Day: March 23, 2022

Reference of 6960-17-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6960-17-4, name is 2,5-Dimethoxypyrimidin-4-amine, molecular formula is C6H9N3O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To the filtrate was added 1.3 g of 2,5-dimethoxy-4-aminopyrimidine,Reacting at 20 C to 30 C for 5 to 8 hours,HPLC analysis,After completion of the reaction,crystallization,To give yellow crystals of ethyl 4- [4- (2,5-dimethoxypyrimidinyl)] – 3-thiourea,2.3 g, purity 99%Yield of about 92%.

According to the analysis of related databases, 6960-17-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Jiangsu Fuding Chemical co., LTD; LIU, DONG WEI; (6 pag.)CN103739606; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 115932-00-8 , The common heterocyclic compound, 115932-00-8, name is Ethyl pyrazolo[1,5-a]pyrimidine-3-carboxylate, molecular formula is C9H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of pyrazolo [1,5-a] pyrimidine-3-carboxylic acid ethyl ester (3.15 g, 16.4 mmol)In ethanol (50 mL) and water (40 mL)Aqueous potassium hydroxide (2M, 40 mL) was added,The resulting reaction was stirred at 50 C for 2 hours,Cool to room temperature and concentrate under reduced pressure. A 1 M aqueous solution of dilute hydrochloric acid was added to the resulting reaction mixture to adjust to pH = 2. A white solid appeared and was filtered. The filter cake was collected to give the title compound as a white solid (2.6 g, 97%).

The synthetic route of 115932-00-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; (88 pag.)CN104650092; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 40497-30-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 40497-30-1, name is 2-Methylpyrimidine-4,6(1H,5H)-dione. A new synthetic method of this compound is introduced below.

4,6-dichloro-2-methylpyrimidine (1.63 g, 10.0 mmol) prepared based on the method described in Production Example 2A above using 2-methyl-1H-pyrimidine-4,6-dione instead of the 2-ethyl-1H-pyrimidine-4,6-dione, was slowly added to a 2-ethoxyethanol (5.0 mL) solution of 3-aminophenol (1.09 g, 10.0 mmol) and the reaction mixture heated for 4 hours at 130C. The reaction was monitored by thin layer chromatography and, following the end of the reaction, the reaction mixture was cooled to room temperature and the precipitated white powder filtered off. The crude product filtered off was used in the subsequent reaction without further purification (1.76 g, crude yield 75%).1H NMR spectrum (DMSO, 400 MHz), delta : 2.42(3H, s), 6.50(1H, m), 6.73(1H, s), 7.05(1H, m), 7.12(1H, m), 7.19(1H, s), 10.00(1H, s). Mass spectrum (EI), m/z: 234 (M-H+)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,40497-30-1, its application will become more common.

Reference:
Patent; Sankyo Company, Limited; EP1473289; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 87253-62-1, name is 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid

General procedure: In 25ml RB flask to a solution of Compound 9 (200 mg) in dry DMF (5ml), EDCI (250 mg, 1.25eq) and DMAP (130 mg,1eq) were added followed by addition of Sulfonamide (1eq). RM was stirred at RT for 4hrs. Solvent from the reaction mixture was evaporated. To the residue water was added and acidified with 6N HCl, solid precipitated out. Solid was filtered and dried. Crude solid was purified by flash chromatography eluating with 4-8% MeOH/DCM as solvent system to give pure product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 87253-62-1, 5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid.

Reference:
Article; Patil, Vikas; Kale, Manoj; Raichurkar, Anandkumar; Bhaskar, Brahatheeswaran; Prahlad, Dwarakanath; Balganesh, Meenakshi; Nandan, Santosh; Shahul Hameed; Bioorganic and Medicinal Chemistry Letters; vol. 24; 9; (2014); p. 2222 – 2225;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149765-15-1, name is N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 149765-15-1

In a 50 mL round-bottomed flask charged with (2R,3R,4R,5R)-4-(benzyloxy)-5- ((benzyloxy)methyl)-3-fluorotetrahydrofuran-2-ol(0.31 g, 0.94 mmol), N-(4-chloro-7H- pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide (0.26 g, 1.03 mmol) and Ph3P (0.54 g, 2.07 mmol) was added dry THF (5 mL) to give a colorless solution under N2. This was cooled to 0C and then DIAD (0.4 mL, 2.07 mmol) was added dropwise to give a yellow solution. After 20 min, ice- water bath was removed and after stirring for 22 hours, solvent was removed in vacuo. The crude material was purified by Si02 column chromatography eluting from hexanes/EtOAc = 6/1 to 5/1 to 4/1 to afford N-(7-((2R,3R,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-3- fluorotetrahydrofuran-2-yl)-4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)pivalamide (0.22 g, 41%) as a white solid. 1H NMR (400 MHz, CDC13) 58.08 (s, 1H), 7.40 – 7.24 (m, 11H), 6.47 (dd, J = 3.8, 0.4 Hz, 1H), 6.26 (dd, J = 19.6, 1.6 Hz, 1H), 5.59 (ddd, J = 53.2, 4.4, 2.0 Hz, 1H), 4.93 (ddd, J = 19.6, 8.0, 4.4 Hz, 1H), 4.83 (d, J= 11.6 Hz, 1H), 4.75 (d, J = 11.6 Hz, 1H), 4.54 (d, J = 11.6 Hz, 1H), 4.49 (d, J= 12.0 Hz, 1H), 4.37 – 4.34 (m, 1H), 3.85 (dd, J= 10.8, 2.4 Hz, 1H), 3.70 (dd, J = 10.8, 4.8 Hz, 1H), 1.33 (d, J= 0.8 Hz, 9H). HRMS C3oH32ClFN404 [M+H+]; calculated: 567.2096, found 567.2180.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 149765-15-1, N-(4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-yl)-2,2-dimethylpropionamide.

Reference:
Patent; EMORY UNIVERSITY; LIOTTA, Dennis, C.; PAINTER, George, R.; BLUEMLING, Gregory, R.; WO2014/124430; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 274-71-5, name is Pyrazolo[2,3-a]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of Pyrazolo[2,3-a]pyrimidine

To a solution of pyrazolo[1,5-ajpyrimidine (1 g, 8.39 mmol) in acetonitrile (5 mL) was added NBS (1.494 g, 8.39 mmol) and the reaction mixture stirred at room temperature for 8 h. The reaction mixture was concentrated under reduced pressure and the residue purified by silica gel chromatography (0-30% petroleum ether/EtOAc) to afford 3-bromopyrazolo[1,5-ajpyrimidine (1.2 g, 6.06 mmol, 72% yield) as a brown solid. LCMS (ESI) m/e 198.0 [(M+H), calcd for C6H5BrN3198.01; LC/MS retention time (method A2): tR = 1.43 mm.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 274-71-5, Pyrazolo[2,3-a]pyrimidine.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BRONSON, Joanne J.; CHEN, Ling; DITTA, Jonathan L.; DZIERBA, Carolyn Diane; JALAGAM, Prasada Rao; LUO, Guanglin; MACOR, John E.; MAISHAL, Tarun Kumar; NARA, Susheel Jethanand; RAJAMANI, Ramkumar; SISTLA, Ramesh Kumar; THANGAVEL, Soodamani; (318 pag.)WO2017/59080; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 59864-30-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59864-30-1, name is 2,6-Dimethoxypyrimidine-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 39b (278 mg, 0.47 mmol) in DMF (5.0 mL) wereadded 4,6-dimethoxypyrimidine-2-carboxylic acid (103 mg,0.56 mmol), DIPEA (160 muL, 0.93 mmol) and HATU (236 mg,0.62 mmol) in an ice-water bath. After stirring at room temperatureovernight, the mixture was quenched with NaHCO3 aq. and extractedwith CHCl3. The organic layer was washed with brine, dried overMgSO4 and concentrated in vacuo. The residue was purified by columnchromatography on silica gel (CHCl3/MeOH/28% NH3 aq.=100:0:0 to90:9:1). EtOAc/IPE was added to the residue, and the resulting precipitatewas filtered and dried. To the precipitate was added EtOH/EtOAc/MeCN, and the mixture was heated to 100 C. After cooling toroom temperature, the resulting precipitate was filtered and dried togive the product (96 mg, 27%) as a colorless solid. 1H NMR (DMSO-d6):delta 0.90 (3H, t, J = 7.2 Hz), 1.46-1.61 (2H, m), 1.74-1.86 (2H, m), 2.14(3H, s), 2.20-2.58 (11H, m), 2.74-2.85 (2H, m), 3.25-3.39 (2H, m),3.67 (3H, s), 4.03 (6H, s), 6.48 (1H, s), 6.82 (1H, d, J = 8.4 Hz),7.16-7.29 (3H, m), 7.51-7.62 (2H, m), 7.77 (1H, dd, J = 7.9, 1.5 Hz),8.13 (1H, s), 8.74-8.87 (1H, m), 9.14 (1H, br s), 9.27 (1H, s), 10.14(1H, br s); MS (ESI) m/z [M+H]+ 762; Anal. Calcd forC36H47N11O6S·1.7H2O: C, 54.56; H, 6.41; N, 19.44; S, 4.05. Found: C,54.55; H, 6.38; N, 19.45; S, 4.02.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59864-30-1, 2,6-Dimethoxypyrimidine-4-carboxylic acid.

Reference:
Article; Amano, Yasushi; Echizen, Yuka; Hirano, Masaaki; Hisamichi, Hiroyuki; Iikubo, Kazuhiko; Iwai, Yoshinori; Kameda, Minoru; Kawamoto, Yuichiro; Kikuchi, Shigetoshi; Kondoh, Yutaka; Kuriwaki, Ikumi; Moritomo, Hiroyuki; Noda, Atsushi; Suzuki, Tomoyuki; Tateishi, Yukihiro; Tomiyama, Hiroshi; Bioorganic and medicinal chemistry; (2020);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 26893-39-0, 2-Amino-1,4,5,6-tetrahydropyrimidine Hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 26893-39-0, blongs to pyrimidines compound. SDS of cas: 26893-39-0

3.1. 2-(Pyridin-4-yl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one A mixture of 8.98g (46.5 mmol) of ethyl 3-(4-pyridyl)-3-oxopropionate and 8.0g (46.5 mmol) of 2-amino-3,4,5,6-tetrahydropyrimidine dihydrochloride (prepared according to J. Org. Chem. 1955, 20, 829.) and 19.3g (139.5 mmol) of potassium carbonate in 60ml of ethanol was heated at reflux temperature during 18 h. The solution cooled, was evaporated to remove solvent. The residue was treated with water and extracted with dichloromethane. The extracts were dried and evaporated to give 8.0g (75%) of product as a white powder. Mp: 219 ØC.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,26893-39-0, 2-Amino-1,4,5,6-tetrahydropyrimidine Hydrochloride, and friends who are interested can also refer to it.

Reference:
Patent; SANOFI-SYNTHELABO; MITSUBISHI PHARMA CORPORATION; EP1340758; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 85386-14-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.85386-14-7, name is Ethyl 2-phenylpyrimidine-5-carboxylate, molecular formula is C13H12N2O2, molecular weight is 228.25, as common compound, the synthetic route is as follows.

To a solution of ethyl 2-phenylpyrimidine-5-carboxylate (4c) (0.080 g, 0.350 mmol) in ethanol(2 mL) was added hydrazine monohydrate 100% (0.351 g, 7.01 mmol). The reaction mixture was stirred at room temperature for 2 h. Ice was added to the reaction flask and the solid, filtered and washed with cold water. The title compound was obtained as a white amorphous solid in 85% yield.

The chemical industry reduces the impact on the environment during synthesis 85386-14-7, I believe this compound will play a more active role in future production and life.

Reference:
Article; Lopes, Alexandra Basilio; Miguez, Eduardo; Kuemmerle, Arthur Eugen; Rumjanek, Victor Marcos; Fraga, Carlos Alberto Manssour; Barreiro, Eliezer J.; Molecules; vol. 18; 10; (2013); p. 11683 – 11704;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 29509-92-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 29509-92-0, name is 4-Chloro-6-methyl-2-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 2-(4-bromophenyl)-4-chloro-6-methylpyrimidine (8a, 2.27 g) in acetonitrile (20 mL) was added ethanolamine (2.0 mL), and the mixture was stirred at 70 C for 14 h. To the reaction mixture was added additional ethanolamine (4.0 mL) and the mixture was stirred at 85 C for 6.5 h. The reaction mixture was cooled down to room temperature, and evaporated in vacuo. To the resulting residue was added 1 M aqueous sodium hydroxide (40 mL), and extracted with ethyl acetate. The organic layer was dried, and the desiccant was removed by filtration, and then the solvent was evaporated in vacuo. The resulting residue was purified by silica gel column chromatography (chloroform-methanol) to obtain 9a (2.03 g, 82%) as a white amorphous solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 29509-92-0, 4-Chloro-6-methyl-2-phenylpyrimidine.

Reference:
Article; Negoro, Kenji; Yonetoku, Yasuhiro; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 7; (2012); p. 2369 – 2375;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia