Day: September 27, 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1211443-61-6, name is 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide. A new synthetic method of this compound is introduced below., SDS of cas: 1211443-61-6

General procedure: tert-butyl (3-((4aminophenyl)sulfonamido)propyl)carbamate (4a, 560mg, 1.70mmol),2-chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (6,497mg, 1.70mmol),Pd(OAc)2 (30mg, 0.1equiv), BINAP (63mg, 0.06equiv), Cs2CO3(1.11g, 3.40mmol) were dissolved in 1,4-dioxane and degassed with argon for 5 min.The resulted mixture was heated to 105 C for 7 h. After monitored by TLC toobserve completion of reaction, the reaction mixture was filtered through Celite aftercooling to 25 C, then the solvents were removed in vacuo. The crude product waspurified by silica gel column chromatography to afford intermediates 7a in 42% yieldaswhite solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1211443-61-6, 2-Chloro-7-cyclopentyl-N,N-dimethyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide.

Reference:
Article; Wang, Xin; Yu, Chenhua; Wang, Cheng; Ma, Yakun; Wang, Tianqi; Li, Yao; Huang, Zhi; Zhou, Manqian; Sun, Peiqing; Zheng, Jianyu; Yang, Shengyong; Fan, Yan; Xiang, Rong; European Journal of Medicinal Chemistry; vol. 181; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 89793-12-4, Ethyl 2-chloropyrimidine-5-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 89793-12-4, blongs to pyrimidines compound. Recommanded Product: 89793-12-4

To a 250 mL single-necked flask equipped with magnetic stirring was added 1,4-dioxane (100 mL) and Compound 1 (10.0 g, 53.59 mmol).Stirring was dissolved, cooled in an ice water bath, and then compound 2 (9.98 g, 53.59 mmol) was added.DIPEA (20.8 mL, 134 mmol) was removed, and the ice bath was removed, and the mixture was stirred at room temperature for 3 hours under a nitrogen atmosphere.The solvent was distilled off under reduced pressure, and silica gel column to give 18.0 g of a white solid, a yield of 99.85%.

The synthetic route of 89793-12-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen Tajirui Bio-pharmaceutical Co., Ltd.; Wang Yihan; Li Huanyin; (47 pag.)CN109970745; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5751-20-2, name is 2-(Methylthio)pyrimidin-4(3H)-one, the common compound, a new synthetic route is introduced below. Safety of 2-(Methylthio)pyrimidin-4(3H)-one

EXAMPLE 8 4-(2-Chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[2-(3,4-dihydro-4-oxo-pyrimidin-2-ylamino)ethoxymethyl]-1,4-dihydropyridine STR32 2-[2-Aminoethoxymethyl]-3-ethoxycarbonyl-4-(2-chlorophenyl)-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine (0.75 g) and 2-methylthio-3H-pyrimid-4-one (0.5 g) were dissolved in ethanol (5 ml) and heated under reflux for 20 hours. The solvent was evaporated and the residue was partitioned between ethyl acetate and water. The organic layer was separated, washed with 2N hydrochloric acid to remove any unreacted amine, and then with dilute sodium hydroxide solution. It was then washed with water, dried, filtered and evaporated to give a yellow gum. Chromatography on silica “Kieselgel 60H” (Trade Mark) eluding with ethyl acetate gave the title compound, which was recrystallized from ethyl acetate, yield 171 mg, m.p. 148°-150°. Analysis percent: Found: C, 57.3; H, 5.55; N, 11.4. Calculated for C24 H27 ClN4 O6: C, 57.3; H, 5.4; N, 11.15.

The synthetic route of 5751-20-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US4572908; (1986); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 7627-44-3, Adding some certain compound to certain chemical reactions, such as: 7627-44-3, name is 2,4-Dichloro-5-(iodomethyl)pyrimidine,molecular formula is C5H3Cl2IN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7627-44-3.

Step 4: Intermediate 4 [00356j A mixture of Intermediate 3 (15.0 g, 47.9 mmol), 3,5-dimethoxyaniline (8.80 g, 57.4 mmol), and K2C03 (14.4 g, 104 mmol) in acetone (150 mL) was stirred at ambient temperature overnight. The solution was cooled in an ice-water bath and filtered to remove the resultant solid. The filtrate was concentrated and the residue was triturated with EtOH (100 mL) then stirred at 0°C for 30 mm. The precipitate was collected by filtration and dried to afford 9.40 g of the title compound. MS mlz: 314.2 (M+Hj. ?H NMR (400 MHz, CDC13): oe 3.73 (s, 6H), 4.22 (br s, 1H), 4.40 (s, 2H), 5.74 (d, 2H), 5.94 (t, 1H), 8.53 (s, 1H).

According to the analysis of related databases, 7627-44-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CELGENE AVILOMICS RESEARCH, INC.; SANOFI; D’AGOSTINO, Laura Akullian; SJIN, Robert Tjin Tham; NIU, Deqiang; MCDONALD, Joseph John; ZHU, Zhendong; LIU, Haibo; MAZDIYASNI, Hormoz; PETTER, Russell C.; SINGH, Juswinder; BARRAGUE, Matthieu; GROSS, Alexandre; MUNSON, Mark; HARVEY, Darren; SCHOLTE, Andrew; MANIAR, Sachin; WO2014/144737; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 157335-93-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 157335-93-8, name is 4,6-Dimethylpyrimidine-5-carboxylic acid, molecular formula is C7H8N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

The deprotected piperidine 1.1 g (5.6 mmol), EDCl hydrochloride (1.6 g), HOBT (1.2 g), diisoproplyethylamine (1.8 g), and 4,6-dimethyl-3-pyrimidine carboxylic acid (1.1 g) were taken up in CH2Cl2 and stirred at rt for 16 h. The solution was diluted with CH2Cl2 and washed with 1 N NaOH(aq.). The aqueous layer was extracted with CH2Cl2. The combined organic layers were dried over Na2SO4. Filtration through Celite and concentration gave 0.94 g (51%) of amide as a foam.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 157335-93-8, 4,6-Dimethylpyrimidine-5-carboxylic acid.

Reference:
Patent; Schering Corporation; US2004/10008; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 4270-27-3 ,Some common heterocyclic compound, 4270-27-3, molecular formula is C4H3ClN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: 6-Chloropyrimidine-2,4(1H, 3H)-dione derivatives 1 (1.0 mmol) and N-hydroxyformimidoyl chloride derivatives 2 (1.2 mmol) were combined and dissolved in methanol (15mL), followed by the addition of triethylamine (3.0 mmol). Subsequently, the reaction mixture was stirred in a round-bottom flask (25mL) at room temperature for 5h. After completion of the reaction as indicated by TLC, the mixture was evaporated by rotary evaporator, extracted with ethyl acetate, dried over Na2SO4, then concentrated and purified by flash column chromatography (PE/EA=5:1) to yield compounds 3a-t.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4270-27-3, 6-Chloropyrimidine-2,4(1H,3H)-dione, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jiang, Kun-Ming; Jin, Yi; Lin, Jun; Tetrahedron; vol. 73; 47; (2017); p. 6662 – 6668;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 1004-40-6 ,Some common heterocyclic compound, 1004-40-6, molecular formula is C4H5N3OS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture of arylidene malonic acids 2a-g (10 mmol), uracil compound 1 (10 mmol) in 15 ml nitrobenzene was stirred at 150oC for 3.0 to 4.5 h. After accomplishment of reaction (observed via TLC), the reaction mixture was cooled to room temperature and extra solvent was evaporated under vacuum. The performed solid was purified by recrystalliza-tion from methanol to afford pyrido[2,3-d]pyrimidines 6 in good yields. 2.1.2.1. 5-(4-hydroxyphenyl)-2-thioxo-2,3-dihydropyrido[2, 3-d]pyrimidine-4,7-dione 6a Yellowish white powder. Yield = 80%. Mp = 216 – 219C. IR (cm-1), 3421 (OH), 3335, 3269, 3189 (3NH), 1671 (C = O amide);1H NMR (500 MHz, DMSO-d6) delta 12.88 (s, 1H, NH exchangeable with D 2 O), 11.87 (s, 1H,NH ex-changeable with D 2 O), 10.62 (s, 1H, NH exchangeable with D 2 O), 8.67 (s, 1H, OH exchangeable with D 2 O), 7.34 (d, J = 9.0 Hz, 2H), 6.80 (d, J = 9.0 Hz, 2H), 6.27 (s, 1H, H3 Pyridine). 13C NMR (125 MHz, DMSO-d6) delta 175.38, 164.67, 157.40, 156.29, 155.85, 153.03, 131.12, 130.17, 114.18, 110.58, 86.48; MS (m/z) = 287, [M+1] = 288; Anal. Calcd for C 13 H 9 N 3 O 3 S: C, 54.35; H, 3.16; N, 14.63. Found: C, 53.87; H, 3.67; N, 15.17.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1004-40-6, 6-Amino-4-hydroxy-2-mercaptopyrimidine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Al-Otaibi, Jamelah S.; Ibrahim, Diaa A.; El Gogary, Tarek M.; Letters in drug design and discovery; vol. 15; 12; (2018); p. 1240 – 1251;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26830-94-4, name is 2,6-Dichloropyrimidine-4-carbonyl chloride. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5HCl3N2O

To a solution of bicyclo[1 .1 .1 ]pentan-1 -amine (1-146) (4 g, 48.2 mmol) in dry THF (300 mL) was added in portions NaH (60% in oil, 5.8 g, 145 mmol) at 0 C under a nitrogen atmosphere. After the addition was completed, the mixture was stirred at 0 C for 30 min. 2,6-dichloropyrimidine-4- carbonyl chloride (1-158) (70% of purity, 21 .8 g, 72.3 mmol) was added dropwise into the reaction mixture. Upon completion of the addition, the reaction mixture was stirred at room temperature for 2 hr. TLC (petroleum ether/EtOAc = 10:1 , Rf ~ 0.6) indicated the reaction was complete. The mixture was quenched by adding AcOH (~40 mL) dropwise at 10 C. The reaction mixture was then filtered off, and washed with EtOAc (100 mL). The filtrate was concentrated. The residue was first neutralized (until no more bubbles formed) with saturated NaHCOs, and then filtered off. The filtrate was extracted with EtOAc (3 x 200 mL). The combined organic layers were washed with brine (2 x 200 mL), dried over Na2S04, and concentrated. The residue was purified by column chromatography on silica gel (petroleum ether to petroleum ether/EtOAc = 300:1 , Rf ~ 0.6 in 10 : 1 petroleum ether/EtOAc) to give N- (bicyclo[1 .1 .1 ]pent-1 -yl)-2,6-dichloropyrimidine-4-carboxamide (1-124) (6.5 g, 47%) as a yellow gum, which was used without further purification.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 26830-94-4, 2,6-Dichloropyrimidine-4-carbonyl chloride.

Reference:
Patent; PFIZER INC.; JOHNSON, Ted William; RICHARDSON, Paul Francis; COLLINS, Michael Raymond; RICHTER, Daniel Tyler; BURKE, Benjamin Joseph; GAJIWALA, Ketan; NINKOVIC, Sacha; LINTON, Maria Angelica; LE, Phuong Thi Quy; HOFFMAN, Jacqui Elizabeth; (335 pag.)WO2016/97918; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 4595-61-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4595-61-3, name is Pyrimidine-5-carboxylic acid, molecular formula is C5H4N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5.115 PYRIMIDINE-5-CARBOXYLIC ACID [2-(2,6-DIOXOPIPERIDIN-3-YL)-1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-4-YLMETHYL]AMIDE A mixture of pyrimidine-5-carboxylic acid (0.25 g, 2.0 mmol) and CDI (0.39 g, 2.4 mmol) in DMF (25 mL) was stirred at ambient temperature under nitrogen for 2 hours. 4-Aminomethyl-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione hydrochloride (0.65 g, 2.0 mmol) and triethylamine (0.61 g, 6.0 mmol) were added, and the mixture was allowed to stir for 16 hours. The solvent was evaporated under vacuum, and the residue was chromatographed using a methylene chloride-methanol gradient, eluting with 95:5 methylene chloride-methanol, providing 0.39 g of the product in 50percent yield: mp >260° C.; 1H NMR (DMSO-d6) delta 2.05-2.10 (m, 1H), 2.53-2.65 (m, 2H), 2.83-2.91 (m, 1H), 4.98 (d, J=5.7 Hz, 2H), 5.18 (dd, J=12.4 Hz, d=5.4 Hz, 1H), 7.84 (s, 3H), 9.24 (s, 2H), 9.35 (s, 1H), 9.52 (t, J=5.7 Hz, 1H), 11.16 (s, 1H); 13C NMR (DMSO-d6) delta 22.0, 30.9, 38.3, 48.9, 122.1, 127.3, 127.5, 131.6, 133.4, 134.9, 138.4, 156.0, 160.1, 163.5, 167.0, 167.5, 169.8, 172.8; Anal. calcd for C19H15N5O5.0.3H2O: C, 57.23; H, 3.94; N, 17.56. Found: C, 57.27; H, 3.71; N, 17.27.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4595-61-3, Pyrimidine-5-carboxylic acid.

Reference:
Patent; Muller, George W.; Chen, Roger Shen-Chu; Man, Hon-Wah; Ruchelman, Alexander L.; US2007/49618; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 7504-94-1, 2-Hydrazinylpyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 7504-94-1, blongs to pyrimidines compound. SDS of cas: 7504-94-1

After adding 53 mg of potassium carbonate, 10 mg of tetrabutylammonium iodide and 53 mg of 2-chloro-N,N-dimethylacetamide to a 1 ml DMF solution containing 100 mg of [2-(2-fluoro-3-hydroxy-5-methoxyphenyl)-2-[4-(5-methyl-[1,2,4]oxadiazol-3-yl)phenylimino]-1-methylsulfanylethylidene]carbamic acid methyl ester (Example (3d)), the mixture was stirred at room temperature for 26 hours and 30 minutes. Ethyl acetate was added to the reaction mixture, PRESEP was used for filtration, and the filtrate was concentrated. The obtained residue was dissolved in 1 ml of DMF, and then 22 mg of 2-hydrazinopyrimidine and 0.046 ml of triethylamine were added to the solution and the mixture was stirred at 85 C. for 12 hours under a nitrogen atmosphere. The reaction mixture was then concentrated. Next, 1 ml of methanol and 0.070 ml of acetic acid were added to dissolve the obtained residue. After then adding 100 mg of sodium cyanotrihydroborate to the solution, it was stirred overnight at room temperature. The reaction mixture was then concentrated. Next, 3 ml of a methanol:water:acetic acid=1:1:1 mixed solvent was added to dissolve the obtained residue. After then adding 121 mg of iron powder to the solution, the mixture was stirred at 60 C. for 13 hours under a nitrogen atmosphere. After filtering the reaction mixture, it was crudely purified by reverse-phase high performance liquid chromatography (acetonitrile-water, 0.1% acetic acid). The obtained crude product was optically resolved using a SUMICHIRAL OA-2500 column, and the first eluting enantiomer (7.60 mg) of the title compound was obtained as a white solid. 1H-NMR (CD3OD) delta 1.91 (s, 3H) 2.96 (s, 3H) 3.08 (s, 3H) 3.69 (s, 3H) 4.87 (s, 2H) 5.95 (s, 1H) 6.57 (dd, J=2.8, 6.8 Hz, 1H) 6.67-6.69 (m, 1H) 6.85 (d J=8.8 Hz, 2H) 7.28-7.30 (m, 1H) 7.60 (d, J=8.8 Hz, 2H) 8.75 (d, J=4.4 Hz, 2H) HPLC retention time: 19 min

The synthetic route of 7504-94-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai R&D Management Co., Ltd.; US2008/15199; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia