Day: March 24, 2022

Reference of 946161-16-6 ,Some common heterocyclic compound, 946161-16-6, molecular formula is C12H17ClN4O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 3 (7R)-2-Chloro-7-ethyl-8-isopropyl-5,7-dihydropteridin-6-one; Methyl (2R)-2-[(2-chloro-5-nitro-pyrimidin-4-yl)-isopropyl-amino]butanoate 22b (7.30 g, 23 mmol) was dissolved in 100 mL acetic acid followed by the addition of 5 g Raney nickel, repeated filled with hydrogen for three times. The reaction mixture was heated to 75C, stirred for 2 hours and filtered. The filtrate was concentrated under reduced pressure, added with 30 mL of ice water resulting in the formation of precipitate. The precipitate was filtered the filter cake was dried by heat to obtain the crude title compound (7R)-2-chloro-7-ethyl-8-isopropyl-5,7-dihydropteridin-6-one 22c (12.10 g, yield: 71.7%) as a gray solid, which was used in the next step without further furification. MS m/z (ESI): 255.1 [M+1]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 946161-16-6, (R)-Methyl 2-((2-chloro-5-nitropyrimidin-4-yl)(isopropyl)amino)butanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Hengrui Medicine Co., Ltd.; Shanghai Hengrui Pharmaceutical Co. Ltd.; EP2481739; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 1260682-15-2 ,Some common heterocyclic compound, 1260682-15-2, molecular formula is C5H3Cl3N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate AN(1)2,4-dichloro-6-(l-phenylvinyl)pyrimidin-5-yl)methanolA mixture of 2,4,6-trichloropyrimidin-5-yl)methanol (1.1 g), 1 -phenylvinylboronic acid (0.8 g), Tetrakis (0.3 g), sodium carbonate (1.64 g) in toluene (14 mL) and water (3 mL) was heated at 100 C for 12 h. Water was added followed by ethyl acetate, the aqueous layer was extracted with ethyl acetate (x3), and the combined organic layers were dried over anhydrous sodium sulfate and then filtered. The filtrate was concentrated, and the residue was purified Biotage eluting with 10-40% EtOAc/Hexanes to give the title compound as a white solid (325 mg). LC-MS (M+H)+ = 281.02. XH NMR (500 MHz, chloroform-i/) delta ppm 7.5 (5H, m), 6.01 (1H, s), 5.67 (1H, s), 4.62 (2H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1260682-15-2, (2,4,6-Trichloropyrimidin-5-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BOY, Kenneth M.; GUERNON, Jason M.; MACOR, John E.; OLSON, Richard E.; SHI, Jianliang; THOMPSON, Lorin A., III.; WU, Yong-Jin; XU, Li; ZHANG, Yunhui; ZUEV, Dmitry S.; WO2012/103297; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 13053-88-8, N-(Pyrimidin-2-yl)acetamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H7N3O, blongs to pyrimidines compound. COA of Formula: C6H7N3O

A solution of 2-ampy (0.15 g, 1.59 mmol) in ethanol (10 cm3)was added to a solution of Na2PdCl4 (0.234 g, 0.796 mmol) inmethanol (10 cm3). The mixture was stirred at room temperaturefor 2 h. The yellow solid thus formed was filtered off, washed withmethanol and dried under vacuum 3: Yellow solid, 95%. Anal. Calc. for C12H14N6O2PdCl2: C, 31.9; H,3.1; N, 18.6. Found: C, 32.0; H, 3.4; N, 18.3%. IR: 3267m, 3227m,3078m, 2925m, 1693s, 1517m, 516m, 355m cm1. 1H NMR(DMSO-d6): d 10.55 (s, 2H, NH), 8.63 (d, 1H, pym-H), 7.15 (t, 1H,pym-H), 2.16 (s, 2H, CH3) ppm, 3J(HH) = 4.8 Hz. Melting point:234-236 C.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13053-88-8, N-(Pyrimidin-2-yl)acetamide, and friends who are interested can also refer to it.

Reference:
Article; Al-Jibori, Subhi A.; Al-Jibori, Qusay K.A.; Schmidt, Harry; Merzweiler, Kurt; Wagner, Christoph; Hogarth, Graeme; Inorganica Chimica Acta; vol. 402; (2013); p. 69 – 74;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 675-11-6, name is 4,6-Difluoropyrimidin-2-amine, the common compound, a new synthetic route is introduced below. Computed Properties of C4H3F2N3

EXAMPLE 3 Preparation of 2-amino-4-fluoro-6-propyloxypyrimidine (Variant A) STR11 29 4 g (0.3 mol) of potassium propylate were reacted as in Example 1 with 39.3 g (0.3 mol) of 2-amino-4,6-difluoropyrimidine in a total of 400 ml of n-propanol. The solvent was removed from the reaction mixture under reduced pressure, and the residue was washed with petroleum ether. It was subsequently stirred in water, filtered off, washed and dried, resulting in 36.1 g (70% of theory) of the title compound of melting point 63-66 C.

The synthetic route of 675-11-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF Aktiengesellschaft; US5011927; (1991); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 206564-00-3, 4-(2-Furyl)pyrimidin-2-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 206564-00-3, blongs to pyrimidines compound. COA of Formula: C8H7N3O

General procedure: The mixture of 8 (1.0 equiv) and 2-amino-pyrimidine derivatives 4-6 (1.0 equiv) in toluene was heated to reflux. Along with the azeotrope of ethanol and toluene was distilled out of the reaction system continuously, a small amount of fresh toluene was added if necessary. Heating was stopped until the complete consumption of 8 which was indicated by TLC. After the reaction mixture was cooled to room temperature, the forming precipitate was collected by suction filtration and washed with small amounts of toluene and ethyl acetate to afford desired compounds 9-11. They could be further purified on silica gel column chromatography (eluted by acetone with petroleum ether).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,206564-00-3, its application will become more common.

Reference:
Article; Chen, Wei; Li, Yuxin; Zhou, Yunyun; Ma, Yi; Li, Zhengming; Chinese Chemical Letters; vol. 30; 12; (2019); p. 2160 – 2162;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Synthetic Route of 70227-50-8 ,Some common heterocyclic compound, 70227-50-8, molecular formula is C8H10ClN3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of compound 270.1 (1 g, 4.6 mmol, WO2006065703) in MeOH (3 ml) was added triethylamine (1 ml, 2 eq) in a sealed tube and stirred at 80 C for 2 hr. After completion of the starting material (by TLC), the reaction mixture was cooled to room temperature and evaporated under reduced pressure. The crude material was diluted with water (15 ml) and extracted with EtOAc (2×15 ml). The combined organic layers was washed with brine solution and dried over Na2SO^ The solvent was evaporated under reduced pressure to afford compound 270.2 (700 mg, 71%) as yellowish oil. 1H-NMR (CDCl3, 200 MHz): delta 9.12 (s, 1H), 4.18 (s, 1H), 1.41 (s, 9H). LCMS m/z = 212 [M+l].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,70227-50-8, its application will become more common.

Reference:
Patent; BIOGEN IDEC MA INC.; SUNESIS PHARMACEUTICALS, INC.; CHUAQUI, Claudio; COSSROW, Jennifer; DOWLING, James; GUAN, Bing; HOEMANN, Michael; ISHCHENKO, Alexey; JONES, John, Howard; KABIGTING, Lori; KUMARAVEL, Gnanasambandam; PENG, Hairuo; POWELL, Noel; RAIMUNDO, Brian; TANAKA, Hiroko; VAN VLOTEN, Kurt; VESSELS, Jeffrey; XIN, Zhili; WO2010/78408; (2010); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 99420-75-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 99420-75-4, name is 5-Methylpyrimidine-2-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of 5-methylpyrimidine-2-carboxylic acid (1 g, 7.24 mmol) in DMF (72.4 mL) was added N,O-dimethylhydroxylamine hydrochloride (0.777 g, 7.96 mmol). The mixture was cooled to 0 C and 1 -propanephosphonic acid cyclic anhydride (50 wt. % solution in EtOAc, 9.21 mL, 14.48 mmol) was added droppwise. The mixture was then allowed to warm to RT overnight. LCMS indicated complete conversion to product. The mixture was then diluted with water, extracted with CHC13 :IPA (3:1) and washed with brine, and a saturated aqueous NaHCO3 solution. The mixture was then dried over Na2 SO4, concentrated in vacuo, and purified by silica gelchromato graph (0-100% Heptanes :EtOAc) providing N-methoxy-N,5-dimethylpyrimidine-2-carboxamide (0.7 g, 3.86 mmol, 53.4 % yield). 1H NMR (500 MHz, CDC13) oe 8.61 – 8.69 (m, 2 H) 3.61 – 3.79 (m, 3 H) 3.27 – 3.47 (m, 3 H) 2.34 – 2.45 (m, 3 H). LCMS-ESI (pos.) m/z: 182.2 (M+H)t

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 99420-75-4, 5-Methylpyrimidine-2-carboxylic acid.

Reference:
Patent; AMGEN INC.; BROWN, Matthew; CHEN, Ning; CHEN, Xiaoqi; CHEN, Yinhong; CHENG, Alan C.; CONNORS, Richard V.; DEIGNAN, Jeffrey; DRANSFIELD, Paul John; DU, Xiaohui; FU, Zice; HARVEY, James S.; HEATH, Julie Anne; HEUMANN, Lars V.; HOUZE, Jonathan; KAYSER, Frank; KHAKOO, Aarif Yusuf; KOPECKY, David J.; LAI, Su-Jen; MA, Zhihua; MEDINA, Julio C.; MIHALIC, Jeffrey T.; OLSON, Steven H.; PATTAROPONG, Vatee; SWAMINATH, Gayathri; WANG, Xiaodong; WANSKA, Malgorzata; YEH, Wen-Chen; (815 pag.)WO2018/97944; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 83942-10-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 83942-10-3 as follows.

EXAMPLE 1 Synthesis of 5-Chloro-4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}-6-methylpyrimidine (Compound No. 12) 1.6 g of 4,5-dichloro-6-methylpyrimidine was dissolved in 50 ml of toluene. 1.0 g of triethylamine and 2.2 g of 2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamine were added to the solution, and the reaction mixture was heated under reflux for 5 hours, whilst stirring. At the end of this time, the reaction mixture was washed with water and dried over anhydrous sodium sulfate. The toluene was removed by distillation under reduced pressure, and the oily product thus obtained was subjected to column chromatography (Wakogel C-200, eluted with a 2:1 by volume mixture of toluene and ethyl acetate) to isolate the product. The crystals thus obtained were recrystallized from hexane to afford 2.6 g of the title compound as colorless needles melting at 57-58 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,83942-10-3, its application will become more common.

Reference:
Patent; Sankyo Company Limited; UBE Industries Limited; US4845097; (1989); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 313339-35-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 313339-35-4, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid. A new synthetic method of this compound is introduced below.

To a solution of 4,6-dichloro-2-methylsulfanylpyrimidine-5-carboxylic acid (5.5 mmol) indioxane (10 mL) are added diphenyl phosphoryl azide (6.6 mmol), triethylamine (6.6 mmol)and allyl alcohol (11 mmol) at room temperature under N2 atmosphere. After stirring at .100 C for 1 h, the reaction mixture is cooled to room temperature and diluted with AcOEt.The organic layer is washed twice with HaO and evaporated in vacua. The resulting residueis purified by silica gel column chromatography to give (4,6-dichloro-2-methylsulfanyl-pyrimidin-5-yl)carbamic acid allyl ester.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,313339-35-4, 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2006/18284; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 434941-55-6, 4-(4-Chlorophenyl)-2-(methylthio)pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines

Step 2: At 0C, mCPBA (70% w/w; 483 mg, 2.02 mmol, 2.2 eq) is added portionwise to intermediate 19 (217 mg, 0.92 mmol, 1.0 eq) in DCM (5 mL). The reaction is stirred at r.t. for 2 h and the solid is filtered and washed with DCM. The organics is washed with saturated aqueous solution of NaHC03 and dried over anhydrous Na2S04. The solvent evaporated under reduced pressure to afford intermediate 20. LC-MS conditions: LC-MS 5

The synthetic route of 434941-55-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; CIANA, Claire-Lise; SIEGRIST, Romain; WO2014/72903; (2014); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia