Synthetic Route of 1209459-80-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1209459-80-2, name is Methyl 6-bromopyrimidine-4-carboxylate. A new synthetic method of this compound is introduced below.
Tripotassium phosphate (2eq) was added in one portion to a stirred solution of 8-chloro-6-(4,4,5,5-tetramethyl- [l,3,2]dioxaborolan-2-yl)-chroman (leq) and methyl 4-bromopyridine-2-carboxylate (2eq) in DMF (lOvol). The mixture was degassed with nitrogen for 5 minutes, after which time Pd(dppf)2C12 (0.2eq) was added in one portion, the mixture was then heated to 60oC and stirred at this temperature for 16 hours under a nitrogen atmosphere. After this time the reaction mixture was cooled to room temperature and partitioned between ethyl acetate (5 vol) and water (5 vol). The organic layer was separated, washed sequentially with water (5vol) then brine (5vol) before being dried (MgS04), filtered andconcentrated. The resulting residue was purified using a Biotage Isolera (lOOg silica column eluting with a gradient from 0% heptane to 80% DCM / 20% heptane) to give the desired compound as a white solid
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1209459-80-2, Methyl 6-bromopyrimidine-4-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; COURTNEY, Stephen Martin; PRIME, Michael; MITCHELL, William; BROWN, Christopher John; DE AGUIAR PENA, Paula C.; JOHNSON, Peter; DOMINGUEZ, Celia; TOLEDO-SHERMAN, Leticia M.; MUNOZ, Ignacio; WO2013/33085; (2013); A1;,
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