Day: April 11, 2022

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Thermal and Volumetric Properties of Five Lactones at Infinite Dilution in Water, published in 2019-04-11, which mentions a compound: 591-12-8, Name is 5-Methylfuran-2(3H)-one, Molecular C5H6O2, Reference of 5-Methylfuran-2(3H)-one.

Mixing enthalpies and densities of highly dilute aqueous solutions of five lactones (namely γ-butyrolactone (GBL), γ-valerolactone (GVL), α-angelica lactone (AAL), γ-hexalactone (GHL), and δ-hexalactone (DHL)) were measured as a function of solution composition at several temperatures in the range from (288.15 to 318.15) K using a tandem flow arrangement of isothermal mixing microcalorimeter and vibrating-tube densimeter. The densities of the neat lactones were measured, also. The dissolution of the lactones in water was exothermic (except for AAL at higher temperatures) and accompanied by volume contraction. On the basis of these systematic measurements, reliable values of partial molar excess enthalpy, partial molar volume, and partial molar excess volume of the studied solutes at infinite dilution in water were determined Precision of our measurements allowed us to evaluate with a good accuracy also resp. temperature derivative properties, i.e., infinite dilution partial molar excess heat capacity, expansion, and excess expansion. The observed thermodn. behavior was governed by hydrogen bonding of water mols. to the oxygen atoms of the lactone group. Several structural effects like those of the alkylation of lactone ring, its enlargement, the introduction of the double bond, and the lactone mol. volume on the determined properties were identified and rationalized on the mol. level.

Here is just a brief introduction to this compound(591-12-8)Reference of 5-Methylfuran-2(3H)-one, more information about the compound(5-Methylfuran-2(3H)-one) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Elucidation of surface active sites by formic acid adsorbed IR studies in the hydrogenation of levulinic acid to valeric acid over rare earth metal doped titania supported nickel catalysts, published in 2021-09-01, which mentions a compound: 591-12-8, Name is 5-Methylfuran-2(3H)-one, Molecular C5H6O2, Safety of 5-Methylfuran-2(3H)-one.

Titania supported Ni catalyst modified by different lanthanides (La, Ce, Pr and Nd) were evaluated for the one-step conversion of levulinic acid (LA) to valeric acid (VA) using formic acid as a hydrogen source. Among these, the La modified Ni/TiO2 demonstrated better VA yields with an optimum LA to VA mole ratio of 1:3. Pyridine and/or formic acid adsorbed IR studies revealed that presence of weak Lewis and strong basic sites present on the Ni-La/TiO2 surface was the reason for higher VA selectivity. The physicochem. characteristics of the modified Ni-M/TiO2 (M = La, Ce, Pr and Nd) catalysts deduced from H2-TPR, N2O titration, TPD of NH3 and catalytic activity data emphasized a combination of metallic Ni with surface acid-base sites were responsible for the formation of VA in single step. Using aqueous γ-valerolactone, 99% selectivity towards VA was achieved. A plausible reaction mechanism has been proposed based on the kinetic data obtained at moderate temperatures and ambient pressures.

Here is just a brief introduction to this compound(591-12-8)Safety of 5-Methylfuran-2(3H)-one, more information about the compound(5-Methylfuran-2(3H)-one) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of bicyclic N-arylmethyl-substituted iminoribitol derivatives as selective nucleoside hydrolase inhibitors, published in 2009-02-28, which mentions a compound: 18436-73-2, Name is 4-Chloro-8-methylquinoline, Molecular C10H8ClN, Category: pyrimidines.

The purine metabolism of Trypanosoma and Leishmania spp. provides a good target in the search for new selective drugs. Bicyclic N-arylmethyl-substituted iminoribitols were developed as inhibitors of T. vivax nucleoside hydrolase, a key enzyme of the purine salvage pathway. The obtained results and structure-activity data confirmed our model for inhibitor binding with a hydrogen bond between a nitrogen atom of the nucleobase mimetic and the protonated Asp40 from the enzyme. This interaction depends on an optimal pKa value, which can be influenced by the electronic properties of the substituents. These compounds are potent, selective inhibitors of nucleoside hydrolase and are inactive toward human nucleoside phosphorylase.

Here is just a brief introduction to this compound(18436-73-2)Category: pyrimidines, more information about the compound(4-Chloro-8-methylquinoline) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 591-12-8, is researched, Molecular C5H6O2, about 5-(Chloromethyl)furfural (CMF): A Platform for Transforming Cellulose into Commercial Products, the main research direction is chloromethylfurfural cellulose.Computed Properties of C5H6O2.

5-(Chloromethyl)furfural (CMF) is a carbohydrate-derived platform mol. that is gaining traction as a more practical alternative to 5-(hydroxymethyl)furfural (HMF). This perspective introduces the chemocatalytic approach to biorefining as the driving force behind the development of multifunctional chem. platforms. The main advantage of CMF over HMF is that it can be produced in high yield under mild conditions directly from raw biomass. Its stability and hydrophobicity markedly facilitate isolation. CMF is also a precursor to levulinic acid (LA), another versatile biobased intermediate. The logistics of CMF production are discussed, including reactor materials, HCl handling and management, byproducts, and the fate of collateral biomass components (hemicellulose, lipids, proteins, lignin). Examples of com. markets that can be unlocked by synthetic manipulation of CMF are broken out into two derivative manifolds, furanic and levulinic, which are distributed over three product family trees: renewable monomers, fuels, and specialty chems. Selected examples of CMF- and LA-based routes to these products are presented. Finally, a model for the integration of the CMF process into biorefinery practice is put forward.

Here is just a brief introduction to this compound(591-12-8)Computed Properties of C5H6O2, more information about the compound(5-Methylfuran-2(3H)-one) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridine, published in 1966, which mentions a compound: 148-51-6, mainly applied to , SDS of cas: 148-51-6.

2,4-Dimethyl- 3 – hydroxy-5- hydroxymethylpyridine (4- deoxypyridoxine) (I) was synthesized via the following intermediates: 2,4-dimethyl-5-cyano-6-pyridone (II), 2,4-dimethyl-3-nitro-5-cyano-6-pyridone (III), and 2,4-dimethyl-3-nitro-5-cyano-6-chloropyridine (IV). Reduction of IV was carried out in 1 step in dilute HCl over Pd-C. 2,4-Dimethyl-3-amino-5-aminomethylpyridine was converted without isolation to I by treatment with NaNO2. Thus, 33 ml. NH4OH (d20 0.9) was added with stirring to 40 g. EtO2CCH2CN, the mixture cooled with ice to 0-2° and the precipitate filtered off, washed at 0° with 20 ml. cold EtOH, and dried to yield 23.8 g. cyanoacetamide (V), m. 120-2°. The filtrate was evaporated to dryness to yield an addnl. 3.95 g. Acetylacetone (10.0 g.) was added at 70° to 8.4 g. V in 50 ml. MeOH and 1.12 ml. Me2NH to precipitate 88.1% II, m. 293.1-4.2°. A suspension of 4.44 g. II in 15 ml. Ac2O is treated with stirring with 2.3 ml. HNO3 (d20 1.4) and 2.3 ml. Ac2O at 35-40°, and the mixture stirred 2 hrs. at 18-20° and poured upon 23 g. crushed ice, to precipitate 56.4% yellow III, m. 272.0-2.6° (alc.). P2O5 (5.3 g.) is added to a suspension of 3.6 g. III in 36 ml. PhCl, the mixture heated with stirring 3 hrs. at 118-120° the solvent removed at 45-50°/10 mm., the residue treated with 3.6 ml. absolute alc., stirred, and left 8 hrs. at 0-4°, the precipitate filtered off, washed at 0° with 2 ml. alc., and dried, and the residue extracted with petr. ether (b. 60-70°) to give 62.2% yellow IV, m. 114-15°. IV (2.4 g.) in 25 ml. ice water was added to a pre-hydrogenated mixture of 0.10 g. PdCl2 with H2O, HCl, and C, the hydrogenation continued until the theoretical H absorption, the catalyst separated and washed with 2 ml. H2O, 2.4 ml. HCl (d20 1.18) added to the solution and washings, and the solution heated 1.5 hrs. at 80-5° during which 1.6 g. NaNO2 in 5 ml. H2O was added, the heating continued 30 more min. (neg. starch-iodide test), the solution evaporated in vacuo, the residue extracted with absolute alc., the extracts treated with activated C and concentrated until the appearance of crystals, the mixture kept 8 hrs. at 0-4°, and the precipitate filtered off, washed at 0° with 1 ml. alc., and dried to give 42.2% I, m. 256.1-7.2°.

Here is just a brief introduction to this compound(148-51-6)SDS of cas: 148-51-6, more information about the compound(5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 276684-04-9, is researched, SMILESS is O=C(C1=NNC(C2=CC=C(Cl)C(Cl)=C2)=C1)O, Molecular C10H6Cl2N2O2Journal, Phosphorus, Sulfur and Silicon and the Related Elements called Utility of β-(3,4-dichlorobenzoyl)-α-(phenylthio)propionic acid in heterocyclic synthesis, Author is Mahmoud, M. R.; Soliman, E. A.; Ibrahim, G. A.; Rabie, A. M., the main research direction is dichlorobenzoylphenylthiopropionic acid preparation reaction nucleophile.Category: pyrimidines.

β-(3,4-Dichlorobenzoyl)-α-(phenylthio)propionic acid (I) was prepared via the treatment of β-(3,4-dichlorobenzoyl)acrylic acid (II) with thiophenol in dry benzene. The reactivity of I and II with different nucleophilic reagents was investigated; the mass spectra of some products are discussed.

Here is just a brief introduction to this compound(276684-04-9)Category: pyrimidines, more information about the compound(5-(3,4-Dichlorophenyl)-1H-pyrazole-3-carboxylic acid) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Postgraduate Medical Journal, Supplement called Antiviral effect of D-penicillamine, Author is Jaffe, Israeli A.; Merryman, Parvin; Ehrenfeld, Ellie, which mentions a compound: 148-51-6, SMILESS is OC1=C(C)C(CO)=CN=C1C.[H]Cl, Molecular C8H12ClNO2, HPLC of Formula: 148-51-6.

Of a series of mercaptan compounds tested, only D-penicillamine [52-67-5] possessed antiviral activity against polio virus in tissue culture. D-penicillamine produced a marked inhibition in viral directed RNA and protein synthesis, which was not dependent upon vitamin B6 antagonism. The effect was completely reversible.

Here is just a brief introduction to this compound(148-51-6)HPLC of Formula: 148-51-6, more information about the compound(5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 35621-01-3, is researched, SMILESS is NC1CCNCC1.[H]Cl.[H]Cl, Molecular C5H14Cl2N2Journal, Journal of Heterocyclic Chemistry called The synthesis of a series of 7-amino-1-cyclopropyl-8-fluoro-1,4-dihydro-4-oxo-1,6-naphthyridine-3-carboxylic acids as potential antibacterial agents, Author is Sanchez, Joseph P.; Gogliotti, Rocco D., the main research direction is aminonaphthyridinecarboxylic acid preparation potential bactericide; Schiemann fluorination pyridyldiazonum salt.Related Products of 35621-01-3.

A series of title compounds I [R = 3-aminopyrrolidin-1-yl, 3-(ethylaminomethyl)pyrrolidin-1-yl, 4-aminopiperidin-1-yl, piperazin-1-yl] was prepared and evaluated for antibacterial activity (no data). I were prepared by the displacement of the chloro substituent from I (R = Cl) with the requisite nitrogen nucleophile. The naphthyridine acid was synthesized in ten steps from pyridinecarboxylate II (R1 = OH, R2 = NO2). The key step in the sequence was a Schiemann reaction of II (R1 = Cl, R2 = N2+ PF6-) to give II (R1 = Cl, R2 = F).

Here is just a brief introduction to this compound(35621-01-3)Related Products of 35621-01-3, more information about the compound(Piperidin-4-amine dihydrochloride) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Product Details of 591-12-8. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 5-Methylfuran-2(3H)-one, is researched, Molecular C5H6O2, CAS is 591-12-8, about Conversion of levulinic acid to γ-valerolactone over ultra-thin TiO2 nanosheets decorated with ultrasmall Ru nanoparticle catalysts under mild conditions. Author is Li, Shaopeng; Wang, Yanyan; Yang, Youdi; Chen, Bingfeng; Tai, Jing; Liu, Huizhen; Han, Buxing.

Herein, we demonstrate that quantum-sized Ru dot decorated ultra-thin anatase TiO2 nanosheets with exposed (001) facets could exhibit highly efficient catalytic activity during the conversion of levulinic acid to γ-valerolactone at room temperature The support effect has been largely attributed to the high energy of TiO2 (001) which can lead to a stronger interaction between the support and the metal. The surface of Ru/TiO2-n contains more Ru(0) and results in higher activity and selectivity.

Here is just a brief introduction to this compound(591-12-8)Product Details of 591-12-8, more information about the compound(5-Methylfuran-2(3H)-one) is in the article, you can click the link below.

Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia