Day: March 25, 2022

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1192711-71-9, name is 2,4-Dichloro-6-methyl-7H-pyrrolo[2,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C7H5Cl2N3

General procedure: A mixture of 2,4-dichloro-7H-pyrrolo[2,3-d]pyrimidine 18a (51.3 g) and 1.36 L of 1 N NaOH was stirred at 80 C overnight. The solution was subsequently chilled and adjusted to pH 6 with AcOH. The resulting precipitate was collected, washed with water and dried to afford 19a as solid (37.3 g, yield: 80.7%).

The synthetic route of 1192711-71-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Xie, Hui; Zeng, Lili; Zeng, Shaogao; Lu, Xin; Zhang, Guicheng; Zhao, Xin; Cheng, Na; Tu, Zhengchao; Li, Zhiyuan; Xu, Hongjiang; Yang, Ling; Zhang, Xiquan; Huang, Min; Zhao, Junling; Hu, Wenhui; European Journal of Medicinal Chemistry; vol. 52; (2012); p. 205 – 212;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 554-01-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 554-01-8, name is 5-Methylcytosine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: The basic system used in the study consisted of 0.1mM XBQ dissolved in acetonitrile (final acetonitrile concentration in the reaction mixture, 2%), 1.0mM H2O2, and 2.0mM 5mdC in 10mM phosphate buffer (pH 7.4) at 37C for 1h unless otherwise stated. The phosphate buffer used for all experiments was pretreated with Chelex-100 ion-exchange resin (Bio-Rad Laboratories, Hercules, CA, USA; 5g/L) overnight to remove trace transition metals probably present in phosphate buffer as contaminants. The reaction solutions were directly injected into an HPLC/triple-quadrupole mass spectrometry (HPLC-MS/MS) system for analysis.

According to the analysis of related databases, 554-01-8, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shao, Jie; Huang, Chun-Hua; Kalyanaraman, Balaraman; Zhu, Ben-Zhan; Free Radical Biology and Medicine; vol. 60; (2013); p. 177 – 182;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5270-94-0, name is 4,6-Dimethoxypyrimidine, molecular formula is C6H8N2O2, molecular weight is 140.14, as common compound, the synthetic route is as follows.HPLC of Formula: C6H8N2O2

B. Preparation of 5-bromo-4,6-dimethoxypyrimidine To the solution of 4,6-dimethoxypyrimidine (5 g, 35.7 mmol) in HOAc (20 mL) at room temperature under argon was added Ac2O (4.6 g, 44.6 mmol). The resulting solution was heated at 100 C. for 10 min and then NBS (7.9 g, 44.6 mmol) was added. Heating was continued at 100 C. for 5 h. Analysis by HPLC/MS indicated that the reaction was complete. After the reaction mixture was cooled to room temperature, water (50 mL) was added. The resulting precipitate was collected by filtration and further washed with water (15 mL*3), then dried under vacuum. The title compound (7.5 g) was obtained as a white solid. 1H NMR (CDCl3): delta 4.05 (s, 6H), 8.32 (s, 1H). 13C NMR (CDCl3): delta 55.2, 89.0, 154.9, 166.8.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5270-94-0, 4,6-Dimethoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; Wu, Gang; Mikkilineni, Amarendra B.; Sher, Philip M.; Murugesan, Natesan; Gu, Zhengxiang; US2006/287341; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31462-58-5, name is 5-Iodopyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Iodopyrimidine

General procedure: To 3-{2-[(tert-butyldimethylsilyl)oxy]ethyl}-13-{4-[5-chloro-2-(lH-l,2,3-triazol- 1 -yl)phenyl]-6-oxo- 1 ,2,3,6-tetrahydropyridin- 1 -yl} -9-methyl-3,4,7, 15-tetraazatricyclo [12.3.1.02’6]octadeca-l(18),2(6),4,14,16-pentaen-8-one was added MeOH (0.7 ml) and cone. HC1 (0.05 ml, 0.60 mmol) and the reaction was stirred for 10 min. The crude product was purified by reverse phase preparative HPLC to yield 13-{4-[5-chloro-2-(lH- 1,2,3-triazol- l-yl)phenyl]-6-oxo- 1,2,3, 6-tetrahydropyridin-l-yl}-3-(2-hydroxyethyl)-9- methyl-3 ,4,7, 15 -tetraazatricyclo[ 12.3.1.02’6] octadeca- 1 ( 18),2(6),4, 14, 16-pentaen-8-one as a white solid (6 mg, 8.22 muiotaetaomicron, 22.2% yield). NMR (500MHz, CD3OD) delta 8.76 – 8.70 (m, 1H), 8.34 – 8.30 (m, 1H), 7.93 – 7.88 (m, 1H), 7.84 – 7.78 (m, 1H), 7.68 – 7.62 (m, 3H), 7.60 (s, 3H), 5.89 – 5.81 (m, 1H), 5.59 – 5.50 (m, 1H), 4.44 – 4.38 (m, 2H), 4.05 – 3.97 (m, 3H), 3.51 – 3.45 (m, 2H), 2.61 – 2.51 (m, 1H), 2.23 – 2.09 (m, 3H), 1.99 – 1.81 (m, 2H), 1.65 – 1.53 (m, 1H), 1.39 – 1.28 (m, 2H), 1.19 – 1.12 (m, 2H), 1.12 – 1.08 (m, 3H). MS(ESI) m/z: 587.5 (M+H)+. Analytical HPLC (Method A): RT = 5.33 min, purity = 96%; Factor XIa Ki = 5.5 nM, Plasma Kallikrein Ki = 140 nM.(9R, 135)- 13- {4- [3 -Chloro-2-fluoro-6-(trifluoromethyl)phenyl]-6-oxo- 1,2,3,6- tetrahydropyridin- 1 -yl} -9-methyl-4-(pyrimidin-5-yl)-3 ,4,7, 15 -tetraazatricyclo[ 12.3.1.026] octadeca- 1(1 8),2,5,14,1 6-pentaen-8-one trifluoroacetate (7.5 mg, 9.85 imol, 18% yield)was prepared according to the procedures described in Example 11 by substituting (2-bromoethoxy)Qert-butyl)dimethylsilane with 5-iodopyrimidine. ?H NMR (500MHz,DMSO-d6) oe 9.58 (s, 1H), 9.39 (s, 2H), 9.19 (s, 1H), 8.80 (s, 1H), 8.68 (d, J=4.9 Hz, 1H),7.85 (t, J=7.8 Hz, 1H), 7.76 (s, 1H), 7.70 (d, J=8.5 Hz, 1H), 7.60 (d, J=4.3 Hz, 1H), 7.266.97 (m, 1H), 5.92 (s, 1H), 5.71 (d, J=8.8 Hz, 1H), 3.97 (br. s., 1H), 3.67 (br. s., 1H), 3.443.36 (m, 1H), 2.73 (br. s., 1H), 2.19 (br. s., 1H), 2.06 (br. s., 1H), 1.76 (br. s., 1H), 1.56(br. s., 1H), 1.34 (br. s., 1H), 0.97 (d, J=6.7 Hz, 3H), 0.69 (br. s., 1H). MS(ESI) m/z:640.1 [M+H]. Analytical HPLC (Method B): RT = 1.84 mm, purity = 99.0%; Factor XIaKi = 5.4 nM, Plasma Kallikrein Ki = 13 nM.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 31462-58-5, 5-Iodopyrimidine.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; DILGER, Andrew, K.; CORTE, James, R.; DE LUCCA, Indawati; FANG, Tianan; YANG, Wu; WANG, Yufeng; PABBISETTY, Kumar Balashanmuga; EWING, William, R.; ZHU, Yeheng; WEXLER, Ruth, R.; PINTO, Donald, J.P.; ORWAT, Michael, J.; SMITH II, Leon, M.; WO2015/116882; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Reference of 31462-58-5, Adding some certain compound to certain chemical reactions, such as: 31462-58-5, name is 5-Iodopyrimidine,molecular formula is C4H3IN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31462-58-5.

General procedure: In a typical experiment, 0.75 mg (0.03 mol%) of 3 was added into a mixture of aryl halide (1.0 mmol), olefin (2 mmol), Et3N (3 mmol) in DMF (2 mL), and the reaction mixture was stirred at 130 C. The formation of coupling product was monitored byTLC/GC analyses. After disappeared of the aryl halide (checking by TLC/GC), the reaction mixture was cold at room temperature and diluted with water and ethyl acetate and the solid Pd(II) complex 3 was separated by filtration. The cross-coupling product was extracted from the aqueous layer with ethyl acetate (3 x 5 mL), dried over MgSO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (ethyl acetate/hexane) to give the corresponding cross-coupling product.

According to the analysis of related databases, 31462-58-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Sarkar, Shaheen M.; Rahman, Md. Lutfor; Chong, Kwok Feng; Yusoff, Mashitah Mohd; Journal of Catalysis; vol. 350; (2017); p. 103 – 110;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 14631-08-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 14631-08-4, name is 2-Chloropyrimidine-4,5-diamine. This compound has unique chemical properties. The synthetic route is as follows.

Step-2: 2-chloro-7H-purin-8(9H)-one [0177] To a solution of 2-chloropyrimidine-4,5-diamine (200 mg, 1.38 mmol) in anhydrous THF (25 mL) was added CDI (225 mg, 1.38 mmol) under N2. The reaction mixture was stirred at room temperature overnight. It was concentrated in vacuum and the residue was purified on ISCO (12 g silica gel column, EtOAc/hexanes 0~100%). The solid obtained was a mixture of the desired product and imidazole. It was dissolved in DCM, washed with 1N HCl (aq.) and water, dried (Na2SO4) and concentrated in vacuum to afford the title compound as a white solid (170 mg, 72%).

According to the analysis of related databases, 14631-08-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FORMA THERAPEUTICS, INC.; ASHWELL, Susan; CAMPBELL, Ann-Marie; CARAVELLA, Justin Andrew; DIEBOLD, R. Bruce; ERICSSON, Anna; GUSTAFSON, Gary; LANCIA, David R.; LIN, Jian; LU, Wei; WANG, Zhongguo; (147 pag.)WO2016/171755; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 890094-38-9, name is 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine. A new synthetic method of this compound is introduced below., HPLC of Formula: C7H9ClN4O2

4-amino-3-fluoro-N-(4-methylpiperidin-1-yl)benzamide(5.0g) was added to a solution of Compound 2-3(4.3g) in n-butanol(150ml). The mixture was reacted at 90C for 4.0 hours, cooled to room temperature, filtered, washed and dried to obtain a yellow solid(6.3g) in a yield of 72.8%. MS m/z(ESI): 432[M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 890094-38-9, 2-Chloro-N-isopropyl-5-nitropyrimidin-4-amine.

Reference:
Patent; Si Chuan University; CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.; YANG, Shengyong; WEI, Yuquan; EP2578584; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 31737-09-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 31737-09-4, name is 6-Chloro-1-methylpyrimidine-2,4(1H,3H)-dione. This compound has unique chemical properties. The synthetic route is as follows.

Intermediate 1 (300 mg, 1 eq.) and tetrahydropyrrole (930 ul, 6 eq.) were dissolved in 5 ml of absolute ethanol and stirred at 70 C for 0.5 h. After the mixture was cooled, the ethanol was distilled off and water was added. The mixture was extracted twice with dichloromethane, rinsed once with saturated brine, dried over magnesium sulfate, filtered and the solvent was evaporated to give 310 mg of intermediate 4a. MS (ESI): 196 (M+H)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 31737-09-4, 6-Chloro-1-methylpyrimidine-2,4(1H,3H)-dione.

Reference:
Patent; Shanghai Institute Of Materia Medica Chinese Academy of Sciences; SHEN, Jianhua; WANG, Yiping; CHEN, Xinde; XU, Wenwei; WANG, Kai; (84 pag.)EP3239135; (2017); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 69205-79-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 69205-79-4, name is 2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, molecular formula is C7H5N5O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

In a dry round bottomed flask under an atmosphere of argon, trityl chloride (1.20 g, 4.28 mmol) was added to a solution of 2-amino-4,7-dihydro-4-oxo-3A/- pyrrolo[2,3-d]pyrimidine-5-carbonitrile (0.50 g, 2.85 mmol) in dry pyridine (29 ml_). The mixture reaction was heated at 90 C for 48 h. The reaction mixture was concentrated under reduced pressure then absorbed on silica gel and purified by flash chromatography on silica gel eluting with dichloromethane/MeOH with a gradient starting at 2% of MeOH and rising to 10%. The desired compound was obtained as a brown solid (0.63 g, 1.5 mmol, 53% yield). Procedure based on Olgen 2008. deltaEta (400 MHz, DMSO-de) delta 11.80 (br s, 1H); 10.64 (br s, 1H), 7.56 (s, 1H), 7.41(s, 1H), 7.29-7.28 (m, 12H), 7.23-7.17 (m, 3H), 5.73 (s, 1H). HRMS (m/z ESI+) : C26Hi8N50 [M-H]+ Found 416.1514 Requires: 416.1511.

According to the analysis of related databases, 69205-79-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN; SOUTHERN, John, Michael; CONNON, Stephen, J.; (37 pag.)WO2016/50804; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13877-55-9, name is 7-Hydroxypyrazolo[4,3-d]pyrimidine. This compound has unique chemical properties. The synthetic route is as follows. category: pyrimidines

[0507] Procedure: To a stirred solution of 1H-pyrazolo[4,3-d]pyrimidin-7-ol (0.2 g, 1.47 mmol) in thionyl chloride (4.2 mL) were added DMF (0.2 mL). Reaction mixture was stirred for 1h at 90 oC. The Progress of the reaction was monitored by TLC. Reaction mixture was diluted with ethyl acetate (50 mL) washed with sat. sodium bicarbonate (30 mL) followed by brine (30mL), dried over anhydrous sodium sulphate, filtered and evaporated under reduced pressureto afford 7-chloro-1H-pyrazolo[4,3-d]pyrimidine as pale yellow solid (0.05 g, 22%). LC-MS (ES) m/z =168.9 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 13877-55-9.

Reference:
Patent; MAVUPHARMA, INC.; GALLATIN, William Michael; ODINGO, Joshua; DIETSCH, Gregory N.; FLORIO, Vincent; VENKATESHAPPA, Chandregowda; DURAISWAMY, Athisayamani Jeyaraj; (273 pag.)WO2019/46778; (2019); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia