Day: March 23, 2022

Related Products of 32998-03-1 , The common heterocyclic compound, 32998-03-1, name is 2,6-Dichloro-N-methylpyrimidin-4-amine, molecular formula is C5H5Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

EXAMPLE 5 2,6-bis-(2–Hydroxyethyl)methylamino-4-methylaminopyrimidine (V) A mixture of 2,6-dichloro-4-methylamino-pyrimidine (III, EXAMPLE 1, 1.78 g) and 2-(methylamino)ethanol (IV, 25 ml) is heated under reflux for about 18 hours, then is allowed to cool and is diluted with ethyl acetate (100 ml). The mixture is washed with aqueous potassium bicarbonate (0.5N), water (4*25 ml) and with saline (50 ml). The aqueous phases are backwashed with ethyl acetate. The organic extracts are combined, dried and concentrated to give the title compound, NMR (CDCl3) 4.82, 3.8, 3.68, 3.11, 3.00 and 2.84delta; CMR (CDCl3) 164.0, 161.76, 71.16, 63.08, 62.47, 52.64, 36.91, 36.49 and 28.35delta.

The synthetic route of 32998-03-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; The Upjohn Company; US5502187; (1996); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 7254-29-7, 2-Amino-5-nitropyrimidin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Amino-5-nitropyrimidin-4(1H)-one, blongs to pyrimidines compound. Quality Control of 2-Amino-5-nitropyrimidin-4(1H)-one

Step 2-Synthesis of 6-chloro-5-nitro-1,6-dihydropyrimidin-2-amine A suspension mixture of 2-amino-5-nitro-3,4-dihydropyrimidin-4-one (1.5 g, 9.61 mmol) and phosphorus oxychloride (27 mL, 0.29 mol) was heated under reflux (100 C.) for 18 hr. The reaction mixture turned into a yellow solution. The mixture was cooled to RT before being concentrated in vacuo. DCM (10 mL) was added and concentrated in vacuo was repeated. Ice (ca 5 g) was added, resulted in a sticky solid. DCM (20 mL) was added and the mixture was quenched by addition to an ice-cold saturated aqueous NaHCO3 solution (150 mL). The pH of mixture was adjusted to basic by final addition of 2M aq K2CO3. Attempt to extract product with DCM resulted in emulsion formation. Emulsion was removed by suction filtration. The aqueous layer was extracted with EtOAc (3*50 mL). The EtOAc extracts were combined with the DCM extract, dried over Na2SO4, filtered and concentrated in vacuo to afford the title compound as a yellow powder: 1H NMR (500 MHz, DMSO) delta 8.40-8.48 (2H, m), 9.02 (1H, s). LC-MS: m/z=+174.9 (M+H)+.

The synthetic route of 7254-29-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Genentech, Inc.; US2012/214762; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 911461-47-7, 4,6-Dichloropyrimidine-5-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C5H3Cl2N3O, blongs to pyrimidines compound. HPLC of Formula: C5H3Cl2N3O

The compound 4,6-dichloropyrimidine-5-carboxamide (1.65 g, 8.6 mmol) was dissolved in methanol (30 mL) and then treated withSodium methoxide (1.15 g, 21.3 mmol) was added thereto, and the mixture was heated to 40 C and the reaction was stirred for 12 hours. Then, the mixedThe material was filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (pure EtOAc) to give the title compound asWhite solid (1.30 g, 83%).

The synthetic route of 911461-47-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Liang; Wu Zuping; Feng Xuejin; Wu Yanjun; (154 pag.)CN104513235; (2017); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 42839-08-7, Ethyl pyrimidine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H8N2O2, blongs to pyrimidines compound. Formula: C7H8N2O2

Step-1: Pyrimidin-2-carboxylic acid hydrazide A mixture of ethyl pyrimidin-2-carboxylate (100 gm) and hydrazine hydrate (50 ml in ethanol (500 ml) was stirred at 30 C. over a period of 14 h. The suspension was filtered at suction and the wet cake washed with small quantity of ethanol (25 ml) followed by diethyl ether (50 ml) to provide title compound in 80 gm quantity (88%) as a white solid. Mass: m/z: 139.0 (M+1) 1H NMR: (400 Mhz, DMSO d6): 4.60 (br s, 2H, exchangeable), 7.64 (t, 1H), 8.91 (d, 2H), 10.00 (br s, 1H, exchangeable)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,42839-08-7, Ethyl pyrimidine-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Trivedi, Bharat Kalidas; Patel, Mahesh Vithalbhai; US2012/142710; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.4214-85-1, name is 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, molecular formula is C5H6N4O3, molecular weight is 170.13, as common compound, the synthetic route is as follows.Formula: C5H6N4O3

(E)-iV.H/V-Dimethyl-Lambdarf-(4-methyl-5-nitro-6-oxo-l,6-dihydropyrimidin-2- yl)formimidamideTo a suspension of 2-Amino-6-methyl-5-nitropyrimidin-4(3H)-one (54.8 g, 0.32 mol) in CH2Cl2 (461 mL) was added DMF-dimethylacetal (103.1 mL, 0.77 mol) and stirred at room temperature for 1.5 h. The reaction mixture was filtered, washed with CH2Cl2, and used for the next step without further purification (31.9 g, 44% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4214-85-1, 2-Amino-6-methyl-5-nitro-3H-pyrimidin-4-one, and friends who are interested can also refer to it.

Reference:
Patent; VALEANT RESEARCH & DEVELOPMENT; WO2006/122003; (2006); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 108-53-2, 2-Aminopyrimidin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 108-53-2, blongs to pyrimidines compound. Recommanded Product: 2-Aminopyrimidin-4(1H)-one

The synthetic route of this comparative example is as follows:Isocytosine (4g) and phosphorus oxybromide (10g) were mixed well at room temperature,The reaction was stirred at 80 C for 2 hours,Then slowly warmed to 135 ,The reaction was held at 135 C until the reaction was complete.The reaction was cooled to 0 C and the pH was adjusted to 12 and 1 g of product was filtered off (16% yield).Elemental analysis showed that the yellow solid could be identified as 2-amino-4-bromopyrimidine. c

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-53-2, its application will become more common.

Reference:
Patent; Shanghai Zaiqi Biological Co., Ltd.; Wang Zhiguo; Song Yanhong; Ma Xiujuan; Tian Beibei; Li Shijiang; Li Chao; Li Qiang; Li Tao; (5 pag.)CN106632077; (2017); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 163263-91-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.163263-91-0, name is 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine, molecular formula is C11H8Cl2N2O, molecular weight is 255.1, as common compound, the synthetic route is as follows.

2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine (1.01 g, 3.92 mmol)And (+/-)-trans-3-aminobicyclo[2.2.2]octane-2-carboxylic acid methyl ester (1.02 g, 5.88 mmol)Dissolved in DMF (20 mL), then added potassium carbonate (0.81 g, 5.88 mmol).The reaction solution was stirred at 50 C overnight, and water (70 mL) was added.After dilution, extract with ethyl acetate (100 mL × 3).The combined organic phases were washed with brine (150 mL)Dry over anhydrous sodium sulfate, filter,The filtrate was concentrated under reduced pressure to dryness.The residue was purified by EtOAc EtOAc EtOAc (EtOAc)The title compound is white solid(1.01 g, 64%).

Statistics shows that 163263-91-0 is playing an increasingly important role. we look forward to future research findings about 2,4-Dichloro-6-(4-methoxyphenyl)pyrimidine.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Tang Changhua; Yin Junjun; Yi Kai; Lei Yibo; Wang Yejun; Zhang Yingjun; (138 pag.)CN108276401; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 34253-03-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 34253-03-7, name is Methyl pyrimidine-2-carboxylate. A new synthetic method of this compound is introduced below.

To a solution of 19D (0.35 g, 1.25 mmol) and 5L (0.173 g, 1.25 mmol) in THF (7 mL) was added sodium methoxide (0.135 g, 2.50 mmol). After stirring at room temperature under argon for one hour, the resultant dark yellow mixture was pored into a saturated solution of ammonium chloride. The mixture was extracted three times with ethyl acetate. The organic extract was dried over sodium sulfate, filtered and concentrated to give a dark brown sticky solid. This material was triturated with toluene and white solids precipitated. The solid was collected by filtration to give 19R. 1H NMR (400 MHz, DMSO) delta9.07-9.05 (d×d, j=1.0 Hz, 4.9 Hz, 2 H), 7.87 (m, 4 H), 7.74-7.71 (t, j=4.9 Hz, 1H). 7.56 (s, 1H) 7.48 (m, 2H), 7.38 (s, 1H), 6.29-6.28 (t, j=2.1 Hz, 2H), 5.44 (s, 4H). ES MS M + 1 = 387.1560.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,34253-03-7, Methyl pyrimidine-2-carboxylate, and friends who are interested can also refer to it.

Reference:
Patent; Payne, Linda S.; Tran, Lekhanh O.; Zhuang, Linghang H.; Young, Steven D.; Egbertson, Melissa S.; Wai, John S.; Embrey, Mark W.; Fisher, Thorsten E.; Guare, James P.; Langford, H. Marie; Melamed, Jeffrey Y.; Clark, David L.; US2003/229079; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1122-47-0, 4-Amino-1-methylpyrimidin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1122-47-0, blongs to pyrimidines compound. Computed Properties of C5H7N3O

To a water solution (5 mL) of 1-Methylcytosine (1-Mecyt) (0.025 g, 0.2 mmol) was added dropwise and under stirring, an aqueous solution of BaCl2·2H2O (0.049 g, 0.2 mmol) at 60 C.The colorless mixture was left to evaporate and afforded colorless crystals within 2-3 days, upon very slow evaporation at room temperature. Yield: 65%; IR (KBr, nu/cm-1): 3421, 3326,3245, 3155 (O-H), 2911 (C-H), 1665, 1632, 1630, 1570 (C=O). Anal. Calcd for C5H9N3O2Cl2Ba(350.91 g mol-1): C, 17.09; H, 2.58; N, 11.96%. Found C, 17.89; H, 2.92; N, 10.99%. Compound 2 was prepared following the same synthetic protocol as for 1 using an aqueous solution(5 mL) of BaBr2·2H2O (0.067 g, 0.2 mmol). Yield: 65%; IR (KBr, nu/cm-1): 3420, 3321, 3236, 3149(O-H), 2907 (C-H), 1670, 1639, 1622, 1569 (C=O). Anal. Calcd for C5H9N3O2Br2Ba (440.28 gmol-1): C, 13.64; H, 2.06; N, 9.54%. Found C, 13.24; H, 2.50; N, 9.05%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1122-47-0, its application will become more common.

Reference:
Article; Marino, Nadia; Bruno, Rosaria; Armentano, Donatella; De Munno, Giovanni; Journal of Coordination Chemistry; vol. 71; 6; (2018); p. 828 – 844;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 63155-11-3, Ethyl 2-(pyrimidin-2-yl)acetate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C8H10N2O2, blongs to pyrimidines compound. HPLC of Formula: C8H10N2O2

Reference Production Example 12 1.97 g of a compound of the formula (24-i), 1.84 g of ethyl (2-pyrimidinyl) acetate, 4.08 g of sodium ethoxide (20% ethanol solution) and 35 ml of ethanol were mixed. The mixture was stirred for 6 hours under reflux with heating. The reaction mixture was allowed to cool to room temperature, the, to the reaction mixture were added ice and 6 ml of 1.71 mol/L hydrochloric acid sequentially, and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, then, mostly concentrated under reduced pressure. The resultant solid was collected by filtration, and the solid was dried under reduced pressure, to obtain 1.63 g of 5-(4-chlorophenyl)-6-methyl-4-(2-pyrimidinyl)-2H-pyridazin-3 -one. 1H-NMR (CDCl3 + DMSO-d6, TMS) delta (ppm): 2.13 (3 H, s), 7.07 (2 H, d, J=8.8 Hz), 7.13 (1 H, t, J=5.1 Hz), 7.23 (2 H, d, J=8.8 Hz), 8.66 (2 H, d, J=5.1 Hz), 12.00 (1 H, br s)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,63155-11-3, Ethyl 2-(pyrimidin-2-yl)acetate, and friends who are interested can also refer to it.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP1958946; (2008); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia