Month: March 2022

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 101257-82-3, name is 4-Amino-5-chloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-Amino-5-chloropyrimidine

AA. [4-(2-Chloro-ethoxy)-3-methyl-pyridin-2-ylmethyl]-(5-chloro-pyrimidin-4-yl)-amine The compound is obtained analogously to Example K starting with ethylenglycol and 4-chloro-2,3-dimethyl-pyridine-N-oxide and reaction of 4-amino-5-chloro-pyrimidine with 4-(2-chloro-ethoxy)-2-chloromethyl-3-methyl-pyridine in the last step.

With the rapid development of chemical substances, we look forward to future research findings about 101257-82-3.

Reference:
Patent; BYK Gulden Lomberg Chemische Fabrik GmbH; US6395732; (2002); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60703-46-0, name is 2,4,6-Trichloro-5-methoxypyrimidine, molecular formula is C5H3Cl3N2O, molecular weight is 213.4491, as common compound, the synthetic route is as follows.Computed Properties of C5H3Cl3N2O

Step 3: Under an atmosphere of nitrogen a solution of 2,4,6-trichloro-5-methoxy- pyrimidine (4.0 g, 18.7 mmol) in DCM (200 mL) was cooled to 0C and treated with boron tribromide (neat, 6.6 mL, 65 mmol) dropwise. After stirring for 18 hours at room temperature LCMS analysis indicated complete reaction. The reaction mixture was cooled and carefully diluted with methanol (25 mL) and the reaction mixture diluted with water (200 mL). The aqueous layer was washed with DCM and the combined organic extracts dried (Na2S04) filtered and concentrated in vacuo to give 2,4,6-trichloro-5-hydroxy-pyrimidine as a pale tan solid (2.55 g, 71%). 13C NMR (DMSO-de): 149.23 (C), 145.25 (C), 145.08 (C). LCMS: RT= 2.65/2.77 [M- H]-= 197/199.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60703-46-0, 2,4,6-Trichloro-5-methoxypyrimidine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA-ROCHE AG; DOTSON, Jennafer; HEALD, Robert Andrew; HEFFRON, Timothy; JONES, Graham Elgin; KRINTEL, Sussie Lerche; MCLEAN, Neville James; NDUBAKU, Chudi; OLIVERO, Alan G.; SALPHATI, Laurent; WANG, Lan; WEI, BinQing; WO2012/82997; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 52854-14-5, name is 4-Chloro-6-methoxy-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 4-Chloro-6-methoxy-5-nitropyrimidine

b) 4-Methoxypyrimidin-5-amine10% Palladium on carbon (1 .10 g) was added to a solution of 4-chloro-6-methoxy-5- nitropyrimidine (Preparation 76a, 1 .97 g, 10.4 mmol) in ethanol (80 mL) and the reaction mixture was stirred at ambient temperature overnight under a hydrogen atmosphere at a pressure of 2 bars. The mixture was then filtered through Celite and the filter cake was washed with ethanol. The combined filtrate and washings were concentrated to give the title compound (1 .30 g, 100%) as a solid.LRMS (m/z): 126 (M+1 )+.1H NMR delta (300 MHz, DMSO-d6): 4.1 1 (s, 3H), 7.91 (s, 1 H), 8.59 (s, 1 H).

With the rapid development of chemical substances, we look forward to future research findings about 52854-14-5.

Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; GONZALEZ RODRIGUEZ, Jacob; GOMEZ CASTILLO, Elena; BACH TANA, Jordi; WO2012/160030; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Related Products of 259809-79-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.259809-79-5, name is tert-Butyl 7,8-dihydro-2-(methylsulfonyl)pyrido[4,3-d]pyrimidine-6(5H)-carboxylate, molecular formula is C13H19N3O4S, molecular weight is 313.3727, as common compound, the synthetic route is as follows.

Stage 4: tert-Butyl 2-(dimethylamino)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylateA mixture of tert-butyl 2-(methylsulfonyl)-7,8-dihydropyrido[4,3-d]pyrimidine-6(5H)-carboxylate (2.8 g, 8.95 mmol, 1.0 eq.), dimethylamine HCl (1.09 g, 13.42 mmol, 1.5 eq.) and DIPEA (4.37 ml, 25.56 mmol, 4.0 eq.) in NMP (6.5 ml) was stirred for 1 hour at 130° C. in a microwave.The reaction mixture was diluted with water (100 ml) and extracted with ethyl acetate (2*150 ml).The combined org.phases were washed with sat. NaCl solution (200 ml), dried over sodium sulfate, concentrated under reduced pressure and purified by column chromatography (silica gel, 18percent ethyl acetate in hexane). Yield: 78percent (1.95 g, 7.01 mmol)

The chemical industry reduces the impact on the environment during synthesis 259809-79-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; GRUENENTHAL GmbH; US2012/71461; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Adding a certain compound to certain chemical reactions, such as: 1618-36-6, 4-Chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C7H6ClN3, blongs to pyrimidines compound. Formula: C7H6ClN3

A. Preparation of 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine; Following the procedure in Pdulo, J. S.; Saxena, N. K.; Nassiri, M. R.; Turk, S. R.; Drach, J. C.; Townsend, L. B. J. Med. Chem. 31:2086 (1988), 4-chloro-5-methyl-7H-pyrrolo[2,3-d]pyrimidine (Example 1A, 20. g, 0.13 mol) was suspended in anhydrous dichloromethane (500 mL), followed by addition of N-chlorosuccinimide (20.8 g, 0.160 mol). The reaction mixture was refluxed at 43 C. for 8 hours. The reaction was cooled down, and the white solid was filtered, washed with dichloromethane (300 mL), and dried to give 4,5-dichloro-7H-pyrrolo[2,3-d]pyrimidine (20 g, 83%)

The synthetic route of 1618-36-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Rawlins, David Brent; Voronkov, Michael Victor; Zhang, Yulian; US2006/189638; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 313339-35-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.313339-35-4, name is 4,6-Dichloro-2-(methylthio)pyrimidine-5-carboxylic acid, molecular formula is C6H4Cl2N2O2S, molecular weight is 239.08, as common compound, the synthetic route is as follows.

A 50-mL 3 -necked round-bottom flask, purged and maintained with an inert atmosphere of nitrogen, was charged with a solution of 4,6-dichloro-2-(methylthio)pyrimidine-5-carboxylic acid (700 mg, 2.93 mmol, 1.50 equiv) and N,N-dimethylformamide (1 drop) in dichloromethane (10 mL). The solution was treated with oxalyl chloride (750 mg, 5.91 mmol, 3.00 equiv) dropwise with stirring, stirred for 2 h at room temperature and then treated with a solution of Intermediate 2 (800 mg, 1.97 mmol, 1.00 equiv) in dichloromethane (10 mL) and DIE A (2 mL) dropwise with stirring at 0 C. The resulting solution was stirred for an additional 1 h at room temperature, concentrated under vacuum and the residue was purified by chromatography on silica gel (1 : 10 ethyl acetate/petroleum ether) to afford the title compound as a colorless oil. HPLC/MS: 626 (M+H+); Rt 4.78 min (LC4).

The chemical industry reduces the impact on the environment during synthesis 313339-35-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; INTERVET INTERNATIONAL B.V.; GRAHAM, Thomas; SHEN, Dong-Ming; LIU, Wensheng; WU, Zhicai; NARGUND, Ravi, P.; DE VITA, Robert, J.; BALKOVEC, James, M.; YU, Yang; WO2013/68439; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 34415-10-6, name is 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid. A new synthetic method of this compound is introduced below., SDS of cas: 34415-10-6

6-Hydroxy-2-methylpyrimidine-4-carboxylic acid (5 g, 32.4 mmol) was added to phosphoryl trichloride (30 mL) at RT and the mixture was stirred at 105 C for 2 h. After cooling to RT, the solution wasconcentrated under reduced pressure. MeOH (30 mL) was added to the mixture dropwise at 0 C andthe solution was stirred for 16 h at RT. The solution was concentrated under reduced pressure. The resulting mixture was quenched by the addition of saturated aqueous sodium bicarbonate (50 mL) and the product was extracted with ethyl acetate (2 x 100 mL). The combined organic extracts were dried with anhydrous sodium sulfate and filtered. The title compound was obtained as a solid andwas used in the next step directly without further purification. MS = 183.1 (+ESI).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 34415-10-6, 2-Methyl-6-oxo-1,6-dihydropyrimidine-4-carboxylic acid.

Reference:
Patent; MERCK SHARP & DOHME CORP.; SHEN, Dong-Ming; WILSON, Jonathan, E.; MCCRACKEN, Troy; (95 pag.)WO2016/179059; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Application of 108-53-2 ,Some common heterocyclic compound, 108-53-2, molecular formula is C4H5N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

REFERENCE EXAMPLE 5 Production of 2-amino-5-bromo-4-hydroxypyrimidine To a solution of isocytosine (1.04 g, 9.36 mmol) in acetic acid (25 ml) are added dropwise bromine (0.51 ml, 9.83 mmol) at room temperature. After the addition is completed, the reaction mixture is stirred for 1 hour at this temperature, successively concentrated under reduced pressure to give the residue, which is washed with ethyl ether, dried to afford white powders(2.49 g, 98%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108-53-2, its application will become more common.

Reference:
Patent; Takeda Chemical Industries, Ltd.; US6194419; (2001); B1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13877-55-9, name is 7-Hydroxypyrazolo[4,3-d]pyrimidine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C5H4N4O

Compound 28: DMF (1.05 mL) was added to a solution containing 27 (1.0 g, 7.3 mmol) in thionyl chloride (21 mL). Heated the stirring solution to 90 C. for 1 hour. Cooled the homogeneous reaction mixture to room temperature. Concentrated to remove volatiles and diluted the reaction mixture with EtOAc followed by ice. Extracted the aqueous layer with EtOAc. Combined the organics, washed with saturated NaHCO3, dried with MgSO4, filtered and concentrated to afford 28 (0.73 g, 64%), ES (+) MS m/e=155.

The synthetic route of 13877-55-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sunesis Pharmaceuticals, Inc.; US2007/27166; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Electric Literature of 38275-43-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 38275-43-3, name is 2-(Methylthio)pyrimidine-5-carbonitrile. A new synthetic method of this compound is introduced below.

Reference Example 231 To a mixture of 4- [3- (methoxymethoxy) propyl]-3- (l-methylethyl)-lH-pyrazole (1.00 g), 2-methylthiopyrimidine-5- carbonitrile (0.80 g) and N, N-dimethylformamide (15 ml) was added sodium hydride (60%, in oil, 0.24 g) at0 C, and, after termination of hydrogen generation, the mixture was stirred at room temperature for2 hours. The reaction mixture was poured into water, and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried(MgS04) and concentrated. A mixture of the obtained residue,conc. hydrochloric acid (3 drops) and methanol (20 ml) was refluxed for 4 hours. The reaction mixture was poured into water, and extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried(MgS04) and concentrated. The residue was subjected to silica gel column chromatography, and2- [4- (3-hydroxypropyl)-3- (l-methylethyl)-lH-pyrazol-1-yl] pyrimidine-5-carbonitrile (450 mg, yield36%) was obtained as colorless crystals from a fraction eluted with ethyl acetate-chloroform (1: 4, volume ratio). melting point:153-154 C. H-NMR (CDC13) 5 : 1.38 (6H, d, J= 7. 0Hz), 1.44 (1H, t, J= 5.2Hz), 1.84-2. 00 (2H, m), 2.62 (2H, t, J= 7.8Hz), 3.10 (1H, septet, J= 7. 0Hz), 3.77 (2H, q, J= 5.9Hz), 8.31 (1H, s), 8.93 (2H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,38275-43-3, 2-(Methylthio)pyrimidine-5-carbonitrile, and friends who are interested can also refer to it.

Reference:
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2003/99793; (2003); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia