Day: March 25, 2022

Reference of 38275-42-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 38275-42-2, name is 5-Chloro-2-(methylthio)pyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 39 2-Methylsulfinyl-5-chloropyrimidine A solution of 2-methylthio-5-chloropyrimidine (13 mmol) in chloroform (85 ml) was cooled to -20 C. and m-chloroperbenzoic acid (17 mmol) added with stirring. The mixture was stirred for 40 min at -20 C. and for 4 h at 0 C. and left at this temperature overnight. The chloroform solution was then washed with 1 M potassium carbonate (3*10 ml) and the dried (MgSO4) solution evaporated. The residual oily material crystallized on standing; yield 80% m.p. 48 C. (n-heptane). 1 H NMR (CDCl3): delta2.93 (Me), 8.83 (2H-4,6).

According to the analysis of related databases, 38275-42-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Nyegaard & Co. A/S; US4423047; (1983); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 25902-86-7, 2-Methoxypyrimidin-4(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 25902-86-7, blongs to pyrimidines compound. Safety of 2-Methoxypyrimidin-4(1H)-one

A mixture of 18 g (0.0779 m) of the 2-methoxypyrimidinone, 12.23 g (0.0779 m) of alpha-furylmethylthioethylamine and 50 ml of toluene was heated at reflux for 12 hours. Toluene (100 ml) was added to the cooled reaction mixture. The separated solid was washed with ethyl acetate and dried to give 20.69 g (74%) of 2-[[2-[(2-furylmethyl)thio]ethyl]amino]-5-[(6-methyl-3-pyridinyl)methyl]-4-(1H)-pyrimidinone. Recrystallization from isopropanol-water gave 14.51 g (52%), m.p. 147-152, of purified compound. Anal. Calcd. for C18 H20 N4 O2 S: C, 60.25; H, 5.65; N, 15.71; S, 8.99. Found: C, 60.29; H, 5.33; N, 15.43; S, 8.50.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,25902-86-7, its application will become more common.

Reference:
Patent; Smithkline Beckman Corporation; US4352933; (1982); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia