Day: September 26, 2021

Application of 50270-27-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 50270-27-4 as follows.

To a solution of 2,4,6-trichloropyrimidine-5-carbaldehyde (19.0 g, 990 mmol) in methanol (300 mL) was added drop-wise a solution of hydrazine monohydrate (4.8 mL) in methanol (80 mL) at 0 °C followed by drop-wise addition of triethylamine (13 mL) in methanol (80 mL) at 0 °C. The mixture was stirred at the same temperature for 30 mm. The solvent was removed and the residue was purified by flash chromatography to afford the title compound (10.3 g, 62percent yield) as a yellow solid. ?H NMR (CDC13, 400IVIHz): 11.56 (br, 1H), 8.43 (s, 1H). MS m/z 190.68 [M+1].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,50270-27-4, its application will become more common.

Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; GRAY, Nathanael, S.; HATCHER, John; CHOI, Hwan, Geun; (198 pag.)WO2016/130920; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 3438-46-8, 4-Methylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 3438-46-8, blongs to pyrimidines compound. SDS of cas: 3438-46-8

Procedure G: Intermediate 7 (1-7) – Pyrimidine-4-carboxaldehyde.; [0091] To a solution of 1.0 g (10 mmol, 1.0 eq.) of 4-methylpyrimidine in 10 mL of />-dioxane was added 1.2 g (10 mmol, 1.0 eq.) of selenium dioxide. The resulting mixture was heated at 100 0C for 5 h and then cooled to room temperature. After adding an additional 0.25 g (2.3 mmol, 0.23 eq.) of selenium dioxide, the reaction mixture was heated at 100 0C for a further 1 h. The mixture was cooled to room temperature and filtered through Celite. The Celite cake was washed with 200 mL of ethyl acetate and the filtrate was concentrated in vacuo. The resulting dark brown oil was suspended in 200 mL of methylene chloride and filtered. The solvent was removed in vacuo to afford 0.3 g (2.8 mmol, 28%) of pyrimidine-4-carboxaldehyde (1-7) as dark brown oil.

The synthetic route of 3438-46-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PHARMACOPEIA, INC.; WO2007/104053; (2007); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 29274-22-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29274-22-4, name is Pyrazolo[1,5-a]pyrimidin-5-ol, molecular formula is C6H5N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of 4H-pyrazolo[1,5-a]pyrimidin-5-one (1 g, 7.40 mmol, 1 .00 equiv) in phosphorus oxychloride ( 1 5 mL) was stirred under nitrogen for 2 h at 1 20 C. The reaction mixture was cooled to rt then concentrated under vacuum. The residue was purified on a si lica gel column eluted with ethyl acetate/petroleum ether ( 1 :2) to give 0.6 g (53%) of the title compound as a light yellow solid. LC/MS (Method I, ESI): RT = 1.21 min, m z = 154.0 [Mu+Eta]

According to the analysis of related databases, 29274-22-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH,INC.; FORMA TM, LLC; BAIR, Kenneth W.; BAUMEISTER, Timm R.; BUCKMELTER, Alexandre J.; CLODFELTER, Kanl H.; DRAGOVICH, Peter; HAN, Bingsong; LIN, Jian; LIU, Xiongcai; REYNOLDS, Dominic J.; SMITH, Chase C.; WANG, Zhongguo; YUEN, Po-Wai; ZAK, Mark; ZHANG, Yamin; ZHENG, Xiaozhang; ZHAO, Guiling; WO2013/127268; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 130838-36-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 130838-36-7, name is 2,6-Dichloropyrimidine-4,5-diamine. This compound has unique chemical properties. The synthetic route is as follows.

This compound was synthesized in two steps starting from 2,6-dichloropyrimidine-4,5-diamine 5 (Axon MedChem BV, Groningen, Netherlands), according to the procedure described by Baenteli R.et al. [22]. Briefly, a sealed microwave vial was charged with a solution of 5 (400 mg, 2.25 mmol) in EtC(OEt)3 (8 mL) and heated at 160 C for 1 h. After cooling to RT, Et2O (10 mL) was added and the mixture was placed in an ice bath for 1 h. The intermediate product was filtered off and rinsed with ice-cold Et2O (10 mL). The solid wasadded to a sealed microwave vial charged with a mixture of NMP and t-BuNH2 (10 mL; 1/4 v:v), and the mixture was heated at 160 C for 2 h. After cooling to RT, the reaction mixture was partitioned between a saturated NaHCO3 aqueous solution (10 mL) and EtOAc (10 mL). Layers were separated and the aqueous layer was extractedwith EtOAc (2 20 mL). The combined organic layers were washed with brine (10 mL), dried over MgSO4 and concentrated under vacuum to an oily residue. Purification by flash chromatography (SiO2, DCM/MeOH, 98/2) yielded compound 6a (250 mg, 44%) as a white solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130838-36-7, 2,6-Dichloropyrimidine-4,5-diamine.

Reference:
Article; Daumar, Pierre; Zeglis, Brian M.; Ramos, Nicholas; Divilov, Vadim; Sevak, Kuntal Kumar; Pillarsetty, Nagavarakishore; Lewis, Jason S.; European Journal of Medicinal Chemistry; vol. 86; (2014); p. 769 – 781;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 74901-69-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.74901-69-2, name is 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine, molecular formula is C6H4Cl2N2S, molecular weight is 207.08, as common compound, the synthetic route is as follows.

1.1 (R)-2-(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-ylamino)-3-methylbutan-1-ol (III-1) 7.2 g 2,4-dichloro-6,7-dihydrothieno[3,2-d]pyrimidine (II) are placed in 36 ml dioxane, first 18 ml diisopropylethylamine, then 6.1 g (R)-(-)-2-amino-3-methyl-1-butanol are added. The reaction mixture is heated to 100 C. until there is no further reaction, and after cooling evaporated down. The residue is treated with petroleum ether/ethyl acetate (9:1) in the ultrasound bath and the solid is suction filtered and dried. 8.3 g (III-1) are obtained as a solid. Analytical HPLC (method A): RT=2.75 min

Statistics shows that 74901-69-2 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-6,7-dihydrothieno[3,2-d]pyrimidine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; Nickolaus, Peter; US2013/225609; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 156-81-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 156-81-0, name is Pyrimidine-2,4-diamine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 8a; Synthesis of {4-[2-(5-chloro-2-fluoro-phenyl)-[1,8]naphthyridin-4-ylamino]-pyrimidin-2-yl}-carbamic acid tert-butyl ester (no. 51) 1 g of commercial 2,4-diamino pyrimidine was treated in 40 ml tert.-butanol with 1.5 g BOC2O in the presence of 3.48 ml DIPEA at ambient temperature for 6 hrs. After evaporation, the product was extracted with ethyl acetate from water, dried with Na2SO4, filtered and evaporated to dryness. After digestion with petrolether:ether 3:1 (vol) and drying 849 mg (4-amino-pyrimidin-2-yl)-carbamic acid tert-butyl ester was obtained as a white powder with Rt1.08 min and correct mass of M+H211

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 156-81-0, Pyrimidine-2,4-diamine.

Reference:
Patent; MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG; US2012/316166; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1753-50-0 ,Some common heterocyclic compound, 1753-50-0, molecular formula is C5H2ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of (S)-2-amino-4-(((R)-2-methoxypropyl) (4-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl) butyl)amino) butanoic acid acetate (100 mg, 228 mumol) in 4:1 THF/H2O (2.5 mL) was added solid NaHCO3 (57 mg, 684 mumol) followed by 2-chloropyrimidine-5-carbonitrile (33 mg, 239 mumol). The resulting mixture was stirred at 70 C. for 1 h and then allowed to cool to rt. The mixture was adjusted to pH=6 by the addition of aq. 1 M HCl and then concentrated in vacuo. The resulting crude residue was purified by reverse phase prep-HPLC to give the title compound. LCMS (ESI+): m/z=482.3 (M+H)+. 1H NMR (400 MHz, Methanol-d4) delta ppm 8.48-8.64 (m, 2H) 7.21 (d, J=7.28 Hz, 1H) 6.42 (d, J=7.28 Hz, 1H) 4.41 (dd, J=6.62, 4.85 Hz, 1H) 3.71 (ddd, J=9.26, 6.06, 3.20 Hz, 1H) 3.36-3.41 (m, 2H) 3.32-3.34 (m, 1H) 3.33 (s, 2H) 3.26 (br dd, J=13.78, 6.73 Hz, 1H) 3.02-3.12 (m, 2H) 2.87-3.01 (m, 3H) 2.71 (t, J=6.06 Hz, 2H) 2.59 (br t, J=7.06 Hz, 2H) 2.22-2.32 (m, 1H) 2.06-2.16 (m, 1H) 1.88 (dt, J=11.52, 6.04 Hz, 2H) 1.72 (br s, 4H) 1.17 (d, J=6.17 Hz, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1753-50-0, its application will become more common.

Reference:
Patent; Pliant Therapeutics, Inc.; CHA, Jacob; DONG, Chengguo; HOM, Timothy; JIANG, Lan; LEFTHERIS, Katerina; LI, Hui; MORGANS, JR., David J.; MUNOZ, Manuel; REILLY, Maureen; ZHENG, Yajun; (232 pag.)US2019/276449; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 34289-60-6, name is 4,6-Dimethylpyrimidin-2-ol hydrochloride, the common compound, a new synthetic route is introduced below. COA of Formula: C6H9ClN2O

General procedure: To themixture of 2hydroxy(mercapto)4,6dimethylpyrimidine hydrochloride (0.0375 mol) and corresponding aldehyde (0.075 mol)in 100 mL of ethanol 7.5 mL of concentrated HCl was added.Reaction mixture was heated to reflux for 5 h, then cooled down,and the bright red hydrochloride precipitate was separated byfiltration and washed with acetone. To transform salt into freebase the precipitate was treated with 10% waterethanol solutionof K2CO3. Formed light yellow precipitate was separated byfiltration and dried in air.2Hydroxy4,6bis[2(4methylphenyl)vinyl]pyrimidine (5).Yield 85%, yellow powder, m.p. >250 . Found (%): C, 80.35;H, 6.08; N, 8.42. C22H20N2O. Calculated (%): C, 80.46; H, 6.14;N, 8.53. IR (nujol), nu/cm-1: 3434. 1 NMR (DMSOd6), delta: 3.43(s, 6 , 2 Me); 6.9 (s, 1 H, OH); 7.02 (d, 2 , 2 =, J = 15.3 Hz); 7.21 (s, 1 , pyrimidine); 7.42 (d, 4 , 2 64, J = 7.8 Hz); 7.68(d, 4 , 2 64, J = 7.8 Hz); 7.92 (d, 2 , 2 =, J = 15.3 Hz).

The synthetic route of 34289-60-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Komissarova; Lunegov; Mayorova; Shklyaeva; Abashev; Russian Chemical Bulletin; vol. 65; 9; (2016); p. 2291 – 2298; Izv. Akad. Nauk, Ser. Khim.; 9; (2016); p. 2291 – 2298,8;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 936643-80-0, name is 2-(Chloromethyl)pyrimidine hydrochloride, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(Chloromethyl)pyrimidine hydrochloride

To methyl 2-(3-acetyl-5-hydroxy-1 H-indazol-1 -yl)acetate (1.80 g, 7.25 mmol) in CH3CN (75 mL) was added 2-(chloromethyl)pyrimidine hydrochloride (1.32 g, 7.98 mmol) and Cs2C03 (5.91 g, 18.13 mmol). The reaction mixture was stirred at 70C for 2 h. The reaction mixture was filtered and washed with CH3CN. The solvent was removed under reduced pressure and the crude residue was purified by flash column chromatography on silica gel (c-hexane/EtOAc 1 :1 to 1 :3). TLC, Rf (c-hexane/EtOAc 1 :3) = 0.35; MS (LC/MS): 340.9 [M+H]+, 363.0 [M+Na]+; tR (HPLC conditions e): 3.64 min.

The synthetic route of 936643-80-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; FLOHR, Stefanie; HOMMEL, Ulrich; LORTHIOIS, Edwige, Liliane, Jeanne; MAIBAUM, Juergen, Klaus; OSTERMANN, Nils; RANDL, Stefan, Andreas; VULPETTI, Anna; QUANCARD, Jean; WO2014/2052; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 57489-77-7, 5,7-Dichloropyrazolo[1,5-a]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 57489-77-7, blongs to pyrimidines compound. SDS of cas: 57489-77-7

To 5,7-dichloropyrazolo[l,5-a]pyrimidine (7.6 g, 40.4 mmol) in a sealed vessel was added NH4OH (100 mL). The vessel was then sealed and heated at 85C for 2.5 hours, at which time the consistency of the white solid had changed (from foamy white solid to free- flowing white solid). The vessel was removed from the heat source and allowed to cool to room temperature overnight. On cooling, the contents of the vessel were collected and dried by vacuum filtration giving 5-chloropyrazolo[l,5-a]pyrimidin-7-amine as a yellow-tinged white solid.

The synthetic route of 57489-77-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; MENG, Zhaoyang; REDDY, Panduranga Adulla P.; SIDDIQUI, M. Arshad; WO2012/47570; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia