Day: September 21, 2022

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Product Details of C4H3BrN2.

Firouzeh, Ebrahim;Kazemi, Foad;Gholinejad, Mohammad;Kaboudin, Babak research published 《 Visible photosensitized sonogashira-hagihara coupling through in situ prepared palladium catalyst in N,N-dimethylformamide under copper and amine-free additives》, the research content is summarized as follows. In this study, copper and amine-free photosensitized Sonogashira-Hagihara coupling reaction using Pd(OAc)₂ and p-nitrobenzophenone in N,N-dimethylformamide(DMF) under blue LED irradiation was reported. Effect of benzophenone, p-methoxybenzophenone and p-nitrobenzophenone as photosensitizers in Sonogashira-Hagihara reaction were studied in which higher yields were achieved using p-nitrobenzophenone. In situ preparation of palladium nanoparticles and the effect of p-nitrobenzophenone were confirmed using UV-Vis and dynamic light scattering (DLS). It was proposed that the DMF affected the formation and stabilization of palladium nanoparticles. Using this catalytic system, aryl iodides and bromides were reacted efficiently with alkynes between 25 and 60°C.

Product Details of C4H3BrN2, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., 4595-59-9.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. HPLC of Formula: 109-12-6.

Filho, Eclair Venturini;Pina, Jorge W. S.;Antoniazi, Mariana K.;Loureiro, Laiza B.;Ribeiro, Marcos A.;Pinheiro, Carlos B.;Guimaraes, Celina J.;de Oliveira, Fatima C. E.;Pessoa, Claudia;Taranto, Alex G.;Greco, Sandro J. research published 《 Synthesis, docking, machine learning and antiproliferative activity of the 6-ferrocene/heterocycle-2-aminopyrimidine and 5-ferrocene-1H-pyrazole derivatives obtained by microwave-assisted Atwal reaction as potential anticancer agents》, the research content is summarized as follows. A simple and fast methodol. under microwave irradiation for the synthesis of 2-aminopyrimidines I [R = H, H₂N, O₂N; R¹ = 2-thienyl, 2-phenyltriazol-4-yl, ferrocenyl, etc.] and pyrazole derivatives II [R² = H, H₂N, O₂N] using Atwal reaction was reported. After the optimization of the reaction conditions, eight 2-aminopyrimidines I containing ferrocene and heterocycles and three ferrocene pyrazoles II were synthesized from the resp. chalcones in good yields. Eight compounds had their structure determined by X-ray diffraction. The mol. hybrid I and II were tested on four cancer cell lines – HCT116, PC3, HL60 and SNB19 – where four pyrimidines I [R = H, R¹ = ferrocenyl; R = H₂N, R¹ = 2-phenyltriazol-4-yl; R = H, R¹ = 1H-pyrrol-2-yl, 2-thienyl] and one pyrazole derivative II [R² = H₂N] showed promising antiproliferative activity. In addition, docking simulation and machine learning methods were carried out to explain the biol. activity achieved by the synthesized compounds

HPLC of Formula: 109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., 109-12-6.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Quality Control of 2927-71-1.

Fensome, Andrew;Ambler, Catherine M.;Arnold, Eric;Banker, Mary Ellen;Brown, Matthew F.;Chrencik, Jill;Clark, James D.;Dowty, Martin E.;Efremov, Ivan V.;Flick, Andrew;Gerstenberger, Brian S.;Gopalsamy, Ariamala;Hayward, Matthew M.;Hegen, Martin;Hollingshead, Brett D.;Jussif, Jason;Knafels, John D.;Limburg, David C.;Lin, David;Lin, Tsung H.;Pierce, Betsy S.;Saiah, Eddine;Sharma, Raman;Symanowicz, Peter T.;Telliez, Jean-Baptiste;Trujillo, John I.;Vajdos, Felix F.;Vincent, Fabien;Wan, Zhao-Kui;Xing, Li;Yang, Xiaojing;Yang, Xin;Zhang, Liying research published 《 Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of ((S)-2,2-Difluorocyclopropyl)((1R,5S)-3-(2-((1-methyl-1H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841)》, the research content is summarized as follows. Cytokine signaling is an important characteristic of autoimmune diseases. Many pro-inflammatory cytokines signal through the Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) pathway. JAK1 is important for the γ-common chain cytokines, interleukin (IL)-6 and type-I interferon (IFN) family, while TYK2 in addition to type-I IFN signaling also plays a role in IL-23 and IL-12 signaling. Intervention with monoclonal antibodies (mAbs) or JAK1 inhibitors has demonstrated efficacy in Phase III psoriasis, psoriatic arthritis, inflammatory bowel disease and rheumatoid arthritis studies, leading to multiple drug approvals. It is hypothesized that a dual JAK1/TYK2 inhibitor will provide addnl. efficacy, while managing risk by optimizing selectivity against JAK2 driven hematopoietic changes. Our program began with a conformationally constrained piperazinyl-pyrimidine Type 1 ATP site inhibitor, subsequent work led to the discovery of PF-06700841 (compound 23), which is in Phase II clin. development (NCT02969018, NCT02958865, NCT03395184, and NCT02974868).

Quality Control of 2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., 2927-71-1.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U). Formula: C4HCl2FN2.

Fensome, Andrew;Ambler, Catherine M.;Arnold, Eric;Banker, Mary Ellen;Clark, James D.;Dowty, Martin E.;Efremov, Ivan V.;Flick, Andrew;Gerstenberger, Brian S.;Gifford, Roger S.;Gopalsamy, Ariamala;Hegen, Martin;Jussif, Jason;Limburg, David C.;Lin, Tsung H.;Pierce, Betsy S.;Sharma, Raman;Trujillo, John I.;Vajdos, Felix F.;Vincent, Fabien;Wan, Zhao-Kui;Xing, Li;Yang, Xiaojing;Yang, Xin research published 《 Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1》, the research content is summarized as follows. Herein, we disclose a new series of TYK2/ JAK1 inhibitors based upon a 3.1.0 azabicyclic substituted pyrimidine scaffold. We illustrate the use of structure-based drug design for the initial design and subsequent optimization of this series of compounds One advanced example 19 met program objectives for potency, selectivity and ADME, and demonstrated oral activity in the adjuvant-induced arthritis rat model.

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Formula: C4HCl2FN2

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 1722-12-9, formula is C4H3ClN2, Name is 2-Chloropyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Computed Properties of 1722-12-9.

Feckova, Michaela;Kahlal, Samia;Roisnel, Thierry;Saillard, Jean-Yves;Boixel, Julien;Hruzd, Mariia;le Poul, Pascal;Gauthier, Sebastien;Robin-le Guen, Francoise;Bures, Filip;Achelle, Sylvain research published 《 Cyclometallated 2-Phenylpyrimidine Derived Platinum Complexes: Synthesis and Photophysical Properties》, the research content is summarized as follows. A series of five platinum (II) complexes based on 2-phenylpyrimidine ligands have been designed. Pyridine and chloride were used as auxiliary ligands. These complexes exhibit a slightly distorted square-planar geometry. The nature and position of substituent on the Ph ring was thoroughly studied. The presence of an electron-donating substituent on the Ph ring in the para position of the platinum atom leads to a red shift of the lowest-energy absorption band, which corresponds to the HOMO→LUMO transition and permits to obtain phosphorescence in deoxygenated CH₂Cl₂ solution All compounds are emissive in the solid state with a significant red shift for complexes bearing electron-donating substituent on the Ph ring of phenylpyrimidine ligand.

1722-12-9, 2-Chloropyrimidine is a monochlorinated pyrimidine with plant growth regulating activity. Chloropyrimidine is a useful reagent in the preparation of antivirals and other biologically active compounds.
2-Chloropyrimidine undergoes cobalt-catalyzed cross-coupling reaction with aryl halides.
2-Chloropyrimidine is a molecule that can be synthesized by the oxidation of pyrimidine with hydrogen peroxide and hydrochloric acid. The reaction proceeds through an electrochemical process in which the oxidation catalyst is a platinum electrode. This reaction is catalyzed by the nucleophilic attack of malonic acid on the chloropyrimidine at the methylene group. This efficient method for making 2-chloropyrimidine has been applied to synthesize aryl halides, including phenyl chloropyrimidine and pyridyl chloropyrimidine, from their corresponding chloride and bromide precursors. The fluorescence properties of 2-chloropyrimidine have been studied in coordination chemistry, where it forms complexes with metal ions such as Mn2+. In this study, it was found that adsorption mechanisms are dependent on molecular size, charge density, kinetic energy, and adsorbent surface area., Computed Properties of 1722-12-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. 554-01-8, formula is C5H7N3O, Name is 4-Amino-5-methylpyrimidin-2(1H)-one. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Synthetic Route of 554-01-8.

Farshidfar, Farshad;Rhrissorrakrai, Kahn;Levovitz, Chaya;Peng, Cong;Knight, James;Bacchiocchi, Antonella;Su, Juan;Yin, Mingzhu;Sznol, Mario;Ariyan, Stephan;Clune, James;Olino, Kelly;Parida, Laxmi;Nikolaus, Joerg;Zhang, Meiling;Zhao, Shuang;Wang, Yan;Huang, Gang;Wan, Miaojian;Li, Xianan;Cao, Jian;Yan, Qin;Chen, Xiang;Newman, Aaron M.;Halaban, Ruth research published 《 Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis》, the research content is summarized as follows. Acral melanoma, the most common melanoma subtype among non-White individuals, is associated with poor prognosis. However, its key mol. drivers remain obscure. Here, we perform integrative genomic and clin. profiling of acral melanomas from 104 patients treated in North America (n = 37) or China (n = 67). We find that recurrent, late-arising focal amplifications of cytoband 22q11.21 are a leading determinant of inferior survival, strongly associated with metastasis, and linked to downregulation of immunomodulatory genes associated with response to immune checkpoint blockade. Unexpectedly, LZTR1 – a known tumor suppressor in other cancers – is a key candidate oncogene in this cytoband. Silencing of LZTR1 in melanoma cell lines causes apoptotic cell death independent of major hotspot mutations or melanoma subtypes. Conversely, overexpression of LZTR1 in normal human melanocytes initiates processes associated with metastasis, including anchorage-independent growth, formation of spheroids, and an increase in MAPK and SRC activities. Our results provide insights into the etiol. of acral melanoma and implicate LZTR1 as a key tumor promoter and therapeutic target.

Synthetic Route of 554-01-8, 5-Methylcytosine is a methylated form of the nucleobase cytosine occurring predominantly in cytosine-phosphate-guanine (CpG) islands that are produced by DNA methyltransferases and may regulate gene expression. Like cytosine, the DNA sequence containing 5-methylcytosine (5-mC) is able to be replicated without error and 5-mC can pair with guanine in double stranded DNA. However, DNA sequences containing a high local concentration of 5-mC may be less transcriptionally active than areas with higher ratios of unmodified cytosine.
5-Methylcytosine belongs to the class of organic compounds known as hydroxypyrimidines. These are organic compounds containing a hydroxyl group attached to a pyrimidine ring. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. 5-Methylcytosine exists as a solid, slightly soluble (in water), and a very weakly acidic compound (based on its pKa). Within the cell, 5-methylcytosine is primarily located in the cytoplasm. 5-Methylcytosine can be biosynthesized from cytosine. Outside of the human body, 5-methylcytosine can be found in tea. This makes 5-methylcytosine a potential biomarker for the consumption of this food product.
5-methylcytosine is a pyrimidine that is a derivative of cytosine, having a methyl group at the 5-position. It has a role as a human metabolite. It is a member of pyrimidines and a methylcytosine. It derives from a cytosine.
5-Methylcytosine is a nucleic acid that is found in the DNA and RNA of the cell. It is an important component of methylation, which is the process by which a methyl group is added to a molecule. This process can lead to cellular transformation, a process that can cause cancer. 5-Methylcytosine has also been shown as a molecular pathogenesis factor in infectious diseases such as HIV and herpes simplex virus type 1. The presence of 5-methylcytosine in nuclear DNA has been detected by analytical techniques such as gas chromatography/mass spectrometry (GC/MS). There are many analytical methods, including GC/MS, that can be used to detect 5-methylcytosine in cellular nuclei., 554-01-8.

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. The pyrimidine ring system has wide occurrence in nature as substituted and ring fused compounds and derivatives, including the nucleotides cytosine, thymine and uracil, thiamine (vitamin B1) and alloxan. Category: pyrimidines.

Farmer, Luc J.;Ledeboer, Mark W.;Hoock, Thomas;Arnost, Michael J.;Bethiel, Randy S.;Bennani, Youssef L.;Black, James J.;Brummel, Christopher L.;Chakilam, Ananthsrinivas;Dorsch, Warren A.;Fan, Bin;Cochran, John E.;Halas, Summer;Harrington, Edmund M.;Hogan, James K.;Howe, David;Huang, Hui;Jacobs, Dylan H.;Laitinen, Leena M.;Liao, Shengkai;Mahajan, Sudipta;Marone, Valerie;Martinez-Botella, Gabriel;McCarthy, Pamela;Messersmith, David;Namchuk, Mark;Oh, Luke;Penney, Marina S.;Pierce, Albert C.;Raybuck, Scott A.;Rugg, Arthur;Salituro, Francesco G.;Saxena, Kumkum;Shannon, Dean;Shlyakter, Dina;Swenson, Lora;Tian, Shi-Kai;Town, Christopher;Wang, Jian;Wang, Tiansheng;Wannamaker, M. Woods;Winquist, Raymond J.;Zuccola, Harmon J. research published 《 Discovery of VX-509 (Decernotinib): A Potent and Selective Janus Kinase 3 Inhibitor for the Treatment of Autoimmune Diseases》, the research content is summarized as follows. While several therapeutic options exist, the need for more effective, safe, and convenient treatment for a variety of autoimmune diseases persists. Targeting the Janus tyrosine kinases (JAKs), which play essential roles in cell signaling responses and can contribute to aberrant immune function associated with disease, has emerged as a novel and attractive approach for the development of new autoimmune disease therapies. We screened our compound library against JAK3, a key signaling kinase in immune cells, and identified multiple scaffolds showing good inhibitory activity for this kinase. A particular scaffold of interest, the 1H-pyrrolo[2,3-b]pyridine series (7-azaindoles), was selected for further optimization in part on the basis of binding affinity (K_i) as well as on the basis of cellular potency. Optimization of this chem. series led to the identification of VX-509 (decernotinib), a novel, potent, and selective JAK3 inhibitor, which demonstrates good efficacy in vivo in the rat host vs. graft model (HvG). On the basis of these findings, it appears that VX-509 offers potential for the treatment of a variety of autoimmune diseases.

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Category: pyrimidines

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 2927-71-1, formula is C4HCl2FN2, Name is 2,4-Dichloro-5-fluoropyrimidine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Quality Control of 2927-71-1.

Farmer, Luc J.;Clark, Michael P.;Boyd, Michael J.;Perola, Emanuele;Jones, Steven M.;Tsai, Alice;Jacobs, Marc D.;Bandarage, Upul K.;Ledeboer, Mark W.;Wang, Tiansheng;Deng, Hongbo;Ledford, Brian;Gu, Wenxin;Duffy, John P.;Bethiel, Randy S.;Shannon, Dean;Byrn, Randal A.;Leeman, Joshua R.;Rijnbrand, Rene;Bennett, Hamilton B.;O’Brien, Colleen;Memmott, Christine;Nti-Addae, Kwame;Bennani, Youssef L.;Charifson, Paul S. research published 《 Discovery of Novel, Orally Bioavailable β-Amino Acid Azaindole Inhibitors of Influenza PB2》, the research content is summarized as follows. In the authors’ efforts to develop novel small-mol. inhibitors for the treatment of influenza, the authors utilized mol. modeling and the x-ray crystal structure of the PB2 subunit of the influenza polymerase to optimize a series of acyclic β-amino acid inhibitors, highlighted by compound (R)-3-((5-fluoro-2-(5-fluoro-1H-pyrrolo[2,3-b]pyridm-3-yl)pyrimidin-4-yl)amino)-4,4-dimethylpentanoic acid (4). Compound 4 showed good oral exposure in both rat and mouse. More importantly, it showed strong potency vs. multiple influenza-A strains, including pandemic 2009 H1N1 and avian H5N1 strains and showed a strong efficacy profile in a mouse influenza model even when treatment was initiated 48 h after infection. Compound 4 offers good oral bioavailability with great potential for the treatment of both pandemic and seasonal influenza.

2927-71-1, 2,4-Dichloro-5-fluoropyrimidine is a useful research compound. Its molecular formula is C4HCl2FN2 and its molecular weight is 166.97 g/mol. The purity is usually 95%.
2,4-Dichloro-5-fluoropyrimidine is an aromatic hydrocarbon that has been shown to inhibit the growth of mouse tumor cells in vitro. It also inhibits the production of amines by reacting with industrial chemicals and sodium carbonate. This compound has potent inhibitory activity against autoimmune diseases and cytotoxic potency on mcf-7 cells. Furthermore, 2,4-Dichloro-5-fluoropyrimidine has been shown to have a chlorinating effect on cancer cells., Quality Control of 2927-71-1

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

Pyrimidine is a nitrogenous base similar to benzene (a six-membered ring) and includes cytosine, thymine, and uracil as bases used for DNA or RNA. 109-12-6, formula is C4H5N3, Name is Pyrimidin-2-amine. Pyrimidine also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. Reference of 109-12-6.

Farhid, Hassan;Shaabani, Ahmad research published 《 Magnetic spent coffee ground as an efficient and green catalyst for aerobic oxidation of alcohols and tandem oxidative Groebke-Blackburn-Bienayme reaction》, the research content is summarized as follows. Abstract: In this work, magnetic spent coffee ground as a green, inexpensive, and abundant material was synthesized and characterized by a variety of techniques, including X-ray diffraction pattern, thermal gravimetric anal., SEM, energy-dispersive spectroscopy, inductively coupled plasma optical emission spectrometry, and Fourier transform IR spectroscopy. The magnetic spent coffee ground was successfully utilized as a catalyst in aerobic oxidation of primary and secondary benzylic alcs. and tandem oxidative Groebke-Blackburn-Bienayme ́reaction. Graphic abstract: [graphic not available: see fulltext].

109-12-6, 2-Aminopyrimidine is a useful research compound. Its molecular formula is C4H5N3 and its molecular weight is 95.1 g/mol. The purity is usually 95%.
2-Aminopyrimidine is an organic compound that belongs to the group of pyridines. It has been shown to have antimicrobial, antitumor, and antiviral properties. 2-Aminopyrimidine has been used as a fungicide and herbicide in horticulture and agriculture, respectively. The molecular geometry of this molecule is octahedral with coordination geometry C2v. This chemical binds to the BCR-ABL kinase receptor and inhibits its activity by competitive inhibition of ATP binding. 2-Aminopyrimidine has been shown to have a hematologic response in vivo models and in vitro assays. It also has anti-inflammatory effects when it is taken orally or applied topically., Reference of 109-12-6

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia

The nomenclature of pyrimidines is straightforward. However, like other heterocyclics, tautomeric hydroxyl groups yield complications since they exist primarily in the cyclic amide form. 4595-59-9, formula is C4H3BrN2, Name is 5-Bromopyrimidine. For example, 2-hydroxypyrimidine is more properly named 2-pyrimidone. A partial list of trivial names of various pyrimidines exists. Electric Literature of 4595-59-9.

Faraggi, Tomer M.;Rouget-Virbel, Caroline;Rincon, Juan A.;Barberis, Mario;Mateos, Carlos;Garcia-Cerrada, Susana;Agejas, Javier;de Frutos, Oscar;MacMillan, David W. C. research published 《 Synthesis of enantiopure unnatural amino acids by metallaphotoredox catalysis》, the research content is summarized as follows. We describe herein a two-step process for the conversion of serine to a wide array of optically pure unnatural amino acids. This method utilizes a photocatalytic cross-electrophile coupling between a bromoalkyl intermediate and a diverse set of aryl halides to produce artificial analogs of phenylalanine, tryptophan, and histidine. The reaction is tolerant of a broad range of functionalities and can be leveraged toward the scalable synthesis of valuable pharmaceutical scaffolds via flow technol.

4595-59-9, 5-Bromopyrimidine is a reactive intermediate that is used in the synthesis of 4-methoxyphenylboronic acid. 5-Bromopyrimidine has been shown to be nucleophilic, reacting with β-amino acids under basic conditions to form the corresponding 2-bromo amide. It also undergoes cross-coupling reactions with halides and can be used as a building block for other organic compounds. 5-Bromopyrimidine has optical properties that are characteristic of aromatic molecules, including strong absorption bands in the ultraviolet region and visible light region.
5-Bromopyrimidine undergoes direct metallation with lithuium diisopropylamide to yield 4-lithio-5-bromopyrimidine., Electric Literature of 4595-59-9

Referemce:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia