Day: September 23, 2021

Adding a certain compound to certain chemical reactions, such as: 815610-16-3, 2-Amino-4-iodopyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 815610-16-3, blongs to pyrimidines compound. Product Details of 815610-16-3

To a solution of 4-iodopyrimidin-2-amine (400 mg, 1.8 MMOL) in THF (10 mL) was added Pd (PPh3) 2CI2 (63 mg, 0.09 MMOL), Cul (34 mg, 0.18 mmol), TMS-acetylene (510 muL, 3.6 MMOL), and TEA (750 SLL, 5.4 MMOL). The mixture was heated to 50C for 1 hr. The solvent was removed in vacuo. THF (8 mL) and MeOH (1 mL) was added to the crude material followed by KF (313 mg, 5.4 MMOL). The material was concentrated and used crude in subsequent reactions

At the same time, in my other blogs, there are other synthetic methods of this type of compound,815610-16-3, 2-Amino-4-iodopyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/16914; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 160199-05-3, name is 2,4-Dichlorobenzo[4,5]thieno[3,2-d]pyrimidine, the common compound, a new synthetic route is introduced below. Formula: C10H4Cl2N2S

4,4,5,5-tetramethyl-2- (naphthalen-2-yl) – (4-methylphenyl) pyridine was added to the starting material 2,4-dichlorobenzo [4,5] thieno [3,2- 1,3,2-dioxaborolane (35 g, 138 mmol), Pd (PPh3) 4 (5.80 g, 5.02 mmol), K2CO3 (52 g, 376.41 mmol), THF (440 ml)The temperature of the reaction was raised to 80 DEG C and stirred for 6 hours. After the completion of the reaction, water was removed from the reaction mixture, and the mixture was filtered under reduced pressure, dried over MgSO 4 and concentrated. The resulting compound was purified by silicagel column and recrystallized19.58 g of the product (yield: 45%) was obtained.

The synthetic route of 160199-05-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Duksan Neolux Co.,Ltd.; Samsung Display Co., Ltd.; Yoon Jin-ho; Cho Hye-min; Park Mu-jin; Lee Jeong-uk; Lee Seon-hui; Kim Tae-gyeong; Lee Yun-gyu; Lee Jeong-seop; (41 pag.)KR2018/133276; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 156-81-0, name is Pyrimidine-2,4-diamine. A new synthetic method of this compound is introduced below., Application In Synthesis of Pyrimidine-2,4-diamine

Reference Example 18 4-Amino-2-(t-butoxycarbonylamino)pyrimidine A 5.52 g portion of 2,4-diaminopyrimidine was added to 150 ml of t-butanol and dissolved by heating to about 60 C., and the solution was cooled to room temperature, mixed with 12.38 g of DIBOC and then stirred at room temperature for about 3 days.. The reaction mixture was evaporated under reduced pressure and the thus formed crude product was purified by a silica gel column chromatography to obtain 7.02 g of the title compound from chloroform-methanol-28% aqueous ammonia (200:9:1, v/v/v) elude as white crystals.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 156-81-0, Pyrimidine-2,4-diamine.

Reference:
Patent; Yamanouchi Pharmaceutical Co. Ltd.; US6673799; (2004); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 60025-09-4, name is 4-Amino-6-chloropyrimidine-5-carbonitrile, the common compound, a new synthetic route is introduced below. COA of Formula: C5H3ClN4

Step 8-14 4-amino-6-(l -(8-methyl- 1 -oxo-2 -phenyl- 1 ,2-dihydropyrrolo[ 1 ,2-a]pyrazin- 3 -yl)ethylamino)pyrimidine-5 -carbonitrile (90) A mixture of 8m (40 mg, 0.15 mmol), 4-amino-6-chloropyrimidine-5-carbonitrile (28 mg, 0.18 mmol) and triethylamine (30 mg, 0.3 mmol) in n-BuOH (1 mL) was reacted under N2 at reflux for 16 hours. The precipitate was collected by filtration, washed with cold n-BuOH and dried to afford Compound 90 as a white solid (38.2 mg, yield: 55%). MS (m/z): 386 (M+H)+. 1H NMR (400 MHz, DMSO-d6) delta: 7.72 (s, 1H), 7.43 (d, / = 7.2 Hz, 1H), 7.41-7.31 (m, 3H), 7.29-7.19 (m, 4H), 7.10 (s, 2H), 6.37 (s, 1H), 4.77-4.69 (m, 1H), 2.38 (s, 3H), 1.26 (d, / = 6.7 Hz, 3H).

The synthetic route of 60025-09-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; HUTCHISON MEDIPHARMA LIMITED; SU, Wei-Guo; DAI, Guangxiu; XIAO, Kun; JIA, Hong; VENABLE, Jennifer Diane; BEMBENEK, Scott Damian; WO2014/15675; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 139756-22-2, 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C17H19ClN4O4S, blongs to pyrimidines compound. Formula: C17H19ClN4O4S

Using the procedure described in Example 1, the reaction solvent and proton scavenger were varied.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,139756-22-2, 4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)benzene-1-sulfonyl chloride, and friends who are interested can also refer to it.

Reference:
Patent; TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC.; WO2005/67936; (2005); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 63200-54-4 ,Some common heterocyclic compound, 63200-54-4, molecular formula is C6H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: 2,4-dichloro-1H-pyrrolo[3,2-d]pyridine (5) was dissolved in a solution of 1:1 THF:DMF underN2. Sodium hydride (60% suspension in oil) was added directly, and the mixture was stirredat room temperature for 1 h. Appropriate halogenated reagent (methanesulfonyl chloride (6),2-nitrobenzenesulfonyl chloride (7), 2,4,6-Triisopropylbenzenesulfonyl chloride (8), benzyl bromide(9), 2,4-dichlorobenzyl bromide (10), 4-methoxybenzyl chloride (11), acetyl chloride (12), isobutyrylchloride (13), diphenylcarbamyl chloride (14), iodoethane (15)) was added and the mixture was stirredat r.t. for 18 h. The solvent was removed and residue dissolved in EtOAc and washed with waterand brine, then dried over MgSO4. Organics were loaded onto Celite and product purified usingsilica column chromatography eluting with 4:1 hexanes:EtOAc or 9:1 DCM:MeOH to obtain product,generally as a white to o-white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,63200-54-4, its application will become more common.

Reference:
Article; Cawrse, Brian M.; Robinson, Nia’mani M.; Lee, Nina C.; Wilson, Gerald M.; Seley-Radtke, Katherine L.; Molecules; vol. 24; 14; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 35808-68-5, 4-Chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 35808-68-5, blongs to pyrimidines compound. Application In Synthesis of 4-Chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine

Step 4. To the solution of 4-chloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine (1.0 g, 5.97 mmol,1.0 eq) and (S)-tert-butyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate (1.32 g, 6.57 mmol,1.1 eq) and PPh3 (3.03 g, 11.94 mmol, 2.0 eq) in THF (50 mL), DIEA (2.08 g, 11.94 mmol,2.0 eq) was added at 00 C. The resulted mixture was stirred and warmed to RT for 12 h.Solvent was removed and purified by column chromatography (eluting with 10 % EtOAc in PE) to afford (S)-tert-butyl 2-((4-chloro-6-methyl-7H-pyrrolo [2,3-d]pyrimidin-7-yl)methyl)pyrrolidine-1-carboxylate as a white solid (2.08 g, 100 % in yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,35808-68-5, its application will become more common.

Reference:
Patent; PRINCIPIA BIOPHARMA INC.; BABLER, Martin; GERRITSEN, Mary E.; WO2014/22569; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55583-59-0, name is 2,5-Diamino-4,6-dichloropyrimidine, the common compound, a new synthetic route is introduced below. Quality Control of 2,5-Diamino-4,6-dichloropyrimidine

Amino derivative 30 (1.05 g, 5.24 mmol), 2,5-diamino-4,6-dichloropyrimidine 17 (1.03 g, 5.76 mmol), and triethylamine (3.1 ml, 22.53 mmol) were suspended in n-butanol (55 ml) and heated to 140 C in a pressure vessel over 48 h. After the reaction was completed, the solvent was evaporated and the residue chromatographed on a silica gel using a linear gradient of ethyl acetate in toluene. The product was obtained in a 56% yield (1.00 g, 2.92 mmol) as a dark orange foam.numax (KBr) 3493 (s), 3405 (s), 3213 (m), 2975 (m), 2934 (m), 2858 (w), 1688 (s), 1617 (s), 1571 (vs), 1502 (m), 1467 (s), 1430 (s), 1442 (s), 1392 (m), 1366 (m), 1308 (w), 1265 (m), 1242 (m), 1174 (m), 1153 (s), 860 (w), 773 (w); deltaH (DMSO, 499.8 MHz, 80 C) 6.06 (1H, br d, JNH-3 7.4 Hz, NH), 3.92 (1H, m, H-3), 5.35 (2H, br s, NH2), 3.82 (1H, m, H-2eq), 3.77 (2H, br s, NH2), 3.63 (1H, m, H-6eq), 2.94-3.01 (2H, m, H-2ax, H-6ax), 1.94 (1H, m, H-4eq), 1.75 (1H, m, H-5eq), 1.51 (1H, m, H-4ax), 1.42 (1H, m, H-5ax), 1.38 (9H, s, (CH3)3); deltaC (DMSO, 125.7 MHz, 80 C) 78.4 (C(CH3)3), 47.7 (C-2), 46.2 (C-3), 43.2 (C-6), 29.6 (C-4), 27.8 (C(CH3)3), 22.9 (C-5); HRMS (ESI) C14H24O2N6Cl (M+H)+ calcd 343.1644, found 343.1645.

The synthetic route of 55583-59-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kova?kova, So?a; Dra?insky, Martin; Rejman, Dominik; Tetrahedron; vol. 67; 7; (2011); p. 1485 – 1500;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 145783-15-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine. A new synthetic method of this compound is introduced below.

Example 1 Synthesis of 2-[((3aR,4S,6R,6aS)-6-[[5-amino-6-chloro-2-(propylthio)pyrimidin-4-yl]amino]-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy]ethanol (Compound I) Take 250mL reaction flask, 4,6-dichloro-2-(propylthio)pyrimidin-5-amine (16.1g, 68mmol), 2-[[(3aR, 4S, 6R, 6aS)-6-amino-2,2-dimethyl-tetrahydro-3aH-cyclopenta[d][1,3]-dioxol-4-yl]oxy]-1-ethanol-dibenzoyl-L-tartaric acid salt (17.3g, 68mmol), N,N-diisopropylethylamine (34.3g, 340mmol) and n-butanol (49mL). The resulting reaction mixture was sealed and heated to 90 ,The temperature was maintained at 35h.Followed by cooling to 30C. The solvent was distilled off. Isopropyl acetate and water, the phases were separated. The aqueous phase was extracted with isopropyl acetate, the combined organic phases, washed. Dried over anhydrous magnesium sulfate. Filter. The solvent was distilled off, give a reddish brown oil. N-heptane was added after a beating, white solid 24.5g, yield 85.8%. HPLC purity was 98.8%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,145783-15-9, its application will become more common.

Reference:
Patent; Qingdao Huanghai Pharmaceutical Co., Ltd.; Zhang, Fuli; Xu, Jianguo; Liu, Xiaohua; Gao, Yongji; He, Xiaoqing; Xu, Taizhi; Hu, Jie; (12 pag.)CN103626745; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4558-59-2, name is 4,6-Dimethoxypyrimidine-5-carbaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4558-59-2

l. 2,6-dimethyl-4-(4′,6′-dimethoxy-5′-pyrimidyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diallyl ester, m.p. 174; from 4,6-dimethoxypyrimidine-5-aldehyde, acetoacetic acid ethyl ester and ammonia.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4558-59-2, 4,6-Dimethoxypyrimidine-5-carbaldehyde.

Reference:
Patent; Bayer Aktiengesellschaft; US4048171; (1977); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia