Month: March 2022

Related Products of 148-51-6. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Synthesis of aflatoxins by the non-growing mycelia of Aspergillus parasiticus and the effect of inhibitors. Author is Gupta, S. R.; Prasanna, H. R.; Viswanathan, L.; Venkitasubramanian, T. A..

Aflatoxins were synthesized by nongrowing mycelia of A. parasiticus, the amount and type (B or G) being dependent on the buffer used in the suspension medium. Incorporation of acetate-14C into aflatoxin was decreased by compounds that inhibit ATP production or interfere with the utilization of certain amino acids. In contrast, the specific activities of aflatoxins were increased by compounds that diverted acetate from metabolic pathways other than those leading to aflatoxin formation.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《4,5-Dihalo and 3-amino analogs of pyridoxine. New route to 4-deoxypyridoxine》. Authors are McCasland, G. E.; Gottwald, L. Kenneth; Furst, Arthur.The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Synthetic Route of C8H12ClNO2. Through the article, more information about this compound (cas:148-51-6) is conveyed.

Dihalo analogs of pyridoxine, expected to show good alkylating activity, were prepared as potential antitumor agents. SOCl2 (15.0 ml.) was added to 2.06 g. powd. dry pyridoxine hydrochloride (I), the mixture refluxed 1 hr., cooled to 0-25° for several days, filtered, and the crystals washed with C6H6, then with 10 ml. Me2CO, m. 140-90°. Recrystallization from absolute EtOH-C6H6 gave 1.6 g. needles. Dissolution in 25 ml. boiling absolute EtOH and treatment with 25 ml. hot C6H6 gave on cooling 0.9 g. 2-methyl-3-hydroxy-4,5-bis(chloromethyl)pyridine hydrochloride (II), m. 175-90° (decomposition), recrystallized from 10 ml. EtOH to yield 0.7 g. product, m.p. unchanged. I (6.2 g.) treated with 43.5 ml. SOCl2 but kept at 25° only 12 hrs. gave after washing with Me2CO 7.1 g. II, m. 185-95° (decomposition). The use of PCl5 in CCl4, or concentrated HCl, failed to yield pure II. I (21.4 g.) and 200 ml. 8.8M HBr was refluxed 15 min., cooled, filtered, and the solid washed with H2O and Me, CO to give 24.2 g. crystalline 2methyl-3-hydroxy-4,5-bis(bromomethyl)pyridine hydrobromide (III), m. 224-8° (decomposition). III (1.88 g.) was stirred with 0.463 g. NaHCO3 in 20 ml. H2O; the mixture turned pink, then red, and after 100 min. stirring was filtered. The solid was washed with H2O and dried to give 0.6 g. brown-red powder, m. above 325°. The pH of the filtrate was 2, indicating displacement of one or both Br atoms from BrCH2. The solid was insoluble at the boiling point in EtOH, H2O, or 6M HCl. I (2.06 g.) boiled with 67.2 g. 7.6M HI gave 1.3 g.2-methyl-3-hydroxy-4,5-bis(iodomethyl)pyridine hydriodide (IV), m. 120-60° (decomposition). III with NaI in Me2CO failed to give IV. 2-Methyl-3-amino-4,5-bis(hydroxymethyl)pyridine monohydrochloride (V), m. 195-7°, with 8.8M HBr gave 34% 2 methyl-3-amino4,5-bis(bromomethyl)pyridine hydrobromide, m. 220° (decomposition). When 1.0 g. V was boiled with 6.5 ml. 7.6M HI, iodine was liberated and one of the HOCH2 groups was reduced to Me to give 0.59 g. black crystalline mass, which was crystallized from absolute EtOH to yield light yellow 2,4-dimethyl-3-amino-5-(hydroxymethyl)pyridine hydriodide (VI), m. 190-6°, VI (50 mg.) was heated 5 min. with 43 mg. AgCl in 1.0 ml. H2O, the mixturefiltered to remove AgI, the filtrate acidified with 0.2 ml. 12M HCl, the acid solution treated with 23 mg. NaNO2 in 1.0 ml. H2O, and the mixture heated until N effervescence ceased (10-15 min.). The solution was vacuum-distilled to dryness, 0.5 ml. 12M HCl added to the residue, the distillation to dryness repeated, the residue extracted with 2.0 ml. absolute EtOH, cooled, and filtered. The filtrate was treated with Et2O and the separated crystals collected and dried to yield 10 mg. 4-deoxypyridoxine hydrochloride, m. 255° (decomposition). V (1.0 g.), 0.8 g. fused NaOAc, and 20 ml. Ac2O was boiled 20 min., the solvent removed by vacuum distillation, the residue extracted with 15 ml. CHCl3, the CHCl3 extract treated with C, and evaporated to give a brown oil, which was stirred with 2.0 ml. Et2O to yield 0.4 g. solid 2-methyl-3-acetamido-4,5-bis(acetoxymethyl)pyridine (VII), m. 103-1° (C6H6). VII (0.42 g.) in 12 ml. 0.5M NaOH was kept 2 hrs. at 20°, the clear solution adjusted to pH 6-7 by addition of HOAc, the solvent evaporated in vacuo, the residue extracted (Soxhlet) 24 hrs. with Me2CO, and the extract cooled to give 0.1 g. crystalline 2-methyl-3-acetamido-4,5-bis(hydroxymethyl)pyridine, m. 185-6°.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Methylfuran-2(3H)-one(SMILESS: O=C1OC(C)=CC1,cas:591-12-8) is researched.Synthetic Route of C4H4N2O. The article 《CuFe2O4 modified expanded graphite synthesized by urea-assisted hydrothermal method for tetracycline treatment through persulfate activation: Characterization, mechanism and degradation intermediates》 in relation to this compound, is published in Chemical Engineering Journal (Amsterdam, Netherlands). Let’s take a look at the latest research on this compound (cas:591-12-8).

Owing to the stable crystal structure and wide range of pH applications, CuFe2O4 particles have been intensively concerned in the field of advanced oxidation, but their serious agglomeration and slow catalytic efficiency are still the stumbling blocks. The composite catalyst (EG-CuFe2O4-U) prepared by urea-assisted hydrothermal method with expanded graphite (EG) as the substrate immobilized CuFe2O4 not only exposed more active sites but also exhibited a higher electron transfer rate. Addnl., EG-CuFe2O4-U showed excellent performance in degrading tetracycline (TC) in model wastewater by activated peroxydisulfate (PDS). The synthesis mechanism of EG-CuFe2O4-U and the principle of urea in the formation of reduction environment were discussed in detail by the exptl. results of key preparation parameters and characterization. Meanwhile, several critical influencing factors were examined including PDS concentration, catalyst dosage, initial pH of the solution, and the change of pH in different systems. Furthermore, the removal efficiency and mineralization efficiency of TC (50 ppm) exceed 91% and 34.6%, on the conditions of 0.4 gL-1 EG-CuFe2O4-U, 6 mM PDS, initial solution pH of 4, and room temperature What′s more, the internal reaction mechanism of free radicals and non-free radicals in the EG-CuFe2O4-U/PDS system was further elaborated via scavenging tests, ESR (EPR). Finally, based on twenty-one principal intermediates of TC, four possible degradation pathways were proposed. In general, the catalyst with a rich pore structure and high catalytic activity has great potential in the effective activation of PDS and is prospective to be further applied in the field of antibiotic wastewater degradation

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Jaffe, Israeli A.; Merryman, Parvin; Ehrenfeld, Ellie published an article about the compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride( cas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl ).Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:148-51-6) through the article.

Of a series of mercaptan compounds tested, only D-penicillamine [52-67-5] possessed antiviral activity against polio virus in tissue culture. D-penicillamine produced a marked inhibition in viral directed RNA and protein synthesis, which was not dependent upon vitamin B6 antagonism. The effect was completely reversible.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(SMILESS: OC1=C(C)C(CO)=CN=C1C.[H]Cl,cas:148-51-6) is researched.Reference of 5,5′-Dimethyl-2,2′-bipyridine. The article 《Separation and identification of water-soluble vitamins and vitamin B6 analogs》 in relation to this compound, is published in Yaowu Fenxi Zazhi. Let’s take a look at the latest research on this compound (cas:148-51-6).

Vitamin B12  [68-19-9], vitamin B1  [59-43-8], folic acid  [59-30-3], calcium pantothenate  [137-08-6], rutin  [153-18-4], vitamin C  [50-81-7], vitamin B2  [83-88-5], nicotinamide  [98-92-0], nicotinic acid  [59-67-6], p-aminobenzoic acid  [150-13-0], pyridoxal 5-phosphate  [54-47-7], pyridoxol-HCl  [58-56-0], pyridoxamine-2HCl  [524-36-7], pyridoxal-HCl  [65-22-5], and 4-deoxypyridoxol-HCl  [148-51-6] were identified by TLC (using various solvent systems), high-performance liquid chromatog., IR and UV spectrophotometry. Characteristics (Rf values, retention times, absorbances) of these compounds are tabulated.

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application In Synthesis of 4-Chloro-8-methylquinoline. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4-Chloro-8-methylquinoline, is researched, Molecular C10H8ClN, CAS is 18436-73-2, about A mild and efficient method for the preparation of 3-(2′-aminoaryl)pyrazoles from 4-chloroquinolines. Author is Borges, Julio C.; de Oliveira, Cesar D.; da Silva Pinheiro, Luiz C.; Marra, Roberta K. F.; Khan, Misbahul Ain; Wardell, James L.; Wardell, Solange M. S. V.; Bernardino, Alice M. R..

The authors described a mild and efficient method for the formation of 3-(2′-aminoaryl)pyrazoles in excellent yields from reactions of 4-chloroquinolines with hydrazine. These heterocyclic ring opening reactions occur under much milder conditions then previously described. The structures of the compounds were determined by spectral data and confirmed by x-ray diffraction anal. of 3-(2′-amino-3′-methylphenyl)pyrazole [monoclinic, C2, a 25.9750(3), b 9.5820(6), c 7.8299(7) Å, β 107.541(3)°, V 1858.2(2) Å3, Z 8].

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Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

HPLC of Formula: 148-51-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Investigation of related impurities in metadoxine by a reversed phase high performance liquid chromatography technique.

A new reversed-phase high-performance liquid chromatog. (RP-HPLC) method has been developed for the separation and identification of impurities present in metadoxine. Herein, we report that one of the impurities eluted from the metadoxine sample is 4-deoxypyridoxine hydrochloride (4-DPH). In HPLC anal., the retention time (RT) of 4-DPH was observed to be at 13.5 min in both the reference and metadoxine samples and the relative retention time (RRT) was 1.71. The presence of 4-DPH in a metadoxine sample was also confirmed by a chromatogram obtained by spiking the 4-DPH standard into the sample. Furthermore, the elution and mass of impurity 4-DPH in metadoxine was proven by LC-mass spectroscopy studies. This method highlights the presence of another unknown impurity that has so far not been observed in earlier methods of metadoxine evaluation. Hence, the developed method achieved superior resolution between metadoxine and impurities and thereby facilitates the production of a purer metadoxine drug.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Product Details of 148-51-6. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, is researched, Molecular C8H12ClNO2, CAS is 148-51-6, about Investigation of related impurities in metadoxine by a reversed phase high performance liquid chromatography technique. Author is Babu, Krishnan Suresh; Paradesi, Deivanayagam.

A new reversed-phase high-performance liquid chromatog. (RP-HPLC) method has been developed for the separation and identification of impurities present in metadoxine. Herein, we report that one of the impurities eluted from the metadoxine sample is 4-deoxypyridoxine hydrochloride (4-DPH). In HPLC anal., the retention time (RT) of 4-DPH was observed to be at 13.5 min in both the reference and metadoxine samples and the relative retention time (RRT) was 1.71. The presence of 4-DPH in a metadoxine sample was also confirmed by a chromatogram obtained by spiking the 4-DPH standard into the sample. Furthermore, the elution and mass of impurity 4-DPH in metadoxine was proven by LC-mass spectroscopy studies. This method highlights the presence of another unknown impurity that has so far not been observed in earlier methods of metadoxine evaluation. Hence, the developed method achieved superior resolution between metadoxine and impurities and thereby facilitates the production of a purer metadoxine drug.

Here is just a brief introduction to this compound(148-51-6)Product Details of 148-51-6, more information about the compound(5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, U.S. Gov’t, P.H.S., Journal of Biological Chemistry called Resonance Raman spectroscopy of pyridoxal Schiff bases, Author is Benecky, Michael J.; Copeland, Robert A.; Hays, Thomas R.; Lobenstine, Eric W.; Rava, Richard P.; Pascal, Robert A. Jr.; Spiro, Thomas G., which mentions a compound: 148-51-6, SMILESS is OC1=C(C)C(CO)=CN=C1C.[H]Cl, Molecular C8H12ClNO2, SDS of cas: 148-51-6.

Resonance Raman (RR) spectra are reported for amino acid and amine adducts of pyridoxal 5′-phosphate (PLP) and 5′-deoxypyridoxal (5′-dPL) in aqueous solution For the valine adducts, a detailed study was carried out on solutions at pH and pD 5, 9, and 13, values at which the pyridine and imine protons are successively ionized, and on the adducts formed from [15N]valine, α-deuterovaline, and N-methyl-PLP. Good quality spectra were obtained, despite the strong fluorescence of pyridoxal Schiff bases, by adding KI as a quencher, and by exciting the mols. on the blue side of their absorption bands: 406.7 nm (cw K+ laser) for the pH 5 and 9 species (λmax = 409 and 414 nm), and 354.7 nm (pulsed YAG laser, 3rd harmonic) for the pH 13 species (λmax = 360 nm). A prominent band at 1646 cm-1 was assigned to the imine C:N stretch via its 13 cm-1 15N shift. A 12 cm-1 downshift of the band in D2O confirmed that the Schiff base linkage is protonated at pH 9. Deprotonation at pH 13 shifted νC:N from 1646 to 1629 cm-1, values typical of conjugated Schiff bases. The strongest band in the spectrum, at 1338 cm-1, shifted to 1347 cm-1 upon pyridine protonation at pH 5, and was assigned to a ring mode with a large component of phenolate C-O stretch. A shoulder on its low-frequency side was assigned to the C4-C4′ stretch. Large enhancements of these modes could be understood qual. in terms of the dominant resonance structures contributing to the ground and resonant excited states. A number of weaker bands were observed, and assigned to pyridine ring modes. These modes gained significantly in intensity, and the exocyclic modes diminished, when the spectra were excited at 266 nm (YAG laser, 4th harmonic) in resonance with ring-localized electronic transitions.

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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The relation between iodine-131 metabolism, tumor growth, and regression》. Authors are Scott, Kenneth G.; Daniels, Marie B..The article about the compound:5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloridecas:148-51-6,SMILESS:OC1=C(C)C(CO)=CN=C1C.[H]Cl).Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride. Through the article, more information about this compound (cas:148-51-6) is conveyed.

Ability of tumors to alter the normal metabolic pathway of I131 and compounds labeled with it (iodide-trapping syndrome) (I) is characterized by higher than normal retention of I131 by skin, muscle, gastrointestinal tract, and plasma, and a lower than normal thyroid uptake and urinary excretion of I131. I was elicited in rats by isografts and homografts of a transmissible fibrosarcoma, but not by homoiografts (which regressed after 5-7 days of growth). The data suggest that local and systemic I parallels progressive tumor growth and is absent in tumor implants destined to regress.

Here is just a brief introduction to this compound(148-51-6)Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride, more information about the compound(5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia