimidine.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/117051; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

06/9/2021 News Extended knowledge of 1193-24-4

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-24-4, its application will become more common.

Application of 1193-24-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1193-24-4 as follows.

A mixture of DMF (64 mL) and POCl3 (200 mL) at 0 C. was stirred for 1 h, treated with 4,6-pyrimidinediol (50.0 g, 446 mmol), and stirred for 0.5 h at rt, and then refluxed for 3 h. The volatiles were removed under reduced pressure, and the residue was poured into ice water and extracted six times with Et2O. The organic phase was washed with satd. aq. NaHCO3 and water, dried over Na2SO4, concentrated, and crystallized (EtOAc-petroleum ether) to give 4,6-dichloro-5-pyrimidinecarbaldehyde; LC-MS (ESI) m/z 177 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1193-24-4, its application will become more common.

Reference:
Patent; AMGEN INC.; US2011/245257; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

06/9/2021 News New learning discoveries about 1005-37-4

The synthetic route of 1005-37-4 has been constantly updated, and we look forward to future research findings.

Electric Literature of 1005-37-4 , The common heterocyclic compound, 1005-37-4, name is 6-Chloro-N4-methylpyrimidine-2,4-diamine, molecular formula is C5H7ClN4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 44 6-(4-aminophenyl)-4-N-methylpyrimidine-2,4-diamine. Tetrakis(triphenylphosphine)palladium (0) (5 mol%) was added to a stirred mixture of 6-chloro-4-N-methylpyrimidine-2,4-diamine (1.0 mmol), 4-(tetramethyl- 1 ,3,2-dioxaborolan-2-yl)aniline (1.3 equiv.), sodium carbonate (3.2 equiv.), 1 ,4- dioxane (4 ml_) and water (1 ml_) in a tube. The tube was sealed and the reaction was heated at 90C for 5 h and then concentrated. The crude material was taken up in ethyl acetate and washed with water. The organic phase was dried over magnesium sulfate, concentrated and purified by flash chromatography (0?15 % MeOH/DCM) to give the title compound. LCMS [M+H]+ 216; 1 H NMR (400 MHz, CDCIs) delta ppm 7.64 (2 H, d, J=8.53 Hz), 6.50 – 6.62 (3 H, m), 6.03 (1 H, s), 5.74 (2 H, s), 5.37 (2 H, s), 2.76 (3 H, d, J=4.77 Hz).

The synthetic route of 1005-37-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; WALLNER, Olov; KOOLMEISTER, Tobias; VALLIN, Karl Sven Axel; HENRIKSSON, Carl Martin; HOMAN, Evert; HELLEDAY, Thomas; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; FISKESUND, Roland Julius Yu; (359 pag.)WO2015/187089; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

06/9/2021 News Some tips on 5751-20-2

With the rapid development of chemical substances, we look forward to future research findings about 5751-20-2.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 5751-20-2

2-Methylsulfanyl- 1 H-pyrimidin-6-one (4.81 g, 33.8 mmol), tert-butyl 4- [[4- [(iS)1-aminoethyllphenyllmethyllpiperazine-1-carboxylate (9.00 g, 28.2 mmol), and DME (56 mL) are split equally into three microwave vessels that are sealed and heated to 120 °C for 4 days. The reaction mixtures are allowed to cool to room temperature, combined, concentrated, and resuspended in CH2C12. The solids are filtered away and the filtrate is adsorbed onto silica gel and chromatographed on silica gel eluting with a gradient of 1- 7percent MeOH/CH2C12 to give the title compound as an off-white solid (10.55 g, 22.45 mmol,88percent purity). ES/MS (mlz): 414 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 5751-20-2.

Reference:
Patent; ELI LILLY AND COMPANY; LUMERAS AMADOR, Wenceslao; BAUER, Renato A.; BOULET, Serge Louis; BURKHOLDER, Timothy Paul; GILMOUR, Raymond; HAHN, Patric James; CARBALLARES MARTIN, Santiago; RANKOVIC, Zoran; (80 pag.)WO2017/213910; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia