At the same time, in my other blogs, there are other synthetic methods of this type of compound,31575-35-6, 2-Fluoropyrimidine, and friends who are interested can also refer to it.
Reference of 31575-35-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 31575-35-6, name is 2-Fluoropyrimidine. A new synthetic method of this compound is introduced below.
To a stirred solution of 1 -[(2E)-3 -(piperidin-4-yl)prop-2-enoyl] -5 ,6-dihydropyridin-2(111)-one TFA salt (100 mg, 0.29 mmol, 1 eq) in ethanol (5 mL) was added DIPEA (0.22 mL,1.28 1 mmol, 4.4 eq) and 2-fluoropyrimidine ( 45 mg, 0.469 mmol, 1.6 eq) and the reaction mixture was allowed to stir at 100C in microwave for 30 minutes. Progress of reaction was monitored by LCMS and TLC. After completion, reaction mixture was concentrated under reduced pressure to yield crude product which further purified by Combi-Flash on silica gelusing ethyl acetate-hexane as eluent to yield 1- { (2E)-3 -[1 -(pyrimidin-2-yl)piperidin-4-yl]prop-2-enoyl}-5,6-dihydropyridin-2(1I])-one (30 mg, 23 %).LCMS: 313 [M+H]1H NMR (400 MHz, CHC13) 5 8.29 (d, 2 H), 6.92 (m, 3 H), 7.00-6.80 (m, 3H), 6.42 (t, 1H), 6.00(d, 1H), 4.80-4.70 (m, 2H), 3.98 (t, 2H), 3.02-2.88 (m, 2H), 2.60-2.39 (m, 3H), 1.90-1.80 (m,2H), 1.63-1.40 (m, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,31575-35-6, 2-Fluoropyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; AURANSA INC.; PROTTER, Andrew, Asher; GREEN, Michael, John; CHANG, Hak, Jin; PHAM, Son, Minh; CHAKRAVARTY, Sarvajit; LUEDTKE, Gregory, R.; (254 pag.)WO2019/103897; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia