Reference of 1005-37-4, Adding some certain compound to certain chemical reactions, such as: 1005-37-4, name is 6-Chloro-N4-methylpyrimidine-2,4-diamine,molecular formula is C5H7ClN4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1005-37-4.
Example 256 tert-butyl 4-{4-[2-am ino-6-(methylamino)pyrimidin-4-yl]-2-(methoxymethyl)phenoxymethyl}piperidine- 1 -carboxylate.mixture of 6-chloro-4-N-methylpyrimidine-2,4-diamine (24 mg, 0.15 mmol), tert15 butyl 4-[4-(dimethoxyboranyl)-2-(methoxymethyl) phenoxymethyl]piperidine- 1-carboxylate (67 mg, 0.17 mmol), potassium carbonate (41 mg, 0.30 mmol) and palladium tetrakis(triphenylphosphine)palladium (0) (9 mg, 0.008 mmol) in 1,4- dioxane (5 mL) and water (1.5 mL) was heated in a sealed tube at 90C overnight. The reaction mixture was concentrated and purified by preparativePLC. LCMS [M+H] 458.
According to the analysis of related databases, 1005-37-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THOMAS HELLEDAYS STIFTELSE FOeR MEDICINSK FORSKNING; SCOBIE, Martin; HELLEDAY, Thomas; KOOLMEISTER, Tobias; JACQUES, Sylvain; DESROSES, Matthieu; JACQUES-CORDONNIER, Marie-Caroline; WO2014/84778; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
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