Day: March 23, 2022

Application of 1211522-68-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211522-68-7, name is 4,6-Dichloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C6H4Cl2N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

After 4,6-dicMoro-3-memyl-lH-pyrazolo[3,4-d]pyrimidine (300.0 mg, 1.5 mmol) was dissolved in ethanol (10 mL), N,N-disopropylethylarnine (695.0 L, 2.2 mmol) and tert-butyl (R)-3-aminopiperidine-l-carboxylate (355.0 mg, 1.8 mmol) were added thereto. The reaction mixture was stirred at 110 C for 12 hours, and then the organic layer was isolated, treated with magnesium sulfate, filtered and then concentrated under reduced pressure. The residue was isolated by column chromatography to obtain a title compound (414.5 mg, yield: 76.3%). (1398) NMR (500MHz, CD3OD) delta 4.59-4.50(m, 1H), 4.30-4.24(m, 1H), 3.93-3.89(m, 1H), 3.72-3.67(m, 1H), 3.19-3.17(m, 1H), 2.59(s, 3H), 2.10-2.00(m, 1H), 1.88-1.77(m, 2H), 1.63-1.30(m, 10H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211522-68-7, 4,6-Dichloro-3-methyl-1H-pyrazolo[3,4-d]pyrimidine.

Reference:
Patent; DAEWOONG PHARMACEUTICAL CO., LTD.; KIM, In Woo; HAN, Mi Ryeong; YOO, Jakyung; OH, Yun Ju; KIM, Ji Duck; KIM, Nam Youn; JUN, Sun Ah; LEE, Jun Hee; PARK, Joon Seok; (197 pag.)WO2018/4306; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 69385-85-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69385-85-9, name is N-(Piperidin-4-yl)pyrimidin-2-amine, molecular formula is C9H14N4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 14 A mixture of 7.9 g of 3,4-dihydro-2H-1-benzopyran-2-methanol 4-methylbenzenesulfonate(ester), 4.5 g N-(4-piperidinyl)-2-pyrimidinamine, 5.3 g of sodium carbonate and 100 ml of 4-methyl-2-pentanone was stirred overnight at reflux temperature. The reaction mixture was evaporated and the residue was diluted with water. The product was extracted with dichloromethane and the extract was dried, filtered and evaporated. The residue was purified by column chromatography (silica gel; CH2 Cl2 100%). The eluent of the desired fraction was evaporated and the residue was crystallized from acetonitrile. The product was filtered off and dried, yielding 28 g (98.8%) of (+-)-N-[1-[(3,4-dihydro-2H-1-benzopyran-2-yl)methyl]-4-piperidinyl]-2-pyrimidinamine; mp. 141.9 C. (comp. 128).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 69385-85-9, N-(Piperidin-4-yl)pyrimidin-2-amine.

Reference:
Patent; Janssen Pharmaceutica N.V.; US5541180; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 946161-16-6, name is (R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate. This compound has unique chemical properties. The synthetic route is as follows. name: (R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate

50 g 23 in 375 ml. of tetrahydrofurane is hydrogenated in the presence of 5 g Platinum on Carbon (5%) at a hydrogene pressure of 3 bar and at 35 0C until no further hydrogene consumed. 2.5 g vanadyl acetylacetonate are added and the hydrogenation is continued. The suspension is filtered to remove the catalysts. The solvent is removed under reduced pressure. 150 ml. 2-propanol are added to the residue and heated to reflux. 300 ml of demineralised water are added. The suspension is cooled slowly to 2 0C. The suspension is suction filtered and washed with a cold mixture of 2- propanol and demineralised water. After drying in a vacuum drying oven at 500C, 36 g (90% of theory) of product 24 is obtained

With the rapid development of chemical substances, we look forward to future research findings about 946161-16-6.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/19205; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 89792-11-0, 2-Methyl-1H-pyrrolo[2,3-d]pyrimidin-4(7H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 89792-11-0, blongs to pyrimidines compound. Recommanded Product: 89792-11-0

2-Methyl-3H-pyrrolo[2,3-d]pyrimidin-4(7H)-one 23-a (10.54 g, 70.6 mmol) was dissolved in Toluene (20 mL) under inert atmosphere. DIPEA (24 mL, 141 mmol, 2 eq.) and POC13 (19.5 mL, 212 mmol, 3 eq.) were added dropwise at 70C and the mixture was then heated to 106C. After 16 hours, the solution was concentrated in vacuo, extracted with ethyl acetate and washed with saturated NaHCO3 solution. Thecombined organic layers were dried over Na2504, and concentrated in vacuo to yield a grey oil which was suspended in water/heptanes to afford a white solid intermediate 23(5.9 g, 50%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89792-11-0, its application will become more common.

Reference:
Patent; JANSSEN SCIENCES IRELAND UC; TAHRI, Abdellah; VENDEVILLE, Sandrine, Marie, Helene; JONCKERS, Tim, Hugo, Maria; RABOISSON, Pierre, Jean-Marie, Bernard; DEMIN, Samuel, Dominique; HU, Lili; COOYMANS, Ludwig, Paul; (105 pag.)WO2016/91774; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(5-Bromopyrimidin-2-yl)acetonitrile

At room temperature, under a nitrogen atmosphere,(5-bromopyrimidin-2-yl) acetonitrile (150 mg, 0.76 mmol),1-octyne (167 mg, 1.51 mmol),PdCl2 (13 mg, 0.08 mmol),Triphenylphosphine (40 mg, 0.15 mmol),CuI (7 mg, 0.04 mmol),Triethylamine (0.81 ml) and THF (1.8 ml) were added and the mixture was stirred at 40 C. for 3 hours.Thereafter, filtration with celite was carried out, and the filtrate was concentrated under reduced pressure to obtain a crude product. The obtained crude product was purified using thin layer column chromatography (hexane: ethyl acetate = 2: 1) to obtain [5- (1-octynyl) pyrimidin-2-yl] acetonitrile. Yield 138 mg, yield 80%, yellow liquid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 831203-15-7, 2-(5-Bromopyrimidin-2-yl)acetonitrile.

Reference:
Patent; NIPPON STEEL & SUMIKIN CHEMICAL COMPANY LIMITED; KYUSHU INSTITUTE OF TECHNOLOGY; NAGAHAMA, TAKUO; KAWADA, ATSUSHI; TAKASHIMA, WATARU; OKAUCHI, TATSUO; NAGAMATSU, SHUICHI; (69 pag.)JP2017/178911; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 911461-47-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 911461-47-7, name is 4,6-Dichloropyrimidine-5-carboxamide, molecular formula is C5H3Cl2N3O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of amine 21 (650 mg, 3.8 mmol), (4,6-dichloropyrimidin-5-yl)formamide (1.21 g, 5.7 mmol; prepared according to a published procedure25), and DIPEA (2.25 mL, 11.4 mmol) in BuOH (20 mL) washeated in a sealed microwave reactor for 2 h at 140 C. The solvent was removed in vacuo and the residue was purified by column chromatography [silica gel (400 g), EtOAc ? EtOAc-toluene-acetone-EtOH (17:4:3:1)] to give a foam; yield: 669 mg (57%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 911461-47-7, 4,6-Dichloropyrimidine-5-carboxamide.

Reference:
Article; ?ala, Michal; Dejmek, Milan; Prochazkova, Eli?ka; H?ebabecky, Hubert; Ryba?ek, Ji?i; Dra?insky, Martin; Novak, Pavel; Rosenbergova, ?arka; Rosenberg, Ivan; Nencka, Radim; Synthesis; vol. 47; 17; (2015); p. 2654 – 2662;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 42212-19-1, name is 6-Amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below., Safety of 6-Amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione

In a microwave reaction vessel at room temperature 6-amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)dione (217.2 mg, 1.0 mmol) and phenyl isocyanate (142.9 mg, 1.2 mmol) was dissolved in nitrobenzene (1 ml). The reaction mixture was allowed to react for 10 to 20 minutes under microwave conditions at 210 . After completion of the reaction was evaporated under reduced pressure and the reaction mixture transferred to a round bottom flask. Hexane and ethyl acetate was purified by silica gel column chromatography to give the titled compound the reaction mixture concentrated to a 6-amino-3-methyl-2,4-oxo Using -N, diphenyl-1,2,3,4-1- to give a tetra hydro-pyrimidine-5-carboxamide (282.5mg, 84%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 42212-19-1, 6-Amino-3-methyl-1-phenylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Dongguk University Academic Cooperation; Chung-Ang University Academic Cooperation; Kong, Young Dae; Min, Kyung Hoon; Yang, Sung Joo; Song, Ji HO; (38 pag.)KR2016/106837; (2016); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 19808-30-1 , The common heterocyclic compound, 19808-30-1, name is 5-Bromopyrimidin-4(3H)-one, molecular formula is C4H3BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Reference Example 6 5-Bromopyrimidin-4(3H)-one (459 mg) was dissolved in N,N-dimethylformamide (13 mL), then with cooling with ice, sodium hydride (55%, 137 mg) was added, followed by stirring at the same temperature for 30 minutes. Then, 1-(chloromethyl)-4-methoxybenzene (392 muL) was added, followed by stirring at room temperature for 15 hours. Water was added to the reaction mixture, followed by extraction with chloroform. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate = 4:1 to 2:1) to obtain 5-bromo-3-(4-methoxybenzyl)pyrimidin-4(3H)-one (382 mg) as a white solid.

The synthetic route of 19808-30-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; EP1947086; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 375857-62-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 375857-62-8, name is 3-Bromo-7-methylimidazo[1,2-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

Finally, the compound of the formula (I) obtained above (323 mg, 1.0 mmol) was added to a 100 ml Schlenk tube.Then Pd(OAc)2 (purchased from Strem) (11.22 mg, 0.05 mmol) as a catalyst, DavePhos as a ligand was added.(2-Dicyclohexylphosphino-2′-(N,N-dimethylamine)-biphenyl, available from Strem) (39.354 mg, 0.1 mmol) and as a baseCs2CO3 (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) (358.82mg, 1.1mmol), and the Schlenk tubeFill the vacuum line with argon three times. Then, under an argon atmosphere, add to the Schlenk tube.3-bromo-7-methylimidazo[1,2-A]pyrimidine (purchased from Shanghai Bi De Pharmaceutical Technology Co., Ltd.) (233.75 mg, 1.1 mmol), then addedN,N-dimethylacetamide (purchased from TCI (Shanghai) Chemical Industry Development Co., Ltd.) (1.0 ml), and the reaction was stirred at room temperature for 4 hours.After the reaction was completed, the reaction mixture was washed with brine and extracted with ethyl acetate.Dry over sodium sulfate and evaporate to dryness on a rotary evaporator. Finally, it was separated through a silica gel column (eluent: petroleum ether: ethyl acetate: 4:1) to afford the compound of formula 7 as a white solid, yield 78%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 375857-62-8, 3-Bromo-7-methylimidazo[1,2-a]pyrimidine.

Reference:
Patent; University of Science and Technology of China; Xiao Bin; Wang Guofu; Song Haijie; (17 pag.)CN108715593; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 34253-03-7, name is Methyl pyrimidine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Methyl pyrimidine-2-carboxylate

1-[5-(4-Fluoro-benzyl)-3-hydroxy-benzofuran-2-yl]-1-pyrimidin-2-yl-methanone A solution of 5-(4-fluorobenzyl)-benzofuran-3-ol (242 mg, 1 mmol) in THF (10 ml) was cooled and treated dropwise with a solution of lithium bistrimethylsilyl amide in THF (1M) (1.3 ml, 1.3 mmol) with keeping the temperature -65C or below. Then the reaction mixture was warmed gradually to 0C, again cooled to -70C, and treated dropwise with a solution of 2-methoxycarbonylpyrimidine (166 mg, 1.3 mmol) in THF (5 ml). The reaction mixture was warmed gradually and stirred at room temperature for 30 minutes. The reaction mixture was added to an aqueous ammoniumchloride, extracted with ethyl acetate, washed, and dried. The solvent was distilled off, and the residue was washed with ether-chloroform to obtain the title compound (30 mg, 0.09 mmol) as a yellow crystal at the yield of 8.6%. Melting point: 258C dec. Recrystallization solvent: Chloroform-etherNMR(d6-DMSO) delta: 4.08(2H, s), 7.12(2H, t, J=8.7Hz), 7.26-7.36(2H, m), 7.44-7.56(2H, m), 7.68(1H, brs), 7.86-7.92(1H, s),9.20(2H, d, J=5.1Hz).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 34253-03-7, Methyl pyrimidine-2-carboxylate.

Reference:
Patent; SHIONOGI & CO., LTD.; EP1297834; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia