Day: March 24, 2022

Related Products of 15846-19-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 15846-19-2 as follows.

Prepared as described for N-cyclohexyl-4-iodopyridin-3-amine (Intermediate 17), to a stirred solution of 4-chloro-6-meth.oxypyrimidin-5-amine (CAS 15846-19-2; 0.15 g, 0.940 mmol) and cyclohexanone (CAS 108-94-1; 0.294 nil, 2.82 mmol) in anhydrous DCM (5 mL) under an atmosphere of nitrogen at 0 C was added T1CI4 solution (lM in DCM, 3.66 mL, 3.66 mmol). The reaction was stirred at room temperature for 2 h. Sodium triacetoxyborohydride (1.94 g, 9.15 mmol) was added portionwise and the reaction stirred at room temperature for 16 h. The crude product was purified by column chromatography (silica, 0-20% EtOAc / petroleum ether) to afford the title compound.MS ES+: 242

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15846-19-2, its application will become more common.

Reference:
Patent; DAVENPORT Richard; DUNN Jonathan; FARNABY William; HANNAH Duncan; HARRISON David; WRIGHT Susanne; WO2015/198046; A1; (2015);,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(5-Bromopyrimidin-2-yl)acetonitrile

General procedure: The title compound of this step was prepared by the method described in Example 1, Step 3,2- (5-bromopyrimidin-2-yl) acetonitrile (0.724 g, 3.66 mmol), 4-chloro-2-fluorophenylboronic acid (0.829 g, 4.75 mmol)Potassium carbonate (1.517 g, 10.98 mmol),Tetrakis (triphenylphosphine) palladium (0.338 g, 0.292 mmol)In toluene (15 mL) with nitrogen at 100 C for 15 hours.The crude product was directly purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / V) = 5/1)The compound (orange solid, 563 g, 62.2%)

With the rapid development of chemical substances, we look forward to future research findings about 831203-15-7.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Wei Dehuo; Xue Yaping; Zhang Yingjun; (44 pag.)CN106674207; (2017); A;,
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Reference of 5807-14-7, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5807-14-7, name is 2,3,4,6,7,8-Hexahydro-1H-pyrimido[1,2-a]pyrimidine, molecular formula is C7H13N3, molecular weight is 139.1982, as common compound, the synthetic route is as follows.

[0119] Red solid benzyl potassium (9.6 g, 73.3 mmol) was added into the solution of 1.5.7-triaza[4.4.0]bicyclo-dec-5-ene (10.2 g, 73.3 mmol) in 350 ml of dry toluene at -40 C. The temperature was allowed to warm to room temperature and the mixture stirred for 16 hours. The colour changed via red to a white slurry. The solvents were removed in a vacuum, the product washed with 3×60 ml of ether and dried in a vacuum to obtain 10.1 g (78%) of white powder. 1H-NMR in THF-d8; delta: 3.17 (t, 4H); 2.98 (t, 4H); 1.69 (t, 4H). The potassium salt product could not be analysed with MS. Elemental analysis calc.: C 47.4%, H 6.8%, N 23.7%, K 22.1%. Elemental analysis found: C 46.0%, H 6.4%, N 23.1%.

Statistics shows that 5807-14-7 is playing an increasingly important role. we look forward to future research findings about 2,3,4,6,7,8-Hexahydro-1H-pyrimido[1,2-a]pyrimidine.

Reference:
Patent; Andell, Ove; Maaranen, Janne; Hoikka, Jouni; Vanne, Tiina; Rautio, Soile; US2003/225275; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 42839-08-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 42839-08-7, name is Ethyl pyrimidine-2-carboxylate. This compound has unique chemical properties. The synthetic route is as follows.

Mg (0.48 g, 20 mmol) was added to a round-bottomed flask dried at room temperature and I2 (0.2 g) and THF (60 mL) were added under a nitrogen stream.After cooling to 01-Bromo-4-chlorobenzene (3.82 g, 20 mmol) was added slowly and the solution was stirred at room temperature for 2 hours.After cooling to 0 Ethyl pyrimidine-2-carboxylate (1.52 g, 10 mmol)Was dissolved in THF (30 mL) and slowly added to the above solution for 1 h and stirred for 2 h.After completion of the reaction, the reaction mixture was extracted with NH4Cl and ethyl acetate. The organic layer was dried over Na2SO4, concentrated under reduced pressure, and purified by column chromatography (EtOAc / Hexane)The target compound, bis(4-chlorophenyl) (pyrimidin-2-yl) methanol (1.88 g, yield 57%).

According to the analysis of related databases, 42839-08-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Doosan Co., Ltd; Lee Yong-hwan; Kim Hoe-mun; (62 pag.)KR2019/33218; (2019); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 147539-23-9 , The common heterocyclic compound, 147539-23-9, name is 1-Boc-4-(6-Chloro-5-nitro-4-pyrimidinyl)piperazine, molecular formula is C13H18ClN5O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

61b) 4-[6-(2-Cyano-ethylamino)-5-nitro-pyrimidin-4-yl]piperazine-1-carboxylic acid t-butyl ester; [] 4-(6-Chloro-5-nitro-pyrimidin-4-yl)piperazine-1-carboxylic acid t-butyl ester (3.0 g) was dissolved in acetonitrile (30 mL), and then 3-aminopropionitrile (0.71 mL) and triethylamine (1.58 mL) were added to this solution. After stirring the reaction solution at room temperature for 14 hours, water (60 mL) was added. The reaction solution was stirred at room temperature for 30 minutes, and then the precipitate was collected by filtration. The obtained yellow solid was washed with water and hexane to give the title compound (1.97 g).

The synthetic route of 147539-23-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Eisai Co., Ltd.; EP1568699; (2005); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87026-45-7, name is 4-Chloro-5-methoxy-2-(methylthio)pyrimidine, the common compound, a new synthetic route is introduced below. name: 4-Chloro-5-methoxy-2-(methylthio)pyrimidine

Step A: 4-F5- (5-METHOXY-2-METHYLSULFANYL-PVRIMIDIN-4-V -THIOPHEN-2-YL]-2-METHYL-BUTAN-2-OL A solution OF 2-METHYL-4-THIOPHEN-2-YL-BUTAN-2-OL (340 mg, 2 mmol)-synthesis see Step A of Example 1-in 20 ml of THF was treated with LDA (2M in THF/HEPTANE/ETHYLBENZENE, 5 ML, 10 mmol) at-78 C under nitrogen and the mixture was stirred for 5 minutes. Then, trimethylborate (1.1 ml, 10 mmol) was added in one portion and the cooling bath was removed. After 15 minutes, the mixture was quenched with 50 ml of saturated ammonium chloride solution and extracted twice with ether. The aqueous layer was then acidified with 2N-HCI and extracted once more with ether. The combined organic extracts were washed with brine and evaporated. This crude boronic acid was redissolved in 10 ml of DME and added to a stirred suspension 4-chloro-5-methoxy-2-methylsulfanyl-pyrimidine (190 mg, 1 mmol), Pd (PPH3) 4 (23 mg, 0.02 mmol), 20 ml of DME and 3 ml of a 10% solution of sodium bicarbonate. This mixture was then kept at reflux (100 C heat bath) for 90 minutes. After cooling, most of the DME was evaporated and the crude was partitioned between water and ether. The organic layer was separated, washed with 0. 2N-HCI, water and brine, dried over sodium sulfate and evaporated. The crude was purified by chromatography on silicagel (EtOAc/hexane: 1/1) to give 4- [5- (5- METHOXY-2-METHYLSULFANYL-PYRIMIDIN-4-YL)-THIOPHEN-2-YL]-2-METHYL-BUTAN-2-OL. Yield: 275 mg (85%).

The synthetic route of 87026-45-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMHBH; WO2004/89913; (2004); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 60703-46-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 60703-46-0 as follows.

EXAMPLE 5 Preparation of 2-morpholino-5-methoxy-4,6-dichloropyrimidine 150 parts by volume of benzene, 34 parts of 5-methoxy-2,4,6-trichloro-pyrimidine and 17.7 parts of N-methyl-morpholine are introduced into a reactor. The mixture is heated under reflux for 3 hours, then filtered and the solution is evaporated. The residue obtained is recrystallized from ethanol. 30 parts of 2-morpholino-5-methoxy-4,6-dichloro-pyrimidine of melting point 116C are thus obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,60703-46-0, its application will become more common.

Reference:
Patent; Societe Generale de Recherches et d’Applications Scientifiques “Sogeras”; US3984411; (1976); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 60703-46-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 60703-46-0, name is 2,4,6-Trichloro-5-methoxypyrimidine, molecular formula is C5H3Cl3N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under an atmosphere of nitrogen a solution of 2,4,6-trichloro-5-methoxy-pyrimidine (4.0 g, 18.7 mmol) in DCM (200 mL) was cooled to 0 C. and treated with boron tribromide (6.6 mL, 65 mmol) dropwise. After stirring for 18 hours at RT the reaction mixture was cooled and diluted with methanol (25 mL, CARE, EXOTHERM.) and the reaction mixture diluted with water (200 mL). The aqueous layer was extracted with DCM and the combined organic extracts dried (Na2SO4) and concentrated in vacuo to give 2,4,6-Trichloro-5-hydroxy-pyrimidine as a pale tan solid (2.55 g, 71%). 13C NMR (DMSO-d6): 149.23 (C), 145.25 (C), 145.08 (C). LCMS (Method C): RT=2.65/2.77. [M-H]+ 197/199.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 60703-46-0, 2,4,6-Trichloro-5-methoxypyrimidine.

Reference:
Patent; Genentech, Inc.; Heald, Robert Andrew; McLean, Neville James; US2014/65136; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 56621-91-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56621-91-1, name is 5-Amino-2-bromopyrimidine. A new synthetic method of this compound is introduced below.

To a stirred solution of compound 2-bromopyrimidin-5-amine (950 mg, 5.46 mmol), 3-((fert- butoxycarbonyl)amino)propanoic acid (1.54 g, 8.14 mmol) in DCM (25 mL) was added TEA (3.02 mL, 21.84 mmol) and T3P (3.47 g, 10.92 mmol) at 0 C and the reaction mixture was stirred at rt for 24 h. The mixture was diluted with DCM and washed with sat NaHCOs, the separated organic layer was dried over anhydrous feSCk The organic layer was concentrated under reduced pressure and the obtained crude compound was purified by flash column chromatography using 45 % of ethyl acetate in pet ether as an eluent to obtain the title compound (900 mg, 47%). (0705) LC-MS (method 1): R. = 1.19 min; m/z = 344.82 (M+H++2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56621-91-1, its application will become more common.

Reference:
Patent; ORYZON GENOMICS, S.A.; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; SALAS SOLANA, Jorge; (129 pag.)WO2018/219478; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 199678-12-1 ,Some common heterocyclic compound, 199678-12-1, molecular formula is C11H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Under an argon atmosphere, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (1.87 g, 9.76 mmol) and dimethylaminopyridine (2.48 g, 20.3 mmol) were added to a solution of compound 18 (2.00 g, 8.13 mmol) and 4-pyrimidin-2-ylbenzoic acid (2.00 g, 10.0 mmol) in dehydrated N,N-dimethylformamide (30 mL) at 0 C. The reaction mixture was left to stand overnight, then poured into ice water and stirred for 0.5 h at 0 C. The precipitate was collected by filtration and dissolved in ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated to afford 2.80 g (88%) of the title compound as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta 9.14 (t, J = 5.6 Hz, 1H), 8.94 (d, J = 4.8 Hz, 2H), 8.49 (d, J = 8.8 Hz, 2H), 8.17 (dd, J = 9.2, 2.8 Hz, 1H), 8.07-8.04 (m, 3H), 7.49 (t, J = 4.8 Hz, 1H), 7.22 (d, J = 8.8 Hz, 1H), 4.52 (d, J = 5.6 Hz, 2H), 4.14 (t, J = 6.4 Hz, 2H), 1.84 – 1.75 (m, 2H), 1.01 (t, J = 7.4 Hz, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 199678-12-1, 4-Pyrimidin-2-yl-benzoic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Ohashi, Masao; Gamo, Kanae; Tanaka, Yuta; Waki, Minoru; Beniyama, Yoko; Matsuno, Kenji; Wada, Jun; Tenta, Masafumi; Eguchi, Jun; Makishima, Makoto; Matsuura, Nobuyasu; Oyama, Takuji; Miyachi, Hiroyuki; European Journal of Medicinal Chemistry; vol. 90; (2015); p. 53 – 67;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia