Day: March 23, 2022

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29133-99-1, name is 4,6-Dichloro-2,5-diphenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. name: 4,6-Dichloro-2,5-diphenylpyrimidine

General procedure: Intermediate 1-4 (5.0 g, 0.009 mol) in 2-methylpyrimidin-4-ylboronic acid (3.0 g, 0.021 mol), Pd (pph3) 4 (0.5 g, 0.0005 mol), potassium carbonate (2.5 g, into a 110 mL THF to 0.018 mol), on reaction with stirring for 18 hours at 65 It turned on. After the reaction cooled to H20: delamination after column purification (n-Hexane: MC) in MC by Compound 130 to 3.8 g (71%) to give Respectively. Intermediates 33-2 (3.0 g, 0.010 mol) to 4, 6-diphenyl-1, 3, 5-triazin-2-ylboronic acid (3.2 g, 0.012 mol) in the embodiment 1-manufacturing e.g. for inserting and removing (5) the same method used in synthesis of intermediate that is 33-3 3.6g (m/z=497) is obtained (yield 73%)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 29133-99-1, 4,6-Dichloro-2,5-diphenylpyrimidine.

Reference:
Patent; PNH TECH; HYUN, SEO YONG; JUNG, SUNG OUK; LEE, RI NA; (142 pag.)KR2015/124637; (2015); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 831203-15-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile, molecular formula is C6H4BrN3, molecular weight is 198.02, as common compound, the synthetic route is as follows.

To a solution of 2-(5-bromopyrimidin-2-yl)acetonitrile (S2, 1 equiv) in DMF/H2O (9:1, 10 vol) was added compound S1 (1 equiv), K2CO3(2 equiv), and tetrakis(triphenylphosphine)palladium (0.1 equiv). The reaction mixture was stirred at 90 C. for 5 h and then concentrated under reduced pressure. The remaining residue was purified by column chromatography on silica gel to give compound S3.

Statistics shows that 831203-15-7 is playing an increasingly important role. we look forward to future research findings about 2-(5-Bromopyrimidin-2-yl)acetonitrile.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAK, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (905 pag.)WO2017/35353; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 42839-08-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.42839-08-7, name is Ethyl pyrimidine-2-carboxylate, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.

A mixture of ethyl pyrimidin-2-carboxylate (100 gm) and hydrazine hydrate (50 ml in ethanol (500 ml) was stirred at 30 C over a period of 14 h. The suspension was filtered at suction and the wet cake washed with small quantity of ethanol (25 ml) followed by diethyl ether (50 ml) to provide title compound in 80 gm quantity (88%) as a white solid.Mass: m/z: 139.0 (M+l)IH NMR: (400 Mhz, DMSO d6): 4.60 (br s, 2H, exchangeable), 7.64 (t, IH), 8.91 (d, 2H),10.00 (br s, IH, exchangeable)

The chemical industry reduces the impact on the environment during synthesis 42839-08-7, I believe this compound will play a more active role in future production and life.

Reference:
Patent; WOCKHARDT RESEARCH CENTRE; TRIVEDI, Bharat Kalidas; PATEL, Mahesh Vithalbhai; WO2010/136971; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 29458-38-6, 6-Methoxypyrimidine-2,4(1H,3H)-dione, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 6-Methoxypyrimidine-2,4(1H,3H)-dione, blongs to pyrimidines compound. Recommanded Product: 6-Methoxypyrimidine-2,4(1H,3H)-dione

A mixture of 2,4-dihydroxy-6-methoxypyrimidine (15g, 0.106mol) in phosphorus (III) oxychloride (400ml) was heated under reflux for 4 hours to give solution. Excess is phosphorus (III) oxychloride was removed by evaporation, the residue treated with ice/water and extracted with EtOAc. The combined extracts were washed with water, dried (Na2SO4) and the solvent removed by evaporation to give 2,4-dichloro-6-methoxypyrimidine (5.5g, 30%) as an oil. NMR.3.96 (3H, s), 6.63 (IH, s); m/z.179 [MH]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,29458-38-6, 6-Methoxypyrimidine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2008/117051; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1513-69-5, name is 2-Amino-4-hydroxy-6-(trifluoromethyl)pyrimidine, the common compound, a new synthetic route is introduced below. category: pyrimidines

33.4 g (0.186 mol) of 4-hydroxy-6-trifluoromethylpyrimidin-2-ylamine are added in portions (in each case ca. 5 g) to a mixture of 85 ml of phosphorus oxychloride and 47.5 ml of dimethylaniline and the mixture is heated at reflux until the added solid has dissolved. The mixture is then heated at reflux for a further 90 minutes. After cooling, the reaction mixture is added to ice water while observing the safety precautions for phosphorus oxychloride. The aqueous phase is extracted with methylene chloride, the organic phase is separated off and dried with sodium sulfate, and the drying agent is filtered off. Following concentration by evaporation, 47.8 g of a crude mixture are obtained. Following column chromatographic separation with ethyl acetate/heptane as eluent, 8.5 g of 4-chloro-6-trifluoromethylpyrimidin-2-ylamine were obtained (solid, 22% yield, purity 95%).

The synthetic route of 1513-69-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER CROPSCIENCE AG; US2010/167935; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 163263-91-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 163263-91-0 as follows.

To a solution of 2, 4-dichloro-6- (4-methoxyphenyl) pyrimidine (1.01 g, 3.92 mmol) and (+/-) -trans-methyl 3-aminobicyclo [2.2.2] octane-2-carboxylate (1.02 g, 5.56 mmol) in N, N-dimethylformamide (20 mL) was added potassium carbonate (0.81 g, 5.88 mmol) . The mixture was stirred at 50 overnight. To the reaction mixture was added water (70 mL) , and the resulting mixture was extracted with ethyl acetate (100 mL × 3) . The combined organic layers were washed with saturated brine (100 mL) , dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo and the residue was purified by silica gel column chromatography (n-hexane/EtOAc (v/v) =20/1-5/1) to give the title compound as a white solid (1.01 g, 64%) .MS-ESI: (ESI, pos. ion) m/z: 402.2 [M+H]+;1H NMR (400 MHz, CDCl3) delta (ppm) : 7.98 (d, J = 8.7 Hz, 2H) , 6.98 (d, J = 8.9 Hz, 2H) , 6.72 (s, 1H) , 5.46 (d, J = 6.3 Hz, 1H) , 4.32 (s, 1H) , 3.88 (s, 4H) , 3.74 (s, 3H) , 2.39 (d, J = 5.1 Hz, 1H) , 2.08 (s, 1H) , 1.90-1.84 (m, 1H) , 1.78-1.71 (m, 2H) , 1.70-1.63 (m, 4H) , 1.58 (d, J = 10.2 Hz, 2H) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,163263-91-0, its application will become more common.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; TANG, Changhua; REN, Qingyun; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (0 pag.)WO2018/157830; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 199678-12-1 , The common heterocyclic compound, 199678-12-1, name is 4-Pyrimidin-2-yl-benzoic acid, molecular formula is C11H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of compound 3 (2g, lOmmol), EDCI (2.3g, l2mmol), HOBT(1 .4g, 1 Ommol), DIEA (2. 6g, 2Ommol) and N,O-dimethylhydroxylamine hydrochloride(1.2g, l2mmol) in DCM, stirred at RT for 2h. Water was added and extracted withDCM. The extracts were concentrated to give 2.5g of compound 4.

The synthetic route of 199678-12-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FORGE LIFE SCIENCE, LLC; REMISZEWSKI, Stacy; KOYUNCU, Emre; SUN, Qun; CHIANG, Lillian; (98 pag.)WO2016/77232; (2016); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 31462-58-5, name is 5-Iodopyrimidine. A new synthetic method of this compound is introduced below., Formula: C4H3IN2

General procedure: Ir[dF(CF3)ppy]2(dtbpy))PF6(5.6 mg, 4.99 mumol) was added to a stirred solution of aryl iodide (1.00 mmol), iminodimethyl-lambda6-sulfanone (102 mg, 1.10 mmol), 4,4′-di-tert-butyl-2,2′-bipyridine (20 mg, 0.07 mmol), TEA (0.279 mL, 2.00 mmol) and NiCl2(glyme) (11 mg, 0.05 mmol) in acetonitrile (5.6 mL). The resulting mixture was irradiated with a blue LED (450 nm, Penn Optical Photoreactor m1) and stirred at 29 C for 16 hours. The reaction mixture was quenched with saturated aqueous NaHCO3(2 mL) and extracted with EtOAc. The organic layer was dried over MgSO4, filtered, and concentrated under reduced pressure.The resulting residue was purified by flash silica chromatography to afford the corresponding products.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 31462-58-5, 5-Iodopyrimidine.

Reference:
Article; Hande, Sudhir; Mfuh, Adelphe; Throner, Scott; Wu, Ye; Ye, Qing; Zheng, XiaoLan; Tetrahedron Letters; vol. 60; 41; (2019);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 38275-42-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 38275-42-2, name is 5-Chloro-2-(methylthio)pyrimidine. A new synthetic method of this compound is introduced below.

EXAMPLE 7 2-(Chloromethyl)thio-5-chloropyrimidine 2-Methylthio-5-chloropyrimidine (75 mmol) and sulfuryl chloride (104 mmol) were heated together in refluxing dichloromethane (100 ml) for 3 h. Evaporation of the mixture left a solid which was recrystallized from ethanol; yield 82%, m.p. 78 C. 1 H NMR (CDCl3): 5.20 (SCH2), 8.54 (H-4, H-6).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38275-42-2, 5-Chloro-2-(methylthio)pyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Nyegaard & Co. A/S; US4423047; (1983); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 1211522-68-7 ,Some common heterocyclic compound, 1211522-68-7, molecular formula is C6H4Cl2N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of ethanol (0.227 g, 4.93 mmol) in THF (60 mL) was added sodium hydride inice bath. After stirred for 20 mm, 4, 6-dichloro-3-methyl-1H-pyrazolo [3,4-d]pyrimidine (1 g,4.93 mmol) was added. The mixture was gradually allowed to room temperature and stirredovernight at room temperature. The mixture was then diluted with water (20 mL),concentrated to remove solvent and diluted with ethyl acetate (220 mL). The organic layerwas washed with water (60 mLx 2), dried over Na2SO4, filtered and concentrated. The crudeproduct (900 mg, 86% yield) was directly used into next step.LCMS: 213[M+H]. tR=2.775 (LCMS condition 1)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1211522-68-7, its application will become more common.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DING, Xiao; LIU, Qian; LONG, Kai; SANG, Yingxia; STASI, Luigi Piero; WAN, Zehong; XU, Qiongfeng; EDGE, Colin Michael; WO2015/113451; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia